Controlled-release/stable nitrogen(N)fertilizers can improve vegetable yields and achieve lower greenhouse gas emissions,resulting in cost-effective and environmentally friendly vegetable production.However,there has ...Controlled-release/stable nitrogen(N)fertilizers can improve vegetable yields and achieve lower greenhouse gas emissions,resulting in cost-effective and environmentally friendly vegetable production.However,there has been limited research on the controlled-release/stable N fertilization in long-term fixed-position vegetable rotation fields.In this study,a five-year field experiment was conducted to examine the effects of long-term controlled-release/stable N fertilization in reducing greenhouse gas emissions and increasing lettuce yield.Six distinct treatments were employed for N fertilization:the control without N fertilizer(CK),normal local farming practices with application of urea fertilizer at 400 kg N ha^(-1)(T1),optimized application of urea at 320 kg N ha^(-1)(T2),optimized application of urea at 320 kg N ha^(-1)with supplementation of 1.0 kg ha^(-1)3,4-dimethylpyrazole phosphate(DMPP)as N inhibitor(T3),application of polyurethane-coated urea at 320 kg N ha^(-1)(T4),and application of polyurethane-coated urea at 320 kg N ha^(-1)with supplementation of 1.0 kg ha^(-1)DMPP(T5).The results showed that the T3,T4,and T5 treatments using controlled-release/stable N fertilization emitted about 12.2%-56.7%less average annual cumulative nitrous oxide(N_(2)O)and 1.31%-10.0%less carbon dioxide(CO_(2))than the T2 treatment.Nitrous oxide and CO_(2)emissions from the T4 and T5 treatments were considerably lower than those from the T3 treatment.No significant seasonal or interannual variability was observed in N_(2)O and CO_(2)emissions.The observed phenomena were attributed to the fluctuations in soil ammonium-and nitrate-N contents.The findings in this study revealed that long-term controlled-release/stable N fertilization resulted in reduced field N loss,benefitting vegetable yields without increasing CO_(2)emissions and highlighting the application potential of this technique for sustainable agricultural production.展开更多
This is an erratum to the published paper titled,“High expression of autophagyrelated gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer.”We have removed the citations to ce...This is an erratum to the published paper titled,“High expression of autophagyrelated gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer.”We have removed the citations to certain articles in subsequent revisions of the manuscript.However,owing to our oversight,the citation marker in the upper right corner was not removed.We apologize for any confusion this may have caused.展开更多
Coarse columnar β grains result in anisotropic mechanical properties in Ti alloys deposited by additive manufacturing. This study reports that Ti-6Al-4V alloy fabricated by coaxial electron beam wire feeding additive...Coarse columnar β grains result in anisotropic mechanical properties in Ti alloys deposited by additive manufacturing. This study reports that Ti-6Al-4V alloy fabricated by coaxial electron beam wire feeding additive manufacturing presents a weak anisotropy, high strength and ductility. The superior tensile property arises from a microstructure with fine equiaxed β grains(EGβ), discontinuous grain boundary α phase and short intragranular α lamellae. A large region of fine EGβ arises from a special combination of the temperature gradient and solidification rate, and attractive α morphology is caused by solid phase transformations during interpass thermal cycling and post heat treatments.展开更多
Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-c...Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.展开更多
At present,replacing the liquid electrolyte in a lithium metal battery with a solid electrolyte is considered to be one of the most powerful strategies to avoid potential safety hazards.Composite solid electrolytes(CP...At present,replacing the liquid electrolyte in a lithium metal battery with a solid electrolyte is considered to be one of the most powerful strategies to avoid potential safety hazards.Composite solid electrolytes(CPEs)have excellent ionic conductivity and flexibility owing to the combination of functional inorganic materials and polymer solid electrolytes(SPEs).Nevertheless,the ionic conductivity of CPEs is still lower than those of commercial liquid electrolytes,so the development of high-performance CPEs has important practical significance.Herein,a novel fast lithium-ion conductor material LiTa_(2)PO_(8) was first filled into poly(ethylene oxide)(PEO)-based SPE,and the optimal ionic conductivity was achieved by filling different concentrations(the ionic conductivity is 4.61×10^(-4)S/cm with a filling content of 15 wt%at 60℃).The enhancement in ionic conductivity is due to the improvement of PEO chain movement and the promotion of LiTFSI dissociation by LiTa_(2)PO_(8).In addition,LiTa_(2)PO_(8) also takes the key in enhancing the mechanical strength and thermal stability of CPEs.The assembled LiFePO_(4) solid-state lithium metal battery displays better rate performance(the specific capacities are as high as 157.3,152,142.6,105 and 53.1 mAh/g under0.1,0.2,0.5,1 and 2 C at 60℃,respectively)and higher cycle performance(the capacity retention rate is86.5%after 200 cycles at 0.5 C and 60℃).This research demonstrates the feasibility of LiTa_(2)PO_(8) as a filler to improve the performance of CPEs,which may provide a fresh platform for developing more advanced solid-state electrolytes.展开更多
A novel and sensitive HPLC-UV method has been developed for the simultaneous determination of twelve major compounds in Longdan Xiegan Pill.The chemical profile of the twelve compounds,including geniposidic acid（1）,...A novel and sensitive HPLC-UV method has been developed for the simultaneous determination of twelve major compounds in Longdan Xiegan Pill.The chemical profile of the twelve compounds,including geniposidic acid（1）,geniposide（2）,gentiopicroside（3）,liquiritin（4）,crocin（5）,baicalin（6）,wogonoside（7）,baicalein（8）,glycyrrhizic acid（9）,wogonin（10）,oroxylin A（11）and aristolochic acid A（12）,was acquired using high-performance liquid chromatography-diode array detector coupled with an electrospray tandem mass spectrometer（HPLC-DAD-ESI-MS）.The analysis was performed on a Dikma Platisil ODS C18 column（250 mm×4.6 mm,5 μm）with a gradient solvent system of acetonitrile-0.1% aqueous formic acid.The validation was carried out and the linearities（r〉0.9996）,repeatability（RSD〈1.8%）,intra-and inter-day precision（RSD〈1.3%）,and recoveries（ranging from 96.6% to 103.4%）were acceptable.The limits of detection（LOD）of these compounds ranged from 0.29 to 4.17 ng.Aristolochic acid A,which is the toxic ingredient,was not detected in all the batches of Longdan Xiegan Pill.Furthermore,hierarchical cluster analysis was used to evaluate the variation of the herbal prescription.The proposed method is simple,effective and suitable for the quality control of this traditional Chinese medicine（TCM）.展开更多
The emergency of high-power electrical appliances has put forward higher requirements for the power density of lithium-ion batteries.Vanadium oxides with large theoretical capacities and high operating voltages are co...The emergency of high-power electrical appliances has put forward higher requirements for the power density of lithium-ion batteries.Vanadium oxides with large theoretical capacities and high operating voltages are considered as prospective alternatives for the cathode of a new generation of lithium-ion batteries.However,the poor rate and cycling performance caused by the sluggish electrons/lithium transportation,irreversible phase changes,vanadium dissolution and large volume changes during the repeated lithium intercalation/deintercalation hinder their commercial development.Several optimizing routes have been carried out and extensively explored to address these problems.Taking V_(2)O_(5),VO_(2)(B),V_(6)O_(13),and V_(2)O_(3)as examples,this article reviewed their crystal structures and lithium storage reactions.Besides,recent progress in modification methods for the electrochemical insufficiencies of vanadium oxides,including nanostructure,heterogeneous atom doping,composite and self-supported electrodes has been systematically summarized and finally,the challenges for the industrialization of vanadium oxide cathodes and their development opportunities are proposed.展开更多
A fundamental problem in the direct manufacturing of flexible devices is the low melting temperature of flexible substrates,which hinders the development of flexible electronics.Proposed here is an electron-cyclotron-...A fundamental problem in the direct manufacturing of flexible devices is the low melting temperature of flexible substrates,which hinders the development of flexible electronics.Proposed here is an electron-cyclotron-resonance sputtering system that can batch-fabricate devices directly on flexible substrates under a low temperature by virtue of the polariton energy transfer between the plasma and the material.Flexible graphene nanosheet-embedded carbon(F-GNEC)films are manufactured directly on polyimide,polyethylene terephthalate,and polydimethylsiloxane,and how the substrate bias(electron energy),microwave power(plasma flux and energy),and magnetic field(electron flux)affect the nanostructure of the F-GNEC films is investigated,indicating that electron energy and flux contribute to the formation of standing graphene nanosheets in the film.The films have good uniformity of distribution in a large size(17 mm×17 mm),and tensile and angle sensors with a high gauge factor(0.92)and fast response(50 ms)for a machine hand are obtained by virtue of the unique nanostructure of the F-GNEC film.This work sheds light on the quantum manufacturing of carbon sensors and its applications for intelligent machine hands and virtual-reality technology.展开更多
Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatos...Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatosteatosis.Oridonin(ORI)is a major bioactive component extracted from the traditional Chinese medicinal herb Rabdosia rubescens.In this paper,we showed that ORI exerted significant protective effects against hepatic steatosis,inflammation and fibrosis,which was dependent on LXRa signaling.It is reported that LXRa regulated lipid homeostasis between triglyceride(TG)and phosphatidylethanolamine(PE)by promoting ATGL and EPT1 expression.Therefore,we implemented the lipidomic strategy and luciferase reporter assay to verify that ORI contributed to the homeostasis of lipids via the regulation of the ATGL gene associated with TG hydrolysis and the EPT1 gene related to PE synthesis in a LXRadependent manner,and the results showed the TG reduction and PE elevation.In detail,hepatic TG overload and lipotoxicity were reversed after ORI treatment by modulating the ATGL and EPT1 genes,respectively.Taken together,the data provide mechanistic insights to explain the bioactivity of ORI in attenuating TG accumulation and cytotoxicity and introduce exciting opportunities for developing novel natural activators of the LXRa-ATGL/EPT1 axis for pharmacologically treating hepatosteatosis and metabolic disorders.展开更多
BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical...BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.展开更多
This study used specularite, a high-gradient magnetic separation concentrate, as a raw material in reverse flotation.An iron concentrate with a grade of 65.1 wt% and a recovery rate of 75.31% were obtained.A centrifug...This study used specularite, a high-gradient magnetic separation concentrate, as a raw material in reverse flotation.An iron concentrate with a grade of 65.1 wt% and a recovery rate of 75.31% were obtained.A centrifugal concentrator served as the deep purification equipment for the preparation of iron oxide red pigments, and its optimal rotating drum speed, feed concentration, and other conditions were determined.Under optimal conditions, a high-purity iron oxide concentrate with a grade of 69.38 wt% and a recovery rate of 80.89% were obtained and used as a raw material for preparing iron oxide red pigment.Calcining with sulfuric acid produced iron red pigments with different hues.Simultaneously, middlings with a grade of 60.20 wt% and a recovery rate of 17.51% were obtained and could be used in blast furnace ironmaking.High-value utilization of specularite beneficiation products was thus achieved.展开更多
BACKGROUND Breast cancer(BC) remains a public health problem. Tamoxifen(TAM) resistance has caused great difficulties for treatment of BC patients. Eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP...BACKGROUND Breast cancer(BC) remains a public health problem. Tamoxifen(TAM) resistance has caused great difficulties for treatment of BC patients. Eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) plays critical roles in the tumorigenesis and progression of BC. However, the expression and mechanism of EIF4EBP1 in determining the efficacy of TAM therapy in BC patients are still unclear.AIM To investigate the expression and functions of EIF4EBP1 in determining the efficacy of TAM therapy in BC patients.METHODS High-throughput sequencing data of breast tumors were downloaded from the Gene Expression Omnibus database. Differential gene expression analysis identified EIF4EBP1 to be significantly upregulated in cancer tissues. Its prognostic value was analyzed. The biological function and related pathways of EIF4EBP1 was analyzed. Subsequently, the expression of EIF4EBP1 was determined by real-time reverse transcription polymerase chain reaction and western blotting. Cell Counting Kit-8 assays, colony formation assay and wound healing assay were used to understand the phenotypes of function of EIF4EBP1.RESULTS EIF4EBP1 was upregulated in the TAM-resistant cells, and EIF4EBP1 was related to the prognosis of BC patients. Gene Set Enrichment Analysis showed that EIF4EBP1 might be involved in Hedgehog signaling pathways. Decreasing the expression of EIF4EBP1 could reverse TAM resistance, whereas overexpression of EIF4EBP1 promoted TAM resistance.CONCLUSION This study indicated that EIF4EBP1 was overexpressed in the BC and TAM-resistant cell line, which increased cell proliferation, invasion, migration and TAM resistance in BC cells.展开更多
To deal with the expected diversification on traffic types, the fundamental waveform of the upcoming5 G standard must be sufficiently flexible. In the 4th generation wireless networks(e.g., cellular LTE and Wi- Fi802....To deal with the expected diversification on traffic types, the fundamental waveform of the upcoming5 G standard must be sufficiently flexible. In the 4th generation wireless networks(e.g., cellular LTE and Wi- Fi802.11ac), orthogonal frequency division multiplexing(OFDM) has been widely adopted to combat frequency selectivity and thus improve the spectrum efficiency. Holding various advantages such as backward compatibility with LTE, ease of hardware implementation, time-localized low-latency transmission and straightforward combination with multi-antenna transmission, OFDM will remain as an important waveform candidate for 5G. However,OFDM alone appears to be insufficient in terms of the requirements faced by 5G waveform, such as high flexibility to accommodate different waveform numerologies for an efficient support of diversified traffic types and channel characteristics. In this work, we present a new waveform format, named as filtered-OFDM(f-OFDM) and illustrate its potential and benefits for serving as the underlying waveform of 5G.展开更多
Vegetable soils with high nitrogen input are major sources of nitrous oxide(N_(2)O)and nitric oxide(NO),and incorporation of the nitrification inhibitor 3,4-dimethylpyrazole phosphate(DMPP)into soils has been document...Vegetable soils with high nitrogen input are major sources of nitrous oxide(N_(2)O)and nitric oxide(NO),and incorporation of the nitrification inhibitor 3,4-dimethylpyrazole phosphate(DMPP)into soils has been documented to effectively reduce emissions.However,the efficiency of DMPP in terms of soil N_(2)O and NO mitigations varies greatly depending on soil temperature and moisture levels.Thus,further evaluations of DMPP efficiency in diverse environments are required to encourage widespread application.A laboratory incubation study(28 d)was established to investigate the interactive effects of DMPP,temperature(15,25,and 35?C),and soil moisture(55% and 80% of water-holding capacity(WHC))on net nitrification rate,N_(2)O and NO productions,and gene abundances of nitrifiers and denitrifiers in an intensive vegetable soil.Results showed that incubating soil with 1%DMPP led to partial inhibition of the net nitrification rate and N_(2)O and NO productions,and the reduction percentage of N_(2)O production was higher than that of NO production(69.3%vs.38.2%)regardless of temperature and soil moisture conditions.The increased temperatures promoted the net nitrification rate but decreased soil N_(2)O and NO productions.Soil moisture influenced NO production more than N_(2)O production,decreasing with the increased moisture level(80%).The inhibitory effect of DMPP on cumulative N_(2)O and NO productions decreased with increased temperatures at 55%WHC.Conversely,the inhibitory effect of DMPP on cumulative N_(2)O production increased with increased temperatures at 80%WHC.Based on the correlation analyses and automatic linear modeling,the mitigation of both N_(2)O and NO productions from the soil induced by DMPP was attributed to the decreases in ammonia-oxidizing bacteria(AOB)amoA gene abundance and NO_(2)^(-)-N concentration.Overall,our study indicated that DMPP reduced both N_(2)O and NO productions by regulating the associated AOB amoA gene abundance and NO_(2)^(-)-N concentration.These findings improve our insights regarding the implications of DMPP for N_(2)O and NO mitigations in vegetable soils under various climate scenarios.展开更多
It has been reported that C-type lectins(CTLs),which are pattern recognition receptors of the insect innate immunity response,may compete with Cry toxin for the receptor alkaline phosphatase to decrease its toxicity i...It has been reported that C-type lectins(CTLs),which are pattern recognition receptors of the insect innate immunity response,may compete with Cry toxin for the receptor alkaline phosphatase to decrease its toxicity in insects.However,to date,which CTLs affect larval susceptibility to Bt in Spodoptera exigua is not clear.In this study,33 CTL genes were identified from S.exigua.Based on the number of carbohydrate-recognition domains(CRDs)and the domain architectures,they were classified into three groups:(1)nineteen CTL-S(single-CRD),(2)eight immulectin(dual-CRD)and(3)six CTL-X(CRD with other domains).RT-qPCR analysis revealed that expression levels of SeCTL-S15,IML-4 and CTL-X6 were upregulated after challenge with Bt and Cry1Ab.Tissue and developmental stage expression analysis showed that only SeCTL-S15 was mainly expressed in the midgut and larva,respectively.Knockdown of SeCTL-S15 significantly increased Bt susceptibility,as indicated by reduced survival and larval weight.These results suggest that CTL-S15 might play a vital role in the low susceptibility of larvae to Bt in S.exigua.Our results provide new insights into CTL function in insects.展开更多
Correction:Natural Products and Bioprospecting(2024)14:33 https://doi.org/10.1007/s13659-024-00455-x Following publication of the original article[1],the authors reported that the original version of this article unfo...Correction:Natural Products and Bioprospecting(2024)14:33 https://doi.org/10.1007/s13659-024-00455-x Following publication of the original article[1],the authors reported that the original version of this article unfortunately contained mistakes.Page 1,section“Abstract”,the originally published texts were:Despite low bioavailability(0.024%),N-hydap exhibited a higher distribution in the lungs(26.26%),accounting for its efficacy against SCLC.展开更多
N-Hydroxyapiosporamide(N-hydap),a marine product derived from a sponge-associated fungus,has shown promising inhibitory effects on small cell lung cancer(SCLC).However,there is limited understanding of its metabolic p...N-Hydroxyapiosporamide(N-hydap),a marine product derived from a sponge-associated fungus,has shown promising inhibitory effects on small cell lung cancer(SCLC).However,there is limited understanding of its metabolic pathways and characteristics.This study explored the in vitro metabolic profiles of N-hydap in human recombinant cytochrome P450s(CYPs)and UDP-glucuronosyltransferases(UGTs),as well as human/rat/mice microsomes,and also the pharmacokinetic properties by HPLC-MS/MS.Additionally,the cocktail probe method was used to investigate the potential to create drug-drug interactions(DDIs).N-Hydap was metabolically unstable in various microsomes after 1 h,with about 50%and 70%of it being eliminated by CYPs and UGTs,respectively.UGT1A3 was the main enzyme involved in glucuronidation(over 80%),making glucuronide the primary metabolite.Despite low bioavailability(0.024%),N-hydap exhibited a higher distribution in the lungs(26.26%),accounting for its efficacy against SCLC.Administering N-hydap to mice at normal doses via gavage did not result in significant toxicity.Furthermore,N-hydap was found to affect the catalytic activity of drug metabolic enzymes(DMEs),particularly increasing the activity of UGT1A3,suggesting potential for DDIs.Understanding the metabolic pathways and properties of N-hydap should improve our knowledge of its drug efficacy,toxicity,and potential for DDIs.展开更多
The muscular system plays a critical role in the human body by governing skeletal movement,cardiovascular function,and the activities of digestive organs.Additionally,muscle tissues serve an endocrine function by secr...The muscular system plays a critical role in the human body by governing skeletal movement,cardiovascular function,and the activities of digestive organs.Additionally,muscle tissues serve an endocrine function by secreting myogenic cytokines,thereby regulating metabolism throughout the entire body.Maintaining muscle function requires iron homeostasis.Recent studies suggest that disruptions in iron metabolism and ferroptosis,a form of iron-dependent cell death,are essential contributors to the progression of a wide range of muscle diseases and disorders,including sarcopenia,cardiomyopathy,and amyotrophic lateral sclerosis.Thus,a comprehensive overview of the mechanisms regulating iron metabolism and ferroptosis in these conditions is crucial for identifying potential therapeutic targets and developing new strategies for disease treatment and/or prevention.This review aims to summarize recent advances in understanding the molecular mechanisms underlying ferroptosis in the context of muscle injury,as well as associated muscle diseases and disorders.Moreover,we discuss potential targets within the ferroptosis pathway and possible strategies for managing muscle disorders.Finally,we shed new light on current limitations and future prospects for therapeutic interventions targeting ferroptosis.展开更多
Rice yield in the black soil region of Northeast China has been declining due to severe soil fertility degradation caused by both biotic and abiotic factors.Artificial humic substance(A-HS)has attracted much attention...Rice yield in the black soil region of Northeast China has been declining due to severe soil fertility degradation caused by both biotic and abiotic factors.Artificial humic substance(A-HS)has attracted much attention due to its high cost-effectiveness and great potential to improve soil fertility.However,the specific effects of A-HS on nutrient contents in rice nursery soils remain unclear.This study systematically investigated the effects of rational application of A-HS on soil nutrient turnover and yield and analyzed the changes in soil nutrients and microbial communities at Qianfeng Farm,Northeast China.The results indicated that the application of A-HS significantly increased soil dissolved organic matter and nutrient contents in the native and seedling soils.In addition,the root growth and yield of the seedlings at maturity were effectively promoted.More interestingly,the application of A-HS significantly altered plant growth-promoting rhizobacteria,such as Noviherbaspirillum,Klebsiella,and Pedobacter,improving natural barrier formation and soil nutrient conversion.It could be concluded that A-HS significantly enhanced crop nutrient uptake and accumulation by altering soil bacterial communities.In general,the application of A-HS could be profitable and sustainable in rice production.The current study from multiple aspects provides valuable insights into the benefits of A-HS in promoting crop growth and development,which could have important implications for agriculture and food security.展开更多
基金supported by the Natural Science Foundation of Shandong Province,China(Nos.ZR2022MD118 and ZR2022MD050)the Beijing Academy of Agricultural and Forestry Sciences Science and Technology Innovation Capacity Construction Project,China(No.20230207)+3 种基金the Humanities and Social Science Foundation Project of Ministry of Education,China(No.22YJCZH166)the Technical System of Ecological Agriculture of Modern Agricultural Technology System in Shandong Province,China(No.SDAIT-30-02)the National Key Research and Development Program of China(No.2023YFD1701901)the Fundamental Research Funds for Central Non-profit Scientific Institution of China(No.1610132023006).
文摘Controlled-release/stable nitrogen(N)fertilizers can improve vegetable yields and achieve lower greenhouse gas emissions,resulting in cost-effective and environmentally friendly vegetable production.However,there has been limited research on the controlled-release/stable N fertilization in long-term fixed-position vegetable rotation fields.In this study,a five-year field experiment was conducted to examine the effects of long-term controlled-release/stable N fertilization in reducing greenhouse gas emissions and increasing lettuce yield.Six distinct treatments were employed for N fertilization:the control without N fertilizer(CK),normal local farming practices with application of urea fertilizer at 400 kg N ha^(-1)(T1),optimized application of urea at 320 kg N ha^(-1)(T2),optimized application of urea at 320 kg N ha^(-1)with supplementation of 1.0 kg ha^(-1)3,4-dimethylpyrazole phosphate(DMPP)as N inhibitor(T3),application of polyurethane-coated urea at 320 kg N ha^(-1)(T4),and application of polyurethane-coated urea at 320 kg N ha^(-1)with supplementation of 1.0 kg ha^(-1)DMPP(T5).The results showed that the T3,T4,and T5 treatments using controlled-release/stable N fertilization emitted about 12.2%-56.7%less average annual cumulative nitrous oxide(N_(2)O)and 1.31%-10.0%less carbon dioxide(CO_(2))than the T2 treatment.Nitrous oxide and CO_(2)emissions from the T4 and T5 treatments were considerably lower than those from the T3 treatment.No significant seasonal or interannual variability was observed in N_(2)O and CO_(2)emissions.The observed phenomena were attributed to the fluctuations in soil ammonium-and nitrate-N contents.The findings in this study revealed that long-term controlled-release/stable N fertilization resulted in reduced field N loss,benefitting vegetable yields without increasing CO_(2)emissions and highlighting the application potential of this technique for sustainable agricultural production.
文摘This is an erratum to the published paper titled,“High expression of autophagyrelated gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer.”We have removed the citations to certain articles in subsequent revisions of the manuscript.However,owing to our oversight,the citation marker in the upper right corner was not removed.We apologize for any confusion this may have caused.
基金supported by the internal funding source from University of Shanghai for Science and Technology.
文摘Coarse columnar β grains result in anisotropic mechanical properties in Ti alloys deposited by additive manufacturing. This study reports that Ti-6Al-4V alloy fabricated by coaxial electron beam wire feeding additive manufacturing presents a weak anisotropy, high strength and ductility. The superior tensile property arises from a microstructure with fine equiaxed β grains(EGβ), discontinuous grain boundary α phase and short intragranular α lamellae. A large region of fine EGβ arises from a special combination of the temperature gradient and solidification rate, and attractive α morphology is caused by solid phase transformations during interpass thermal cycling and post heat treatments.
基金supported by funds from the National Natural Science Foundation of China(Grant Nos.81830002,81830004,82070168,and 32070951)the Translational Research grant of NCRCH(Grant No.2020ZKZC04)National Key R&D Program of China(Grant No.2021YFA1100800)。
文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.
基金supported by the National Natural Science Foundation of China(NSFC,Nos.52073212,51772205,51772208)the General Program of Municipal Natural Science Foundation of Tianjin(Nos.17JCYBJC17000,17JCYBJC22700)。
文摘At present,replacing the liquid electrolyte in a lithium metal battery with a solid electrolyte is considered to be one of the most powerful strategies to avoid potential safety hazards.Composite solid electrolytes(CPEs)have excellent ionic conductivity and flexibility owing to the combination of functional inorganic materials and polymer solid electrolytes(SPEs).Nevertheless,the ionic conductivity of CPEs is still lower than those of commercial liquid electrolytes,so the development of high-performance CPEs has important practical significance.Herein,a novel fast lithium-ion conductor material LiTa_(2)PO_(8) was first filled into poly(ethylene oxide)(PEO)-based SPE,and the optimal ionic conductivity was achieved by filling different concentrations(the ionic conductivity is 4.61×10^(-4)S/cm with a filling content of 15 wt%at 60℃).The enhancement in ionic conductivity is due to the improvement of PEO chain movement and the promotion of LiTFSI dissociation by LiTa_(2)PO_(8).In addition,LiTa_(2)PO_(8) also takes the key in enhancing the mechanical strength and thermal stability of CPEs.The assembled LiFePO_(4) solid-state lithium metal battery displays better rate performance(the specific capacities are as high as 157.3,152,142.6,105 and 53.1 mAh/g under0.1,0.2,0.5,1 and 2 C at 60℃,respectively)and higher cycle performance(the capacity retention rate is86.5%after 200 cycles at 0.5 C and 60℃).This research demonstrates the feasibility of LiTa_(2)PO_(8) as a filler to improve the performance of CPEs,which may provide a fresh platform for developing more advanced solid-state electrolytes.
基金supported by program NCET Foundation,NSFC(30725045)the Special Program for New Drug Innovation of the Ministry of Science and Technology,China(2009ZX09311-001,2008ZX09101-Z-029)+1 种基金Shanghai Leading Academic Discipline Project(B906)by the Scientific Foundation of Shanghai,China(07DZ19728,09DZ1975700,09DZ1971500)
文摘A novel and sensitive HPLC-UV method has been developed for the simultaneous determination of twelve major compounds in Longdan Xiegan Pill.The chemical profile of the twelve compounds,including geniposidic acid（1）,geniposide（2）,gentiopicroside（3）,liquiritin（4）,crocin（5）,baicalin（6）,wogonoside（7）,baicalein（8）,glycyrrhizic acid（9）,wogonin（10）,oroxylin A（11）and aristolochic acid A（12）,was acquired using high-performance liquid chromatography-diode array detector coupled with an electrospray tandem mass spectrometer（HPLC-DAD-ESI-MS）.The analysis was performed on a Dikma Platisil ODS C18 column（250 mm×4.6 mm,5 μm）with a gradient solvent system of acetonitrile-0.1% aqueous formic acid.The validation was carried out and the linearities（r〉0.9996）,repeatability（RSD〈1.8%）,intra-and inter-day precision（RSD〈1.3%）,and recoveries（ranging from 96.6% to 103.4%）were acceptable.The limits of detection（LOD）of these compounds ranged from 0.29 to 4.17 ng.Aristolochic acid A,which is the toxic ingredient,was not detected in all the batches of Longdan Xiegan Pill.Furthermore,hierarchical cluster analysis was used to evaluate the variation of the herbal prescription.The proposed method is simple,effective and suitable for the quality control of this traditional Chinese medicine（TCM）.
基金supported by the National Natural Science Foundation of China,NSFC(51772205,51772208)the General Program of Municipal Natural Science Foundation of Tianjin(17JCYBJC17000,17JCYBJC22700)。
文摘The emergency of high-power electrical appliances has put forward higher requirements for the power density of lithium-ion batteries.Vanadium oxides with large theoretical capacities and high operating voltages are considered as prospective alternatives for the cathode of a new generation of lithium-ion batteries.However,the poor rate and cycling performance caused by the sluggish electrons/lithium transportation,irreversible phase changes,vanadium dissolution and large volume changes during the repeated lithium intercalation/deintercalation hinder their commercial development.Several optimizing routes have been carried out and extensively explored to address these problems.Taking V_(2)O_(5),VO_(2)(B),V_(6)O_(13),and V_(2)O_(3)as examples,this article reviewed their crystal structures and lithium storage reactions.Besides,recent progress in modification methods for the electrochemical insufficiencies of vanadium oxides,including nanostructure,heterogeneous atom doping,composite and self-supported electrodes has been systematically summarized and finally,the challenges for the industrialization of vanadium oxide cathodes and their development opportunities are proposed.
基金support of the National Natural Science Foundation of China(Grant Nos.52275565,NSFC-JSPS:52011540005,and 62104155)the Natural Science Foundation of Guangdong Province(Grant No.2022A1515011667)the Guangdong Kangyi Special Fund(Grant No.2020KZDZX1173).
文摘A fundamental problem in the direct manufacturing of flexible devices is the low melting temperature of flexible substrates,which hinders the development of flexible electronics.Proposed here is an electron-cyclotron-resonance sputtering system that can batch-fabricate devices directly on flexible substrates under a low temperature by virtue of the polariton energy transfer between the plasma and the material.Flexible graphene nanosheet-embedded carbon(F-GNEC)films are manufactured directly on polyimide,polyethylene terephthalate,and polydimethylsiloxane,and how the substrate bias(electron energy),microwave power(plasma flux and energy),and magnetic field(electron flux)affect the nanostructure of the F-GNEC films is investigated,indicating that electron energy and flux contribute to the formation of standing graphene nanosheets in the film.The films have good uniformity of distribution in a large size(17 mm×17 mm),and tensile and angle sensors with a high gauge factor(0.92)and fast response(50 ms)for a machine hand are obtained by virtue of the unique nanostructure of the F-GNEC film.This work sheds light on the quantum manufacturing of carbon sensors and its applications for intelligent machine hands and virtual-reality technology.
基金supported by the National Natural Science Foundation of China(Grant No.:81973388)Marine Economy Development Project of Guangdong Province(Project No.:GDNRC[2021]52)the Key Research and Development Program of Guangdong Province(Program No.:2020B1111030005).
文摘Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatosteatosis.Oridonin(ORI)is a major bioactive component extracted from the traditional Chinese medicinal herb Rabdosia rubescens.In this paper,we showed that ORI exerted significant protective effects against hepatic steatosis,inflammation and fibrosis,which was dependent on LXRa signaling.It is reported that LXRa regulated lipid homeostasis between triglyceride(TG)and phosphatidylethanolamine(PE)by promoting ATGL and EPT1 expression.Therefore,we implemented the lipidomic strategy and luciferase reporter assay to verify that ORI contributed to the homeostasis of lipids via the regulation of the ATGL gene associated with TG hydrolysis and the EPT1 gene related to PE synthesis in a LXRadependent manner,and the results showed the TG reduction and PE elevation.In detail,hepatic TG overload and lipotoxicity were reversed after ORI treatment by modulating the ATGL and EPT1 genes,respectively.Taken together,the data provide mechanistic insights to explain the bioactivity of ORI in attenuating TG accumulation and cytotoxicity and introduce exciting opportunities for developing novel natural activators of the LXRa-ATGL/EPT1 axis for pharmacologically treating hepatosteatosis and metabolic disorders.
文摘BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.
基金jointly funded by the National Natural Science Foundation of China (No.51304181)the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (No.QYZDJ-SSW-JSC021)the Key Research Program of Chinese Academy of Sciences (No.ZDRW-ZS-2018-1)。
文摘This study used specularite, a high-gradient magnetic separation concentrate, as a raw material in reverse flotation.An iron concentrate with a grade of 65.1 wt% and a recovery rate of 75.31% were obtained.A centrifugal concentrator served as the deep purification equipment for the preparation of iron oxide red pigments, and its optimal rotating drum speed, feed concentration, and other conditions were determined.Under optimal conditions, a high-purity iron oxide concentrate with a grade of 69.38 wt% and a recovery rate of 80.89% were obtained and used as a raw material for preparing iron oxide red pigment.Calcining with sulfuric acid produced iron red pigments with different hues.Simultaneously, middlings with a grade of 60.20 wt% and a recovery rate of 17.51% were obtained and could be used in blast furnace ironmaking.High-value utilization of specularite beneficiation products was thus achieved.
文摘BACKGROUND Breast cancer(BC) remains a public health problem. Tamoxifen(TAM) resistance has caused great difficulties for treatment of BC patients. Eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) plays critical roles in the tumorigenesis and progression of BC. However, the expression and mechanism of EIF4EBP1 in determining the efficacy of TAM therapy in BC patients are still unclear.AIM To investigate the expression and functions of EIF4EBP1 in determining the efficacy of TAM therapy in BC patients.METHODS High-throughput sequencing data of breast tumors were downloaded from the Gene Expression Omnibus database. Differential gene expression analysis identified EIF4EBP1 to be significantly upregulated in cancer tissues. Its prognostic value was analyzed. The biological function and related pathways of EIF4EBP1 was analyzed. Subsequently, the expression of EIF4EBP1 was determined by real-time reverse transcription polymerase chain reaction and western blotting. Cell Counting Kit-8 assays, colony formation assay and wound healing assay were used to understand the phenotypes of function of EIF4EBP1.RESULTS EIF4EBP1 was upregulated in the TAM-resistant cells, and EIF4EBP1 was related to the prognosis of BC patients. Gene Set Enrichment Analysis showed that EIF4EBP1 might be involved in Hedgehog signaling pathways. Decreasing the expression of EIF4EBP1 could reverse TAM resistance, whereas overexpression of EIF4EBP1 promoted TAM resistance.CONCLUSION This study indicated that EIF4EBP1 was overexpressed in the BC and TAM-resistant cell line, which increased cell proliferation, invasion, migration and TAM resistance in BC cells.
文摘To deal with the expected diversification on traffic types, the fundamental waveform of the upcoming5 G standard must be sufficiently flexible. In the 4th generation wireless networks(e.g., cellular LTE and Wi- Fi802.11ac), orthogonal frequency division multiplexing(OFDM) has been widely adopted to combat frequency selectivity and thus improve the spectrum efficiency. Holding various advantages such as backward compatibility with LTE, ease of hardware implementation, time-localized low-latency transmission and straightforward combination with multi-antenna transmission, OFDM will remain as an important waveform candidate for 5G. However,OFDM alone appears to be insufficient in terms of the requirements faced by 5G waveform, such as high flexibility to accommodate different waveform numerologies for an efficient support of diversified traffic types and channel characteristics. In this work, we present a new waveform format, named as filtered-OFDM(f-OFDM) and illustrate its potential and benefits for serving as the underlying waveform of 5G.
基金supported by Jiangsu Province Special Project for Carbon Peak&Carbon Neutral Science and Technology Innovation,China(No.BE2022309)the National Natural Science Foundation of China(Nos.41977078 and 42377292)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(No.KYCX20_0591)。
文摘Vegetable soils with high nitrogen input are major sources of nitrous oxide(N_(2)O)and nitric oxide(NO),and incorporation of the nitrification inhibitor 3,4-dimethylpyrazole phosphate(DMPP)into soils has been documented to effectively reduce emissions.However,the efficiency of DMPP in terms of soil N_(2)O and NO mitigations varies greatly depending on soil temperature and moisture levels.Thus,further evaluations of DMPP efficiency in diverse environments are required to encourage widespread application.A laboratory incubation study(28 d)was established to investigate the interactive effects of DMPP,temperature(15,25,and 35?C),and soil moisture(55% and 80% of water-holding capacity(WHC))on net nitrification rate,N_(2)O and NO productions,and gene abundances of nitrifiers and denitrifiers in an intensive vegetable soil.Results showed that incubating soil with 1%DMPP led to partial inhibition of the net nitrification rate and N_(2)O and NO productions,and the reduction percentage of N_(2)O production was higher than that of NO production(69.3%vs.38.2%)regardless of temperature and soil moisture conditions.The increased temperatures promoted the net nitrification rate but decreased soil N_(2)O and NO productions.Soil moisture influenced NO production more than N_(2)O production,decreasing with the increased moisture level(80%).The inhibitory effect of DMPP on cumulative N_(2)O and NO productions decreased with increased temperatures at 55%WHC.Conversely,the inhibitory effect of DMPP on cumulative N_(2)O production increased with increased temperatures at 80%WHC.Based on the correlation analyses and automatic linear modeling,the mitigation of both N_(2)O and NO productions from the soil induced by DMPP was attributed to the decreases in ammonia-oxidizing bacteria(AOB)amoA gene abundance and NO_(2)^(-)-N concentration.Overall,our study indicated that DMPP reduced both N_(2)O and NO productions by regulating the associated AOB amoA gene abundance and NO_(2)^(-)-N concentration.These findings improve our insights regarding the implications of DMPP for N_(2)O and NO mitigations in vegetable soils under various climate scenarios.
基金supported by the National Key Research and Development Program of China(2022YFD1401200)the National Natural Science Foundation of China(32172397).
文摘It has been reported that C-type lectins(CTLs),which are pattern recognition receptors of the insect innate immunity response,may compete with Cry toxin for the receptor alkaline phosphatase to decrease its toxicity in insects.However,to date,which CTLs affect larval susceptibility to Bt in Spodoptera exigua is not clear.In this study,33 CTL genes were identified from S.exigua.Based on the number of carbohydrate-recognition domains(CRDs)and the domain architectures,they were classified into three groups:(1)nineteen CTL-S(single-CRD),(2)eight immulectin(dual-CRD)and(3)six CTL-X(CRD with other domains).RT-qPCR analysis revealed that expression levels of SeCTL-S15,IML-4 and CTL-X6 were upregulated after challenge with Bt and Cry1Ab.Tissue and developmental stage expression analysis showed that only SeCTL-S15 was mainly expressed in the midgut and larva,respectively.Knockdown of SeCTL-S15 significantly increased Bt susceptibility,as indicated by reduced survival and larval weight.These results suggest that CTL-S15 might play a vital role in the low susceptibility of larvae to Bt in S.exigua.Our results provide new insights into CTL function in insects.
文摘Correction:Natural Products and Bioprospecting(2024)14:33 https://doi.org/10.1007/s13659-024-00455-x Following publication of the original article[1],the authors reported that the original version of this article unfortunately contained mistakes.Page 1,section“Abstract”,the originally published texts were:Despite low bioavailability(0.024%),N-hydap exhibited a higher distribution in the lungs(26.26%),accounting for its efficacy against SCLC.
基金supported by the National Natural Science Foundation of China(Nos.82274002,42376124)Marine Economy Development Project of Guangdong Province(GDNRC[2021]52)+1 种基金Hainan Provincial Natural Science Foundation of China(823CXTD393)Key-Area Research and Development Program of Guangdong Province(2023B1111050008)。
文摘N-Hydroxyapiosporamide(N-hydap),a marine product derived from a sponge-associated fungus,has shown promising inhibitory effects on small cell lung cancer(SCLC).However,there is limited understanding of its metabolic pathways and characteristics.This study explored the in vitro metabolic profiles of N-hydap in human recombinant cytochrome P450s(CYPs)and UDP-glucuronosyltransferases(UGTs),as well as human/rat/mice microsomes,and also the pharmacokinetic properties by HPLC-MS/MS.Additionally,the cocktail probe method was used to investigate the potential to create drug-drug interactions(DDIs).N-Hydap was metabolically unstable in various microsomes after 1 h,with about 50%and 70%of it being eliminated by CYPs and UGTs,respectively.UGT1A3 was the main enzyme involved in glucuronidation(over 80%),making glucuronide the primary metabolite.Despite low bioavailability(0.024%),N-hydap exhibited a higher distribution in the lungs(26.26%),accounting for its efficacy against SCLC.Administering N-hydap to mice at normal doses via gavage did not result in significant toxicity.Furthermore,N-hydap was found to affect the catalytic activity of drug metabolic enzymes(DMEs),particularly increasing the activity of UGT1A3,suggesting potential for DDIs.Understanding the metabolic pathways and properties of N-hydap should improve our knowledge of its drug efficacy,toxicity,and potential for DDIs.
基金the National Natural Science Foundation of China(82471593 to J.M.32330047 and 31930057 to F.W.+2 种基金and 82071970 to Y.W.and 82072506 to Y.L.)the Science Fund for Distinguished Young Scholars of Hubei Province(2023AFA109 to Y.W.)Hubei Provincial Natural Science Foundation of China(2024AFB963 to Q.R.).
文摘The muscular system plays a critical role in the human body by governing skeletal movement,cardiovascular function,and the activities of digestive organs.Additionally,muscle tissues serve an endocrine function by secreting myogenic cytokines,thereby regulating metabolism throughout the entire body.Maintaining muscle function requires iron homeostasis.Recent studies suggest that disruptions in iron metabolism and ferroptosis,a form of iron-dependent cell death,are essential contributors to the progression of a wide range of muscle diseases and disorders,including sarcopenia,cardiomyopathy,and amyotrophic lateral sclerosis.Thus,a comprehensive overview of the mechanisms regulating iron metabolism and ferroptosis in these conditions is crucial for identifying potential therapeutic targets and developing new strategies for disease treatment and/or prevention.This review aims to summarize recent advances in understanding the molecular mechanisms underlying ferroptosis in the context of muscle injury,as well as associated muscle diseases and disorders.Moreover,we discuss potential targets within the ferroptosis pathway and possible strategies for managing muscle disorders.Finally,we shed new light on current limitations and future prospects for therapeutic interventions targeting ferroptosis.
基金the financial support by the National Key Research and Development Program of China(No.2022YFD1500100)the National Natural Science Foundation of China(No.52279034)+5 种基金the Outstanding Youth Project of Heilongjiang Province,China(No.JQ2021D001)the Young Longjiang Scholar,China,the Science and Technology Project of Henan Province,China(No.252102321157)the Scientific Research Foundation for Doctoral Talents at Shangqiu Normal University,China(No.700125017)the Natural Science Foundation of Heilongjiang Province,China(No.LH2022D003)the Heilongjiang Postdoctoral Fund,China(No.LBH-Z21037)the Science and Technology Project of Henan Province,China(No.252102110185)。
文摘Rice yield in the black soil region of Northeast China has been declining due to severe soil fertility degradation caused by both biotic and abiotic factors.Artificial humic substance(A-HS)has attracted much attention due to its high cost-effectiveness and great potential to improve soil fertility.However,the specific effects of A-HS on nutrient contents in rice nursery soils remain unclear.This study systematically investigated the effects of rational application of A-HS on soil nutrient turnover and yield and analyzed the changes in soil nutrients and microbial communities at Qianfeng Farm,Northeast China.The results indicated that the application of A-HS significantly increased soil dissolved organic matter and nutrient contents in the native and seedling soils.In addition,the root growth and yield of the seedlings at maturity were effectively promoted.More interestingly,the application of A-HS significantly altered plant growth-promoting rhizobacteria,such as Noviherbaspirillum,Klebsiella,and Pedobacter,improving natural barrier formation and soil nutrient conversion.It could be concluded that A-HS significantly enhanced crop nutrient uptake and accumulation by altering soil bacterial communities.In general,the application of A-HS could be profitable and sustainable in rice production.The current study from multiple aspects provides valuable insights into the benefits of A-HS in promoting crop growth and development,which could have important implications for agriculture and food security.
