Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectio...Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectional study aims to investigate the current situation and change in county people's demand for endoscopy to promote the development of endoscopy centers in county hospitals in southeast China.Methods From October to December 2021,patients and their family members who came to the Gastroenterology Department in Suichang County People's Hospital of Zhejiang Province were randomly selected to complete the questionnaire.A total of 838 valid questionnaires were collected.Additionally,the original software data of the Endoscopy Center were sampled and retrieved(from October to December every year from 2018 to 2021)for statistical analysis of real-world data.Those who would choose painless endoscopy the next time in the valid questionnaires were included in the painless endoscopy group,while those who would choose ordinary endoscopy the next time were included in the ordinary endoscopy group.Results The stepwise forward binary logistic regression model analysis showed that,patients with“secondhand smoke exposure”were more willing to choose painless endoscopy(OR=1.459,95%CI:1.050-2.028,p=0.025).However,patients with an education level of“primary and below”and“junior high school”,and patients who are suffering from“currently experiencing abdominal distension”,were more willing to choose ordinary endoscopy(OR=0.270,95%CI:0.149-0.488,p<0.001;OR=0.528,95%CI:0.330-0.845,p=0.008;OR=0.536,95%CI:0.334-0.861,p=0.010).Patients with previous experience in painless endoscopy tended to choose painless endoscopy the next time,while patients with previous experience in ordinary endoscopy tended to choose ordinary endoscopy the next time(χ^(2)=140.97,p<0.001).From 2018 to 2021,the proportion of painless endoscopy has increased yearly(p<0.001).Most patients indicated that they would“regularly review gastroenteroscopy”(477/838,56.9%).Conclusions With Suichang County of Zhejiang Province as the representative,the demand for painless endoscopy for people's gastrointestinal cancer detection in southeast China has been increasing yearly.The development of endoscopy centers in county-level hospitals can basically meet the demand growth.Meanwhile,advanced concepts such as comfortable medical care and regular follow-up are gradually popularized at the grassroots level in southeast China.展开更多
目的:利用神经细胞原代培养体系研究内质网钙通道蛋白三磷酸肌醇受体2(IP3R2)的拮抗剂对小鼠少突胶质细胞增殖分化的作用。方法:分离并纯化新生小鼠大脑皮质来源的少突胶质前体细胞(OPC)。利用real time RT-PCR检测不同分化阶段少突胶...目的:利用神经细胞原代培养体系研究内质网钙通道蛋白三磷酸肌醇受体2(IP3R2)的拮抗剂对小鼠少突胶质细胞增殖分化的作用。方法:分离并纯化新生小鼠大脑皮质来源的少突胶质前体细胞(OPC)。利用real time RT-PCR检测不同分化阶段少突胶质细胞中IP3R2 mRNA的表达水平;利用细胞钙成像观察给予IP3R2拮抗剂2-氨基乙氧基二苯基硼酸盐(2-APB)对OPC的Ca^(2+)活动影响;利用免疫荧光染色法检测2-APB对OPC中Ki67、2′,3′-环核苷酸3′-磷酸二酯酶(CNPase)和髓鞘碱性蛋白(MBP)的表达情况以及对细胞周期的影响。结果:IP3R2 mRNA水平在未成熟少突胶质细胞阶段最高;2-APB处理OPC可显著降低细胞内Ca^(2+)浓度;Ki67标记的增殖OPC比例在2-APB处理组显著降低;且2-APB的处理可以延长OPC的细胞周期进程。在诱导分化的少突胶质细胞培养物中,2-APB处理可以使CNPase^(+)与MBP^(+)细胞数量显著增加。结论:IP3R2介导的细胞内钙库释放对于OPC的增殖与分化具有重要的调控作用,为治疗其异常相关疾病提供了重要的思路。展开更多
China has made many strides in large-scale development and centralized integration of wind power in recent years.The wind power penetration of some regions has reached a high level,which brings significant challenges ...China has made many strides in large-scale development and centralized integration of wind power in recent years.The wind power penetration of some regions has reached a high level,which brings significant challenges for power system dispatch due to the inherent variability and uncertainty of wind resources.To increase the dispatch capabilities of wind power generation,the spatial smoothing effect among adjacent wind farms needs to be fully utilized.This paper presents the concept of hierarchical coordinated dispatch for wind power based on a new concept of a virtual power generator.The spatial smoothing effect of wind power is analyzed first.Next,the virtual power generator method of a wind farm cluster is defined and established.Then,the hierarchical coordinated dispatch mode is compared with an existing wind power dispatch mode for individual wind farms.Finally,the proposed concept is implemented on a simulation case to demonstrate applicability and effectiveness.展开更多
Phase imaging always deals with the problem of phase invisibility when capturing objects with existing light sensors.However,there is a demand for multiplane full intensity measurements and iterative propagation proce...Phase imaging always deals with the problem of phase invisibility when capturing objects with existing light sensors.However,there is a demand for multiplane full intensity measurements and iterative propagation process or reliance on reference in most conventional approaches.In this paper,we present an end-to-end compressible phase imaging method based on deep neural networks,which can implement phase estimation using only binary measurements.A thin diffuser as a preprocessor is placed in front of the image sensor to implicitly encode the incoming wavefront information into the distortion and local variation of the generated speckles.Through the trained network,the phase profile of the object can be extracted from the discrete grains distributed in the low-bit-depth pattern.Our experiments demonstrate the faithful reconstruction with reasonable quality utilizing a single binary pattern and verify the high redundancy of the information in the intensity mcasurement for phase recovery.In addition to the advantages of efficiency and simplicity compared to now available imaging methods,our model provides significant compressibility for imaging data and can therefore facilitate the low-cost detection and efficient data transmission.展开更多
The presence of distributed generators(DGs)with high penetration poses new challenges in the management and operation of electrical grids.Due to the local character of DGs,they could in principle be used in emergency ...The presence of distributed generators(DGs)with high penetration poses new challenges in the management and operation of electrical grids.Due to the local character of DGs,they could in principle be used in emergency situations to prevent a voltage instability event of the grid.In this paper,a certain method is proposed to coordinate the operation of virtual power plant(VPP)and conventional voltage regulation device to improve the static voltage stability of distribution network with the multi-agent framework.The concept and the general framework of this coordinated control system is introduced,and the voltage instable nodes are determined based on the voltage instability indicator.The voltage coordinated control model of the distribution system is established according to the multi-agent consistency control theory and the coordinated controllers for agents are designed by solving a problem with bilinear matrix inequality constraints.The suggested method is implemented on an IEEE 33 nodes test system and the simulation results show its efficiency and validity.展开更多
基金supported by the National Natural Science Foundation of China(82073160).
文摘Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectional study aims to investigate the current situation and change in county people's demand for endoscopy to promote the development of endoscopy centers in county hospitals in southeast China.Methods From October to December 2021,patients and their family members who came to the Gastroenterology Department in Suichang County People's Hospital of Zhejiang Province were randomly selected to complete the questionnaire.A total of 838 valid questionnaires were collected.Additionally,the original software data of the Endoscopy Center were sampled and retrieved(from October to December every year from 2018 to 2021)for statistical analysis of real-world data.Those who would choose painless endoscopy the next time in the valid questionnaires were included in the painless endoscopy group,while those who would choose ordinary endoscopy the next time were included in the ordinary endoscopy group.Results The stepwise forward binary logistic regression model analysis showed that,patients with“secondhand smoke exposure”were more willing to choose painless endoscopy(OR=1.459,95%CI:1.050-2.028,p=0.025).However,patients with an education level of“primary and below”and“junior high school”,and patients who are suffering from“currently experiencing abdominal distension”,were more willing to choose ordinary endoscopy(OR=0.270,95%CI:0.149-0.488,p<0.001;OR=0.528,95%CI:0.330-0.845,p=0.008;OR=0.536,95%CI:0.334-0.861,p=0.010).Patients with previous experience in painless endoscopy tended to choose painless endoscopy the next time,while patients with previous experience in ordinary endoscopy tended to choose ordinary endoscopy the next time(χ^(2)=140.97,p<0.001).From 2018 to 2021,the proportion of painless endoscopy has increased yearly(p<0.001).Most patients indicated that they would“regularly review gastroenteroscopy”(477/838,56.9%).Conclusions With Suichang County of Zhejiang Province as the representative,the demand for painless endoscopy for people's gastrointestinal cancer detection in southeast China has been increasing yearly.The development of endoscopy centers in county-level hospitals can basically meet the demand growth.Meanwhile,advanced concepts such as comfortable medical care and regular follow-up are gradually popularized at the grassroots level in southeast China.
文摘目的:利用神经细胞原代培养体系研究内质网钙通道蛋白三磷酸肌醇受体2(IP3R2)的拮抗剂对小鼠少突胶质细胞增殖分化的作用。方法:分离并纯化新生小鼠大脑皮质来源的少突胶质前体细胞(OPC)。利用real time RT-PCR检测不同分化阶段少突胶质细胞中IP3R2 mRNA的表达水平;利用细胞钙成像观察给予IP3R2拮抗剂2-氨基乙氧基二苯基硼酸盐(2-APB)对OPC的Ca^(2+)活动影响;利用免疫荧光染色法检测2-APB对OPC中Ki67、2′,3′-环核苷酸3′-磷酸二酯酶(CNPase)和髓鞘碱性蛋白(MBP)的表达情况以及对细胞周期的影响。结果:IP3R2 mRNA水平在未成熟少突胶质细胞阶段最高;2-APB处理OPC可显著降低细胞内Ca^(2+)浓度;Ki67标记的增殖OPC比例在2-APB处理组显著降低;且2-APB的处理可以延长OPC的细胞周期进程。在诱导分化的少突胶质细胞培养物中,2-APB处理可以使CNPase^(+)与MBP^(+)细胞数量显著增加。结论:IP3R2介导的细胞内钙库释放对于OPC的增殖与分化具有重要的调控作用,为治疗其异常相关疾病提供了重要的思路。
基金supported in part by Chinese National Key Technologies R&D Program(2013BAA01B03)National Natural Science Foundation of China(51190101)industrial project of State Grid Corporation of China(No.NY71-13-043).
文摘China has made many strides in large-scale development and centralized integration of wind power in recent years.The wind power penetration of some regions has reached a high level,which brings significant challenges for power system dispatch due to the inherent variability and uncertainty of wind resources.To increase the dispatch capabilities of wind power generation,the spatial smoothing effect among adjacent wind farms needs to be fully utilized.This paper presents the concept of hierarchical coordinated dispatch for wind power based on a new concept of a virtual power generator.The spatial smoothing effect of wind power is analyzed first.Next,the virtual power generator method of a wind farm cluster is defined and established.Then,the hierarchical coordinated dispatch mode is compared with an existing wind power dispatch mode for individual wind farms.Finally,the proposed concept is implemented on a simulation case to demonstrate applicability and effectiveness.
基金Narional Key Research and Development Program of China(2017YFB1002900)Shanghai Aerospace Technology Renovation Fund(SAST2019-096).
文摘Phase imaging always deals with the problem of phase invisibility when capturing objects with existing light sensors.However,there is a demand for multiplane full intensity measurements and iterative propagation process or reliance on reference in most conventional approaches.In this paper,we present an end-to-end compressible phase imaging method based on deep neural networks,which can implement phase estimation using only binary measurements.A thin diffuser as a preprocessor is placed in front of the image sensor to implicitly encode the incoming wavefront information into the distortion and local variation of the generated speckles.Through the trained network,the phase profile of the object can be extracted from the discrete grains distributed in the low-bit-depth pattern.Our experiments demonstrate the faithful reconstruction with reasonable quality utilizing a single binary pattern and verify the high redundancy of the information in the intensity mcasurement for phase recovery.In addition to the advantages of efficiency and simplicity compared to now available imaging methods,our model provides significant compressibility for imaging data and can therefore facilitate the low-cost detection and efficient data transmission.
文摘The presence of distributed generators(DGs)with high penetration poses new challenges in the management and operation of electrical grids.Due to the local character of DGs,they could in principle be used in emergency situations to prevent a voltage instability event of the grid.In this paper,a certain method is proposed to coordinate the operation of virtual power plant(VPP)and conventional voltage regulation device to improve the static voltage stability of distribution network with the multi-agent framework.The concept and the general framework of this coordinated control system is introduced,and the voltage instable nodes are determined based on the voltage instability indicator.The voltage coordinated control model of the distribution system is established according to the multi-agent consistency control theory and the coordinated controllers for agents are designed by solving a problem with bilinear matrix inequality constraints.The suggested method is implemented on an IEEE 33 nodes test system and the simulation results show its efficiency and validity.
