Objective: This study aims to explore the application effects of Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion in preventing and treating gastrointestinal reactions induced by chemotherapy, particularly ...Objective: This study aims to explore the application effects of Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion in preventing and treating gastrointestinal reactions induced by chemotherapy, particularly its efficacy in managing chemotherapy-induced nausea and vomiting (CINV). Methods: A total of 100 patients with gastrointestinal reactions who were hospitalized in the oncology department of Nanning Third People’s Hospital from January to December 2023 were selected as study subjects. They were randomly divided into two groups: the observation group (n = 50) received standard antiemetic treatment in conjunction with Shen-Shi Zhi-Tong plaster and Lei-Huo moxibustion, while the control group (n = 50) received only standard antiemetic treatment and Lei-Huo moxibustion. The occurrence of nausea and vomiting during chemotherapy was recorded using a CINV nursing log, and the incidence rates of acute and delayed vomiting were statistically analyzed. Results: The incidence rate of acute vomiting in the observation group was 42%, significantly lower than the control group’s 64% (P = 0.0300);the incidence rate of delayed vomiting was 36% in the observation group compared to 48% in the control group (P = 0.1900). The mean nausea grade in the observation group was 1.08, significantly lower than 2.02 in the control group (P Conclusion: Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion can effectively reduce the incidence of nausea and vomiting in patients undergoing highly emetogenic chemotherapy and shows good clinical application prospects. This study provides strong support for the adoption of such combined therapies in the prevention and treatment of CINV in the future.展开更多
Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI ...Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.展开更多
Nonfullerene organic solar cells(OSCs)have achieved breakthrough with pushing the efficiency exceeding 17%.While this shed light on OSC commercialization,high-performance flexible OSCs should be pursued through soluti...Nonfullerene organic solar cells(OSCs)have achieved breakthrough with pushing the efficiency exceeding 17%.While this shed light on OSC commercialization,high-performance flexible OSCs should be pursued through solution manufacturing.Herein,we report a solution-processed flexible OSC based on a transparent conducting PEDOT:PSS anode doped with trifluoromethanesulfonic acid(CF3SO3H).Through a low-concentration and low-temperature CF3SO3H doping,the conducting polymer anodes exhibited a main sheet resistance of 35Ωsq−1(minimum value:32Ωsq−1),a raised work function(≈5.0 eV),a superior wettability,and a high electrical stability.The high work function minimized the energy level mismatch among the anodes,hole-transporting layers and electron-donors of the active layers,thereby leading to an enhanced carrier extraction.The solution-processed flexible OSCs yielded a record-high efficiency of 16.41%(maximum value:16.61%).Besides,the flexible OSCs afforded the 1000 cyclic bending tests at the radius of 1.5 mm and the long-time thermal treatments at 85°C,demonstrating a high flexibility and a good thermal stability.展开更多
Precise control over the isomorphic selfassembly of nanocluster superstructures via weak interactions remains a fundamental challenge in materials science,primarily due to the lack of directional guidance.Inspired by ...Precise control over the isomorphic selfassembly of nanocluster superstructures via weak interactions remains a fundamental challenge in materials science,primarily due to the lack of directional guidance.Inspired by the ancient mortise-and-tenon joint,we herein report a series of crystalline nanocluster superstructures(MTC-1 and MTC-2)that were exclusively assembled by such molecular joints,representing the first paradigm of its kind.Despite alterations in functional groups(methyl and ethyl),the supramolecular packing motif remains invariant,underscoring the robustness of this directed assembly strategy.Notably,the ethyl groups in MTC-2 serve as“locking pins”,resulting in MTC-2 a fascinating Luban lock-like construction.This ingenious design endows MTC-2 with enhanced photogenerated charge migration and superior O2 adsorption capability,achieving a record-high photocatalytic H_(2)O_(2) production rate(19,978μmol·g^(-1)·h^(-1))among all isolated crystalline cluster-based materials,an order-of-magnitude enhancement over existing benchmarks.This work not only presents a record-breaking photocatalyst but also establishes a general assembly strategy,the mortise-and-tenon joint,which is expected to guide the rational design of functional superstructures across diverse nanocluster systems.展开更多
Aluminum-metal batteries show great potential as next-generation energy storage due to their abundant resources and intrinsic safety.However,the crucial limitations of metallic Al anodes,such as dendrite and corrosion...Aluminum-metal batteries show great potential as next-generation energy storage due to their abundant resources and intrinsic safety.However,the crucial limitations of metallic Al anodes,such as dendrite and corrosion problems in conventional aluminum-metal batteries,remain challenging and elusive.Here,we report a novel electrodeposition strategy to prepare an optimized 3D Al anode on carbon cloth with an uniform deposition morphology,low local current density,and mitigatory volume change.The symmetrical cells with the 3D Al anode show superior stable cycling(>450 h)and low-voltage hysteresis(~170 mV)at 0.5 mA cm^(−2).High reversibility(~99.7%)is achieved for the Al plating/stripping.The graphite||Al‐4/CC full batteries show a long lifespan of 800 cycles with 54 mAh g^(−1) capacity at a high current density of 1000 mA g^(−1),benefiting from the high capacitive-controlled distribution.This study proposes a novel strategy to design 3D Al anodes for metallic-Al-based batteries by eliminating the problems of planar Al anodes and realizing the potential applications of aluminum-graphite batteries.展开更多
In this work,titanium-capped cobalt clathrochelates have been applied as secondary building units(SBUs) fo r the construction of supramolecular rings.Two heterometallic wheel-like [Ti_(6) Co_(12)] complexes based on c...In this work,titanium-capped cobalt clathrochelates have been applied as secondary building units(SBUs) fo r the construction of supramolecular rings.Two heterometallic wheel-like [Ti_(6) Co_(12)] complexes based on cobalt clathrochelates,[C_(6)H_(15)N_(4)]_(2)[TiCo_(2)(μ_(2)-Oipr)(Oipr)_(2)(Dmg)_(3)]_(6)(2,Dmg=dimethy[glyoxime) and H_(6)[TiCo_(2)(μ_(2)-Oipr)(Oipr)_(2)(Dmg)_(3)]_(6)(3),have been successfully synthesized and characterized.The supramolecular stacking modes of these wheels are largely dependent on the applied synthetic conditions,which further impact their gas adsorption properties.展开更多
Supramolecular transformations of coordination cage or capsule have received much attention recently,which help elucidate this natural self-assembly behavior in biological systems.The current study describes the first...Supramolecular transformations of coordination cage or capsule have received much attention recently,which help elucidate this natural self-assembly behavior in biological systems.The current study describes the first supramolecular transformation of titanium-o rganic coordination capsule triggered by phenol(and H_(3) PO_(3)).The structural alterations are accompanied by the reconstruction of 5-coordinated Ti centers to 6-coordinated ones.Meanwhile,different amounts of encapsulated phenol vip molecules can be identified,dependent on the sizes of the obtained cavities.In addition,they display much better visible light absorption and air stability than the isopropanol stabilized ones.展开更多
Inflammatory bowel disease(IBD)is a chronic and refractory condition characterized by disrupted epithelial barrier,dysregulated immune balance,and altered gut microbiota.Nano-enabled interventions for restoring gut ho...Inflammatory bowel disease(IBD)is a chronic and refractory condition characterized by disrupted epithelial barrier,dysregulated immune balance,and altered gut microbiota.Nano-enabled interventions for restoring gut homeostasis have the potential to alleviate inflammation in IBD.Herein,we developed a combination of olsalazine(Olsa)-based nanoneedles and microbiota-regulating inulin gel to reshape intestinal homeostasis and relieve inflammation.The Olsa-derived nanoneedles exhibited reactive oxygen species scavenging ability and anti-inflammatory effects in lipopolysaccharide-simulated macrophages.The composite of nanoneedles and inulin gel(Cu2(Olsa)/Gel)displayed a macroporous structure,improved bio-adhesion,and enhanced colon retention after oral administration.Mechanistically,the composite effectively downregulated pro-inflammatory cytokine levels and promoted epithelial barrier repair through anti-inflammatory and antioxidant therapies,resulting in significant alleviation of colitis in three animal models of IBD.Furthermore,analysis of gut microbiota revealed that Cu2(Olsa)/Gel treatment increased the diversity of intestinal microflora and decreased the relative abundance of pathogenic bacteria such as Proteobacteria.Overall,this study provides a self-delivering nanodrug and dietary fiber hydrogel composite for IBD therapy,offering an efficient approach to restore intestinal homeostasis.展开更多
文摘Objective: This study aims to explore the application effects of Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion in preventing and treating gastrointestinal reactions induced by chemotherapy, particularly its efficacy in managing chemotherapy-induced nausea and vomiting (CINV). Methods: A total of 100 patients with gastrointestinal reactions who were hospitalized in the oncology department of Nanning Third People’s Hospital from January to December 2023 were selected as study subjects. They were randomly divided into two groups: the observation group (n = 50) received standard antiemetic treatment in conjunction with Shen-Shi Zhi-Tong plaster and Lei-Huo moxibustion, while the control group (n = 50) received only standard antiemetic treatment and Lei-Huo moxibustion. The occurrence of nausea and vomiting during chemotherapy was recorded using a CINV nursing log, and the incidence rates of acute and delayed vomiting were statistically analyzed. Results: The incidence rate of acute vomiting in the observation group was 42%, significantly lower than the control group’s 64% (P = 0.0300);the incidence rate of delayed vomiting was 36% in the observation group compared to 48% in the control group (P = 0.1900). The mean nausea grade in the observation group was 1.08, significantly lower than 2.02 in the control group (P Conclusion: Shen-Shi Zhi-Tong plaster combined with Lei-Huo moxibustion can effectively reduce the incidence of nausea and vomiting in patients undergoing highly emetogenic chemotherapy and shows good clinical application prospects. This study provides strong support for the adoption of such combined therapies in the prevention and treatment of CINV in the future.
基金supported by the Hong Kong Polytechnic University(1-WZ1Y,1-W34U,4-YWER).
文摘Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.
基金The authors acknowledge funding from the National Natural Science Foundation of China(61974150 and 51773213)Key Research Program of Frontier Sciences,CAS(QYZDB-SSW-JSC047)+1 种基金the Fundamental Research Funds for the Central Universities,the CAS-EU S&T cooperation partner program(174433KYSB20150013)the Natural Science Foundation of Ningbo(2018A610135).
文摘Nonfullerene organic solar cells(OSCs)have achieved breakthrough with pushing the efficiency exceeding 17%.While this shed light on OSC commercialization,high-performance flexible OSCs should be pursued through solution manufacturing.Herein,we report a solution-processed flexible OSC based on a transparent conducting PEDOT:PSS anode doped with trifluoromethanesulfonic acid(CF3SO3H).Through a low-concentration and low-temperature CF3SO3H doping,the conducting polymer anodes exhibited a main sheet resistance of 35Ωsq−1(minimum value:32Ωsq−1),a raised work function(≈5.0 eV),a superior wettability,and a high electrical stability.The high work function minimized the energy level mismatch among the anodes,hole-transporting layers and electron-donors of the active layers,thereby leading to an enhanced carrier extraction.The solution-processed flexible OSCs yielded a record-high efficiency of 16.41%(maximum value:16.61%).Besides,the flexible OSCs afforded the 1000 cyclic bending tests at the radius of 1.5 mm and the long-time thermal treatments at 85°C,demonstrating a high flexibility and a good thermal stability.
基金supported by the National Natural Science Foundation of China(Nos.22575048,22101048,22271046,and 22373015)the National Science Fund for Distinguished Young Scholars of China(No.22425102)+1 种基金the Natural Science Foundation of Fujian Province(No.2025J01628)the Open Project of the National Key Laboratory of Structural Chemistry(No.20250002).
文摘Precise control over the isomorphic selfassembly of nanocluster superstructures via weak interactions remains a fundamental challenge in materials science,primarily due to the lack of directional guidance.Inspired by the ancient mortise-and-tenon joint,we herein report a series of crystalline nanocluster superstructures(MTC-1 and MTC-2)that were exclusively assembled by such molecular joints,representing the first paradigm of its kind.Despite alterations in functional groups(methyl and ethyl),the supramolecular packing motif remains invariant,underscoring the robustness of this directed assembly strategy.Notably,the ethyl groups in MTC-2 serve as“locking pins”,resulting in MTC-2 a fascinating Luban lock-like construction.This ingenious design endows MTC-2 with enhanced photogenerated charge migration and superior O2 adsorption capability,achieving a record-high photocatalytic H_(2)O_(2) production rate(19,978μmol·g^(-1)·h^(-1))among all isolated crystalline cluster-based materials,an order-of-magnitude enhancement over existing benchmarks.This work not only presents a record-breaking photocatalyst but also establishes a general assembly strategy,the mortise-and-tenon joint,which is expected to guide the rational design of functional superstructures across diverse nanocluster systems.
基金This study was funded by the Science and Technology Development Fund,Macao SAR(File no.0191/2017/A3,0041/2019/A1,0046/2019/AFJ,0021/2019/AIR)the University of Macao(File no.MYRG2017-00216-FST and MYRG2018-00192-IAPME)+2 种基金the UEA funding,Science and Technology Program of Guangzhou(2019050001)the National Key Research and Development Program of China(2019YFE0198000)Fuming Chen acknowledges the Pearl River Talent Program(2019QN01L951).
文摘Aluminum-metal batteries show great potential as next-generation energy storage due to their abundant resources and intrinsic safety.However,the crucial limitations of metallic Al anodes,such as dendrite and corrosion problems in conventional aluminum-metal batteries,remain challenging and elusive.Here,we report a novel electrodeposition strategy to prepare an optimized 3D Al anode on carbon cloth with an uniform deposition morphology,low local current density,and mitigatory volume change.The symmetrical cells with the 3D Al anode show superior stable cycling(>450 h)and low-voltage hysteresis(~170 mV)at 0.5 mA cm^(−2).High reversibility(~99.7%)is achieved for the Al plating/stripping.The graphite||Al‐4/CC full batteries show a long lifespan of 800 cycles with 54 mAh g^(−1) capacity at a high current density of 1000 mA g^(−1),benefiting from the high capacitive-controlled distribution.This study proposes a novel strategy to design 3D Al anodes for metallic-Al-based batteries by eliminating the problems of planar Al anodes and realizing the potential applications of aluminum-graphite batteries.
基金supported by the National Natural Science Foundation of China (NSFC,Nos.21673238 and 21922111)the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB20000000)。
文摘In this work,titanium-capped cobalt clathrochelates have been applied as secondary building units(SBUs) fo r the construction of supramolecular rings.Two heterometallic wheel-like [Ti_(6) Co_(12)] complexes based on cobalt clathrochelates,[C_(6)H_(15)N_(4)]_(2)[TiCo_(2)(μ_(2)-Oipr)(Oipr)_(2)(Dmg)_(3)]_(6)(2,Dmg=dimethy[glyoxime) and H_(6)[TiCo_(2)(μ_(2)-Oipr)(Oipr)_(2)(Dmg)_(3)]_(6)(3),have been successfully synthesized and characterized.The supramolecular stacking modes of these wheels are largely dependent on the applied synthetic conditions,which further impact their gas adsorption properties.
基金supported by the National Natural Science Foundation of China (NSFC,No.21922111)the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB20000000)。
文摘Supramolecular transformations of coordination cage or capsule have received much attention recently,which help elucidate this natural self-assembly behavior in biological systems.The current study describes the first supramolecular transformation of titanium-o rganic coordination capsule triggered by phenol(and H_(3) PO_(3)).The structural alterations are accompanied by the reconstruction of 5-coordinated Ti centers to 6-coordinated ones.Meanwhile,different amounts of encapsulated phenol vip molecules can be identified,dependent on the sizes of the obtained cavities.In addition,they display much better visible light absorption and air stability than the isopropanol stabilized ones.
基金supported by the National Natural Science Foundation of China(51903172,52073216)the Sichuan Science and Technology Program(2022NSFSC1939).
文摘Inflammatory bowel disease(IBD)is a chronic and refractory condition characterized by disrupted epithelial barrier,dysregulated immune balance,and altered gut microbiota.Nano-enabled interventions for restoring gut homeostasis have the potential to alleviate inflammation in IBD.Herein,we developed a combination of olsalazine(Olsa)-based nanoneedles and microbiota-regulating inulin gel to reshape intestinal homeostasis and relieve inflammation.The Olsa-derived nanoneedles exhibited reactive oxygen species scavenging ability and anti-inflammatory effects in lipopolysaccharide-simulated macrophages.The composite of nanoneedles and inulin gel(Cu2(Olsa)/Gel)displayed a macroporous structure,improved bio-adhesion,and enhanced colon retention after oral administration.Mechanistically,the composite effectively downregulated pro-inflammatory cytokine levels and promoted epithelial barrier repair through anti-inflammatory and antioxidant therapies,resulting in significant alleviation of colitis in three animal models of IBD.Furthermore,analysis of gut microbiota revealed that Cu2(Olsa)/Gel treatment increased the diversity of intestinal microflora and decreased the relative abundance of pathogenic bacteria such as Proteobacteria.Overall,this study provides a self-delivering nanodrug and dietary fiber hydrogel composite for IBD therapy,offering an efficient approach to restore intestinal homeostasis.
