背景:沸石基咪唑盐框架8及其衍生物凭借优异的药物控释能力在组织工程领域展现出广泛的应用潜力。目的:综述沸石基咪唑盐框架8及其改性材料在活性氧生成与清除中的作用机制,探讨它们在抗肿瘤、抗菌及组织保护领域的应用潜力,分析未来发...背景:沸石基咪唑盐框架8及其衍生物凭借优异的药物控释能力在组织工程领域展现出广泛的应用潜力。目的:综述沸石基咪唑盐框架8及其改性材料在活性氧生成与清除中的作用机制,探讨它们在抗肿瘤、抗菌及组织保护领域的应用潜力,分析未来发展方向与挑战。方法:由第一作者通过中国知网、PubMed等数据库检索2000-2024年相关文献,中文检索关键词为“沸石基咪唑盐框架8,活性氧,抗菌,抗肿瘤,活性氧吸收,活性氧平衡,组织修复”,英文检索关键词为“ZIF-8,ROS,antibacterial,antitumor,ROS absorption,Balance of ROS,Tissue regeneration”,最终筛选69篇高质量文献进行综述分析。结果与结论:通过调控沸石基咪唑盐框架8及其改性材料的带隙结构、优化电子转移效率可显著提升光生载流子的分离与迁移效率,从而增强催化反应性能,提高活性氧的产生效率,实现更高效、更具靶向性的抗肿瘤及抗菌作用;同时,采用抗氧化酶系统或表面改性技术构建的活性氧清除装置,能够精准平衡多余活性氧,实现对细胞的有效保护。这种基于带隙调控与电子转移优化的双向调控机制,为动态管理活性氧生成与清除提供了重要策略,在抗肿瘤、抗菌及组织保护等领域展现出广阔的应用前景。展开更多
Semicarbazide has become an important pollutant in the environment,but there was no comprehensive literature on its advances.In this review,the source,biotoxicity and detection methods are summarized.Among the sources...Semicarbazide has become an important pollutant in the environment,but there was no comprehensive literature on its advances.In this review,the source,biotoxicity and detection methods are summarized.Among the sources is the material of chemical reaction,a metabolite of nitrofurazone,food processing(production by azobisformamide and hypochlorite treatment),endogenous substances,etc.Semicarbazide is demonstrated to be accumulative and reproductive toxicity,mutagenicity and genotoxicity,endocrine disruptors,and neurotoxicity.There are still many controversies on the effect of genotoxicity and no clear result on the carcinogenic mechanism.HPLC-MS/MS is the mainstream of the detection methods.Other methods,including HPLC,immunoassay method,biosensor method,electrochemical detection,capillary electrophoresis technique,and spectral techniques mainly,have become less and less in recent years.On all these counts,to reduce the content of semicarbazide in the environment,the key is to control the use of nitrofurazone as the banned drug effectively.Meanwhile the toxicity data should be supplemented to reveal its toxic mechanism.展开更多
文摘背景:沸石基咪唑盐框架8及其衍生物凭借优异的药物控释能力在组织工程领域展现出广泛的应用潜力。目的:综述沸石基咪唑盐框架8及其改性材料在活性氧生成与清除中的作用机制,探讨它们在抗肿瘤、抗菌及组织保护领域的应用潜力,分析未来发展方向与挑战。方法:由第一作者通过中国知网、PubMed等数据库检索2000-2024年相关文献,中文检索关键词为“沸石基咪唑盐框架8,活性氧,抗菌,抗肿瘤,活性氧吸收,活性氧平衡,组织修复”,英文检索关键词为“ZIF-8,ROS,antibacterial,antitumor,ROS absorption,Balance of ROS,Tissue regeneration”,最终筛选69篇高质量文献进行综述分析。结果与结论:通过调控沸石基咪唑盐框架8及其改性材料的带隙结构、优化电子转移效率可显著提升光生载流子的分离与迁移效率,从而增强催化反应性能,提高活性氧的产生效率,实现更高效、更具靶向性的抗肿瘤及抗菌作用;同时,采用抗氧化酶系统或表面改性技术构建的活性氧清除装置,能够精准平衡多余活性氧,实现对细胞的有效保护。这种基于带隙调控与电子转移优化的双向调控机制,为动态管理活性氧生成与清除提供了重要策略,在抗肿瘤、抗菌及组织保护等领域展现出广阔的应用前景。
基金The work was supported by the National Key R&D Program of China(No.2017YFC1600702)the Key Lab of Marine Bioactive Substance and Modern Analytical Technique,SOA(No.MBSMAT-2019-04)+1 种基金the Modern Agro-Industry Technology Research System in Shandong Pro-vince(No.SDAIT-26-05)the National Natural Science Foundation of China(No.31901787).
文摘Semicarbazide has become an important pollutant in the environment,but there was no comprehensive literature on its advances.In this review,the source,biotoxicity and detection methods are summarized.Among the sources is the material of chemical reaction,a metabolite of nitrofurazone,food processing(production by azobisformamide and hypochlorite treatment),endogenous substances,etc.Semicarbazide is demonstrated to be accumulative and reproductive toxicity,mutagenicity and genotoxicity,endocrine disruptors,and neurotoxicity.There are still many controversies on the effect of genotoxicity and no clear result on the carcinogenic mechanism.HPLC-MS/MS is the mainstream of the detection methods.Other methods,including HPLC,immunoassay method,biosensor method,electrochemical detection,capillary electrophoresis technique,and spectral techniques mainly,have become less and less in recent years.On all these counts,to reduce the content of semicarbazide in the environment,the key is to control the use of nitrofurazone as the banned drug effectively.Meanwhile the toxicity data should be supplemented to reveal its toxic mechanism.
