Based on the relative and absolute gravity measurements in the southern South-North Seismic Belt since 2015,we analyzed the dynamic change of the regional gravity field and its relationship with the Yangbi M_(S)6.4 ea...Based on the relative and absolute gravity measurements in the southern South-North Seismic Belt since 2015,we analyzed the dynamic change of the regional gravity field and its relationship with the Yangbi M_(S)6.4 earthquake that occurred on May 21,2021.The results show that:(1)The regional gravity field changes are closely related to the Weixi-Qiaohou fault,which reflects the surface gravity field changes caused by the fault activity from 2015 to 2021;(2)The gravity field change related to the preparation of Yangbi earthquake has experienced the evolution process of"steady state-regional gravity anomaly-local gravity anomaly-four-quadrant distribution-large area positive anomaly-earthquake occurring in the reverse change process";(3)The cumulative and differential change images of the gravity field show that there were significant gravity changes in the two years preceding the Yangbi earthquake,and the earthquake occurred in the high-gradient belt of gravity variation,the center of the four-quadrant,and close to the zero contour turn;(4)The dynamic evolution image of the gravity field can well reflect the precursory phenomena during the preparation for the Yangbi MS6.4 earthquake.Based on the anomaly change of mobile gravity,a certain degree of medium-term prediction was made before the Yangbi M_(S)6.4 earthquake,especially the determination of strong earthquake location.展开更多
信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)是一种核转录因子,其功能除调节细胞周期、细胞存活相关基因的表达之外,还参与肿瘤相关免疫应答反应。STAT3活化可以驱动肿瘤细胞增殖,抵抗细胞凋亡...信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)是一种核转录因子,其功能除调节细胞周期、细胞存活相关基因的表达之外,还参与肿瘤相关免疫应答反应。STAT3活化可以驱动肿瘤细胞增殖,抵抗细胞凋亡,促进肿瘤的血管生成和转移等,且STAT3的异常激活与肿瘤预后不良相关。STAT3是介导肿瘤免疫逃逸的主要驱动因素之一,因此其成为免疫治疗中有效靶点之一。本文将从STAT3在固有免疫、适应性免疫及肿瘤免疫中的作用等几个方面进行阐述,并展望未来亟待解决的问题及进一步的研究方向。展开更多
Elevated atmospheric carbon dioxide concentration([CO_(2)])can stimulate crop growth and increase yield,but the effect may be constrained by soil contamination with heavy metals.In a free-air carbon dioxide enrichment...Elevated atmospheric carbon dioxide concentration([CO_(2)])can stimulate crop growth and increase yield,but the effect may be constrained by soil contamination with heavy metals.In a free-air carbon dioxide enrichment experiment over three seasons,we found that soil heavy metal contamination can constrain or even reverse the projected CO_(2)fertilization effect on rice yield.Elevated[CO_(2)]produced opposing effects on the accumulation of arsenic and cadmium in rice grain.Breeding crops for heavy-metal resistance and low arsenic accumulation may become necessary with continuing climate change.展开更多
The simultaneous integration of high energy density,low sensitivity,and thermal stability in energetic materials has constituted a century-long scientific challenge.Herein,we address this through a dualzwitterionic el...The simultaneous integration of high energy density,low sensitivity,and thermal stability in energetic materials has constituted a century-long scientific challenge.Herein,we address this through a dualzwitterionic electronic delocalization strategy,yielding TYX-3,the first bis-inner salt triazolo-tetrazine framework combining these mutually exclusive properties.Uniformπ-electron distribution and elevated bond dissociation energy confer exceptional thermal stability(T_(d)=365℃)with TATB-level insensitivity(impact sensitivity IS>40 J,friction sensitivity FS>360 N).Engineeredπ-stacked networks enable record density(1.99 g·cm^(-3))with detonation performance surpassing HMX benchmarks(detonation velocity 9315 m·s^(-1),detonation pressure 36.6 GPa).Practical implementation in Poly(3-nitratomethyl-3-methyloxetane)(PNMMFO)solid propellants demonstrates 5.4-fold safety enhancement over conventional HMX-based formulations while maintaining equivalent specific impulse.This work establishes a new design paradigm for energetic materials,overcoming the historical trade-offs between molecular stability and energy output through rational zwitterionic engineering.展开更多
基金funded by the General Program of National Natural Science Foundation of China(No.41874092,No.U1939205)Natural Science Foundation of Shaanxi Province(No.2023-JC-QN-0329).
文摘Based on the relative and absolute gravity measurements in the southern South-North Seismic Belt since 2015,we analyzed the dynamic change of the regional gravity field and its relationship with the Yangbi M_(S)6.4 earthquake that occurred on May 21,2021.The results show that:(1)The regional gravity field changes are closely related to the Weixi-Qiaohou fault,which reflects the surface gravity field changes caused by the fault activity from 2015 to 2021;(2)The gravity field change related to the preparation of Yangbi earthquake has experienced the evolution process of"steady state-regional gravity anomaly-local gravity anomaly-four-quadrant distribution-large area positive anomaly-earthquake occurring in the reverse change process";(3)The cumulative and differential change images of the gravity field show that there were significant gravity changes in the two years preceding the Yangbi earthquake,and the earthquake occurred in the high-gradient belt of gravity variation,the center of the four-quadrant,and close to the zero contour turn;(4)The dynamic evolution image of the gravity field can well reflect the precursory phenomena during the preparation for the Yangbi MS6.4 earthquake.Based on the anomaly change of mobile gravity,a certain degree of medium-term prediction was made before the Yangbi M_(S)6.4 earthquake,especially the determination of strong earthquake location.
文摘信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)是一种核转录因子,其功能除调节细胞周期、细胞存活相关基因的表达之外,还参与肿瘤相关免疫应答反应。STAT3活化可以驱动肿瘤细胞增殖,抵抗细胞凋亡,促进肿瘤的血管生成和转移等,且STAT3的异常激活与肿瘤预后不良相关。STAT3是介导肿瘤免疫逃逸的主要驱动因素之一,因此其成为免疫治疗中有效靶点之一。本文将从STAT3在固有免疫、适应性免疫及肿瘤免疫中的作用等几个方面进行阐述,并展望未来亟待解决的问题及进一步的研究方向。
基金supported by KeyArea Research and Development Program of Guangdong ProvinceChina(2020B020201006)to Chunwu Zhu+5 种基金National Natural Science Foundation of China(31870423)to Chunwu ZhuNational Natural Science Foundation of China(41930758)to Fang-Jie ZhaoJiangsu Science and Technology Department(BM20222002)to Chunwu ZhuCarbon Peaking and Carbon Neutrality Special Fund for Science and Technology from Nanjing Science and Technology Bureau(20221103)to Chunwu ZhuKey Research and Development Program of Jiangsu Province(BE2022308)to Chunwu ZhuErdos City Science and Technology Major Project(2022EEDSKJZDZX010)to Chunwu Zhu。
文摘Elevated atmospheric carbon dioxide concentration([CO_(2)])can stimulate crop growth and increase yield,but the effect may be constrained by soil contamination with heavy metals.In a free-air carbon dioxide enrichment experiment over three seasons,we found that soil heavy metal contamination can constrain or even reverse the projected CO_(2)fertilization effect on rice yield.Elevated[CO_(2)]produced opposing effects on the accumulation of arsenic and cadmium in rice grain.Breeding crops for heavy-metal resistance and low arsenic accumulation may become necessary with continuing climate change.
基金supported by the National Natural Science Foundation of China(Grant Nos.22105156,22175139,22171136,and 22302156)the China National Science Fund for Distinguished Young Scholars(Grant No.22325504)。
文摘The simultaneous integration of high energy density,low sensitivity,and thermal stability in energetic materials has constituted a century-long scientific challenge.Herein,we address this through a dualzwitterionic electronic delocalization strategy,yielding TYX-3,the first bis-inner salt triazolo-tetrazine framework combining these mutually exclusive properties.Uniformπ-electron distribution and elevated bond dissociation energy confer exceptional thermal stability(T_(d)=365℃)with TATB-level insensitivity(impact sensitivity IS>40 J,friction sensitivity FS>360 N).Engineeredπ-stacked networks enable record density(1.99 g·cm^(-3))with detonation performance surpassing HMX benchmarks(detonation velocity 9315 m·s^(-1),detonation pressure 36.6 GPa).Practical implementation in Poly(3-nitratomethyl-3-methyloxetane)(PNMMFO)solid propellants demonstrates 5.4-fold safety enhancement over conventional HMX-based formulations while maintaining equivalent specific impulse.This work establishes a new design paradigm for energetic materials,overcoming the historical trade-offs between molecular stability and energy output through rational zwitterionic engineering.
