Cardiovascular disease(CVD)represents the foremost cause of mortality globally,imposing a substantial economic burden.In 2021,approximately 19.4 million deaths were attributed to cardiovascular conditions,constituting...Cardiovascular disease(CVD)represents the foremost cause of mortality globally,imposing a substantial economic burden.In 2021,approximately 19.4 million deaths were attributed to cardiovascular conditions,constituting 32%of global mortality[1].Over three-quarters of these fatalities occurred in low and middle-income nations.Notably,ischemic heart disease and stroke were responsible for 84%of CVD-related deaths.Among them,the number of cases of ischemic cardiomyopathy increased by 68%in 2021 compared to 1990(Figure 1A).展开更多
[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and ex...[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and explore an integrated management path that is applicable to rural areas.[Methods]A cross-sectional survey,in conjunction with a retrospective cohort analysis,was conducted.The samples were obtained from the National Management Information System for Severe Mental Disorders(2020-2024),and all registered rural patients in Zhushan County were included through cluster sampling.All participants provided informed consent,and the study received approval from the Ethics Committee of the Zhushan County Mental Health Center.Diagnoses were made in accordance with the International Classification of Diseases,10 th Revision(ICD-10).The research utilized a self-developed socio-ecological scale,which was validated through two rounds of the Delphi method conducted by an expert group,yielding a Cronbach sαof 0.82.The data were collected by trained investigators who conducted household visits.The data entry process involved double entry by two individuals to ensure accuracy for system review.Statistical analysis was performed using SPSS 26.0,employing the chi-square(χ2)test and logistic regression models for analysis.[Results]Schizophrenia was identified as the predominant disorder,affecting 68.4%of the patient population,followed by bipolar disorder,which accounted for 18.8%.Notably,individuals aged over 60 years constituted 40.36%of the sample.Furthermore,the poverty rate within this population was alarmingly high at 87.87%,while the illiteracy rate stood at 41.37%.The treatment experienced a significant delay,with a median duration of 14.2 months.Additionally,there was a substantial gap in standardized treatment,measured at 23.59%.The family care function was found to be inadequate,particularly for families lacking guardianship capacity,which was reported at 11.31%.An analysis of the underlying causes indicates that social structural imbalances(such as left-behind children and marital breakdown),along with economic poverty and insufficient educational opportunities,were critical risk factors contributing to these issues.The development of a model that integrates dynamic screening,full-chain intervention,and collaborative management is beneficial for fostering the efficient and systematic advancement of the rural mental health system.[Conclusions]Patients with mental disorders residing in rural areas face dual vulnerabilities.Therefore,it is essential to implement integrated management that encompasses early screening,standardized treatment,family support,and policy assistance.It is recommended that these elements should be integrated into the framework for local health policy development to enhance equitable access to mental health services and to provide psychological support for rural revitalization efforts.展开更多
This study reviewed the clinical characteristics of adolescent bipolar disorder,the shortcomings of traditional treatment models in a systematical manner,analyzed the application status of virtual reality(VR)technolog...This study reviewed the clinical characteristics of adolescent bipolar disorder,the shortcomings of traditional treatment models in a systematical manner,analyzed the application status of virtual reality(VR)technology in mental and psychological diseases,and explored the potential mechanism of VR intervention for adolescent bipolar disorder patients,especially the value of PET/CT in the evaluation of brain energy metabolism.Studies have shown that VR treatment may optimize the neurological function of patients with bipolar disorder by enhancing the prefrontal-limbic system network,regulating the reward circuit and improving the executive function,and show positive changes in the metabolism of key brain areas at the PET/CT imaging level.展开更多
Although cisplatin is a widely used chemotherapeutic agent,it is severely toxic and causes irreversible hearing loss,restricting its application in clinical settings.This study aimed to determine the molecular mechani...Although cisplatin is a widely used chemotherapeutic agent,it is severely toxic and causes irreversible hearing loss,restricting its application in clinical settings.This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity.Here,we established in vitro and in vivo ototoxicity models of cisplatininduced hair cell loss,and our results showed that reducing STING levels decreased inflammatory factor expression and hair cell death.In addition,we found that cisplatin-induced mitochondrial dysfunction was accompanied by cytosolic DNA,which may act as a critical linker between the cyclic GMP-AMP synthesis−stimulator of interferon genes(cGASSTING)pathway and the pathogenesis of cisplatin-induced hearing loss.H-151,a specific inhibitor of STING,reduced hair cell damage and ameliorated the hearing loss caused by cisplatin in vivo.This study underscores the role of cGASSTING in cisplatin ototoxicity and presents H-151 as a promising therapeutic for hearing loss.展开更多
Negative air ions(NAIs)in indoor environments have been suggested to positively impact human health by effectively reducing particulate contamination and gaseous pollutants,as well as inhibiting the growth of microorg...Negative air ions(NAIs)in indoor environments have been suggested to positively impact human health by effectively reducing particulate contamination and gaseous pollutants,as well as inhibiting the growth of microorganisms,bacteria and viruses.This study investigates the common ionizers with different module types,and the mechanism of NAIs for enhancing indoor air quality,as well as the positive and negative impacts on human health.The association between NAI concentrations and human health outcomes is examined,and alternative measures to balance beneficial and unavailing effects are investigated.While NAIs demonstrate efficacy in removing particulate pollutants,alleviating depression,enhancing cognitive function and even stimulating sympathetic activity,it is pertinent to acknowledge the presence of contradictory findings concerning their effects on cardiac autonomic function and respiratory physiology.To address this complexity,it is imperative to consider alternative measures that strike a balance between the beneficial and unavailing effects of NAIs.These measures can encompass a general assessment of the characteristics of particulate pollutants,a strategic selection of ionizer technologies,and adherence to the recommended optimal concentration thresholds of NAIs.展开更多
基金supported by the National Natural Science Foundation of China(No.82270364)Science and Technology Program of Guizhou Province(No.ZK[2023]321)+3 种基金Guizhou Provincial Youth Science and Technology Talents Growth Project(No.KY[2022]214)Excellent Young Talents Plan of Guizhou Medical University(No.[2023]112)Guizhou Medical University Key Laboratory of Cardiovascular Disease Basic and Clinical Research(No.2024001)Start-up Fund of Guizhou Medical University(No.J2021032).
文摘Cardiovascular disease(CVD)represents the foremost cause of mortality globally,imposing a substantial economic burden.In 2021,approximately 19.4 million deaths were attributed to cardiovascular conditions,constituting 32%of global mortality[1].Over three-quarters of these fatalities occurred in low and middle-income nations.Notably,ischemic heart disease and stroke were responsible for 84%of CVD-related deaths.Among them,the number of cases of ischemic cardiomyopathy increased by 68%in 2021 compared to 1990(Figure 1A).
基金Supported by TCM Scientific Research Guidance Program of Hubei Provincial Administration of Traditional Chinese Medicine(ZY2023F074).
文摘[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and explore an integrated management path that is applicable to rural areas.[Methods]A cross-sectional survey,in conjunction with a retrospective cohort analysis,was conducted.The samples were obtained from the National Management Information System for Severe Mental Disorders(2020-2024),and all registered rural patients in Zhushan County were included through cluster sampling.All participants provided informed consent,and the study received approval from the Ethics Committee of the Zhushan County Mental Health Center.Diagnoses were made in accordance with the International Classification of Diseases,10 th Revision(ICD-10).The research utilized a self-developed socio-ecological scale,which was validated through two rounds of the Delphi method conducted by an expert group,yielding a Cronbach sαof 0.82.The data were collected by trained investigators who conducted household visits.The data entry process involved double entry by two individuals to ensure accuracy for system review.Statistical analysis was performed using SPSS 26.0,employing the chi-square(χ2)test and logistic regression models for analysis.[Results]Schizophrenia was identified as the predominant disorder,affecting 68.4%of the patient population,followed by bipolar disorder,which accounted for 18.8%.Notably,individuals aged over 60 years constituted 40.36%of the sample.Furthermore,the poverty rate within this population was alarmingly high at 87.87%,while the illiteracy rate stood at 41.37%.The treatment experienced a significant delay,with a median duration of 14.2 months.Additionally,there was a substantial gap in standardized treatment,measured at 23.59%.The family care function was found to be inadequate,particularly for families lacking guardianship capacity,which was reported at 11.31%.An analysis of the underlying causes indicates that social structural imbalances(such as left-behind children and marital breakdown),along with economic poverty and insufficient educational opportunities,were critical risk factors contributing to these issues.The development of a model that integrates dynamic screening,full-chain intervention,and collaborative management is beneficial for fostering the efficient and systematic advancement of the rural mental health system.[Conclusions]Patients with mental disorders residing in rural areas face dual vulnerabilities.Therefore,it is essential to implement integrated management that encompasses early screening,standardized treatment,family support,and policy assistance.It is recommended that these elements should be integrated into the framework for local health policy development to enhance equitable access to mental health services and to provide psychological support for rural revitalization efforts.
文摘This study reviewed the clinical characteristics of adolescent bipolar disorder,the shortcomings of traditional treatment models in a systematical manner,analyzed the application status of virtual reality(VR)technology in mental and psychological diseases,and explored the potential mechanism of VR intervention for adolescent bipolar disorder patients,especially the value of PET/CT in the evaluation of brain energy metabolism.Studies have shown that VR treatment may optimize the neurological function of patients with bipolar disorder by enhancing the prefrontal-limbic system network,regulating the reward circuit and improving the executive function,and show positive changes in the metabolism of key brain areas at the PET/CT imaging level.
基金supported by grants from the National Natural Science Foundation of China(82222017,82271183,and 81970883)the Key Research and Development Program of Hubei Province(2022BCA046)funding from the Fundamental Research Funds for the Central Universities(2042022kf0059).
文摘Although cisplatin is a widely used chemotherapeutic agent,it is severely toxic and causes irreversible hearing loss,restricting its application in clinical settings.This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity.Here,we established in vitro and in vivo ototoxicity models of cisplatininduced hair cell loss,and our results showed that reducing STING levels decreased inflammatory factor expression and hair cell death.In addition,we found that cisplatin-induced mitochondrial dysfunction was accompanied by cytosolic DNA,which may act as a critical linker between the cyclic GMP-AMP synthesis−stimulator of interferon genes(cGASSTING)pathway and the pathogenesis of cisplatin-induced hearing loss.H-151,a specific inhibitor of STING,reduced hair cell damage and ameliorated the hearing loss caused by cisplatin in vivo.This study underscores the role of cGASSTING in cisplatin ototoxicity and presents H-151 as a promising therapeutic for hearing loss.
基金Research Project of Marine Design and Research Institute of China。
文摘Negative air ions(NAIs)in indoor environments have been suggested to positively impact human health by effectively reducing particulate contamination and gaseous pollutants,as well as inhibiting the growth of microorganisms,bacteria and viruses.This study investigates the common ionizers with different module types,and the mechanism of NAIs for enhancing indoor air quality,as well as the positive and negative impacts on human health.The association between NAI concentrations and human health outcomes is examined,and alternative measures to balance beneficial and unavailing effects are investigated.While NAIs demonstrate efficacy in removing particulate pollutants,alleviating depression,enhancing cognitive function and even stimulating sympathetic activity,it is pertinent to acknowledge the presence of contradictory findings concerning their effects on cardiac autonomic function and respiratory physiology.To address this complexity,it is imperative to consider alternative measures that strike a balance between the beneficial and unavailing effects of NAIs.These measures can encompass a general assessment of the characteristics of particulate pollutants,a strategic selection of ionizer technologies,and adherence to the recommended optimal concentration thresholds of NAIs.
