目的 探讨STAT活化抑制蛋白2(protein inhibitor of the activated STAT2, PIAS2)基因在前列腺癌中的表达水平及其与临床病理特征的关系,以及PIAS2对前列腺癌脂质代谢重编程的潜在作用。方法 采用癌症基因图谱(The Cancer Genome Atlas ...目的 探讨STAT活化抑制蛋白2(protein inhibitor of the activated STAT2, PIAS2)基因在前列腺癌中的表达水平及其与临床病理特征的关系,以及PIAS2对前列腺癌脂质代谢重编程的潜在作用。方法 采用癌症基因图谱(The Cancer Genome Atlas Program,TCGA)数据库和人类蛋白图谱(Human Protein Atas,HPA)免疫组化分析显示PIAS2蛋白的表达情况;采用qRT-PCR、Western bolt及免疫组化检测前列腺癌组织和周围癌旁组织中PIAS2的表达,并分析其与患者临床病理特征的关系;慢病毒感染前列腺癌细胞株PC-3M,稳定敲低PIAS2,通过超高效液相色谱质谱技术(UPLC-MS)进行脂质组学分析。结果 TCGA分析显示PIAS2在前列腺癌组织的表达高于癌旁组织,HPA免疫组化分析显示PIAS2蛋白在前列腺癌组织高表达;PIAS2 mRNA和蛋白在前列腺癌中的表达量相较于癌旁组织均有显著提升,差异有统计学意义(P<0.05);免疫组织化学显示PIAS2蛋白表达主要定位在前列腺的细胞核,且前列腺癌组织的AOD值显著高于癌旁组织:临床病理参数研究结果显示,PIAS2与Gleason评分、TNM分期具有相关性(P<0.05),而与患者年龄、PSA及淋巴结转移之间相关性无统计学意义(P > 0.05);UPLC-MS分析提示,敲降PIAS2影响10种脂类变化,与shNC组相比,shPIAS2组的磷脂酰胆碱和磷脂酰乙醇胺的含量下调,磷脂酰肌醇、磷脂酰丝氨酸、二酰基甘油和三酰基甘油的含量上调。结论 PIAS2蛋白的表达量在前列腺癌组织中明显升高,提示PIAS2与前列腺癌的发生发展有关,其发病机制可能与前列腺癌的脂质代谢异常相关。展开更多
BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention.A simple,practical,and safe method can effectively relieve thirst symptom...BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention.A simple,practical,and safe method can effectively relieve thirst symptoms in such patients.AIM To evaluate the enhanced recovery after surgery(ERAS)-based evidence-based care(EBC)plus ice stimulation therapy for thirst management of convalescent patients following digestive surgery performed under general anesthesia.METHODS A total of 191 patients convalescing after digestive surgery performed under general anesthesia between March 2020 and February 2023 and experiencing thirst were selected.In total,89 patients and 102 patients in the control and research groups received routine care and ERAS-based EBC plus ice stimulation therapy,respectively.The following data were comparatively analyzed:(1)Thirst degree(thirst intensity numerical rating scale)and thirst distress(TD)degree(TD scale);(2)Oral mucosal wetness;(3)Unstimulated whole salivary flow rate(UWSFR);(4)Adverse reactions(palpitation,fatigue,chapped lips,and nausea and vomiting);and(5)Nursing satisfaction.RESULTS After nursing,thirst degree and distress were statistically lower in the research group than in the control group.Additionally,compared with the control group,the research group exhibited a lower degree of oral mucosal wetness,higher UWSFR,fewer adverse reactions,and more total nursing satisfaction.CONCLUSION ERAS-based EBC plus ice stimulation therapy can effectively alleviate thirst in convalescent patients recovering from a digestive surgery performed under general anesthesia.It can alleviate xerostomia symptoms,reduce adverse reactions,and improve patient comfort.展开更多
Li_(6)PS_(5)Cl is a highly wanted sulfide-solid-electrolyte(SSE)for developing all-solid-state lithium batteries,due to its high ionic conductivity,good processability and abundant compositional elements.However,its c...Li_(6)PS_(5)Cl is a highly wanted sulfide-solid-electrolyte(SSE)for developing all-solid-state lithium batteries,due to its high ionic conductivity,good processability and abundant compositional elements.However,its cyclability is poor because of harmful side reactions at the Li_(6)PS_(5)Cl/Li interface and growth of lithium dendrites inside Li_(6)PS_(5)Cl phase.Herein,we report a simple interface-engineering remedy to boost the electrochemical performance of Li_(6)PS_(5)Cl,by coating its surface with a Li-compatible electrolyte Li3OCl having low electronic conductivity.The obtainedLi_(6)PS_(5)Cl@Li_(3)OCl core@shell structure exhibits a synergistic effect.Consequently,compared with the bare Li_(6)PS_(5)Cl,this composite electrolyte exhibits great performance improvements:1)In Li|electrolyte|Li symmetric cells,the critical current density at 30℃gets increased from 0.6 mA cm^(-2)to 1.6 mA cm^(-2),and the lifetime gets prolonged from 320 h to 1400 h at the cycling current of 0.2 mA cm^(-2)or from 10 h to 900 h at the cycling current of 0.5 mA cm^(-2);2)In Li|electrolyte|NCM721 full cells running at 30℃,the cycling capacity at 0.2 C(or 0.5 C)gets enhanced by 20%(or from unfeasible to be feasible)for 100 cycles and the rate capability reaches up to 2 C from 0.2 C;and in full cells running at 60℃,the cycling capacity is increased by 7%at 0.2 C and the rate capability is enhanced to 3.0 C from 0.5 C.The experimental studies and theoretical computations show that the performance enhancements are due to the confined electron penetration and suppressed lithium dendrites growth at theLi_(6)PS_(5)Cl@Li_(3)OCl interface.展开更多
Silicon suboxide(SiO_(x),0<x<2)is an appealing anode material to replace traditional graphite owing to its much higher theoretical specific capacity enabling higher-energy-density lithium batteries.Nevertheless,...Silicon suboxide(SiO_(x),0<x<2)is an appealing anode material to replace traditional graphite owing to its much higher theoretical specific capacity enabling higher-energy-density lithium batteries.Nevertheless,the huge volume change and rapid capacity decay of SiO_(x)electrodes during cycling pose huge challenges to their large-scale practical applications.To eliminate this bottleneck,a dragonfly wing microstructure-inspired polymer electrolyte(denoted as PPM-PE)is developed based on in-situ polymerization of bicyclic phosphate ester-and urethane motif-containing monomer and methyl methacrylate in traditional liquid electrolyte.PPM-PE delivers excellent mechanical properties,highly correlated with the formation of a micro-phase separation structure similar with dragonfly wings.By virtue of superior mechanical properties and the in-situ solidified preparation method,PPM-PE can form a 3D polymer network buffer against stress within the electrode particles gap,enabling much suppressed electrode volume expansion and more stabilized solid electrolyte interface along with evidently decreased electrolyte decomposition.Resultantly,PPM-PE shows significant improvements in both cycling and rate performance in button and soft package batteries with SiO_(x)-based electrodes,compared with the liquid electrolyte counterpart.Such a dragonfly wing microstructure-inspired design philosophy of in-situ solidified polymer electrolytes helps facilitate the practical implementation of high-energy lithium batteries with SiO_(x)-based anodes.展开更多
Southern corn leaf blight(SCLB)caused by Cochliobolus heterostrophus,is a widespread foliar disease that has a substantial impact on maize yield in the Huang-Huai-Hai Region of China.Pydiflumetofen(Pyd),a new succinat...Southern corn leaf blight(SCLB)caused by Cochliobolus heterostrophus,is a widespread foliar disease that has a substantial impact on maize yield in the Huang-Huai-Hai Region of China.Pydiflumetofen(Pyd),a new succinate dehydrogenase inhibitor(SDHI),has been found as a promising fungicide for the efficient control of SCLB,however,resistance of C.heterostrophus to Pyd has not been studied well.Here,five Pyd-resistant mutants were generated through fungicide adaptation.Sequence alignment analysis revealed that these mutants primarily mutated in ChSdhB and ChSdhD,with three genotypes:ChSdhB^(H277Y),ChSdhB^(I279T)and ChSdhD^(H133Y),exhibiting two distinct categories of resistance:high resistance(HR)and moderate resistance(MR),among which the resistance factors were 214.22 and 44.33-53.67,respectively.These mutants were more pathogenic than the wild-type parental strains,but there was a significant reduction in mycelial growth rate and sporulation in the resistant mutants,indicating a significant fitness cost associated with resistance to Pyd.In addition,this study revealed a positive cross-resistance between Pyd and another SDHI fungicide cyclobutrifluram.However,no cross-resistance was found between Pyd and other classes of fungicides,including prochloraz,fludioxonil,iprodione or pyraclostrobin.Homology modeling and molecular docking further confirmed that point mutations of ChSdhB^(H277Y),ChSdhB^(I279T),and ChSdhD^(H133Y)could reduce binding affinity between Pyd and its target subunits from-74.07,-74.07,-152.52 kcal mol^(-1)to-3.90,-4.95,-9.93 kcal mol^(-1),respectively.These findings not only provided valuable insights for managing SCLB caused by C.heterostrophus,but also enhanced our understanding of molecular mechanism underlying plant pathogen resistance to Pyd.展开更多
Hydraulic sandblasting perforation plays a crucial role in the fracturing and reconstruction of unconventional oil and gas reservoirs.The jet nozzle is an essential part of the hydraulic perforation tool.Insufficient ...Hydraulic sandblasting perforation plays a crucial role in the fracturing and reconstruction of unconventional oil and gas reservoirs.The jet nozzle is an essential part of the hydraulic perforation tool.Insufficient penetration depth,caused by excessive jet distances,presents challenges during the perforation process.To overcome this,an optimization design of the nozzle structure is required to enhance the perforation efficiency.In this paper,a computational fluid-dynamic model for conical-cylindrical nozzles has been elaborated.To further improve the rock-breaking efficiency of the jet nozzle,a fillet design is introduced at the nozzle inlet section.The SST k-ωmodel is employed to account for turbulent flow effects in submerged conditions.The results indicate that the nozzle’s geometric parameters greatly influence the flow characteristics.The orthogonal experimental method is employed to optimize the flow channel structure of the nozzle,taking the length of constant velocity core as the evaluation index.The following optimized geometric parameters for the conical-cylindrical nozzle have been determined accordingly:a cylindrical segment diameter of 3.2 mm,a contraction angle of 12°,a contraction segment length of 8 mm,a cylindrical segment length of 6.4 mm,and a fillet radius of 2 mm.展开更多
Rice bakanae disease(RBD)is a devastating plant disease caused by Fusarium fujikuroi.This study aimed to evaluate the potential of cyclobutrifuram,a novel succinate dehydrogenase inhibitor(SDHI),to control RBD,and det...Rice bakanae disease(RBD)is a devastating plant disease caused by Fusarium fujikuroi.This study aimed to evaluate the potential of cyclobutrifuram,a novel succinate dehydrogenase inhibitor(SDHI),to control RBD,and determine the risk and mechanism of resistance to cyclobutrifuram in F.fujikuroi.In vitro experiments showed that cyclobutrifuram significantly inhibited mycelial growth and spore germination,and altered the morphology of mycelia and conidia.Treatment with cyclobutrifuram signifcantly decreased mycotoxin production and increased cell membrane permeability in F.fujikuroi.The baseline sensitivity of 72 F.fujikuroi isolates to cyclobutrifuram was determined using mycelial growth and spore germination inhibition assays,which revealed EC50values of 0.0114-0.1304 and 0.0012-0.016μg mL^(-1),with mean EC50values of(0.0410±0.0470)and(0.0038±0.0015)μg mL^(-1),respectively.Pot experiments demonstrated that the protective effect of cyclobutrifluram against F.fujikuroi was more significant than that of phenamacril and azoxystrobin,indicating that cyclobutrifuram is a promising antifungal agent for the control of RBD.Six cyclobutrifuramresistant mutants of F.fujikuroi were obtained via fungicide adaptation.Moreover,these mutants exhibited weaker ftness than their parental isolate and positive cross-resistance with other SDHI fungicides,including pydifumetofen and penfufen;however,no cross-resistance was detected with other classes of fungicides,including phenamacril,fudioxonil,prochloraz,or azoxystrobin.These results indicated that the resistance risk of F.fujikuroi to cyclobutrifuram might be moderate.Sequencing analysis revealed that mutations,including H248D in Ff Sdh B,A83V in Ff Sdh C2,and S106F and E166K in Ff Sdh D,contributed to resistance,which was confrmed by molecular docking and homologous replacement experiments.The results suggest a high potential for cyclobutrifuram to control RBD and a moderate resistance risk of F.fujikuroi to cyclobutrifuram,which are meaningful fndings for the scientifc application of cyclobutrifuram.展开更多
Sodium-ion batteries with ZnIn_(2)S_(4)(ZIS)anodes promise a high capacity and abundant resources.However,their inherent low conductivity,large volume expansion and sluggish Na+diffusion limit the development of the w...Sodium-ion batteries with ZnIn_(2)S_(4)(ZIS)anodes promise a high capacity and abundant resources.However,their inherent low conductivity,large volume expansion and sluggish Na+diffusion limit the development of the wide-temperature sodium storage.This study pioneers a scalable synthesis of hierarchical hollow structural ZIS/C heterostructure through in situ confined growth of ZIS nanosheets in porous hollow carbon spheres(PHCSs)via a hydrothermal method.This unique structure exhibits abundant heterostructures to facilitate charge transport,rich porous structures to promote electrolyte wettability,efficient space utilization to relieve volume expansion,as well as interconnected carbon networks to ensure framework stability.Consequently,ZIS/C exhibits exceptional cycling stability with 92%capacity retention after 1000 cycles.Notably,ZIS/C demonstrates good wide-temperature performance operating at–50∼90°C,especially,at–30°C with a capacity of 208 mA h g^(−1)at 0.3A g^(−1).The full cell of ZIS/C||Na_(3)V_(2)(PO_(4))_(3)exhibits excellent high-rate capability(178 mA h g^(−1)at 6A g^(−1)).展开更多
The present study aims to fabricate heterogeneous electro-Fenton(HEF)cathode catalysts for the in-situ generation of H2O2 and the degradation of organic pollutants in water.To achieve this,preparation of Fe and N co-d...The present study aims to fabricate heterogeneous electro-Fenton(HEF)cathode catalysts for the in-situ generation of H2O2 and the degradation of organic pollutants in water.To achieve this,preparation of Fe and N co-doped MXene composites(FeCN/MXene-x,where x represents the loading content of FeCN)and construction of the HEF system for the degradation of sulfathiazole(STZ)were carried out.The characterization results showed that Fe,C and N mainly existed in the form of Fe3C and Fe3N in the FeCN/MXene catalysts,which were favorable for promoting the ORR reaction in the HEF system.Among them,FeCN/MXene-2 exhibited the highest redox electron transfer rate and H2O2 selectivity(86%).The catalytic oxidation mechanism of the FeCN/MXene-2/HEF system was investigated by free radical quenching,electron paramagnetic resonance and frontier orbital theory studies.These studies demonstrated that the main active substances for the degradation of STZ were·OH and 1O2.In addition,the excellent stability and practical performance of the prepared cathodic catalysts were demonstrated by cycling experiments and real water sample tests.展开更多
0 INTRODUCTION The Qinling Mountains(QM),located at the geographical center of China,serve as a crucial dividing line between the northern and southern and play a vital role as an ecological security barrier,significa...0 INTRODUCTION The Qinling Mountains(QM),located at the geographical center of China,serve as a crucial dividing line between the northern and southern and play a vital role as an ecological security barrier,significantly influencing the country's geological,geographical,and ecological landscape(Jia et al.,2023;Peng et al.,2023).The QM stretch from the White Stone Mountain in the northern part of Lintan County,Gansu Province,to the Funiu Mountains in Henan Province in the east.展开更多
From September 1 7 to 1 9, the 5th China International Copy-right Expo （CICE） took place in Chengdu, capital city of Sichuan province. CICE, dubbed as ＂copy-right Olympics＂, featured the theme of＂ copyright in...From September 1 7 to 1 9, the 5th China International Copy-right Expo （CICE） took place in Chengdu, capital city of Sichuan province. CICE, dubbed as ＂copy-right Olympics＂, featured the theme of＂ copyright innovation and development＂ this year. i2 thematic events were held during the expo,展开更多
文摘BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention.A simple,practical,and safe method can effectively relieve thirst symptoms in such patients.AIM To evaluate the enhanced recovery after surgery(ERAS)-based evidence-based care(EBC)plus ice stimulation therapy for thirst management of convalescent patients following digestive surgery performed under general anesthesia.METHODS A total of 191 patients convalescing after digestive surgery performed under general anesthesia between March 2020 and February 2023 and experiencing thirst were selected.In total,89 patients and 102 patients in the control and research groups received routine care and ERAS-based EBC plus ice stimulation therapy,respectively.The following data were comparatively analyzed:(1)Thirst degree(thirst intensity numerical rating scale)and thirst distress(TD)degree(TD scale);(2)Oral mucosal wetness;(3)Unstimulated whole salivary flow rate(UWSFR);(4)Adverse reactions(palpitation,fatigue,chapped lips,and nausea and vomiting);and(5)Nursing satisfaction.RESULTS After nursing,thirst degree and distress were statistically lower in the research group than in the control group.Additionally,compared with the control group,the research group exhibited a lower degree of oral mucosal wetness,higher UWSFR,fewer adverse reactions,and more total nursing satisfaction.CONCLUSION ERAS-based EBC plus ice stimulation therapy can effectively alleviate thirst in convalescent patients recovering from a digestive surgery performed under general anesthesia.It can alleviate xerostomia symptoms,reduce adverse reactions,and improve patient comfort.
基金supported by the National Key Research and Development Program of China (2018YFE0111600)Haihe Laboratory of Sustainable Chemical Transformations for financial supportpartially supported by the Graduate Top-notch Innovation Award Plan in Liberal Arts and Science of Tianjin University for the Year of 2023 (B2-2023-012)
文摘Li_(6)PS_(5)Cl is a highly wanted sulfide-solid-electrolyte(SSE)for developing all-solid-state lithium batteries,due to its high ionic conductivity,good processability and abundant compositional elements.However,its cyclability is poor because of harmful side reactions at the Li_(6)PS_(5)Cl/Li interface and growth of lithium dendrites inside Li_(6)PS_(5)Cl phase.Herein,we report a simple interface-engineering remedy to boost the electrochemical performance of Li_(6)PS_(5)Cl,by coating its surface with a Li-compatible electrolyte Li3OCl having low electronic conductivity.The obtainedLi_(6)PS_(5)Cl@Li_(3)OCl core@shell structure exhibits a synergistic effect.Consequently,compared with the bare Li_(6)PS_(5)Cl,this composite electrolyte exhibits great performance improvements:1)In Li|electrolyte|Li symmetric cells,the critical current density at 30℃gets increased from 0.6 mA cm^(-2)to 1.6 mA cm^(-2),and the lifetime gets prolonged from 320 h to 1400 h at the cycling current of 0.2 mA cm^(-2)or from 10 h to 900 h at the cycling current of 0.5 mA cm^(-2);2)In Li|electrolyte|NCM721 full cells running at 30℃,the cycling capacity at 0.2 C(or 0.5 C)gets enhanced by 20%(or from unfeasible to be feasible)for 100 cycles and the rate capability reaches up to 2 C from 0.2 C;and in full cells running at 60℃,the cycling capacity is increased by 7%at 0.2 C and the rate capability is enhanced to 3.0 C from 0.5 C.The experimental studies and theoretical computations show that the performance enhancements are due to the confined electron penetration and suppressed lithium dendrites growth at theLi_(6)PS_(5)Cl@Li_(3)OCl interface.
基金financially supported by the National Key R&D Program of China(2023YFC2812700)the Key Scientific and Technological Innovation Project of Shandong(2022CXGC020301)+6 种基金the National Natural Science Foundation of China(22279153,U22A2044,22479154,52303287)the Taishan Scholars of Shandong Province(No.ts201511063)the Shandong Energy Institute(Grant No.SEI I202108)the Postdoctoral Fellowship Program of CPSF(E31Z3F04)China Postdoctoral Science Foundation(2024 M753350)the Natural Science Foundation of Shandong Province(ZR2023QB208)Qingdao Natural Science Foundation(23-2-1-77-zyyd-jch)。
文摘Silicon suboxide(SiO_(x),0<x<2)is an appealing anode material to replace traditional graphite owing to its much higher theoretical specific capacity enabling higher-energy-density lithium batteries.Nevertheless,the huge volume change and rapid capacity decay of SiO_(x)electrodes during cycling pose huge challenges to their large-scale practical applications.To eliminate this bottleneck,a dragonfly wing microstructure-inspired polymer electrolyte(denoted as PPM-PE)is developed based on in-situ polymerization of bicyclic phosphate ester-and urethane motif-containing monomer and methyl methacrylate in traditional liquid electrolyte.PPM-PE delivers excellent mechanical properties,highly correlated with the formation of a micro-phase separation structure similar with dragonfly wings.By virtue of superior mechanical properties and the in-situ solidified preparation method,PPM-PE can form a 3D polymer network buffer against stress within the electrode particles gap,enabling much suppressed electrode volume expansion and more stabilized solid electrolyte interface along with evidently decreased electrolyte decomposition.Resultantly,PPM-PE shows significant improvements in both cycling and rate performance in button and soft package batteries with SiO_(x)-based electrodes,compared with the liquid electrolyte counterpart.Such a dragonfly wing microstructure-inspired design philosophy of in-situ solidified polymer electrolytes helps facilitate the practical implementation of high-energy lithium batteries with SiO_(x)-based anodes.
基金supported by the National Key Research and Development Program of China(2023YFD1401504)the Open Project of Anhui Province Key Laboratory of Pesticide Resistance Management on Grain and Vegetable Pests,China(PKLPRMGVP202402)+3 种基金the Programs for the Scientific Research Activities of Academic and Technical Leaders of Anhui Province,China(2020D251)the Development Fund for Talent Personnel of Anhui Agricultural University,China(rc342006)the University Synergy Innovation Program of Anhui Province,China(GXXT-2021-059)Anhui Province Agricultural Eco-Environmental Protection and Quality Safety Industry Technology System,China。
文摘Southern corn leaf blight(SCLB)caused by Cochliobolus heterostrophus,is a widespread foliar disease that has a substantial impact on maize yield in the Huang-Huai-Hai Region of China.Pydiflumetofen(Pyd),a new succinate dehydrogenase inhibitor(SDHI),has been found as a promising fungicide for the efficient control of SCLB,however,resistance of C.heterostrophus to Pyd has not been studied well.Here,five Pyd-resistant mutants were generated through fungicide adaptation.Sequence alignment analysis revealed that these mutants primarily mutated in ChSdhB and ChSdhD,with three genotypes:ChSdhB^(H277Y),ChSdhB^(I279T)and ChSdhD^(H133Y),exhibiting two distinct categories of resistance:high resistance(HR)and moderate resistance(MR),among which the resistance factors were 214.22 and 44.33-53.67,respectively.These mutants were more pathogenic than the wild-type parental strains,but there was a significant reduction in mycelial growth rate and sporulation in the resistant mutants,indicating a significant fitness cost associated with resistance to Pyd.In addition,this study revealed a positive cross-resistance between Pyd and another SDHI fungicide cyclobutrifluram.However,no cross-resistance was found between Pyd and other classes of fungicides,including prochloraz,fludioxonil,iprodione or pyraclostrobin.Homology modeling and molecular docking further confirmed that point mutations of ChSdhB^(H277Y),ChSdhB^(I279T),and ChSdhD^(H133Y)could reduce binding affinity between Pyd and its target subunits from-74.07,-74.07,-152.52 kcal mol^(-1)to-3.90,-4.95,-9.93 kcal mol^(-1),respectively.These findings not only provided valuable insights for managing SCLB caused by C.heterostrophus,but also enhanced our understanding of molecular mechanism underlying plant pathogen resistance to Pyd.
基金The authors gratefully acknowledge the financial support by the National Natural Science Foundation of China(No.52405272)the CNOOC’s major project during the 14th Five-Year Plan period“Key Technologies and Equipment for Measurement,Recording,and Testing-Development and Engineering of Integrated Perforation Technology Equipment Based on Reservoir Geology”and the National Science Foundation of Jiangsu Province(No.BK20220533).
文摘Hydraulic sandblasting perforation plays a crucial role in the fracturing and reconstruction of unconventional oil and gas reservoirs.The jet nozzle is an essential part of the hydraulic perforation tool.Insufficient penetration depth,caused by excessive jet distances,presents challenges during the perforation process.To overcome this,an optimization design of the nozzle structure is required to enhance the perforation efficiency.In this paper,a computational fluid-dynamic model for conical-cylindrical nozzles has been elaborated.To further improve the rock-breaking efficiency of the jet nozzle,a fillet design is introduced at the nozzle inlet section.The SST k-ωmodel is employed to account for turbulent flow effects in submerged conditions.The results indicate that the nozzle’s geometric parameters greatly influence the flow characteristics.The orthogonal experimental method is employed to optimize the flow channel structure of the nozzle,taking the length of constant velocity core as the evaluation index.The following optimized geometric parameters for the conical-cylindrical nozzle have been determined accordingly:a cylindrical segment diameter of 3.2 mm,a contraction angle of 12°,a contraction segment length of 8 mm,a cylindrical segment length of 6.4 mm,and a fillet radius of 2 mm.
基金the National Natural Science Fundation of China(32302392)the Key Project of the Natural Science Foundation of Anhui Provincial Department of Education,China(2022AH050877 and 2023AH040129)+4 种基金the Programs for the Scientific Research Activities of Academic and Technical Leaders of Anhui Province,China(2020D251)the Development Fund for Talent Personnel of Anhui Agricultural University,China(rc342006 and rc342008)the University Synergy Innovation Program of Anhui Province,China(GXXT-2021-059)the Grants from Anhui Agricultural University,China(2020zd27)the Anhui Province Agricultural Eco-Environmental Protection and Quality Safety Industry Technology System,China。
文摘Rice bakanae disease(RBD)is a devastating plant disease caused by Fusarium fujikuroi.This study aimed to evaluate the potential of cyclobutrifuram,a novel succinate dehydrogenase inhibitor(SDHI),to control RBD,and determine the risk and mechanism of resistance to cyclobutrifuram in F.fujikuroi.In vitro experiments showed that cyclobutrifuram significantly inhibited mycelial growth and spore germination,and altered the morphology of mycelia and conidia.Treatment with cyclobutrifuram signifcantly decreased mycotoxin production and increased cell membrane permeability in F.fujikuroi.The baseline sensitivity of 72 F.fujikuroi isolates to cyclobutrifuram was determined using mycelial growth and spore germination inhibition assays,which revealed EC50values of 0.0114-0.1304 and 0.0012-0.016μg mL^(-1),with mean EC50values of(0.0410±0.0470)and(0.0038±0.0015)μg mL^(-1),respectively.Pot experiments demonstrated that the protective effect of cyclobutrifluram against F.fujikuroi was more significant than that of phenamacril and azoxystrobin,indicating that cyclobutrifuram is a promising antifungal agent for the control of RBD.Six cyclobutrifuramresistant mutants of F.fujikuroi were obtained via fungicide adaptation.Moreover,these mutants exhibited weaker ftness than their parental isolate and positive cross-resistance with other SDHI fungicides,including pydifumetofen and penfufen;however,no cross-resistance was detected with other classes of fungicides,including phenamacril,fudioxonil,prochloraz,or azoxystrobin.These results indicated that the resistance risk of F.fujikuroi to cyclobutrifuram might be moderate.Sequencing analysis revealed that mutations,including H248D in Ff Sdh B,A83V in Ff Sdh C2,and S106F and E166K in Ff Sdh D,contributed to resistance,which was confrmed by molecular docking and homologous replacement experiments.The results suggest a high potential for cyclobutrifuram to control RBD and a moderate resistance risk of F.fujikuroi to cyclobutrifuram,which are meaningful fndings for the scientifc application of cyclobutrifuram.
基金supported by the National Natural Science Foundation of China(U23B2075)the Natural Science Foundation of Shandong Province(ZR202111290333)the China Postdoctoral Science Foundation(2023M730640,2024M750490).
文摘Sodium-ion batteries with ZnIn_(2)S_(4)(ZIS)anodes promise a high capacity and abundant resources.However,their inherent low conductivity,large volume expansion and sluggish Na+diffusion limit the development of the wide-temperature sodium storage.This study pioneers a scalable synthesis of hierarchical hollow structural ZIS/C heterostructure through in situ confined growth of ZIS nanosheets in porous hollow carbon spheres(PHCSs)via a hydrothermal method.This unique structure exhibits abundant heterostructures to facilitate charge transport,rich porous structures to promote electrolyte wettability,efficient space utilization to relieve volume expansion,as well as interconnected carbon networks to ensure framework stability.Consequently,ZIS/C exhibits exceptional cycling stability with 92%capacity retention after 1000 cycles.Notably,ZIS/C demonstrates good wide-temperature performance operating at–50∼90°C,especially,at–30°C with a capacity of 208 mA h g^(−1)at 0.3A g^(−1).The full cell of ZIS/C||Na_(3)V_(2)(PO_(4))_(3)exhibits excellent high-rate capability(178 mA h g^(−1)at 6A g^(−1)).
基金supported by the National Key R&D Program of China(No.2019YFC0408500)the Key Science and Technology Projects of Anhui Province(No.202003a07020004)the Open Foundation of the Key Lab(Center)of Anhui Institute of Ecological Civilization(No.W2023JSKF0152).
文摘The present study aims to fabricate heterogeneous electro-Fenton(HEF)cathode catalysts for the in-situ generation of H2O2 and the degradation of organic pollutants in water.To achieve this,preparation of Fe and N co-doped MXene composites(FeCN/MXene-x,where x represents the loading content of FeCN)and construction of the HEF system for the degradation of sulfathiazole(STZ)were carried out.The characterization results showed that Fe,C and N mainly existed in the form of Fe3C and Fe3N in the FeCN/MXene catalysts,which were favorable for promoting the ORR reaction in the HEF system.Among them,FeCN/MXene-2 exhibited the highest redox electron transfer rate and H2O2 selectivity(86%).The catalytic oxidation mechanism of the FeCN/MXene-2/HEF system was investigated by free radical quenching,electron paramagnetic resonance and frontier orbital theory studies.These studies demonstrated that the main active substances for the degradation of STZ were·OH and 1O2.In addition,the excellent stability and practical performance of the prepared cathodic catalysts were demonstrated by cycling experiments and real water sample tests.
基金supported by two Special Programs of the National Natural Science Foundation of China(Nos.42341101,42442045)the National Key R&D Program of China(No.2024YFF1306502)the Basic Scientific Research Business Funds of Central Universities(No.300102263401)。
文摘0 INTRODUCTION The Qinling Mountains(QM),located at the geographical center of China,serve as a crucial dividing line between the northern and southern and play a vital role as an ecological security barrier,significantly influencing the country's geological,geographical,and ecological landscape(Jia et al.,2023;Peng et al.,2023).The QM stretch from the White Stone Mountain in the northern part of Lintan County,Gansu Province,to the Funiu Mountains in Henan Province in the east.
文摘From September 1 7 to 1 9, the 5th China International Copy-right Expo （CICE） took place in Chengdu, capital city of Sichuan province. CICE, dubbed as ＂copy-right Olympics＂, featured the theme of＂ copyright innovation and development＂ this year. i2 thematic events were held during the expo,
