BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD....BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.展开更多
Aberrant RNA modification has been linked to the pathogenesis of various diseases;however,its specific molecular mechanisms in spinal cord injury remain poorly understood.The objective of this study was to explore RNA...Aberrant RNA modification has been linked to the pathogenesis of various diseases;however,its specific molecular mechanisms in spinal cord injury remain poorly understood.The objective of this study was to explore RNA modification-related biomarkers of spinal cord injury.The mRNA expression profiles of mice with spinal cord injury were retrieved from the Gene Expression Omnibus(GEO)database(GSE18179).We identified 185 differentially expressed genes using bioinformatics approaches.Functional enrichment analysis demonstrated aberrant activation or inhibition of common metabolism-related pathways,including sulfur metabolism and steroid biosynthesis,in mice with spinal cord injury.An integrated strategy comprising weighted gene co-expression network analysis,a random forest model,a support vector machine model,and a generalized linear model was employed to identify four genes whose aberrant RNA modification was linked to spinal cord injury:Elovl6,Idi1,Sqle,and Stbd1.We verified the expression levels and diagnostic performance of these four genes in the original training dataset and mouse samples via receiver operating characteristic curve analysis.Quantitative reverse transcription-polymerase chain reaction demonstrated variations in the mRNA levels of the four genes between the Sham and spinal cord injury groups at different time points following injury.We also constructed microRNA-mRNA and transcription factor-mRNA interaction networks using Cytoscape.Additionally,we evaluated the proportions of 22 types of immune cells in the spinal cords of mice using the CIBERSORT tool,revealing significant alterations in the numbers of memory B cells,resting dendritic cells,M0 macrophages,activated mast cells,resting mast cells,and CD8+T cells in spinal cord injury mice compared with Sham controls.Microglia and T cells were identified as key cell types by single-cell sequencing analysis.These findings provide new directions for the development of RNA modification-related therapeutic strategies for spinal cord injury and suggest that Elovl6,Idi1,Sqle,and Stbd1 are potential biomarkers of spinal cord injury.展开更多
Among various advanced oxidation processes(AOPs),heterogeneous catalytic ozonation has garnered extensive attention in wastewater treatment owing to its broad pH range applicability and the elimination of the need for...Among various advanced oxidation processes(AOPs),heterogeneous catalytic ozonation has garnered extensive attention in wastewater treatment owing to its broad pH range applicability and the elimination of the need for additional energy input.Enhancing catalyst activity by introducing oxygen vacancies has been used extensively in heterogeneous catalytic ozonation.This paper reviews prevalent methods for the construction and characterization of oxygen vacancies.Based on a thorough examination of existing research,the role of oxygen vacancies is categorized according to their primary mechanisms of action in heterogeneous catalytic ozonation.For example,modulation of the catalyst electronic structure to enhance electron transfer;participation in the reaction as an active site to generate radicals and non-radicals;and exposure of more metal sites to enhance the reaction.Lastly,the paper delineates the limitations and future research directions concerning the role of oxygen vacancies in catalytic ozonation.This review addresses the gap in existing literature concerning the role of oxygen vacancies in catalytic ozone systems,establishes a comprehensive theoretical framework to aid in the design of efficient ozone catalysts,and delves into the functionality of oxygen vacancies in heterogeneous catalytic ozone reactions.展开更多
Magnetic resonance imaging(MRI)is a powerful tool for diagnosing and monitoring brain diseases,but its low sensitivity can hinder early detection.To address this challenge,we utilized chemical exchange saturation tran...Magnetic resonance imaging(MRI)is a powerful tool for diagnosing and monitoring brain diseases,but its low sensitivity can hinder early detection.To address this challenge,we utilized chemical exchange saturation transfer(CEST)MRI,which greatly enhances sensitivity for detecting low-concentration compounds.In this study,we developed a CEST contrast agent based on a recombinant adeno-associated viruses(rAAVs)encoding the protamine-1(PRM1)MRI reporter gene.CEST MRI revealed that PRM1 contrast agent effectively highlighted caudate putamen region after injection of the rAAVs into the mouse brain,clearly distinguishing it from the surrounding tissue,with no observable damage.This method provides a sensitive,metal-free CEST contrast agent for in vivo brain cell detection,demonstrating potential for both diagnostic and therapeutic applications in brain diseases.展开更多
Advances in optical coherence tomography(OCT)technology allow a clear view of the vitreoretinal interface(VRI).The abnormality of the VRI is one of the common symptoms of high myopia,mainly including posterior vitreou...Advances in optical coherence tomography(OCT)technology allow a clear view of the vitreoretinal interface(VRI).The abnormality of the VRI is one of the common symptoms of high myopia,mainly including posterior vitreous detachment(PVD)and epiretinal membrane(ERM).They can cause severe damage to the structure and function of the retina,leading to permanent vision loss.Therefore,fully automated detection of abnormalities at the VRI is crucial for the management of high myopia.This paper presents a DS-YOLOv7 network aimed at accurately identifying abnormalities,including partial PVD,complete PVD,and ERM from retinal OCT images.Built upon the YOLOv7 network,the proposed model integrates the advanced dynamic snake convolution(DSConv)module to capture the curvilinear characteristics of lesions,and the mixture of attention and convolution(ACMix)module to improve the precision and robustness of feature extraction through effective fusion of self-attention mechanisms and convolution.Moreover,the introduction of the efficient complete intersection-over-union(ECIoU)loss function further enhances the coordinate regression capability of the model.Threefold cross-validation on a dataset with 1973 OCT B-scans from 46 patients shows that the DS-YOLOv7 achieved superior performance in vitreoretinal interface abnormality detection,with mAP@0.5 of 0.714,mAP@0.75 of 0.438,and mAP@0.5:0.95 of 0.424.The proposed model can provide an accurate and efficient diagnostic tool for patients with high myopia.展开更多
The January 2022 eruption of Hunga injected unprecedented volumes of water vapor(150 Tg)and modest sulfur dioxide(SO_(2))into the stratosphere,producing accelerated sulfate aerosol formation in the early plume.As the ...The January 2022 eruption of Hunga injected unprecedented volumes of water vapor(150 Tg)and modest sulfur dioxide(SO_(2))into the stratosphere,producing accelerated sulfate aerosol formation in the early plume.As the aerosols gradually spread into the global stratosphere,the role of water vapor,among other factors in the spread and residence time of the sulfate aerosols,remained unclear.We used multisatellite observations to better understand the role of water vapor in the spread and lifetime of Hunga volcanic aerosols.Stratospheric circulation transported the plumes to~26 km within the polar vortices-the Antarctic by August 2022 and the Arctic by January 2023-with the arrival of aerosols lagging behind that of water vapor by months.Even though high injection altitudes(58 km)and strong Brewer-Dobson circulation contributed to prolonging the residence time of aerosols,the water vapor enhanced particle growth and thus accelerated gravitational settling,with the half lifetime of aerosols being 14 months.Our analysis revealed a critical trade-off:after the eruption of the Hunga volcano,an extremely high injection height and strong upward motion slowed the removal of aerosols,but extreme water vapor loading still had a certain impact on the half lifetime of the aerosols.These findings highlight the role of water vapor in the persistence of aerosols from submarine eruptions.展开更多
Passengers typically spend much time in commercial zones of terminals for retail,meals,and other services.Enhancing the study of thermal comfort in this local space is necessary.The climate in the Eastern China Region...Passengers typically spend much time in commercial zones of terminals for retail,meals,and other services.Enhancing the study of thermal comfort in this local space is necessary.The climate in the Eastern China Region is variable and complex,making it more challenging to maintain the indoor thermal environment.This study conducted field measurements in winter in a commercial zone of one terminal to assess the thermal environment.Numerical simulations and PMV-PPD analyses were performed using the Computational Fluid Dynamics(CFD)program The results showed that the overall humidity in the commercial zone was low.There were notable differences in the temperatures and velocities of supply air among different air vents on the commercial island.Based on these initial conditions obtained by measurements,the simulations showed that localized areas under the breathing plane are either too hot(24℃and above)or too cold(18℃and below).The dissatisfaction percentage of the population exceeds 27%.This paper proposed that through enhancements in the air vent dimensions,layout,and air supply conditions,the temperature can be maintained in the range of 20-24℃.Furthermore,the PMV could be controlled within the range of-0.5 to 0.5.PPD was below 10%,reflecting compliance with Class I heating standards.Overall,findings from this study provide a less costly modification for thermal comfort improvement in commercial zones,and serve as a reference for the design and operation of air-conditioning systems to ensure thermal comfort in airport terminals’commercial zones.展开更多
The increasing popularity of quantum computing has resulted in a considerable rise in demand for cloud quantum computing usage in recent years.Nevertheless,the rapid surge in demand for cloud-based quantum computing r...The increasing popularity of quantum computing has resulted in a considerable rise in demand for cloud quantum computing usage in recent years.Nevertheless,the rapid surge in demand for cloud-based quantum computing resources has led to a scarcity.In order to meet the needs of an increasing number of researchers,it is imperative to facilitate efficient and flexible access to computing resources in a cloud environment.In this paper,we propose a novel quantum computing paradigm,Virtual QPU(VQPU),which addresses this issue and enhances quantum cloud throughput with guaranteed circuit fidelity.The proposal introduces three innovative concepts:(1)The integration of virtualization technology into the field of quantum computing to enhance quantum cloud throughput.(2)The introduction of an asynchronous execution of circuits methodology to improve quantum computing flexibility.(3)The development of a virtual QPU allocation scheme for quantum tasks in a cloud environment to improve circuit fidelity.The concepts have been validated through the utilization of a self-built simulated quantum cloud platform.展开更多
Layered transition metal oxides have emerged as promising cathode materials for sodium ion batteries.However,irreversible phase transitions cause structural distortion and cation rearrangement,leading to sluggish Na+d...Layered transition metal oxides have emerged as promising cathode materials for sodium ion batteries.However,irreversible phase transitions cause structural distortion and cation rearrangement,leading to sluggish Na+dynamics and rapid capacity decay.In this study,we propose a medium-entropy cathode by simultaneously introducing Fe,Mg,and Li dopants into a typical P2-type Na_(0.75)Ni_(0.25)Mn_(0.75)O_(2)cathode.The modified Na_(0.75)Ni_(0.2125)Mn_(0.6375)Fe_(0.05)Mg_(0.05)Li_(0.05)O_(2)cathode predominantly exhibits a main P2 phase(93.5%)with a minor O3 phase(6.5%).Through spectroscopy techniques and electrochemical investigations,we elucidate the redox mechanisms of Ni^(2+/3+/4+),Mn^(3+/4+),Fe^(3+/4+),and O_(2)-/O_(2)^(n-)during charging/discharging.The medium-entropy doping mitigates the detrimental P2-O_(2)phase transition at high-voltage,replacing it with a moderate and reversible structural evolution(P2-OP4),thereby enhancing structural stability.Consequently,the modified cathode exhibits a remarkable rate capacity of 108.4 mAh·g^(-1)at 10C,with a capacity retention of 99.0%after 200 cycles at 1C,82.5%after 500 cycles at 5C,and 76.7%after 600 cycles at 10C.Furthermore,it also demonstrates superior electrochemical performance at high cutoff voltage of 4.5 V and extreme temperature(55 and 0℃).This work offers solutions to critical challenges in sodium ion batteries cathode materials.展开更多
The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can serio...The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.展开更多
Laser powder bed fusion(LPBF)has been extensively investigated owing to its high geometry formation accuracy and excellent mechanical properties.However,the LPBFed Haynes 230 parts typically display poor tensile and w...Laser powder bed fusion(LPBF)has been extensively investigated owing to its high geometry formation accuracy and excellent mechanical properties.However,the LPBFed Haynes 230 parts typically display poor tensile and wear properties due to internal porosity.In this work,the ultrasonic impact treatment(UIT)was applied as a post-treatment to the LPBFed Haynes 230 alloy,porosity and microstructure mod-ulation were performed to improve the strength properties and wear resistance.The pore closure and mi-crostructure were studied by numerical simulations and experiments,and the mechanisms of increasing densification and strength were discussed.Results show that UIT can effectively close pores and reduce porosity,the internal porosity of the ultrasonic impacted layer for one,two,and three times decreases by 63.6%,70.9%,and 81.8%,respectively.Pore closure is attributed to the residual compressive stress and shear stress introduced by UIT.Besides,the UIT weakened texture strength and refined grains,especially promoting the formation of fine grains.Meanwhile,it also promotes the formation of a high disloca-tion density and improves the phase structure distribution.Furthermore,the ultimate tensile and yield strengths of the optimal impact process increased by 9.6%and 34.6%,respectively.The improvement in strength was attributed to dislocation,grain boundary,and promoting densification strengthening.The average friction coefficient reduces by 4.9%-14.6%by refining the surface grains and increasing dislo-cation density.This work has verified the feasibility of improving the mechanical properties and pore closure of the LPBFed Haynes 230 alloy by UIT.展开更多
Co-precipitation strengthening of the L1_(2)nano-particles along with hard intermetallic phases,including L2_(1),B2,σandη,demonstrates significant potential for the development of advanced CoCrFeNi high-entropy allo...Co-precipitation strengthening of the L1_(2)nano-particles along with hard intermetallic phases,including L2_(1),B2,σandη,demonstrates significant potential for the development of advanced CoCrFeNi high-entropy alloys(HEAs)with favorable strength-ductility balances.Understanding the alloying effect of Al and Ti on the formation and stability of these intermetallic phases in the CoCrFeNi HEAs is crucial for efficiently exploring the multi-component space for future alloy designs.In the present work,stepwise compositionally graded CoCrFeNi-AlTi HEAs comprising 35 different compositions were fabricated using high-throughput additive manufacturing(AM)and analyzed through a suite of localized characterization techniques.Our analysis confirmed the existence of two primary solid solution phases,face-centered cubic(FCC)and body-centered cubic(BCC),as well as four distinct intermetallic phases,which include L1_(2),L2_(1),σandη.By overlapping the zero phase fraction(ZPF)lines of these phases,the pseudo-ternary phase diagram of the multi-component CoCrFeNi-AlTi system at 800℃was determined,demonstrating good agreement with the literature results.Furthermore,the composition-dependent microstructural evolution and Vickers hardness(HV)were also established,providing numerous opportunities to design CoCrFeNi-AlTi HEAs with superior microstructure stability and balanced strength-ductility properties for structural applications at elevated temperatures.展开更多
Extreme precipitation events cause severe environmental and societal damage worldwide.Southwest China(SWC)is sensitive to such effects because of its overpopulation,underdevelopment,and fragile ecosystems.Using daily ...Extreme precipitation events cause severe environmental and societal damage worldwide.Southwest China(SWC)is sensitive to such effects because of its overpopulation,underdevelopment,and fragile ecosystems.Using daily observations from 108 rain-gauge stations,the authors investigated the frequency of extreme precipitation events and their contribution to total precipitation in SWC since the late 1970 s.Results indicate that total precipitation is decreasing insignificantly,but rainfall-events frequency is decreasing significantly,whereas the region is experiencing more frequent and intense extreme precipitation events.Note that although fewer stations are statistically significant,about 60%of the rain-gauge stations show an increasing trend in the frequency and intensity of extreme precipitation.Furthermore,there is an increasing trend in the contribution of total extreme precipitation to total precipitation,with extreme precipitation becoming dominant in the increasingly arid SWC region.The results carry important implications for policymakers,who should place greater emphasis on extreme precipitation and associated floods and landslides when drafting water-resource management policies.展开更多
基金Supported by Science and Technology Department of Sichuan Province,No.2020YFS0376National Natural Science Foundation of China,No.81900599Science and Technology Program of Hospital of TCM,Southwest Medical University,No.2022-CXTD-01.
文摘BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.
文摘Aberrant RNA modification has been linked to the pathogenesis of various diseases;however,its specific molecular mechanisms in spinal cord injury remain poorly understood.The objective of this study was to explore RNA modification-related biomarkers of spinal cord injury.The mRNA expression profiles of mice with spinal cord injury were retrieved from the Gene Expression Omnibus(GEO)database(GSE18179).We identified 185 differentially expressed genes using bioinformatics approaches.Functional enrichment analysis demonstrated aberrant activation or inhibition of common metabolism-related pathways,including sulfur metabolism and steroid biosynthesis,in mice with spinal cord injury.An integrated strategy comprising weighted gene co-expression network analysis,a random forest model,a support vector machine model,and a generalized linear model was employed to identify four genes whose aberrant RNA modification was linked to spinal cord injury:Elovl6,Idi1,Sqle,and Stbd1.We verified the expression levels and diagnostic performance of these four genes in the original training dataset and mouse samples via receiver operating characteristic curve analysis.Quantitative reverse transcription-polymerase chain reaction demonstrated variations in the mRNA levels of the four genes between the Sham and spinal cord injury groups at different time points following injury.We also constructed microRNA-mRNA and transcription factor-mRNA interaction networks using Cytoscape.Additionally,we evaluated the proportions of 22 types of immune cells in the spinal cords of mice using the CIBERSORT tool,revealing significant alterations in the numbers of memory B cells,resting dendritic cells,M0 macrophages,activated mast cells,resting mast cells,and CD8+T cells in spinal cord injury mice compared with Sham controls.Microglia and T cells were identified as key cell types by single-cell sequencing analysis.These findings provide new directions for the development of RNA modification-related therapeutic strategies for spinal cord injury and suggest that Elovl6,Idi1,Sqle,and Stbd1 are potential biomarkers of spinal cord injury.
基金support from the Key R&D Program of Zhejiang province(No.2024C03136).
文摘Among various advanced oxidation processes(AOPs),heterogeneous catalytic ozonation has garnered extensive attention in wastewater treatment owing to its broad pH range applicability and the elimination of the need for additional energy input.Enhancing catalyst activity by introducing oxygen vacancies has been used extensively in heterogeneous catalytic ozonation.This paper reviews prevalent methods for the construction and characterization of oxygen vacancies.Based on a thorough examination of existing research,the role of oxygen vacancies is categorized according to their primary mechanisms of action in heterogeneous catalytic ozonation.For example,modulation of the catalyst electronic structure to enhance electron transfer;participation in the reaction as an active site to generate radicals and non-radicals;and exposure of more metal sites to enhance the reaction.Lastly,the paper delineates the limitations and future research directions concerning the role of oxygen vacancies in catalytic ozonation.This review addresses the gap in existing literature concerning the role of oxygen vacancies in catalytic ozone systems,establishes a comprehensive theoretical framework to aid in the design of efficient ozone catalysts,and delves into the functionality of oxygen vacancies in heterogeneous catalytic ozone reactions.
基金financially supported by the National Natural Science Foundation of China(82127802,22374157)Strategic Priority Research Program,CAS(XDB0540000,XDC0170000)CAS Youth Interdisciplinary Team(JCTD-2022-13).In addition,Xin Zhou acknowledges the support from the Tencent Foundation through the XPLORER PRIZE.
文摘Magnetic resonance imaging(MRI)is a powerful tool for diagnosing and monitoring brain diseases,but its low sensitivity can hinder early detection.To address this challenge,we utilized chemical exchange saturation transfer(CEST)MRI,which greatly enhances sensitivity for detecting low-concentration compounds.In this study,we developed a CEST contrast agent based on a recombinant adeno-associated viruses(rAAVs)encoding the protamine-1(PRM1)MRI reporter gene.CEST MRI revealed that PRM1 contrast agent effectively highlighted caudate putamen region after injection of the rAAVs into the mouse brain,clearly distinguishing it from the surrounding tissue,with no observable damage.This method provides a sensitive,metal-free CEST contrast agent for in vivo brain cell detection,demonstrating potential for both diagnostic and therapeutic applications in brain diseases.
基金supported by the National Natural Science Foundation of China(62271337,62371326,and 62371328)the National Key Research and Development Program of China(2019FYC1710204)+1 种基金the National Clinical Key Specialty Construction Project(10000015Z155080000004)the Natural Science Foundation of Jiangsu Province(BK20231310).
文摘Advances in optical coherence tomography(OCT)technology allow a clear view of the vitreoretinal interface(VRI).The abnormality of the VRI is one of the common symptoms of high myopia,mainly including posterior vitreous detachment(PVD)and epiretinal membrane(ERM).They can cause severe damage to the structure and function of the retina,leading to permanent vision loss.Therefore,fully automated detection of abnormalities at the VRI is crucial for the management of high myopia.This paper presents a DS-YOLOv7 network aimed at accurately identifying abnormalities,including partial PVD,complete PVD,and ERM from retinal OCT images.Built upon the YOLOv7 network,the proposed model integrates the advanced dynamic snake convolution(DSConv)module to capture the curvilinear characteristics of lesions,and the mixture of attention and convolution(ACMix)module to improve the precision and robustness of feature extraction through effective fusion of self-attention mechanisms and convolution.Moreover,the introduction of the efficient complete intersection-over-union(ECIoU)loss function further enhances the coordinate regression capability of the model.Threefold cross-validation on a dataset with 1973 OCT B-scans from 46 patients shows that the DS-YOLOv7 achieved superior performance in vitreoretinal interface abnormality detection,with mAP@0.5 of 0.714,mAP@0.75 of 0.438,and mAP@0.5:0.95 of 0.424.The proposed model can provide an accurate and efficient diagnostic tool for patients with high myopia.
基金funding from the National Natural Science Foundation of China(Grant Nos.U2442210 and 42275059)supported by funding from Chengdu University of Information Technology(Grant No.X202310621039).
文摘The January 2022 eruption of Hunga injected unprecedented volumes of water vapor(150 Tg)and modest sulfur dioxide(SO_(2))into the stratosphere,producing accelerated sulfate aerosol formation in the early plume.As the aerosols gradually spread into the global stratosphere,the role of water vapor,among other factors in the spread and residence time of the sulfate aerosols,remained unclear.We used multisatellite observations to better understand the role of water vapor in the spread and lifetime of Hunga volcanic aerosols.Stratospheric circulation transported the plumes to~26 km within the polar vortices-the Antarctic by August 2022 and the Arctic by January 2023-with the arrival of aerosols lagging behind that of water vapor by months.Even though high injection altitudes(58 km)and strong Brewer-Dobson circulation contributed to prolonging the residence time of aerosols,the water vapor enhanced particle growth and thus accelerated gravitational settling,with the half lifetime of aerosols being 14 months.Our analysis revealed a critical trade-off:after the eruption of the Hunga volcano,an extremely high injection height and strong upward motion slowed the removal of aerosols,but extreme water vapor loading still had a certain impact on the half lifetime of the aerosols.These findings highlight the role of water vapor in the persistence of aerosols from submarine eruptions.
基金supported by the National Natural Science Foundation of China(52478098)the Natural Science Foundation of Shanghai Municipality(21ZR1444800)the Shanghai Sailing Program(21YF1430700).
文摘Passengers typically spend much time in commercial zones of terminals for retail,meals,and other services.Enhancing the study of thermal comfort in this local space is necessary.The climate in the Eastern China Region is variable and complex,making it more challenging to maintain the indoor thermal environment.This study conducted field measurements in winter in a commercial zone of one terminal to assess the thermal environment.Numerical simulations and PMV-PPD analyses were performed using the Computational Fluid Dynamics(CFD)program The results showed that the overall humidity in the commercial zone was low.There were notable differences in the temperatures and velocities of supply air among different air vents on the commercial island.Based on these initial conditions obtained by measurements,the simulations showed that localized areas under the breathing plane are either too hot(24℃and above)or too cold(18℃and below).The dissatisfaction percentage of the population exceeds 27%.This paper proposed that through enhancements in the air vent dimensions,layout,and air supply conditions,the temperature can be maintained in the range of 20-24℃.Furthermore,the PMV could be controlled within the range of-0.5 to 0.5.PPD was below 10%,reflecting compliance with Class I heating standards.Overall,findings from this study provide a less costly modification for thermal comfort improvement in commercial zones,and serve as a reference for the design and operation of air-conditioning systems to ensure thermal comfort in airport terminals’commercial zones.
文摘The increasing popularity of quantum computing has resulted in a considerable rise in demand for cloud quantum computing usage in recent years.Nevertheless,the rapid surge in demand for cloud-based quantum computing resources has led to a scarcity.In order to meet the needs of an increasing number of researchers,it is imperative to facilitate efficient and flexible access to computing resources in a cloud environment.In this paper,we propose a novel quantum computing paradigm,Virtual QPU(VQPU),which addresses this issue and enhances quantum cloud throughput with guaranteed circuit fidelity.The proposal introduces three innovative concepts:(1)The integration of virtualization technology into the field of quantum computing to enhance quantum cloud throughput.(2)The introduction of an asynchronous execution of circuits methodology to improve quantum computing flexibility.(3)The development of a virtual QPU allocation scheme for quantum tasks in a cloud environment to improve circuit fidelity.The concepts have been validated through the utilization of a self-built simulated quantum cloud platform.
基金supported by the National Natural Science Foundation of China(No.21805018)by Sichuan Science and Technology Program(Nos.2022ZHCG0018,2023NSFSC0117 and 2023ZHCG0060)Yibin Science and Technology Program(No.2022JB005)and China Postdoctoral Science Foundation(No.2022M722704).
文摘Layered transition metal oxides have emerged as promising cathode materials for sodium ion batteries.However,irreversible phase transitions cause structural distortion and cation rearrangement,leading to sluggish Na+dynamics and rapid capacity decay.In this study,we propose a medium-entropy cathode by simultaneously introducing Fe,Mg,and Li dopants into a typical P2-type Na_(0.75)Ni_(0.25)Mn_(0.75)O_(2)cathode.The modified Na_(0.75)Ni_(0.2125)Mn_(0.6375)Fe_(0.05)Mg_(0.05)Li_(0.05)O_(2)cathode predominantly exhibits a main P2 phase(93.5%)with a minor O3 phase(6.5%).Through spectroscopy techniques and electrochemical investigations,we elucidate the redox mechanisms of Ni^(2+/3+/4+),Mn^(3+/4+),Fe^(3+/4+),and O_(2)-/O_(2)^(n-)during charging/discharging.The medium-entropy doping mitigates the detrimental P2-O_(2)phase transition at high-voltage,replacing it with a moderate and reversible structural evolution(P2-OP4),thereby enhancing structural stability.Consequently,the modified cathode exhibits a remarkable rate capacity of 108.4 mAh·g^(-1)at 10C,with a capacity retention of 99.0%after 200 cycles at 1C,82.5%after 500 cycles at 5C,and 76.7%after 600 cycles at 10C.Furthermore,it also demonstrates superior electrochemical performance at high cutoff voltage of 4.5 V and extreme temperature(55 and 0℃).This work offers solutions to critical challenges in sodium ion batteries cathode materials.
文摘The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.
基金supported by the National Key Research and Development Program of China(No.2022YFB4600800)the Fundamental Research Funds for the Central Universities(No.2042024kf0015).
文摘Laser powder bed fusion(LPBF)has been extensively investigated owing to its high geometry formation accuracy and excellent mechanical properties.However,the LPBFed Haynes 230 parts typically display poor tensile and wear properties due to internal porosity.In this work,the ultrasonic impact treatment(UIT)was applied as a post-treatment to the LPBFed Haynes 230 alloy,porosity and microstructure mod-ulation were performed to improve the strength properties and wear resistance.The pore closure and mi-crostructure were studied by numerical simulations and experiments,and the mechanisms of increasing densification and strength were discussed.Results show that UIT can effectively close pores and reduce porosity,the internal porosity of the ultrasonic impacted layer for one,two,and three times decreases by 63.6%,70.9%,and 81.8%,respectively.Pore closure is attributed to the residual compressive stress and shear stress introduced by UIT.Besides,the UIT weakened texture strength and refined grains,especially promoting the formation of fine grains.Meanwhile,it also promotes the formation of a high disloca-tion density and improves the phase structure distribution.Furthermore,the ultimate tensile and yield strengths of the optimal impact process increased by 9.6%and 34.6%,respectively.The improvement in strength was attributed to dislocation,grain boundary,and promoting densification strengthening.The average friction coefficient reduces by 4.9%-14.6%by refining the surface grains and increasing dislo-cation density.This work has verified the feasibility of improving the mechanical properties and pore closure of the LPBFed Haynes 230 alloy by UIT.
基金supported by Taishan Scholars Program of Shandong Province(Nos.tsqn201909081,tsqn202211115,and tsqn202306162)Shandong Natural Science Foundation of China(Nos.ZR2021QE102,ZR2020ZD05,and ZR2022ME067)+1 种基金the Science Foundation Program for Distinguished Young Scholars(Overseas)of Shandong Province(No.2022HWYQ-084)the Talent Training Program for Shandong Province Higher Educational Youth Innovative Teams(2021).
文摘Co-precipitation strengthening of the L1_(2)nano-particles along with hard intermetallic phases,including L2_(1),B2,σandη,demonstrates significant potential for the development of advanced CoCrFeNi high-entropy alloys(HEAs)with favorable strength-ductility balances.Understanding the alloying effect of Al and Ti on the formation and stability of these intermetallic phases in the CoCrFeNi HEAs is crucial for efficiently exploring the multi-component space for future alloy designs.In the present work,stepwise compositionally graded CoCrFeNi-AlTi HEAs comprising 35 different compositions were fabricated using high-throughput additive manufacturing(AM)and analyzed through a suite of localized characterization techniques.Our analysis confirmed the existence of two primary solid solution phases,face-centered cubic(FCC)and body-centered cubic(BCC),as well as four distinct intermetallic phases,which include L1_(2),L2_(1),σandη.By overlapping the zero phase fraction(ZPF)lines of these phases,the pseudo-ternary phase diagram of the multi-component CoCrFeNi-AlTi system at 800℃was determined,demonstrating good agreement with the literature results.Furthermore,the composition-dependent microstructural evolution and Vickers hardness(HV)were also established,providing numerous opportunities to design CoCrFeNi-AlTi HEAs with superior microstructure stability and balanced strength-ductility properties for structural applications at elevated temperatures.
基金jointly supported by the National Natural Science Foundation of China[grant numbers U20A2097,42175042,41905037,41805054]the China Scholarship Council[grant numbers 201908510031 and 201908510032]the Plateau and Basin Rainstorm,Drought and Flood Key Laboratory of Sichuan Province[grant number SCQXKJZD202102-6]。
文摘Extreme precipitation events cause severe environmental and societal damage worldwide.Southwest China(SWC)is sensitive to such effects because of its overpopulation,underdevelopment,and fragile ecosystems.Using daily observations from 108 rain-gauge stations,the authors investigated the frequency of extreme precipitation events and their contribution to total precipitation in SWC since the late 1970 s.Results indicate that total precipitation is decreasing insignificantly,but rainfall-events frequency is decreasing significantly,whereas the region is experiencing more frequent and intense extreme precipitation events.Note that although fewer stations are statistically significant,about 60%of the rain-gauge stations show an increasing trend in the frequency and intensity of extreme precipitation.Furthermore,there is an increasing trend in the contribution of total extreme precipitation to total precipitation,with extreme precipitation becoming dominant in the increasingly arid SWC region.The results carry important implications for policymakers,who should place greater emphasis on extreme precipitation and associated floods and landslides when drafting water-resource management policies.
