Traditional studies of microbial succession under iron-carbon composite(Fe-C)amendment application have focused on the entire microbial community,with limited attention to the responses and ecological roles of abundan...Traditional studies of microbial succession under iron-carbon composite(Fe-C)amendment application have focused on the entire microbial community,with limited attention to the responses and ecological roles of abundant or rare taxa.Herein,a 90-day microcosm incubation was conducted to investigate the effects of three Fe-C amendments,including Fe_(3)O_(4)-modified biochar(FeC-B),ferrihydrite-natural humic acid(FeC-N),and ferrihydrite-synthetic humic-like acid(FeC-S),on distribution patterns,assembly processes,and ecological functions of both abundant and rare subcommunities.Our results showed that Fe-C amendments significantly affected theα-diversity of rare taxa,particularly under FeC-B treatment,with minimal impact on abundant taxa.Fe-C amendments also reshaped the community structures of both groups.Rare taxa,representing 63.9%of Operational Taxonomic Unit(OTU)richness but only 1.6%of total abundance,played a key role in community diversity and were more susceptible to Fe-C amendments.Certain rare taxa transitioned to abundant status,demonstrating their potential as a microbial seed bank.Abundant taxa were positioned more centrally within the networks,and Fe-C applications promoted cooperative interactions between abundant and rare species.Deterministic processes dominated the assembly of the rare subcommunity,while stochastic processes primarily influenced the abundant bacterial community.Fe-C amendments reduced community differentiation among rare taxa while increasing variability among abundant groups.Functional diversity of rare groups surpassed that of abundant groups,with notable enhancement in nitrogen cycling-related genes under Fe-C treatments.This study highlights the complementary roles of abundant and rare taxa in soil remediation,providing insights for optimizing remediation strategies.展开更多
The association between dietary fat types and obesity is controversial,and the underlying mechanism remains unclear.This study aimed to evaluate the effect of different dietary fat sources(lard,corn oil or canola oil)...The association between dietary fat types and obesity is controversial,and the underlying mechanism remains unclear.This study aimed to evaluate the effect of different dietary fat sources(lard,corn oil or canola oil)on obesity in mice.The results revealed that lard-fed mice showed a lean phenotype,as well as lower serum cholesterol level compared with mice fed corn oil or canola oil.The 16S rRNA gene sequencing showed that the lard-fed mice had higherα-diversity of gut microbiota.In addition,the lard group had similar relative abundance of Lactobacillus,unclassified_f_Lachnospiraceae and Bacteroides compared with the control group.Targeted metabolomics analysis of caecal bile acid(BA)profile suggested the levels of chenodeoxycholic acid,lithocholic acid,deoxycholic acid and cholic acid in the lard group were higher than those in the corn oil and canola oil groups.Meanwhile,the levels of BA receptor farnesoid X receptor(Fxr)gene in lard-fed mice were higher than vegetable oil groups.These results suggested that lard could reduce the risk of obesity compared with corn oil and canola oil,which may be associated with more balanced gut microbiota and BA composition as well as activated FXR signaling.展开更多
BACKGROUND Postpartum pulmonary arterial hypertension(PAH)complicated with hereditary hemorrhagic telangiectasia(HHT)is a rare condition.Diagnosing and treating PAH in patients with HHT can be challenging.To the best ...BACKGROUND Postpartum pulmonary arterial hypertension(PAH)complicated with hereditary hemorrhagic telangiectasia(HHT)is a rare condition.Diagnosing and treating PAH in patients with HHT can be challenging.To the best of our knowledge,no previous reports have investigated the efficacy of pulmonary vasodilators in improving hemodynamics in postpartum patients with this disease.CASE SUMMARY In this paper,we report a postpartum case of HHT combined with PAH,pre-senting with worsening dyspnea.Genetic testing revealed that the patient carried a heterozygous variant of activin receptor-like kinase 1.The patient received various treatments,including diuretics,anticoagulants,sildenafil,macitentan,inhalation of nitric oxide,and iloprost.Changes in PaO2/FiO2,pulmonary artery systolic pressure as assessed by echocardiography,and N-terminus pro-brain natriuretic peptide levels suggested that,except for iloprost inhalation,the other treatments appeared to have limited efficacy.CONCLUSION To our knowledge,this is the first report on efficacy of pulmonary vasodilators in postpartum patients with HHT and PAH.展开更多
Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive ...Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.展开更多
Protozoan infections(e.g.,malaria,trypanosomiasis,and toxoplasmosis)pose a considerable global burden on public health and socioeconomic problems,leading to high rates of morbidity and mortality.Due to the limited ars...Protozoan infections(e.g.,malaria,trypanosomiasis,and toxoplasmosis)pose a considerable global burden on public health and socioeconomic problems,leading to high rates of morbidity and mortality.Due to the limited arsenal of effective drugs for these diseases,which are associated with devastating side effects and escalating drug resistance,there is an urgent need for innovative antiprotozoal drugs.The emergence of drug repurposing offers a low-cost approach to discovering new therapies for protozoan diseases.In this review,we summarize recent advances in drug repurposing for various human protozoan diseases and explore cost-effective strategies to identify viable new treatments.We highlight the cross-applicability of repurposed drugs across diverse diseases and harness common chemical motifs to provide new insights into drug design,facilitating the discovery of new antiprotozoal drugs.Challenges and opportunities in the field are discussed,delineating novel directions for ongoing and future research.展开更多
All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization losses.However,the challenges encompass the oxidation of Sn^(2...All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization losses.However,the challenges encompass the oxidation of Sn^(2+)to Sn^(4+)and uncontrolled crystallization kinetics in Sn-Pb perovskites,leading to nonradiative recombination and compositional heterogeneity to decrease photovoltaic efficiency and operational stability.Herein,we introduced an ionic liquid additive,1-ethyl-3-methylimidazolium iodide (EMIMI) into Sn-Pb perovskite precursor to form low-dimensional Sn-rich/pure-Sn perovskites at grain boundaries,which mitigates oxidation of Sn^(2+)to Sn^(4+)and regulates the film-forming dynamics of Sn/Pb-based perovskite films.The optimized single-junction Sn-Pb perovskite devices incorporating EMIMI achieved a high efficiency of 22.87%.Furthermore,combined with wide-bandgap perovskite sub-cells in tandem device,we demonstrate 2-terminal all-perovskite tandem solar cells with a power conversion efficiency of 28.34%,achieving improved operational stability.展开更多
Herein,an alkyne-terminated acid/base responsive amphiphilic [2]rotaxane shuttle was synthesized,and then modified onto the glass surface through “click” reaction.The XPS N 1s spectrum and contactangle measurement w...Herein,an alkyne-terminated acid/base responsive amphiphilic [2]rotaxane shuttle was synthesized,and then modified onto the glass surface through “click” reaction.The XPS N 1s spectrum and contactangle measurement were performed to prove the successful immobilization.The amphiphilic [2]rotaxane functionalized surface presented controllable wettability responding to external acid-base stimuli.This bistable rotaxane modified material system promoted the practical application of molecular machines.展开更多
基金supported by the National Natural Science Foundation of China(No.42007128)the Fundamental Research Funds for the Central Universities(No.2024QNYL30)the Graduate Research and Practice Projects of Minzu University of China(No.SZKY2024034).
文摘Traditional studies of microbial succession under iron-carbon composite(Fe-C)amendment application have focused on the entire microbial community,with limited attention to the responses and ecological roles of abundant or rare taxa.Herein,a 90-day microcosm incubation was conducted to investigate the effects of three Fe-C amendments,including Fe_(3)O_(4)-modified biochar(FeC-B),ferrihydrite-natural humic acid(FeC-N),and ferrihydrite-synthetic humic-like acid(FeC-S),on distribution patterns,assembly processes,and ecological functions of both abundant and rare subcommunities.Our results showed that Fe-C amendments significantly affected theα-diversity of rare taxa,particularly under FeC-B treatment,with minimal impact on abundant taxa.Fe-C amendments also reshaped the community structures of both groups.Rare taxa,representing 63.9%of Operational Taxonomic Unit(OTU)richness but only 1.6%of total abundance,played a key role in community diversity and were more susceptible to Fe-C amendments.Certain rare taxa transitioned to abundant status,demonstrating their potential as a microbial seed bank.Abundant taxa were positioned more centrally within the networks,and Fe-C applications promoted cooperative interactions between abundant and rare species.Deterministic processes dominated the assembly of the rare subcommunity,while stochastic processes primarily influenced the abundant bacterial community.Fe-C amendments reduced community differentiation among rare taxa while increasing variability among abundant groups.Functional diversity of rare groups surpassed that of abundant groups,with notable enhancement in nitrogen cycling-related genes under Fe-C treatments.This study highlights the complementary roles of abundant and rare taxa in soil remediation,providing insights for optimizing remediation strategies.
基金funded by Basic Research Fund of Chinese Academy of Agricultural Sciences(CAAS)(1610072021001)the China Agriculture Research System(CARS-35)the Agricultural Science and Technology Innovation Program of CAAS。
文摘The association between dietary fat types and obesity is controversial,and the underlying mechanism remains unclear.This study aimed to evaluate the effect of different dietary fat sources(lard,corn oil or canola oil)on obesity in mice.The results revealed that lard-fed mice showed a lean phenotype,as well as lower serum cholesterol level compared with mice fed corn oil or canola oil.The 16S rRNA gene sequencing showed that the lard-fed mice had higherα-diversity of gut microbiota.In addition,the lard group had similar relative abundance of Lactobacillus,unclassified_f_Lachnospiraceae and Bacteroides compared with the control group.Targeted metabolomics analysis of caecal bile acid(BA)profile suggested the levels of chenodeoxycholic acid,lithocholic acid,deoxycholic acid and cholic acid in the lard group were higher than those in the corn oil and canola oil groups.Meanwhile,the levels of BA receptor farnesoid X receptor(Fxr)gene in lard-fed mice were higher than vegetable oil groups.These results suggested that lard could reduce the risk of obesity compared with corn oil and canola oil,which may be associated with more balanced gut microbiota and BA composition as well as activated FXR signaling.
基金Supported by the Shanghai Sailing Program,No.21YF1440300 and No.22YF1407700and the National Natural Science Foundation of China,No.82200061.
文摘BACKGROUND Postpartum pulmonary arterial hypertension(PAH)complicated with hereditary hemorrhagic telangiectasia(HHT)is a rare condition.Diagnosing and treating PAH in patients with HHT can be challenging.To the best of our knowledge,no previous reports have investigated the efficacy of pulmonary vasodilators in improving hemodynamics in postpartum patients with this disease.CASE SUMMARY In this paper,we report a postpartum case of HHT combined with PAH,pre-senting with worsening dyspnea.Genetic testing revealed that the patient carried a heterozygous variant of activin receptor-like kinase 1.The patient received various treatments,including diuretics,anticoagulants,sildenafil,macitentan,inhalation of nitric oxide,and iloprost.Changes in PaO2/FiO2,pulmonary artery systolic pressure as assessed by echocardiography,and N-terminus pro-brain natriuretic peptide levels suggested that,except for iloprost inhalation,the other treatments appeared to have limited efficacy.CONCLUSION To our knowledge,this is the first report on efficacy of pulmonary vasodilators in postpartum patients with HHT and PAH.
基金the National Natural Science Foundation of China(Nos.21801063,22305070 and U20041101)the Top-Notch Talents Program of Henan Agricultural University(Nos.30501049 and 30501032)for financial support。
文摘Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.:32270690 and 32070671)the Postdoctor Research Fund of West China Hospital,Sichuan University,China(Grant No.:2024HXBH059)。
文摘Protozoan infections(e.g.,malaria,trypanosomiasis,and toxoplasmosis)pose a considerable global burden on public health and socioeconomic problems,leading to high rates of morbidity and mortality.Due to the limited arsenal of effective drugs for these diseases,which are associated with devastating side effects and escalating drug resistance,there is an urgent need for innovative antiprotozoal drugs.The emergence of drug repurposing offers a low-cost approach to discovering new therapies for protozoan diseases.In this review,we summarize recent advances in drug repurposing for various human protozoan diseases and explore cost-effective strategies to identify viable new treatments.We highlight the cross-applicability of repurposed drugs across diverse diseases and harness common chemical motifs to provide new insights into drug design,facilitating the discovery of new antiprotozoal drugs.Challenges and opportunities in the field are discussed,delineating novel directions for ongoing and future research.
基金National Key Research and Development Program of China (2022YFB420030)National Natural Science Foundation of China (2227903)+1 种基金Innovation Project of Optics Valley Laboratory (OVL2021BG008)Foundation of State Key Laboratory of New Textile Materials and Advanced Processing Technologies (FZ2021011)。
文摘All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization losses.However,the challenges encompass the oxidation of Sn^(2+)to Sn^(4+)and uncontrolled crystallization kinetics in Sn-Pb perovskites,leading to nonradiative recombination and compositional heterogeneity to decrease photovoltaic efficiency and operational stability.Herein,we introduced an ionic liquid additive,1-ethyl-3-methylimidazolium iodide (EMIMI) into Sn-Pb perovskite precursor to form low-dimensional Sn-rich/pure-Sn perovskites at grain boundaries,which mitigates oxidation of Sn^(2+)to Sn^(4+)and regulates the film-forming dynamics of Sn/Pb-based perovskite films.The optimized single-junction Sn-Pb perovskite devices incorporating EMIMI achieved a high efficiency of 22.87%.Furthermore,combined with wide-bandgap perovskite sub-cells in tandem device,we demonstrate 2-terminal all-perovskite tandem solar cells with a power conversion efficiency of 28.34%,achieving improved operational stability.
基金supported by the National Natural Science Foundation of China(Nos.21901063,U20041101)Young Talents Personnel Fund of Henan Agricultural University(No.30500604)Key Science and Technology Foundation of Henan Province(Nos.242102230178,232102310379)。
文摘Herein,an alkyne-terminated acid/base responsive amphiphilic [2]rotaxane shuttle was synthesized,and then modified onto the glass surface through “click” reaction.The XPS N 1s spectrum and contactangle measurement were performed to prove the successful immobilization.The amphiphilic [2]rotaxane functionalized surface presented controllable wettability responding to external acid-base stimuli.This bistable rotaxane modified material system promoted the practical application of molecular machines.
