Owing to the close correlation of development of oil and gas reservoir and spatial geological place, the technique of GIS can be introduced into the process of development and management of oil and gas reservoir. But ...Owing to the close correlation of development of oil and gas reservoir and spatial geological place, the technique of GIS can be introduced into the process of development and management of oil and gas reservoir. But development of oil and gas reservoir has its particularity, development and management GIS of oil and gas reservoir should use the other techniques to extend the forms of representation to make up the shortages of GIS in representation. The development and management GIS of oil and gas reservoir will be perfect besides the basic functions of GIS. This paper expatiates how to use other techniques to extend GIS in development and management of oil and gas reservoir mainly from productive dynamic curve of well, layers of map piling up, 3 D geological model and replaying maps, etc. Through extended GIS in development and management of oil and gas reservoir, the forms of representation of geological information are enriched, representations of information are more direct and visual, spatial descriptive ability and forms of representation of GIS are built up and the single information system will be developed into a management and decision making system.展开更多
Manipulation of mouse genome has merged as one of the most important approaches for studying genefunction and establishing the disease model because of the high homology between human genome and mouse genome. In this ...Manipulation of mouse genome has merged as one of the most important approaches for studying genefunction and establishing the disease model because of the high homology between human genome and mouse genome. In this study, the chemical mutagen ethylnitrosourea (ENU) was employed for inducing germ cell mutations in maleC57BL/6J mice. The first generation (G1) of the backcrossof these mutated mice, totally 3172, was screened for abnor-mal phenotypes on gross morphology, behavior, learning and memory, auditory brainstem response (ABR), electrocardio-gram (ECG), electroretinogram (ERG), flash-visual evoked potential (F-VEP), bone mineral density, and blood sugarlevel. 595 mice have been identified with specific dominantabnormalities. Fur color changes, eye defects and hearing loss occurred at the highest frequency. Abnormalities related to metabolism alteration are least frequent. Interestingly, eye defects displayed significant left-right asymmetry and sexpreference. Sex preference is also observed in mice with ab-normal bone mineral density. Among 104 G1 generation mutant mice examined for inheritability, 14 of them have been confirmed for passing abnormal phenotypes to their progenies. However, we did not observe behavior abnormali-ties of G1 mice to be inheritable, suggesting multi-gene con-trol for these complicated functions in mice. In conclusion, the generation of these mutants paves the way for under-standing molecular and cellular mechanisms of these ab-normal phenotypes, and accelerates the cloning of disease-related genes.展开更多
文摘Owing to the close correlation of development of oil and gas reservoir and spatial geological place, the technique of GIS can be introduced into the process of development and management of oil and gas reservoir. But development of oil and gas reservoir has its particularity, development and management GIS of oil and gas reservoir should use the other techniques to extend the forms of representation to make up the shortages of GIS in representation. The development and management GIS of oil and gas reservoir will be perfect besides the basic functions of GIS. This paper expatiates how to use other techniques to extend GIS in development and management of oil and gas reservoir mainly from productive dynamic curve of well, layers of map piling up, 3 D geological model and replaying maps, etc. Through extended GIS in development and management of oil and gas reservoir, the forms of representation of geological information are enriched, representations of information are more direct and visual, spatial descriptive ability and forms of representation of GIS are built up and the single information system will be developed into a management and decision making system.
基金supported by the State“863”High-Tech Project and the National Gongguan Project
文摘Manipulation of mouse genome has merged as one of the most important approaches for studying genefunction and establishing the disease model because of the high homology between human genome and mouse genome. In this study, the chemical mutagen ethylnitrosourea (ENU) was employed for inducing germ cell mutations in maleC57BL/6J mice. The first generation (G1) of the backcrossof these mutated mice, totally 3172, was screened for abnor-mal phenotypes on gross morphology, behavior, learning and memory, auditory brainstem response (ABR), electrocardio-gram (ECG), electroretinogram (ERG), flash-visual evoked potential (F-VEP), bone mineral density, and blood sugarlevel. 595 mice have been identified with specific dominantabnormalities. Fur color changes, eye defects and hearing loss occurred at the highest frequency. Abnormalities related to metabolism alteration are least frequent. Interestingly, eye defects displayed significant left-right asymmetry and sexpreference. Sex preference is also observed in mice with ab-normal bone mineral density. Among 104 G1 generation mutant mice examined for inheritability, 14 of them have been confirmed for passing abnormal phenotypes to their progenies. However, we did not observe behavior abnormali-ties of G1 mice to be inheritable, suggesting multi-gene con-trol for these complicated functions in mice. In conclusion, the generation of these mutants paves the way for under-standing molecular and cellular mechanisms of these ab-normal phenotypes, and accelerates the cloning of disease-related genes.
