A semi-quantum model for energy transport in collagen molecules is presented. Soliton-like dynamics of this model is investigated numerically without and with the temperature effect taking into account. It is found th...A semi-quantum model for energy transport in collagen molecules is presented. Soliton-like dynamics of this model is investigated numerically without and with the temperature effect taking into account. It is found that in both the cases energy can transport for a long distance along the collagen chain. This indicates that collagen molecules can be taken as a candidate for the acupuncture channel.展开更多
Background Many patients with obstructive sleep apnea syndrome (OSAS) have complicated with hypertension and may be prescribed with antihypertension medications to control their blood pressure But whether antihyperte...Background Many patients with obstructive sleep apnea syndrome (OSAS) have complicated with hypertension and may be prescribed with antihypertension medications to control their blood pressure But whether antihypertension medications can also decrease arterial stiffness or control the blood pressure increasing following obstructive events is not well described This study aimed to investigate whether antihypertensive medications can ameliorate the changes in arterial stiffness and blood pressure associated with OSA Methods Sixtyone OSAS patients [13 women, 48 men, mean age (534±123) years], 26 normotensive patients (N), 7 hypertensive patients on no antihypertension medications (H), and 28 hypertensive patients on various combination antihypertension therapy (HM), were prospectively diagnosed with standard nocturnal polysomnography Beattobeat blood pressure was continuously recorded from the radial artery by applanation tonometry during baseline sleep As a measure of arterial stiffness, arterial augmentation index (AAI) was calculated as the ratio of augmented systolic blood pressure (SBP) to pulse pressure and expressed as a percentage for the following conditions: awakening, the first 10 ('early apnea') and last 10 ('late apnea') cardiac cycles of obstructive events (apnea or hypopnea), and the first 15 cardiac cycles following event termination ('post apnea') for all events with nadir O2 saturation ≤89% Results Systolic blood pressure (SBP) postapnea [(14274±1306) mmHg (N), (13706±2656) mmHg (H), (13694±141) mmHg (HM)] was significantly increased from awakening [(13576±1476) mmHg (N), (13558±2317) mmHg (H), (12977±1400) mmHg (HM)], early apnea [(13053±1265) mmHg (N), (12447±2497) mmHg (H), (12604±1312) mmHg (HM)], and late apnea [(1298±1268) mmHg(N), (12478±2515) mmHg (H), (12448±1382) mmHg (HM)] respectively (P<0001, repeated measures ANOVA) AAI was significantly increased for the N group (P<0001) from awakening to late apnea [(1045±262)% vs (1443±321)%] and from early apnea to late apnea [(1061±234)% vs (1443±321)%], and also for H group (P<005) from awakening to late apnea [(1123±387)% vs (1632±802)%] and from early apnea to late apnea [(1175±379)% vs (1632±802)%] Meanwhile, no significant differences in AAI among awakening, early apnea, late apnea, and postapnea conditions were found in HM group Conclusions The current data demonstrate that systemic blood pressure increases significantly during the postapneic phase of OSAS, compared with that during awakening and intraapnea phases even with the use of combined antihypertensive therapy which could normalize BP during awakening in the hypertensive patients However, increases in arterial stiffness during obstructive events could be ameliorated by combined antihypertension medications展开更多
文摘A semi-quantum model for energy transport in collagen molecules is presented. Soliton-like dynamics of this model is investigated numerically without and with the temperature effect taking into account. It is found that in both the cases energy can transport for a long distance along the collagen chain. This indicates that collagen molecules can be taken as a candidate for the acupuncture channel.
文摘Background Many patients with obstructive sleep apnea syndrome (OSAS) have complicated with hypertension and may be prescribed with antihypertension medications to control their blood pressure But whether antihypertension medications can also decrease arterial stiffness or control the blood pressure increasing following obstructive events is not well described This study aimed to investigate whether antihypertensive medications can ameliorate the changes in arterial stiffness and blood pressure associated with OSA Methods Sixtyone OSAS patients [13 women, 48 men, mean age (534±123) years], 26 normotensive patients (N), 7 hypertensive patients on no antihypertension medications (H), and 28 hypertensive patients on various combination antihypertension therapy (HM), were prospectively diagnosed with standard nocturnal polysomnography Beattobeat blood pressure was continuously recorded from the radial artery by applanation tonometry during baseline sleep As a measure of arterial stiffness, arterial augmentation index (AAI) was calculated as the ratio of augmented systolic blood pressure (SBP) to pulse pressure and expressed as a percentage for the following conditions: awakening, the first 10 ('early apnea') and last 10 ('late apnea') cardiac cycles of obstructive events (apnea or hypopnea), and the first 15 cardiac cycles following event termination ('post apnea') for all events with nadir O2 saturation ≤89% Results Systolic blood pressure (SBP) postapnea [(14274±1306) mmHg (N), (13706±2656) mmHg (H), (13694±141) mmHg (HM)] was significantly increased from awakening [(13576±1476) mmHg (N), (13558±2317) mmHg (H), (12977±1400) mmHg (HM)], early apnea [(13053±1265) mmHg (N), (12447±2497) mmHg (H), (12604±1312) mmHg (HM)], and late apnea [(1298±1268) mmHg(N), (12478±2515) mmHg (H), (12448±1382) mmHg (HM)] respectively (P<0001, repeated measures ANOVA) AAI was significantly increased for the N group (P<0001) from awakening to late apnea [(1045±262)% vs (1443±321)%] and from early apnea to late apnea [(1061±234)% vs (1443±321)%], and also for H group (P<005) from awakening to late apnea [(1123±387)% vs (1632±802)%] and from early apnea to late apnea [(1175±379)% vs (1632±802)%] Meanwhile, no significant differences in AAI among awakening, early apnea, late apnea, and postapnea conditions were found in HM group Conclusions The current data demonstrate that systemic blood pressure increases significantly during the postapneic phase of OSAS, compared with that during awakening and intraapnea phases even with the use of combined antihypertensive therapy which could normalize BP during awakening in the hypertensive patients However, increases in arterial stiffness during obstructive events could be ameliorated by combined antihypertension medications
