Objective: to explore the healing-promoting effect of quercetin wound-healing sponge dressing on the back wound of SD rats. Methods: SD rats were randomly divided into quercetin dressing group, blank control group and...Objective: to explore the healing-promoting effect of quercetin wound-healing sponge dressing on the back wound of SD rats. Methods: SD rats were randomly divided into quercetin dressing group, blank control group and vaseline gauze group, with 10 rats in each group. Full-thickness skin excision was performed to establish a back wound model, and local dressing change was started on the day of model establishment;The wound healing rate was calculated on days 0, 3, 7 and 10 of dressing change, and the new tissue of wound healing site on day 7 of dressing change was collected for HE staining. Results: on the 10th day of dressing change, the healing rate of the back wound of SD rats in the quercetin dressing group was significantly higher than that of the blank control group and the vaseline gauze group (P < 0.05). The collagen staining intensity, inflammatory cell distribution, angiogenesis rate and fibroblast distribution score in the wound tissue of SD rats in quercetin dressing group were significantly higher than those in the blank control group and vaseline gauze group (p < 0.05). Conclusion: quercetin wound-healing sponge dressing can promote the healing of the wounds on the back of SD rats with good efficacy, which is worthy of further scientific verification for clinical marketing.展开更多
文摘Objective: to explore the healing-promoting effect of quercetin wound-healing sponge dressing on the back wound of SD rats. Methods: SD rats were randomly divided into quercetin dressing group, blank control group and vaseline gauze group, with 10 rats in each group. Full-thickness skin excision was performed to establish a back wound model, and local dressing change was started on the day of model establishment;The wound healing rate was calculated on days 0, 3, 7 and 10 of dressing change, and the new tissue of wound healing site on day 7 of dressing change was collected for HE staining. Results: on the 10th day of dressing change, the healing rate of the back wound of SD rats in the quercetin dressing group was significantly higher than that of the blank control group and the vaseline gauze group (P < 0.05). The collagen staining intensity, inflammatory cell distribution, angiogenesis rate and fibroblast distribution score in the wound tissue of SD rats in quercetin dressing group were significantly higher than those in the blank control group and vaseline gauze group (p < 0.05). Conclusion: quercetin wound-healing sponge dressing can promote the healing of the wounds on the back of SD rats with good efficacy, which is worthy of further scientific verification for clinical marketing.
