Photodynamic therapy(PDT)has emerged as a promising approach for tumor treatment due to its noninvasiveness and high selectivity.However,the off-target activation of phototoxicity and the limited availability of tumor...Photodynamic therapy(PDT)has emerged as a promising approach for tumor treatment due to its noninvasiveness and high selectivity.However,the off-target activation of phototoxicity and the limited availability of tumor-specific biomarkers pose challenges for effective PDT.Here,we present the development of a novel ratiometric near-infrared-II(NIR-II)fluorescent organic nanoprobe,BTz-IC@IR1061,which responds specifically to hypochlorite(HClO)within tumors.This nanoprobe allows ratiometric fluorescence imaging to monitor and guide activated tumor PDT.BTz-IC@IR1061 nanoparticles were synthesized by codoping the small molecule dye BTz-IC,which generates reactive oxygen species(ROS),with the commercial dye IR1061.The presence of HClO selectively activates the fluorescence and photodynamic properties of BTz-IC while destroying IR1061,enabling controlled release of ROS for tumor therapy.We demonstrated the high selectivity of the nanoprobe for HClO,as well as its excellent photostability,photoacoustic imaging capability,and photothermal effects.Furthermore,in vivo studies revealed effective tumor targeting and remarkable tumor growth inhibition through tumor-activated PDT.Our findings highlight the potential of BTz-IC@IR1061 as a promising tool for tumor-specific PDT,providing new opportunities for precise and controlled cancer therapy.展开更多
Artificial intelligence(AI)is upending industries and,in many cases,supplanting traditional computer science techniques.This transition from an emerging technology to an established one is putting new burdens on unive...Artificial intelligence(AI)is upending industries and,in many cases,supplanting traditional computer science techniques.This transition from an emerging technology to an established one is putting new burdens on universities to adapt.The Fifth Global Forum on Development of Computer Science convened at Tsinghua University in the spring of this year to discuss these changes under the theme of“Development of Computer Science in the AI Era”with the aim of reaching a consensus regarding these challenges.Six heads of computer science departments shared keynotes exploring issues such as how to adapt academic and research programs to align with the advancement of AI,how to align educational programs to provide necessary AI skills,how to raise awareness around AI ethics,and how to evaluate researcher productivity.Throughout these discussions,various approaches emerged,including structurally distinguishing AI initiatives from core programs to support more targeted programs,introducing new programs that expand access to AI education,and using AI tools to support personalized education.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22374040,U21A20287,21974039,21890744)the Key Projects of National Natural Science Foundation of China(No.22234003)+1 种基金the National Key R&D Program of China(No.2019YFA0210100)the Fundamental Research Funds for the Central Universities.
文摘Photodynamic therapy(PDT)has emerged as a promising approach for tumor treatment due to its noninvasiveness and high selectivity.However,the off-target activation of phototoxicity and the limited availability of tumor-specific biomarkers pose challenges for effective PDT.Here,we present the development of a novel ratiometric near-infrared-II(NIR-II)fluorescent organic nanoprobe,BTz-IC@IR1061,which responds specifically to hypochlorite(HClO)within tumors.This nanoprobe allows ratiometric fluorescence imaging to monitor and guide activated tumor PDT.BTz-IC@IR1061 nanoparticles were synthesized by codoping the small molecule dye BTz-IC,which generates reactive oxygen species(ROS),with the commercial dye IR1061.The presence of HClO selectively activates the fluorescence and photodynamic properties of BTz-IC while destroying IR1061,enabling controlled release of ROS for tumor therapy.We demonstrated the high selectivity of the nanoprobe for HClO,as well as its excellent photostability,photoacoustic imaging capability,and photothermal effects.Furthermore,in vivo studies revealed effective tumor targeting and remarkable tumor growth inhibition through tumor-activated PDT.Our findings highlight the potential of BTz-IC@IR1061 as a promising tool for tumor-specific PDT,providing new opportunities for precise and controlled cancer therapy.
文摘Artificial intelligence(AI)is upending industries and,in many cases,supplanting traditional computer science techniques.This transition from an emerging technology to an established one is putting new burdens on universities to adapt.The Fifth Global Forum on Development of Computer Science convened at Tsinghua University in the spring of this year to discuss these changes under the theme of“Development of Computer Science in the AI Era”with the aim of reaching a consensus regarding these challenges.Six heads of computer science departments shared keynotes exploring issues such as how to adapt academic and research programs to align with the advancement of AI,how to align educational programs to provide necessary AI skills,how to raise awareness around AI ethics,and how to evaluate researcher productivity.Throughout these discussions,various approaches emerged,including structurally distinguishing AI initiatives from core programs to support more targeted programs,introducing new programs that expand access to AI education,and using AI tools to support personalized education.
