BACKGROUND Neurofibromatosis type 1(NF1)is an inherited autosomal dominant disorder affecting many parts of the body with caféau lait spots,skeletal deformity,and scoliosis.A familial case of NF1 with scoliosis a...BACKGROUND Neurofibromatosis type 1(NF1)is an inherited autosomal dominant disorder affecting many parts of the body with caféau lait spots,skeletal deformity,and scoliosis.A familial case of NF1 with scoliosis and a painless mass had not yet been reported.CASE SUMMARY We describe the case of a 15-year-old male patient with a painless lump on the left side of his neck for 10 years and scoliosis.His right shoulder was about 5 cm lower than the left,the left side of his face was deformed,and the left submandibular skin was relaxed.The folding and drooping were obvious and movement was poor.Computed tomography revealed the involvement of the neck,upper chest wall,and surrounding left shoulder,accompanied by bone changes and scoliosis.Histological evaluation showed subepidermal pale blue mucoid degeneration,fibrous fusiform cells in the dermis in a fascicular,woven arrangement.His mother had the same medical history.The diagnosis was neurofibromatosis of the left neck.Various parts of the tumor tissue were serially resected during several visits.Eight months after surgery,there was a slight tendency to regrow.CONCLUSION This case of slow-progressing NF1 highlights the importance of early diagnosis and treatment to reduce its impact on the patient’s growth and development.展开更多
Oral squamous cell carcinoma(OSCC)is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial cells.Different OSCC-related biomarkers have been reported in circulation in the perip...Oral squamous cell carcinoma(OSCC)is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial cells.Different OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of OSCC.Recent advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood biomarkers.Hence,blood biomarker detection has become an efficient screening tool for the early diagnosis of OSCC.The growing data available in public cancer and gene databases have provided new foundations for OSCC research.In particular,the identification of OSCC biomarkers using bioinformatic tools has shed new light on the underlying mechanisms as well as on the genetic landscape of OSCC.More recently,mRNA targeting therapies have emerged as valuable anticancer treatment strategies,as they allow for the regulation of the expression of certain functional proteins to reverse genetic abnormalities or induce tissue repair.Thus,mRNA-targeting therapies can be used to regulate the expression of antigens,antibodies,or cellular receptors by immune cells.Particularly,anti-cancer cellular immunotherapy carrying specific mRNAs has attracted significant attention in OSCC treatment.Here,we review the present knowledge on the role of peripheral blood mRNAs in the diagnosis,treatment,development,and prognosis of OSCC.Moreover,we address future research prospects of mRNAs in the peripheral blood in OSCC and the opportunities and challenges that may arise in future clinical therapeutic applications.展开更多
In 2021,the Department of Culture and Tourism of Xinjiang Uygur Autonomous Region vigorously promoted the development of"music plus tourism".It made use of song composition as an important step for strengthe...In 2021,the Department of Culture and Tourism of Xinjiang Uygur Autonomous Region vigorously promoted the development of"music plus tourism".It made use of song composition as an important step for strengthening the influence of tourism,and launched a new brand of the integration of culture and tourism,i.e.,"Traveling in Xinjiang by Singing",which took music as the engine to open a new path for tourism promotion.展开更多
Performance Management is the core course of human resource management major,but its knowledge points lack multi-dimensional correlations.There are problems such as scattered content and unclear system,and it is urgen...Performance Management is the core course of human resource management major,but its knowledge points lack multi-dimensional correlations.There are problems such as scattered content and unclear system,and it is urgent to reconstruct the content system of the course.Knowledge graph technology can integrate massive and scattered information into an organic structure through semantic correlation and reasoning.The application of knowledge graph to education and teaching can promote scientific and personalized teaching evaluation and better realize individualized teaching.This paper systematically combs the knowledge points of Performance Management course and forms a comprehensive knowledge graph.The knowledge point is associated with specific questions to form the problem map of the course,and then the knowledge point is further associated with the ability target to form the ability map of the course.Then,the knowledge point is associated with teaching materials,question bank and expansion resources to form a systematic teaching database,thereby giving the method of building the content system of Performance Management course based on the knowledge map.This research can be further extended to other core management courses to realize the deep integration of knowledge graph and teaching.展开更多
Deepening the integration of industry and education is an effective way to cultivate high-quality applied talents.However,integration of industry and education is still at a relatively low level,and the mode is relati...Deepening the integration of industry and education is an effective way to cultivate high-quality applied talents.However,integration of industry and education is still at a relatively low level,and the mode is relatively single,without realizing the deep integration of collaborative education and industry.This paper takes the course"Performance Management"of Human Resource Management as an example to build an industry-education integration system with curriculum construction as a carrier.We introduce enterprise tutors and enterprise scenarios from the aspects of teaching syllabus,teaching content,teaching design,teaching process,teaching resources,and teaching evaluation to study the construction of professional courses under the background of industry-education integration.Through the Performance Management course study,we summarize the methods and modes of industry-education integration in human resource management(HRM)courses and extend and apply the research results to other courses of HRM majors to complete the construction of courses aiming at industry-education integration in HRM majors.展开更多
Knowledge graphs,as an important supporting technology for digital and intelligent education,are driving the teaching model of vocational education to shift from being driven by experience to being driven by data.This...Knowledge graphs,as an important supporting technology for digital and intelligent education,are driving the teaching model of vocational education to shift from being driven by experience to being driven by data.This paper focuses on knowledge graphs and conducts research on the innovation and practice of higher vocational teaching models.Relying on the"Xuexitong"platform,a knowledge map for the"Performance Management"course was constructed.Based on this,an integrated teaching model of"teaching-learning-assessment-application"supported by the knowledge map was designed,achieving the complete connection of the entire process from pre-class self-study,task-driven in class,to data feedback after class.The results indicate that this model can effectively enhance the structuring of course resources and the personalization of the learning process,facilitate the collaborative transformation of the roles of teachers and students,and achieve precise alignment between course content and job competency standards.This research provides a feasible practical approach and theoretical reference for higher vocational colleges to promote digital and intelligent teaching reforms and deepen industry-education integration.展开更多
The rapid advancement of digital intelligence technologies(DITs)has become an important way to promote the in-depth integration of industry and education in higher vocational colleges.Through systematic analysis of na...The rapid advancement of digital intelligence technologies(DITs)has become an important way to promote the in-depth integration of industry and education in higher vocational colleges.Through systematic analysis of nation policy frameworks and institutional case studies,this paper proposes three strategic empowerment pathways,namely the empowerment of educational subjects,the educational resources,and the educational models.By building digital platforms,virtual simulation systems and school-enterprise collaboration platforms,etc.,it promotes the multi-party collaborative interaction of educational entities,facilitates the allocation of educational resources optimally and the matching of industrial demands precisely,innovates teaching methods and enhances practical abilities,providing theoretical support and practical pathways to the higher vocational colleges’digital education reform.展开更多
Dear Editor,Coronavirus disease 2019(COVID-19)has spread globally as a severe pandemic,which is caused by a novel coronavirus named Severe Acute Respiratory Syndrome coronavirus 2(SARS-CoV-2).1 COVID-19 is a serious t...Dear Editor,Coronavirus disease 2019(COVID-19)has spread globally as a severe pandemic,which is caused by a novel coronavirus named Severe Acute Respiratory Syndrome coronavirus 2(SARS-CoV-2).1 COVID-19 is a serious threat to healthcare systems,economies,and is devastating to some populations,such as the elderly and those with comorbidities.It is likely to coexist with human beings for a long time.Unfortunately,there is still no effective cure for COVID-19,especially the critically ill patients.展开更多
After online publication of the article1 we noticed an error in citations for affiliation in the supplementary materials published in this article.The citations for affiliation in the article were reordered during the...After online publication of the article1 we noticed an error in citations for affiliation in the supplementary materials published in this article.The citations for affiliation in the article were reordered during the production process to match the order of authors in the author group.Unfortunately,this was not reflected in the supplementary material.展开更多
基金the National Natural Science Foundation of Guangdong,No.2019A1515011911the Guangdong Province High-level Clinical Key Specialist,No.SZGSP008.
文摘BACKGROUND Neurofibromatosis type 1(NF1)is an inherited autosomal dominant disorder affecting many parts of the body with caféau lait spots,skeletal deformity,and scoliosis.A familial case of NF1 with scoliosis and a painless mass had not yet been reported.CASE SUMMARY We describe the case of a 15-year-old male patient with a painless lump on the left side of his neck for 10 years and scoliosis.His right shoulder was about 5 cm lower than the left,the left side of his face was deformed,and the left submandibular skin was relaxed.The folding and drooping were obvious and movement was poor.Computed tomography revealed the involvement of the neck,upper chest wall,and surrounding left shoulder,accompanied by bone changes and scoliosis.Histological evaluation showed subepidermal pale blue mucoid degeneration,fibrous fusiform cells in the dermis in a fascicular,woven arrangement.His mother had the same medical history.The diagnosis was neurofibromatosis of the left neck.Various parts of the tumor tissue were serially resected during several visits.Eight months after surgery,there was a slight tendency to regrow.CONCLUSION This case of slow-progressing NF1 highlights the importance of early diagnosis and treatment to reduce its impact on the patient’s growth and development.
基金funded by the Key Project of Basic Research of Shenzhen Science and Technology Innovation Commission(Grant Number JCYJ20200109140208058)the Guangdong Provincial High Level Clinical Key Specialty(Grant Number SZGSP008).
文摘Oral squamous cell carcinoma(OSCC)is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial cells.Different OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of OSCC.Recent advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood biomarkers.Hence,blood biomarker detection has become an efficient screening tool for the early diagnosis of OSCC.The growing data available in public cancer and gene databases have provided new foundations for OSCC research.In particular,the identification of OSCC biomarkers using bioinformatic tools has shed new light on the underlying mechanisms as well as on the genetic landscape of OSCC.More recently,mRNA targeting therapies have emerged as valuable anticancer treatment strategies,as they allow for the regulation of the expression of certain functional proteins to reverse genetic abnormalities or induce tissue repair.Thus,mRNA-targeting therapies can be used to regulate the expression of antigens,antibodies,or cellular receptors by immune cells.Particularly,anti-cancer cellular immunotherapy carrying specific mRNAs has attracted significant attention in OSCC treatment.Here,we review the present knowledge on the role of peripheral blood mRNAs in the diagnosis,treatment,development,and prognosis of OSCC.Moreover,we address future research prospects of mRNAs in the peripheral blood in OSCC and the opportunities and challenges that may arise in future clinical therapeutic applications.
文摘In 2021,the Department of Culture and Tourism of Xinjiang Uygur Autonomous Region vigorously promoted the development of"music plus tourism".It made use of song composition as an important step for strengthening the influence of tourism,and launched a new brand of the integration of culture and tourism,i.e.,"Traveling in Xinjiang by Singing",which took music as the engine to open a new path for tourism promotion.
基金Education and Teaching Reform Research Project of Chongqing Institute of Engineering(JY2023206)。
文摘Performance Management is the core course of human resource management major,but its knowledge points lack multi-dimensional correlations.There are problems such as scattered content and unclear system,and it is urgent to reconstruct the content system of the course.Knowledge graph technology can integrate massive and scattered information into an organic structure through semantic correlation and reasoning.The application of knowledge graph to education and teaching can promote scientific and personalized teaching evaluation and better realize individualized teaching.This paper systematically combs the knowledge points of Performance Management course and forms a comprehensive knowledge graph.The knowledge point is associated with specific questions to form the problem map of the course,and then the knowledge point is further associated with the ability target to form the ability map of the course.Then,the knowledge point is associated with teaching materials,question bank and expansion resources to form a systematic teaching database,thereby giving the method of building the content system of Performance Management course based on the knowledge map.This research can be further extended to other core management courses to realize the deep integration of knowledge graph and teaching.
文摘Deepening the integration of industry and education is an effective way to cultivate high-quality applied talents.However,integration of industry and education is still at a relatively low level,and the mode is relatively single,without realizing the deep integration of collaborative education and industry.This paper takes the course"Performance Management"of Human Resource Management as an example to build an industry-education integration system with curriculum construction as a carrier.We introduce enterprise tutors and enterprise scenarios from the aspects of teaching syllabus,teaching content,teaching design,teaching process,teaching resources,and teaching evaluation to study the construction of professional courses under the background of industry-education integration.Through the Performance Management course study,we summarize the methods and modes of industry-education integration in human resource management(HRM)courses and extend and apply the research results to other courses of HRM majors to complete the construction of courses aiming at industry-education integration in HRM majors.
基金Supported by the Chongqing Municipal Education Science Planning Project.Research on the Path of Digital Intelligence Empowering the Deep Integration of Industry and Education in Higher Vocational Colleges(No.K24YG3260033)Supported by Education and Teaching Reform Research Project of Chongqing Institute of Engineering(No.JY2024210)Supported by the Chongqing Academy of commerce(No.2025XJZX01)。
文摘Knowledge graphs,as an important supporting technology for digital and intelligent education,are driving the teaching model of vocational education to shift from being driven by experience to being driven by data.This paper focuses on knowledge graphs and conducts research on the innovation and practice of higher vocational teaching models.Relying on the"Xuexitong"platform,a knowledge map for the"Performance Management"course was constructed.Based on this,an integrated teaching model of"teaching-learning-assessment-application"supported by the knowledge map was designed,achieving the complete connection of the entire process from pre-class self-study,task-driven in class,to data feedback after class.The results indicate that this model can effectively enhance the structuring of course resources and the personalization of the learning process,facilitate the collaborative transformation of the roles of teachers and students,and achieve precise alignment between course content and job competency standards.This research provides a feasible practical approach and theoretical reference for higher vocational colleges to promote digital and intelligent teaching reforms and deepen industry-education integration.
基金Chongqing Municipal Education Science Planning Project:Research on the Path of Digital Intelligence Empowering the Deep Integration of Industry and Education in Higher Vocational Colleges(K24YG3260033).
文摘The rapid advancement of digital intelligence technologies(DITs)has become an important way to promote the in-depth integration of industry and education in higher vocational colleges.Through systematic analysis of nation policy frameworks and institutional case studies,this paper proposes three strategic empowerment pathways,namely the empowerment of educational subjects,the educational resources,and the educational models.By building digital platforms,virtual simulation systems and school-enterprise collaboration platforms,etc.,it promotes the multi-party collaborative interaction of educational entities,facilitates the allocation of educational resources optimally and the matching of industrial demands precisely,innovates teaching methods and enhances practical abilities,providing theoretical support and practical pathways to the higher vocational colleges’digital education reform.
基金grants from National Key Research and Development Program of China(2020YFA0509102)National Natural Science Foundation of China(32030024,31830112,31525016 to J.F.C.,31970702,31701219 to C.D.L.)+4 种基金Program of Shanghai Academic Research Leader(19XD1404200)Personalized Medicines-Molecular Signature-based Drug Discovery and Development,the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12010101)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020266)the Young Elite Scientist Sponsorship Program by CAST(2019QNRC001)National Ten Thousand Talents Program.
文摘Dear Editor,Coronavirus disease 2019(COVID-19)has spread globally as a severe pandemic,which is caused by a novel coronavirus named Severe Acute Respiratory Syndrome coronavirus 2(SARS-CoV-2).1 COVID-19 is a serious threat to healthcare systems,economies,and is devastating to some populations,such as the elderly and those with comorbidities.It is likely to coexist with human beings for a long time.Unfortunately,there is still no effective cure for COVID-19,especially the critically ill patients.
文摘After online publication of the article1 we noticed an error in citations for affiliation in the supplementary materials published in this article.The citations for affiliation in the article were reordered during the production process to match the order of authors in the author group.Unfortunately,this was not reflected in the supplementary material.
