针对观测站机动前目标距离未知导致无法计算Fisher信息矩阵(Fisher information matrix,FIM)的问题,从粗估目标初始距离和减小粗估误差对FIM行列式影响两方面着手,提出在转向前计算FIM进而设计机动策略的方法。首先,在修正极坐标系下建...针对观测站机动前目标距离未知导致无法计算Fisher信息矩阵(Fisher information matrix,FIM)的问题,从粗估目标初始距离和减小粗估误差对FIM行列式影响两方面着手,提出在转向前计算FIM进而设计机动策略的方法。首先,在修正极坐标系下建立系统模型,描述了观测站leg-by-leg机动模式下FIM的计算方法。其次,通过假设目标速度实现目标初始状态粗估,提出使归一化初始距离粗估误差最小的目标速度假设方法。然后,对FIM行列式进行近似及多项式展开,通过控制前后leg段比例以减小状态粗估误差对FIM行列式的影响。最后,利用仿真验证了所提机动策略设计方法的可行性和有效性。结果表明,对于典型的水下目标跟踪场景,FIM行列式的有效估计概率为76.7%,平均的相对估计误差为0.12。展开更多
Objectives:To explore the underlying pharmacological mechanisms and its potential effects of Chinese medicine herbal formula Sini Powder(SNP)on hepatocellular carcinoma(HCC).Methods:The active components of SNP and th...Objectives:To explore the underlying pharmacological mechanisms and its potential effects of Chinese medicine herbal formula Sini Powder(SNP)on hepatocellular carcinoma(HCC).Methods:The active components of SNP and their in vivo distribution were identified using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.Construction of component-target-disease networks,protein-protein interaction network,Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis,and molecular docking were employed to analyze the active components and anti-HcC mechanisms of SNP.Cell viability assay and wound healing assay were utilized to confirm the effect of SNP-containing serum(2.5%,5.0%,10%,20%,and 40%),isoprenaline or propranolol(both 10,100,and 1,000μmol/L)on proliferation and migration of HepG 2 or Huh7 cells.Meanwhile,the effect of isoprenaline or propranolol on theβ2 adrenergic receptor(ADRB2)mRNA expression on HepG2 cells were measured by real-time quantitative reverse transcription(RT-qPCR).Mice with subcutaneous tumors were either subjected to chronic restraint stress(CRS)followed by SNP administration(364 mg/mL)or directly treated with SNP(364 mg/mL).These two parallel experiments were performed to validate the effects of SNP on stress responses.Stress-related proteins and hormones were quantified using RT-qPCR,enzyme-linked immunosorbent assay,and immunohistochemistry.Metagenomic sequencing was performed to confirm the influence of SNP on the gut microbiota in the tumor-bearing CRS mice.Results:The distribution of the 12 active components of SNP was confimed in various tissues and feces.Network pharmacology analysis confirmed the anti-HCC effects of the 5 active components.The potential anti-HCC mechanisms of SNP may involve the epidermal growth factor receptor(EGFR),proto-oncogene tyrosine-protein kinase Src(SRC)and signal transducer and activator of transcription 3(STAT3)pathways.SNP-containing serum inhibited the proliferation of HepG2 and Huh7 cells at concentrations of 2.5%and 5.0%,respectively,after 24 h of treatment.Furthermore,SNP suppressed tumor progression in tumor-bearing mice exposed to CRS.SNP treatment also downregulated the expressions of stressrelated proteins and pro-inflammatory cytokines,primarily by modulating the gut microbiota.Specifically,the abundance of Alistipes and Prevotella,which belong to the phylum Bacteroidetes,increased in the SNP-treated group,whereas Lachnospira,in the phylum Firmicutes,decreased.Conclusion:SNP can combat HCC by alleviating stress responses through the regulation of gut microbiota.展开更多
社会信任作为非正式制度,在社会发展的历程中不可或缺。就审计而言,社会信任对审计意见购买行为是否具有显著影响及如何影响,尚缺乏相关研究。本文以A股非金融类上市公司2010~2018年数据及中国综合社会调查(Chinese general social surv...社会信任作为非正式制度,在社会发展的历程中不可或缺。就审计而言,社会信任对审计意见购买行为是否具有显著影响及如何影响,尚缺乏相关研究。本文以A股非金融类上市公司2010~2018年数据及中国综合社会调查(Chinese general social survey,CGSS)数据为样本,研究社会信任是否对审计意见购买产生影响。实证结果显示,社会信任水平增加了审计意见购买行为发生的可能性。进一步看,法治水平和盈余管理削弱了社会信任与审计意见购买之间的正向关系,分析师跟踪则使两者关系弱化。我们从多角度进行了稳健性检验,结论依然成立。本文拓展了社会信任对上市公司行为影响的研究,丰富了审计意见购买行为影响因素的研究文献,也可为监管层决策提供相关的理论参考和现实指导意义。展开更多
文摘针对观测站机动前目标距离未知导致无法计算Fisher信息矩阵(Fisher information matrix,FIM)的问题,从粗估目标初始距离和减小粗估误差对FIM行列式影响两方面着手,提出在转向前计算FIM进而设计机动策略的方法。首先,在修正极坐标系下建立系统模型,描述了观测站leg-by-leg机动模式下FIM的计算方法。其次,通过假设目标速度实现目标初始状态粗估,提出使归一化初始距离粗估误差最小的目标速度假设方法。然后,对FIM行列式进行近似及多项式展开,通过控制前后leg段比例以减小状态粗估误差对FIM行列式的影响。最后,利用仿真验证了所提机动策略设计方法的可行性和有效性。结果表明,对于典型的水下目标跟踪场景,FIM行列式的有效估计概率为76.7%,平均的相对估计误差为0.12。
基金Supported by Natural Science Foundation of Hunan Province(No.2023JJ40481)fundings from the Education Department of Hunan Province(No.21B0374)Hunan University of Chinese Medicine(No.2024XJZA001)。
文摘Objectives:To explore the underlying pharmacological mechanisms and its potential effects of Chinese medicine herbal formula Sini Powder(SNP)on hepatocellular carcinoma(HCC).Methods:The active components of SNP and their in vivo distribution were identified using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.Construction of component-target-disease networks,protein-protein interaction network,Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis,and molecular docking were employed to analyze the active components and anti-HcC mechanisms of SNP.Cell viability assay and wound healing assay were utilized to confirm the effect of SNP-containing serum(2.5%,5.0%,10%,20%,and 40%),isoprenaline or propranolol(both 10,100,and 1,000μmol/L)on proliferation and migration of HepG 2 or Huh7 cells.Meanwhile,the effect of isoprenaline or propranolol on theβ2 adrenergic receptor(ADRB2)mRNA expression on HepG2 cells were measured by real-time quantitative reverse transcription(RT-qPCR).Mice with subcutaneous tumors were either subjected to chronic restraint stress(CRS)followed by SNP administration(364 mg/mL)or directly treated with SNP(364 mg/mL).These two parallel experiments were performed to validate the effects of SNP on stress responses.Stress-related proteins and hormones were quantified using RT-qPCR,enzyme-linked immunosorbent assay,and immunohistochemistry.Metagenomic sequencing was performed to confirm the influence of SNP on the gut microbiota in the tumor-bearing CRS mice.Results:The distribution of the 12 active components of SNP was confimed in various tissues and feces.Network pharmacology analysis confirmed the anti-HCC effects of the 5 active components.The potential anti-HCC mechanisms of SNP may involve the epidermal growth factor receptor(EGFR),proto-oncogene tyrosine-protein kinase Src(SRC)and signal transducer and activator of transcription 3(STAT3)pathways.SNP-containing serum inhibited the proliferation of HepG2 and Huh7 cells at concentrations of 2.5%and 5.0%,respectively,after 24 h of treatment.Furthermore,SNP suppressed tumor progression in tumor-bearing mice exposed to CRS.SNP treatment also downregulated the expressions of stressrelated proteins and pro-inflammatory cytokines,primarily by modulating the gut microbiota.Specifically,the abundance of Alistipes and Prevotella,which belong to the phylum Bacteroidetes,increased in the SNP-treated group,whereas Lachnospira,in the phylum Firmicutes,decreased.Conclusion:SNP can combat HCC by alleviating stress responses through the regulation of gut microbiota.
文摘社会信任作为非正式制度,在社会发展的历程中不可或缺。就审计而言,社会信任对审计意见购买行为是否具有显著影响及如何影响,尚缺乏相关研究。本文以A股非金融类上市公司2010~2018年数据及中国综合社会调查(Chinese general social survey,CGSS)数据为样本,研究社会信任是否对审计意见购买产生影响。实证结果显示,社会信任水平增加了审计意见购买行为发生的可能性。进一步看,法治水平和盈余管理削弱了社会信任与审计意见购买之间的正向关系,分析师跟踪则使两者关系弱化。我们从多角度进行了稳健性检验,结论依然成立。本文拓展了社会信任对上市公司行为影响的研究,丰富了审计意见购买行为影响因素的研究文献,也可为监管层决策提供相关的理论参考和现实指导意义。
