Somatic mutations accumulate with age in human tissues.Clonal amplifi-cation of some mutations causes cancers and other diseases.However,it is unclear if random mutation accumulation affects cellular function without ...Somatic mutations accumulate with age in human tissues.Clonal amplifi-cation of some mutations causes cancers and other diseases.However,it is unclear if random mutation accumulation affects cellular function without clonal amplification.We tested this in cell culture,avoiding the lim-itation that mutation accumulation in vivo leads to cancer.展开更多
基金supported by the American Federation for Aging Research(the Sagol Network GerOmic Award for Junior Faculty)the US National Institutes of Health(P01AG017242,P01 AG047200,P01 AI172501,P01HL132825,P01 HL160476,P30 AG038072,R00 AG056656,U01 ES029519,U01 HL145560,and U19 AG056278)+2 种基金the University of Minnesota(Fesler-Lampert Chair for Aging Studies)the Veteran’s Affairs Medical Center of Boston(36C24122N0769)the European Union’s Horizon 2020 Research and Innovation Programme(810115-DYNASNET).
文摘Somatic mutations accumulate with age in human tissues.Clonal amplifi-cation of some mutations causes cancers and other diseases.However,it is unclear if random mutation accumulation affects cellular function without clonal amplification.We tested this in cell culture,avoiding the lim-itation that mutation accumulation in vivo leads to cancer.
