Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily...Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.展开更多
Over the past several decades,much research effort has been dedicated to the study of optical windows,with two primary themes emerging as key focuses.The first of these centers on investigating the optical properties ...Over the past several decades,much research effort has been dedicated to the study of optical windows,with two primary themes emerging as key focuses.The first of these centers on investigating the optical properties of typical transparent single crystals under shock or ramp compression,which helps in the selection of appropriate optical windows for high-pressure experiments.The second involves the exploration of novel optical windows,particularly transparent polycrystalline ceramics,which not only match the shock impedance of the samples,but also preserve transparency under dynamic compression.In this study,we first integrate existing research on the evolution of optical properties in transparent single crystals and polycrystalline ceramics subjected to shock or ramp loading,proposing a mechanism that links mesoscopic damage to macroscopic optical transparency.Subsequently,through a systematic integration of experiments and computational analyses on polycrystalline transparent ceramics,we demonstrate that shock transparency can be enhanced by optimizing grain size and that shock impedance can be designed via compositional tuning.Notably,our results reveal that nano-grained MgAl_(2)O_(4) ceramics exhibit outstanding optical transparency under high shock pressures,highlighting a promising strategy for designing optical windows that retain transparency under extreme dynamic loading conditions.展开更多
The 2024 MRE HP Special Volume selects papers on new theoretical and experimental developments in the use of static largevolume presses(LVPs)1–3 and dynamic compression4,5 for studies under extreme high-pressure and ...The 2024 MRE HP Special Volume selects papers on new theoretical and experimental developments in the use of static largevolume presses(LVPs)1–3 and dynamic compression4,5 for studies under extreme high-pressure and high-temperature(HPHT)conditions.It also continues the previous year’s6 contemporary focus on superhydrides7–11 with extremely high superconducting temperatures Tc and addresses some controversial issues.12–14 In addition,it explores unconventional pressure-induced chemistry,particularly novel chemical stoichiometry and its impact on geochemistry and cosmochemistry in the deep interiors of Earth and other planets.18–21.展开更多
1T-MoS_(2)nanosheets,with metallic conductivity and high capacity,hold great potential for lithium-ion capacitors(LICs),but suffer from sluggish reaction kinetics due to dense stacking.Herein,1T-MoS_(2)nanosheets with...1T-MoS_(2)nanosheets,with metallic conductivity and high capacity,hold great potential for lithium-ion capacitors(LICs),but suffer from sluggish reaction kinetics due to dense stacking.Herein,1T-MoS_(2)nanosheets with enlarged interlayer spacing,vertically bonded to reduced graphene oxide(rGO)(1T-MoS_(2)/rGO),were designed using a hydrothermal-assisted dispersion and intercalation strategy.The active nitrogen species derived from N,N-dimethylformamide(DMF)not only bridge the rGO and MoS_(2)through strong Mo-N-C bonds to promote the formation of dispersed MoS_(2)nanosheets,but also intercalate into the MoS_(2)structure,further enlarging the interlayer spacing.This unique structure synergistically enhances meso-and microscale mass transfer outside and inside of the few-layered nanosheets,significantly improving electrochemical reaction kinetics and reducing the kinetic mismatch between the anode and cathode.Consequently,the resulting 1T-MoS_(2)/rGO achieves a capacity of 500 mAh g^(-1)after 500 cycles at 5 A g^(-1)and a high rate performance of 587 mAh g^(-1)at a high rate of 10 A g^(-1).Moreover,the assembled 3D vertical 1T-MoS_(2)/rGO//AC LIC delivers a high energy density of 100.3 Wh kg^(-1)at a power density of1.0 kW kg^(-1),and long cycle stability with capacity retention as high as 91.02%after 5000 cycles at 2 A g^(-1).This work provides a generalizable strategy for engineering two-dimensional material-based electrodes,offering new insights into high-performance energy storage systems.展开更多
Traditional federated learning(FL)frameworks rely heavily on terrestrial networks,whose coverage limitations and increasing bandwidth congestion significantly hinder model convergence.Fortunately,the advancement of lo...Traditional federated learning(FL)frameworks rely heavily on terrestrial networks,whose coverage limitations and increasing bandwidth congestion significantly hinder model convergence.Fortunately,the advancement of low-Earth-orbit(LEO)satellite networks offers promising new communication avenues to augment traditional terrestrial FL.Despite this potential,the limited satellite-ground communication bandwidth and the heterogeneous operating environments of ground devices—including variations in data,bandwidth,and computing power—pose substantial challenges for effective and robust satellite-assisted FL.To address these challenges,we propose SatFed,a resource-efficient satellite-assisted heterogeneous FL framework.SatFed implements freshness-based model-prioritization queues to optimize the use of highly constrained satellite-ground bandwidth,ensuring the transmission of the most critical models.Additionally,a multigraph is constructed to capture the real-time heterogeneous relationships between devices,including data distribution,terrestrial bandwidth,and computing capability.This multigraph enables SatFed to aggregate satellite-transmitted models into peer guidance,improving local training in heterogeneous environments.Extensive experiments with real-world LEO satellite networks demonstrate that SatFed achieves superior performance and robustness compared with state-of-the-art benchmarks.展开更多
A series of Co3O4-CeO2 binary oxides with various Co/(Ce+Co)molar ratios were synthesized using a citric acid method,and their catalytic properties toward the total oxidation of propane were examined.The activities of...A series of Co3O4-CeO2 binary oxides with various Co/(Ce+Co)molar ratios were synthesized using a citric acid method,and their catalytic properties toward the total oxidation of propane were examined.The activities of the catalysts decrease in the order CoCeOx-70>CoCeOx-90>Co3O4>CoCeOx-50>CoCeOx-20>CeO2.CoCeOx-70(Co/(Ce+Co)=70% molar ratio)exhibits the highest catalytic activity toward the total oxidation of propane,of which the T90 is 310℃(GHSV=120000 mL h^-1 g^-1],which is 25℃ lower than that of pure Co3 O4.The enhancement of the catalytic performance of CoCeOx-70 is attributed to the strong interaction between CeO2 and Co3O4,the improvement of the low-temperature reducibility,and the increase in the number of active oxygen species.In-situ DRIFTS and reaction kinetics measurement reveal that Ce addition does not change the reaction mechanism,but promotes the adsorption and activation of propane on the catalyst surface.The addition of water vapor and CO2 in reactant gas has a negative effect on the propane conversion,and the catalyst is more sensitive to water vapor than to CO2.In addition,CoCeOx-70 exhibits excellent stability and reusability in water vapor and CO2 atmosphere.展开更多
Many of our previous studies have discussed the shock response of symmetrical grain boundaries in iron bicrystals.In this paper, the molecular dynamics simulation of an iron bicrystal containing Σ3 [110] asymmetry ti...Many of our previous studies have discussed the shock response of symmetrical grain boundaries in iron bicrystals.In this paper, the molecular dynamics simulation of an iron bicrystal containing Σ3 [110] asymmetry tilt grain boundary(ATGB) under shock-loading is performed. We find that the shock response of asymmetric grain boundaries is quite different from that of symmetric grain boundaries. Especially, our simulation proves that shock can induce migration of asymmetric grain boundary in iron. We also find that the shape and local structure of grain boundary(GB) would not be changed during shock-induced migration of Σ3 [110] ATGB, while the phase transformation near the GB could affect migration of GB. The most important discovery is that the shock-induced shear stress difference between two sides of GB is the key factor leading to GB migration. Our simulation involves a variety of piston velocities, and the migration of GB seems to be less sensitive to the piston velocity. Finally, the kinetics of GB migration at lattice level is discussed. Our work firstly reports the simulation of shock-induced grain boundary migration in iron. It is of great significance to the theory of GB migration and material engineering.展开更多
Objective:To explore the association between the Lung Immune Prognostic Index(LIPI)and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease(IIM-ILD).Methods:Pa...Objective:To explore the association between the Lung Immune Prognostic Index(LIPI)and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease(IIM-ILD).Methods:Patients who were diagnosed with IIM-ILD at West China Hospital,Sichuan University from January 2008 to December 2021 were retrospectively included and categorized into three groups based on LIPI.Univariable and multivariable Cox proportional hazards models were conducted to explore potential association between the LIPI and patients'mortality.Results:A total of 1116 patients were screened,and 830 were included in this study.The multivariable Cox analysis showed that,compared with patients with poor LIPI,the hazard ratio(HR)for all-cause 1-year mortality was 0.22(95%CI 0.05-0.93,P=0.04)for patients in the good LIPI group(LDH<250 IU/L and dNLR<3).After excluding patients lost to follow-up within one year,a similar result was found for LIPI(HR 0.20,95%CI 0.05-0.86;P=0.03).Conclusions:Good LIPI was independently associated with decreased risk of all-cause 1-year mortality in patients with IIM-ILD.This easy-to-obtain index might be served as a potential marker for assessing the prognosis of IIM-ILD.展开更多
Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emergin...Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications.展开更多
How plant metabolic flux alters gene expression to optimize plant growth and response to stress remains largely unclear. Here, we report that Arabidopsis thaliana NAD＊-dependent histone deacetylase AtSRT1 negatively ...How plant metabolic flux alters gene expression to optimize plant growth and response to stress remains largely unclear. Here, we report that Arabidopsis thaliana NAD＊-dependent histone deacetylase AtSRT1 negatively regulates plant tolerance to stress and glycolysis but stimulates mitochondrial respiration. We found that AtSRT1 interacts with Arabidopsis cMyc-Binding Protein 1 （AtMBP-1）, a transcriptional repressor produced by alternative translation of the cytosolic glycolytic enolase gene LOS2/EN02. We demonstrated that AtSRT1 could associate with the chromatin of AtMBP-I targets LOS2/EN02 and STZ/ZATIO, both of which encode key stress regulators, and reduce the H3K9ac levels at these genes to repress their transcription. Overexpression of both AtSRT1 and AtMBP-1 had synergistic effects on the expression of glycolytic genes, glycolytic enzymatic activities, and mitochondrial respiration. Furthermore, we found that AtMBP-1 is lysine-acetylated and vulnerable to proteasomal protein degradation, while AtSRT1 could remove its lysine acetylation and significantly enhance its stability in vivo. Taken together, these results indicate that AtSRT1 regulates primary metabolism and stress response by both epigenetic regulation and modulation of AtMBP-1 transcriptional activity in Arabidopsis.展开更多
Plants have evolved a sophisticated set of mechanisms to adapt to drought stress.Transcription factors play crucial roles in plant responses to various environmental stimuli by modulating the expression of numerous st...Plants have evolved a sophisticated set of mechanisms to adapt to drought stress.Transcription factors play crucial roles in plant responses to various environmental stimuli by modulating the expression of numerous stress-responsive genes.However,how the crosstalk between different transcription factor families orchestrates initiation of the key transcriptional network and the role of posttranscriptional modification of transcription factors,especially in cellular localization/trafficking in response to stress in rice,remain still largely unknown.In this study,we isolated an Osmybr57 mutant that displays a drought-sensitive phenotype through a genetic screen for drought stress sensitivity.We found that OsMYBR57,an MYB-related protein,directly regulates the expression of several key drought-related OsbZ/Ps in response to drought treatment.Further studies revealed that OsMYBR57 interacts with a homeodomain transcription factor,OsHB22,which also plays a positive role in drought signaling.We further demonstrate that OsFTIP6 interacts with OsHB22 and promotes the nucleocytoplasmic translocation of OsHB22 into the nucleus,where OsHB22 cooperates with OsMYBR57 to regulate the expression of drought-responsive genes.Our findings have revealed a mechanistic framework underlying the OsFTIP6-0sHB22-0sMYBR57 module-mediated regulation of drought response in rice.The OsFTIP6-mediated OsHB22 nucleocytoplasmic shuttling and OsMYBR57-0sHB22 regulation of OsbZIP transcription ensure precise control of expression of OsLEA3 and Rab21,and thereby regulate the response to water deficiency in rice.展开更多
Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordinat...Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are fabricated.While exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune responses.Highly effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune responses.Interestingly,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor microenvironment.Thus,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T treatment.Moreover,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary tumors.Therefore,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment.展开更多
The development of space-air-ground integrated networks (SAGIN) requires sophisticated satellite Internet emulation tools that can handle complex, dynamic topologies and offer in-depth analysis. Existing emulation pla...The development of space-air-ground integrated networks (SAGIN) requires sophisticated satellite Internet emulation tools that can handle complex, dynamic topologies and offer in-depth analysis. Existing emulation platforms struggle with challenges like the need for detailed implementation across all network layers, real-time response, and scalability. This paper proposes a digital twin system based on microservices for satellite Internet emulation,namely Plotinus,which aims to solve these problems. Plotinus features a modular design, allowing for easy replacement of the physical layer to emulate different aerial vehicles and analyze channel interference. It also enables replacing of path computation methods to simplify testing and deploying algorithms. In particular, Plotinus allows for real-time emulation with live network traffic,enhancing practical network models. The evaluation result shows Plotinus’s effective emulation of dynamic satellite networks with real-world devices. Its adaptability for various communication models and algorithm testing highlights Plotinus’s role as a vital tool for developing and analyzing SAGIN systems, offering a cross-layer,real-time,and scalable digital twin system.展开更多
Shock wave is associated with dynamic loading that can result in phase transition(PT), optical and mechanical property changing, and chemical reaction on materials. Here, we report recent progress about shockinduced P...Shock wave is associated with dynamic loading that can result in phase transition(PT), optical and mechanical property changing, and chemical reaction on materials. Here, we report recent progress about shockinduced PT of polycrystalline iron, the underlying mechanism of the optical emission from sapphire, and the synthesis from single-phase Ru Si in the National Key Laboratory of Shock Wave and Detonation Physics.Results indicated that grain boundary(GB) could affect the PT pressure threshold and rate of iron, the pressure threshold decreases with decreasing GB defects, and the PT rate shows a variation with increasing GB size; wavelength-dependent optical emissivity(non-gray-body emission) would be generated that was not revealed previously for shocked sapphire, and the observed luminescence was from the shock-induced shear bands, but without superheating phenomenon; shock compression could be an effective way to synthesis Ru-Si nanocrystals, when the shock pressure was appropriate; and Ru-Si powder could completely transform to fine-grain structure Cs Cl-type RuSi at 40.4 GPa.展开更多
Background:Nasal insertion is the preferred method for non-intubated patients in flexible bronchoscopy;however,the relatively narrow nasal cavity results in difficulties related to bronchoscope insertion.This study ai...Background:Nasal insertion is the preferred method for non-intubated patients in flexible bronchoscopy;however,the relatively narrow nasal cavity results in difficulties related to bronchoscope insertion.This study aimed to investigate whether pre-operative nasal probe tests could reduce the time to pass the glottis,improve the first-pass success rate and patients’tolerance,and reduce postoperative bleeding.Methods:This three-arm prospective randomized controlled trial was conducted in a tertiary hospital between May and October 2020.Three hundred patients requiring diagnosis and treatment using flexible bronchoscopy were randomly allocated to three groups:control group,simple cotton bud detection group(CD group),and adrenaline+lidocaine detection group(AD group).The primary outcome was the time to pass the glottis.Secondary outcomes included the first-pass success rate,the patients’tolerance scores,and post-operative bleeding.One-way analysis of variance,Kruskal-WallisH test,Chi-squared test,Fisher’s exact test,and Bonferroni’s multiple comparison tests were used in this study.Results:In total,189 men and 111 women were enrolled in this study,with a mean age of 55.72±12.86 years.The insertion time was significantly shorter in the AD group than in the control group(18.00 s[12.00–26.50 s]vs.24.00 s[14.50–45.50 s],P=0.005).Both the AD(99%vs.83%,χ2=15.62,P<0.001)and CD groups(94%vs.83%,χ2=5.94,P=0.015)had a significantly higher first-pass success rate than the control group.Compared with the control group,post-operative bleeding(1%vs.13%,χ2=11.06,P<0.001)was significantly lower in the AD group.However,no significant difference was found in the patients’tolerance scores.Conclusions:Pre-operative nasal cavity probe tests especially with adrenaline and lidocaine during flexible bronchoscopy can significantly reduce the time to pass the glottis,improve the first-pass success rate,and reduce post-operative nasal bleeding.Pre-operative nasal probe tests are recommended as a time-saving procedure for patients undergoing flexible bronchoscopy.Trial registration:Chinese Clinical Trial Registry(ChiCTR),ChiCTR2000032668;http://www.chictr.org.cn/showprojen.aspx?proj=53321.展开更多
Chlorambucil is a classic nitrogen mustard drug that has been used in the treatment of cancers. It may induce neutropenia, thrombocytopenia and other side effects because of its short lifetime and off-target effect. I...Chlorambucil is a classic nitrogen mustard drug that has been used in the treatment of cancers. It may induce neutropenia, thrombocytopenia and other side effects because of its short lifetime and off-target effect. In this report, chlorambucil-tetrapeptide （AAAK, A3K） conjugate vesicles were developed to improve the stability and bioactivity of chlorambucil. First of all, chlorambucil-A3K conjugate was synthesized by solid phase synthesis strategy. Sec- ondly, the chlorambucil-A3K conjugate was assembled and characterized by critical aggregation concentration, cir- cular dichroism, dynamic light scattering and transmission electron microscopy. The results indicated that the chlo- rambucil-A3K conjugate can be assembled to form spherical vesicles with an average diameter of 390.5 nm, and high drug loading about 47.1% is reached. Surprisingly, the preliminary biological evaluation of the chlorambu- cil-A3K conjugate vesicles revealed the best in vitro anticancer activity against HeLa, HepG-2 and MCF-7 cell lines compared with chlorambucil and chlorambucil-A3K conjugate free drugs. Furthermore, conjugate vesicles showed excellent in vivo antitumoral activity. It can be partly attributed to their vesicular structure which isolates chloram- bucil active moiety from aqueous solution to retard degradation before killing cancer cells. Therefore, chlorambu- cil-peptide （A3K） conjugate vesicles may be an alternative delivery system of chlorambucil.展开更多
Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally i...Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally invasive technique for patients with severe hyperinflation and advanced emphysema.To date,the most investigated form of ELVR isvalve implantation,which is toplacevalves in all the segments of an emphysematous lobe.However,valve replacements do not achieve adequate lung volume reduction in the,presence of interlobar collateral ventilation(CV).l1 in addition,with the heterogeneity existing withinthe treatment lobe,complete lobar treatment from implants may result in excessive reduction of the less diseased segments.Thus,a more targeted approach of the most severe emphysematous parts of the lobe is warranted.展开更多
Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Z...Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Zn-ions and 4-phenylimidazole(PI),the latter of which is an inhibitor of indoleamine 2,3-dioxygenase(IDO)and acts as an organic bridging ligand via Zn–N coordination bonds.展开更多
ZnO films coated with reduced graphene oxide（RGO-ZnO） were prepared by a simple chemical approach. The graphene oxide（GO） films transferred onto ZnO films by spin coating were reduced to RGO films by two steps（ex...ZnO films coated with reduced graphene oxide（RGO-ZnO） were prepared by a simple chemical approach. The graphene oxide（GO） films transferred onto ZnO films by spin coating were reduced to RGO films by two steps（exposed to hydrazine vapor for 12 h and annealed at 600 °C）. The crystal structures, electrical and photoluminescence properties of RGO-ZnO films on quartz substrates were systematically studied. The SEM images illustrated that RGO layers have successfully been coated on the ZnO films very tightly. The PL properties of RGO-ZnO were studied. PL spectra show two sharp peaks at 390 nm and a broad visible emission around 490 nm.The resistivity of RGO-ZnO films was measured by a Hall measurement system, RGO as nanofiller considerably decrease the resistivity of ZnO films. An electrode was fabricated, using RGO-ZnO films deposited on Si substrate as active materials, for super capacitor application. By comparison of different results, we conclude that the RGOZnO composite material couples possess the properties of super capacitor.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC)the National Key R&D Program of China,No.2023YFE0209500(to JC)+4 种基金China Postdoctoral Science Foundation,No.2023M732380(to NY)Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC)Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC)National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM)Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。
文摘Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.
基金financially supported by the National Natural Science Foundation of China(Grant No.11872344)the Innovatory Development Foundation of the China Academy of Engineering Physics(Grant No.CX20210026).
文摘Over the past several decades,much research effort has been dedicated to the study of optical windows,with two primary themes emerging as key focuses.The first of these centers on investigating the optical properties of typical transparent single crystals under shock or ramp compression,which helps in the selection of appropriate optical windows for high-pressure experiments.The second involves the exploration of novel optical windows,particularly transparent polycrystalline ceramics,which not only match the shock impedance of the samples,but also preserve transparency under dynamic compression.In this study,we first integrate existing research on the evolution of optical properties in transparent single crystals and polycrystalline ceramics subjected to shock or ramp loading,proposing a mechanism that links mesoscopic damage to macroscopic optical transparency.Subsequently,through a systematic integration of experiments and computational analyses on polycrystalline transparent ceramics,we demonstrate that shock transparency can be enhanced by optimizing grain size and that shock impedance can be designed via compositional tuning.Notably,our results reveal that nano-grained MgAl_(2)O_(4) ceramics exhibit outstanding optical transparency under high shock pressures,highlighting a promising strategy for designing optical windows that retain transparency under extreme dynamic loading conditions.
基金financial support from the Shanghai Key Laboratory of MFree,China(Grant No.22dz2260800)the Shanghai Science and Technology Committee,China(Grant No.22JC1410300).
文摘The 2024 MRE HP Special Volume selects papers on new theoretical and experimental developments in the use of static largevolume presses(LVPs)1–3 and dynamic compression4,5 for studies under extreme high-pressure and high-temperature(HPHT)conditions.It also continues the previous year’s6 contemporary focus on superhydrides7–11 with extremely high superconducting temperatures Tc and addresses some controversial issues.12–14 In addition,it explores unconventional pressure-induced chemistry,particularly novel chemical stoichiometry and its impact on geochemistry and cosmochemistry in the deep interiors of Earth and other planets.18–21.
基金the financial support from the National Natural Science Foundation of China(No.52225208 and 51802131)the Training Program for academic and technical leaders in major disciplines of Jiangxi Province-Young Talents(No.20212BCJ23021)the Natural Science Foundation of Jiangxi Province,China(No.20232BAB204020).
文摘1T-MoS_(2)nanosheets,with metallic conductivity and high capacity,hold great potential for lithium-ion capacitors(LICs),but suffer from sluggish reaction kinetics due to dense stacking.Herein,1T-MoS_(2)nanosheets with enlarged interlayer spacing,vertically bonded to reduced graphene oxide(rGO)(1T-MoS_(2)/rGO),were designed using a hydrothermal-assisted dispersion and intercalation strategy.The active nitrogen species derived from N,N-dimethylformamide(DMF)not only bridge the rGO and MoS_(2)through strong Mo-N-C bonds to promote the formation of dispersed MoS_(2)nanosheets,but also intercalate into the MoS_(2)structure,further enlarging the interlayer spacing.This unique structure synergistically enhances meso-and microscale mass transfer outside and inside of the few-layered nanosheets,significantly improving electrochemical reaction kinetics and reducing the kinetic mismatch between the anode and cathode.Consequently,the resulting 1T-MoS_(2)/rGO achieves a capacity of 500 mAh g^(-1)after 500 cycles at 5 A g^(-1)and a high rate performance of 587 mAh g^(-1)at a high rate of 10 A g^(-1).Moreover,the assembled 3D vertical 1T-MoS_(2)/rGO//AC LIC delivers a high energy density of 100.3 Wh kg^(-1)at a power density of1.0 kW kg^(-1),and long cycle stability with capacity retention as high as 91.02%after 5000 cycles at 2 A g^(-1).This work provides a generalizable strategy for engineering two-dimensional material-based electrodes,offering new insights into high-performance energy storage systems.
基金supported by the National Natural Science Foundation of China(62341105).
文摘Traditional federated learning(FL)frameworks rely heavily on terrestrial networks,whose coverage limitations and increasing bandwidth congestion significantly hinder model convergence.Fortunately,the advancement of low-Earth-orbit(LEO)satellite networks offers promising new communication avenues to augment traditional terrestrial FL.Despite this potential,the limited satellite-ground communication bandwidth and the heterogeneous operating environments of ground devices—including variations in data,bandwidth,and computing power—pose substantial challenges for effective and robust satellite-assisted FL.To address these challenges,we propose SatFed,a resource-efficient satellite-assisted heterogeneous FL framework.SatFed implements freshness-based model-prioritization queues to optimize the use of highly constrained satellite-ground bandwidth,ensuring the transmission of the most critical models.Additionally,a multigraph is constructed to capture the real-time heterogeneous relationships between devices,including data distribution,terrestrial bandwidth,and computing capability.This multigraph enables SatFed to aggregate satellite-transmitted models into peer guidance,improving local training in heterogeneous environments.Extensive experiments with real-world LEO satellite networks demonstrate that SatFed achieves superior performance and robustness compared with state-of-the-art benchmarks.
基金supported by the National Key R&D Program of China(2016YFB0600305)~~
文摘A series of Co3O4-CeO2 binary oxides with various Co/(Ce+Co)molar ratios were synthesized using a citric acid method,and their catalytic properties toward the total oxidation of propane were examined.The activities of the catalysts decrease in the order CoCeOx-70>CoCeOx-90>Co3O4>CoCeOx-50>CoCeOx-20>CeO2.CoCeOx-70(Co/(Ce+Co)=70% molar ratio)exhibits the highest catalytic activity toward the total oxidation of propane,of which the T90 is 310℃(GHSV=120000 mL h^-1 g^-1],which is 25℃ lower than that of pure Co3 O4.The enhancement of the catalytic performance of CoCeOx-70 is attributed to the strong interaction between CeO2 and Co3O4,the improvement of the low-temperature reducibility,and the increase in the number of active oxygen species.In-situ DRIFTS and reaction kinetics measurement reveal that Ce addition does not change the reaction mechanism,but promotes the adsorption and activation of propane on the catalyst surface.The addition of water vapor and CO2 in reactant gas has a negative effect on the propane conversion,and the catalyst is more sensitive to water vapor than to CO2.In addition,CoCeOx-70 exhibits excellent stability and reusability in water vapor and CO2 atmosphere.
基金Project supported by the Fundamental Research for the Central Universities of Chinathe National Key Laboratory Project of Shock Wave and Detonation Physics of China+4 种基金the Science and Technology Foundation of National Key Laboratory of Shock Wave and Detonation Physics of Chinathe National Key R&D Program of China(Grant No.2017YFB0202303)the National Natural Science Foundation of China(Grant Nos.51871094,51871095,51571088,NSFC-NSAF U1530151,and U1830138)the Natural Science Foundation of Hunan Province of China(Grant No.2018JJ2036)the Science Challenge Project of China(Grant No.TZ2016001)
文摘Many of our previous studies have discussed the shock response of symmetrical grain boundaries in iron bicrystals.In this paper, the molecular dynamics simulation of an iron bicrystal containing Σ3 [110] asymmetry tilt grain boundary(ATGB) under shock-loading is performed. We find that the shock response of asymmetric grain boundaries is quite different from that of symmetric grain boundaries. Especially, our simulation proves that shock can induce migration of asymmetric grain boundary in iron. We also find that the shape and local structure of grain boundary(GB) would not be changed during shock-induced migration of Σ3 [110] ATGB, while the phase transformation near the GB could affect migration of GB. The most important discovery is that the shock-induced shear stress difference between two sides of GB is the key factor leading to GB migration. Our simulation involves a variety of piston velocities, and the migration of GB seems to be less sensitive to the piston velocity. Finally, the kinetics of GB migration at lattice level is discussed. Our work firstly reports the simulation of shock-induced grain boundary migration in iron. It is of great significance to the theory of GB migration and material engineering.
基金supported by grants from the National High Technology Research and Development Program of China(Grant No.2022YFC3601500)Sichuan Science and Technology Program(Grant No.2020YFQ0011).
文摘Objective:To explore the association between the Lung Immune Prognostic Index(LIPI)and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease(IIM-ILD).Methods:Patients who were diagnosed with IIM-ILD at West China Hospital,Sichuan University from January 2008 to December 2021 were retrospectively included and categorized into three groups based on LIPI.Univariable and multivariable Cox proportional hazards models were conducted to explore potential association between the LIPI and patients'mortality.Results:A total of 1116 patients were screened,and 830 were included in this study.The multivariable Cox analysis showed that,compared with patients with poor LIPI,the hazard ratio(HR)for all-cause 1-year mortality was 0.22(95%CI 0.05-0.93,P=0.04)for patients in the good LIPI group(LDH<250 IU/L and dNLR<3).After excluding patients lost to follow-up within one year,a similar result was found for LIPI(HR 0.20,95%CI 0.05-0.86;P=0.03).Conclusions:Good LIPI was independently associated with decreased risk of all-cause 1-year mortality in patients with IIM-ILD.This easy-to-obtain index might be served as a potential marker for assessing the prognosis of IIM-ILD.
基金the National Research Programs from Ministry of Science and Technology (MOST) of China (No.2016YFA0201200)the National Natural Science Foundation of China (Nos.51525203 and 51761145041)+1 种基金Collaborative Innovation Center of Suzhou Nano Science and Technologya Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
文摘Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications.
文摘How plant metabolic flux alters gene expression to optimize plant growth and response to stress remains largely unclear. Here, we report that Arabidopsis thaliana NAD＊-dependent histone deacetylase AtSRT1 negatively regulates plant tolerance to stress and glycolysis but stimulates mitochondrial respiration. We found that AtSRT1 interacts with Arabidopsis cMyc-Binding Protein 1 （AtMBP-1）, a transcriptional repressor produced by alternative translation of the cytosolic glycolytic enolase gene LOS2/EN02. We demonstrated that AtSRT1 could associate with the chromatin of AtMBP-I targets LOS2/EN02 and STZ/ZATIO, both of which encode key stress regulators, and reduce the H3K9ac levels at these genes to repress their transcription. Overexpression of both AtSRT1 and AtMBP-1 had synergistic effects on the expression of glycolytic genes, glycolytic enzymatic activities, and mitochondrial respiration. Furthermore, we found that AtMBP-1 is lysine-acetylated and vulnerable to proteasomal protein degradation, while AtSRT1 could remove its lysine acetylation and significantly enhance its stability in vivo. Taken together, these results indicate that AtSRT1 regulates primary metabolism and stress response by both epigenetic regulation and modulation of AtMBP-1 transcriptional activity in Arabidopsis.
基金Foundation of China(LR21C130001)Leading Innovative and EntrepreneurTeam Introduction Program of Zhejiang(2019R01002)+3 种基金Key Research and Development Program of Zhejiang(2020C02002)Zhejiang Provincial Special Key project of New Rice Variety Breeding(2021C02063-1)the Singapore National Research Foundation lnvestigatorship Programme(NRF-NRFl2016-02)Hundred-Talent Program of Zhejiang University.
文摘Plants have evolved a sophisticated set of mechanisms to adapt to drought stress.Transcription factors play crucial roles in plant responses to various environmental stimuli by modulating the expression of numerous stress-responsive genes.However,how the crosstalk between different transcription factor families orchestrates initiation of the key transcriptional network and the role of posttranscriptional modification of transcription factors,especially in cellular localization/trafficking in response to stress in rice,remain still largely unknown.In this study,we isolated an Osmybr57 mutant that displays a drought-sensitive phenotype through a genetic screen for drought stress sensitivity.We found that OsMYBR57,an MYB-related protein,directly regulates the expression of several key drought-related OsbZ/Ps in response to drought treatment.Further studies revealed that OsMYBR57 interacts with a homeodomain transcription factor,OsHB22,which also plays a positive role in drought signaling.We further demonstrate that OsFTIP6 interacts with OsHB22 and promotes the nucleocytoplasmic translocation of OsHB22 into the nucleus,where OsHB22 cooperates with OsMYBR57 to regulate the expression of drought-responsive genes.Our findings have revealed a mechanistic framework underlying the OsFTIP6-0sHB22-0sMYBR57 module-mediated regulation of drought response in rice.The OsFTIP6-mediated OsHB22 nucleocytoplasmic shuttling and OsMYBR57-0sHB22 regulation of OsbZIP transcription ensure precise control of expression of OsLEA3 and Rab21,and thereby regulate the response to water deficiency in rice.
基金the National Research Programs of China(No.2016YFA0201200)the National Natural Science Foundation of China(Nos.91959104,21927803,51903182,51525203,)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20190826)Collaborative Innovation Center of Suzhou Nano Science and Technology,and the 111 Program from the Ministry of Education of China.
文摘Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are fabricated.While exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune responses.Highly effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune responses.Interestingly,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor microenvironment.Thus,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T treatment.Moreover,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary tumors.Therefore,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment.
基金supported in part by the National Natural Science Foundation of China under Grant 62341105.
文摘The development of space-air-ground integrated networks (SAGIN) requires sophisticated satellite Internet emulation tools that can handle complex, dynamic topologies and offer in-depth analysis. Existing emulation platforms struggle with challenges like the need for detailed implementation across all network layers, real-time response, and scalability. This paper proposes a digital twin system based on microservices for satellite Internet emulation,namely Plotinus,which aims to solve these problems. Plotinus features a modular design, allowing for easy replacement of the physical layer to emulate different aerial vehicles and analyze channel interference. It also enables replacing of path computation methods to simplify testing and deploying algorithms. In particular, Plotinus allows for real-time emulation with live network traffic,enhancing practical network models. The evaluation result shows Plotinus’s effective emulation of dynamic satellite networks with real-world devices. Its adaptability for various communication models and algorithm testing highlights Plotinus’s role as a vital tool for developing and analyzing SAGIN systems, offering a cross-layer,real-time,and scalable digital twin system.
基金partially supported by the National Natural Science Foundation of China(U1230202,11072227and 11272294)the Foundation of National Key Laboratory of Shock Wave and Detonation Physics(9140C670302130C67239)the Science and Technology Foundation of China Academy of Engineering Physics(2012A0201007)
文摘Shock wave is associated with dynamic loading that can result in phase transition(PT), optical and mechanical property changing, and chemical reaction on materials. Here, we report recent progress about shockinduced PT of polycrystalline iron, the underlying mechanism of the optical emission from sapphire, and the synthesis from single-phase Ru Si in the National Key Laboratory of Shock Wave and Detonation Physics.Results indicated that grain boundary(GB) could affect the PT pressure threshold and rate of iron, the pressure threshold decreases with decreasing GB defects, and the PT rate shows a variation with increasing GB size; wavelength-dependent optical emissivity(non-gray-body emission) would be generated that was not revealed previously for shocked sapphire, and the observed luminescence was from the shock-induced shear bands, but without superheating phenomenon; shock compression could be an effective way to synthesis Ru-Si nanocrystals, when the shock pressure was appropriate; and Ru-Si powder could completely transform to fine-grain structure Cs Cl-type RuSi at 40.4 GPa.
基金National Natural Science Foundation of China(NSFC No.81770072)The"1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYJC18021)Chengdu Science and Technology Bureau(No.2018-CY02-00064-GX)。
文摘Background:Nasal insertion is the preferred method for non-intubated patients in flexible bronchoscopy;however,the relatively narrow nasal cavity results in difficulties related to bronchoscope insertion.This study aimed to investigate whether pre-operative nasal probe tests could reduce the time to pass the glottis,improve the first-pass success rate and patients’tolerance,and reduce postoperative bleeding.Methods:This three-arm prospective randomized controlled trial was conducted in a tertiary hospital between May and October 2020.Three hundred patients requiring diagnosis and treatment using flexible bronchoscopy were randomly allocated to three groups:control group,simple cotton bud detection group(CD group),and adrenaline+lidocaine detection group(AD group).The primary outcome was the time to pass the glottis.Secondary outcomes included the first-pass success rate,the patients’tolerance scores,and post-operative bleeding.One-way analysis of variance,Kruskal-WallisH test,Chi-squared test,Fisher’s exact test,and Bonferroni’s multiple comparison tests were used in this study.Results:In total,189 men and 111 women were enrolled in this study,with a mean age of 55.72±12.86 years.The insertion time was significantly shorter in the AD group than in the control group(18.00 s[12.00–26.50 s]vs.24.00 s[14.50–45.50 s],P=0.005).Both the AD(99%vs.83%,χ2=15.62,P<0.001)and CD groups(94%vs.83%,χ2=5.94,P=0.015)had a significantly higher first-pass success rate than the control group.Compared with the control group,post-operative bleeding(1%vs.13%,χ2=11.06,P<0.001)was significantly lower in the AD group.However,no significant difference was found in the patients’tolerance scores.Conclusions:Pre-operative nasal cavity probe tests especially with adrenaline and lidocaine during flexible bronchoscopy can significantly reduce the time to pass the glottis,improve the first-pass success rate,and reduce post-operative nasal bleeding.Pre-operative nasal probe tests are recommended as a time-saving procedure for patients undergoing flexible bronchoscopy.Trial registration:Chinese Clinical Trial Registry(ChiCTR),ChiCTR2000032668;http://www.chictr.org.cn/showprojen.aspx?proj=53321.
文摘Chlorambucil is a classic nitrogen mustard drug that has been used in the treatment of cancers. It may induce neutropenia, thrombocytopenia and other side effects because of its short lifetime and off-target effect. In this report, chlorambucil-tetrapeptide （AAAK, A3K） conjugate vesicles were developed to improve the stability and bioactivity of chlorambucil. First of all, chlorambucil-A3K conjugate was synthesized by solid phase synthesis strategy. Sec- ondly, the chlorambucil-A3K conjugate was assembled and characterized by critical aggregation concentration, cir- cular dichroism, dynamic light scattering and transmission electron microscopy. The results indicated that the chlo- rambucil-A3K conjugate can be assembled to form spherical vesicles with an average diameter of 390.5 nm, and high drug loading about 47.1% is reached. Surprisingly, the preliminary biological evaluation of the chlorambu- cil-A3K conjugate vesicles revealed the best in vitro anticancer activity against HeLa, HepG-2 and MCF-7 cell lines compared with chlorambucil and chlorambucil-A3K conjugate free drugs. Furthermore, conjugate vesicles showed excellent in vivo antitumoral activity. It can be partly attributed to their vesicular structure which isolates chloram- bucil active moiety from aqueous solution to retard degradation before killing cancer cells. Therefore, chlorambu- cil-peptide （A3K） conjugate vesicles may be an alternative delivery system of chlorambucil.
基金This work was supported by grants from the National Natural Science Foundationof China(NSFC No.81770072)the“1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYJC18021)”Chengdu Science and Technology Bureau(No.2018SZ0240).
文摘Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally invasive technique for patients with severe hyperinflation and advanced emphysema.To date,the most investigated form of ELVR isvalve implantation,which is toplacevalves in all the segments of an emphysematous lobe.However,valve replacements do not achieve adequate lung volume reduction in the,presence of interlobar collateral ventilation(CV).l1 in addition,with the heterogeneity existing withinthe treatment lobe,complete lobar treatment from implants may result in excessive reduction of the less diseased segments.Thus,a more targeted approach of the most severe emphysematous parts of the lobe is warranted.
基金supported by the National Research Programs of China(no.2016YFA0201200)the National Natural Science Foundation of China(nos.51525203,51761145041,and 51572180)+2 种基金the China Postdoctoral Science Foundation(no.2020M671143)Collaborative Innovation Center of Suzhou Nano Science and Technology,a Jiangsu Natural Science Fund for Distinguished Young Scholars(no.BK20170063)and a Project Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,and a Project Funded for Postgraduate Research&Practice Innovation Program of Jiangsu Province(no.2019 SJKY19_2282).
文摘Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Zn-ions and 4-phenylimidazole(PI),the latter of which is an inhibitor of indoleamine 2,3-dioxygenase(IDO)and acts as an organic bridging ligand via Zn–N coordination bonds.
基金supported by the National Natural Science Foundation of China(Nos.61464005,51562015)the Natural Science Foundation of Jiangxi Province(Nos.20143ACB21004,20151BAB212008,20171BAB216015)+2 种基金the Jiangxi Province Foreign Cooperation Projects,China(No.20151BDH80031)the Leader Training Object Project of Major Disciplines Academic and Technical of Jiangxi Province(No.20123BCB22002)the Key Technology R&D Program of the Jiangxi Provine of Science and Technology(No.20171BBE50053)
文摘ZnO films coated with reduced graphene oxide（RGO-ZnO） were prepared by a simple chemical approach. The graphene oxide（GO） films transferred onto ZnO films by spin coating were reduced to RGO films by two steps（exposed to hydrazine vapor for 12 h and annealed at 600 °C）. The crystal structures, electrical and photoluminescence properties of RGO-ZnO films on quartz substrates were systematically studied. The SEM images illustrated that RGO layers have successfully been coated on the ZnO films very tightly. The PL properties of RGO-ZnO were studied. PL spectra show two sharp peaks at 390 nm and a broad visible emission around 490 nm.The resistivity of RGO-ZnO films was measured by a Hall measurement system, RGO as nanofiller considerably decrease the resistivity of ZnO films. An electrode was fabricated, using RGO-ZnO films deposited on Si substrate as active materials, for super capacitor application. By comparison of different results, we conclude that the RGOZnO composite material couples possess the properties of super capacitor.
