IntuiGrasp is a novel three-fingered dexterous hand that pioneers bio-inspired demonstrations with intuitive priors(BDIP)to bridge the gap between human tactile intuition and robotic execution.Unlike conven-tional pro...IntuiGrasp is a novel three-fingered dexterous hand that pioneers bio-inspired demonstrations with intuitive priors(BDIP)to bridge the gap between human tactile intuition and robotic execution.Unlike conven-tional programming,BDIP leverages human's innate priors(e.g.,“A pack of tissues requires gentle grasps,cups demand firm contact”)by enabling real-time transfer of gesture and force policies during physical demon-stration.When a human demonstrator wears IntuiGrasp,driven rings provide real-time haptic feedback on contact stress and slip,while inte-grated tactile sensors translate these human policies into image data,offering valuable data for imitation learning.In this study,human teachers use IntuiGrasp to demonstrate how to grasp three types of objects:a cup,a crumpled tissue pack,and a thin playing card.IntuiGrasp translates the policies for grasping these objects into image information that describes tactile sensations in real time.展开更多
The Antarctic Bottom Water formation site Vincennes Bay,East Antarctica is experiencing a substantial intrusion of modified Circumpolar Deep Water(mCDW),which may inhibit the formation of Dense Shelf Water(DSW)and dri...The Antarctic Bottom Water formation site Vincennes Bay,East Antarctica is experiencing a substantial intrusion of modified Circumpolar Deep Water(mCDW),which may inhibit the formation of Dense Shelf Water(DSW)and drive basal melting of the ice shelves.Based on hydrographic data obtained from March to November in 2012,we evaluated the spatial spread of mCDW over the continental shelf region of Vincennes Bay and the associated temporal evolution of water properties,as well as the sea ice formation effect on water column in the coastal polynya.Results show that two branches of mCDW occupied the deep layers of the continental shelf,distinguished by the potential density(smaller than 27.8 kg/m^(3) or not)when potential temperatureθ=0.5°C in theθ-salinity space.The warmer and less dense branch observed on the east plateau,accessed the eastern ice shelves in the coastal polynya to drive basal melting of ice shelves.In contrast,the other colder and denser branch in the mid-depression reached the western Underwood Ice Shelf.DSW formation was detectable in the coastal polynya during September-November,proving the occurrence of deep convection.Surface heat loss and brine rejection during the intensive sea ice formation contributed to the destratification of the water column in the coastal polynya.It was estimated that at least 1.11±0.79 TW heat carried by mCDW into the inner part of the polynya.展开更多
Xinjiang, China is affected by geographical terrain and other factors, and is prone to lightning disasters. In order to effectively carry out lightning protection and disaster reduction work and improve defense capabi...Xinjiang, China is affected by geographical terrain and other factors, and is prone to lightning disasters. In order to effectively carry out lightning protection and disaster reduction work and improve defense capabilities, based on the data of lightning location monitoring in Xinjiang in 2017 and the statistics reports of the lightning disasters from 2015 to 2017, the characteristics of the cloud-to-ground (CG) lightning activities and disasters in Xinjiang were statistically analyzed. The results show that the CG lightning in Xinjiang is mainly the negative one, accounting for 79.7% of the total lightning. In 2017, the distribution of positive, negative and total the CG lightning months mainly focuses on June to August, and the main occurrence period is from 14 to 23 hours. The intensity of total the CG lightning and negative the CG lightning mainly distributes from 20 to 40 kA, and the peak value appears in 30 kA. The CG lightning intensity is mainly distributed in 30 - 70 kA. The distribution of the CG lightning density in Xinjiang is larger in the north than in the south and larger in the west than in the east. Lightning disasters mainly occur from May to August, accounting for 93.2 percent of the total, with the largest number in June. From 2005 to 2017, 44.6% of lightning accidents occurred in farming and pastoral areas, followed by civil electronic equipment damage. In addition, electrical equipment, buildings and factory equipment are damaged by lightning strikes to varying degrees.展开更多
Plant growth regulators(PGRs)are chemical substances that imitate the functions of phytohormones to enhance the crop yield and the harvest process.Phenylurea-derived plant growth regulators are known for their excelle...Plant growth regulators(PGRs)are chemical substances that imitate the functions of phytohormones to enhance the crop yield and the harvest process.Phenylurea-derived plant growth regulators are known for their excellent efficacy in promoting fruit growth,particularly in kiwifruit,grapes,and melons.Phenylurea derivatives represent one class of the highly efficient and versatile PGRs.Specifically,forchlorfenuron(CPPU,N-(2-chloro-4-pyridinyl)-N0-phenylurea)exhibits similar growth-regulating efficacy to cytokinins and has a significant impact on the plant growth and the crop yield.As a result,there is growing interest in exploring the incorporation of various phenylurea moieties into agrochemicals to enhance their regulatory properties on crops.This review aims to provide a comprehensive overview on representative synthetic approaches for phenylurea derived PGRs.Additionally,we provide our perspective on the future development in this active researchfield.展开更多
To the Editor:Immunotherapy has overtaken chemotherapy(Chemo)as the frontline mode of treatment for advanced non-small cell lung cancer(NSCLC).The efficacy of immunotherapies such as immune checkpoint inhibitors(ICIs)...To the Editor:Immunotherapy has overtaken chemotherapy(Chemo)as the frontline mode of treatment for advanced non-small cell lung cancer(NSCLC).The efficacy of immunotherapies such as immune checkpoint inhibitors(ICIs)can be further increased by combining them with Chemo and/or anti-angiogenic therapy.However,these combination treatments are associated with more adverse events,which need to be carefully managed.Although previous meta-analyses have shown that ICI use increased gastrointestinal and skin toxicities,the association between ICIs and hematological toxicity has not been adequately assessed.A study by Kramer et al[1]found that 0.6%of the 7626 ICI-treated patients experienced hematological adverse events;however,only 16%of this group of patients received ICIs+Chemo.Thus,the risks associated with combining ICIs and Chemo may not be fully appreciated.The present study reviewed data from phase III trials of ICIs used in combination with Chemo and/or anti-angiogenic agents to evaluate the hematological toxicity in advanced NSCLC.展开更多
文摘IntuiGrasp is a novel three-fingered dexterous hand that pioneers bio-inspired demonstrations with intuitive priors(BDIP)to bridge the gap between human tactile intuition and robotic execution.Unlike conven-tional programming,BDIP leverages human's innate priors(e.g.,“A pack of tissues requires gentle grasps,cups demand firm contact”)by enabling real-time transfer of gesture and force policies during physical demon-stration.When a human demonstrator wears IntuiGrasp,driven rings provide real-time haptic feedback on contact stress and slip,while inte-grated tactile sensors translate these human policies into image data,offering valuable data for imitation learning.In this study,human teachers use IntuiGrasp to demonstrate how to grasp three types of objects:a cup,a crumpled tissue pack,and a thin playing card.IntuiGrasp translates the policies for grasping these objects into image information that describes tactile sensations in real time.
基金Supported by the National Natural Science Foundation of China(No.42130402)the International Science and Technology Cooperation Key Special Project of the National Key Research and Development Program of China(No.2023YFE0104500)。
文摘The Antarctic Bottom Water formation site Vincennes Bay,East Antarctica is experiencing a substantial intrusion of modified Circumpolar Deep Water(mCDW),which may inhibit the formation of Dense Shelf Water(DSW)and drive basal melting of the ice shelves.Based on hydrographic data obtained from March to November in 2012,we evaluated the spatial spread of mCDW over the continental shelf region of Vincennes Bay and the associated temporal evolution of water properties,as well as the sea ice formation effect on water column in the coastal polynya.Results show that two branches of mCDW occupied the deep layers of the continental shelf,distinguished by the potential density(smaller than 27.8 kg/m^(3) or not)when potential temperatureθ=0.5°C in theθ-salinity space.The warmer and less dense branch observed on the east plateau,accessed the eastern ice shelves in the coastal polynya to drive basal melting of ice shelves.In contrast,the other colder and denser branch in the mid-depression reached the western Underwood Ice Shelf.DSW formation was detectable in the coastal polynya during September-November,proving the occurrence of deep convection.Surface heat loss and brine rejection during the intensive sea ice formation contributed to the destratification of the water column in the coastal polynya.It was estimated that at least 1.11±0.79 TW heat carried by mCDW into the inner part of the polynya.
文摘Xinjiang, China is affected by geographical terrain and other factors, and is prone to lightning disasters. In order to effectively carry out lightning protection and disaster reduction work and improve defense capabilities, based on the data of lightning location monitoring in Xinjiang in 2017 and the statistics reports of the lightning disasters from 2015 to 2017, the characteristics of the cloud-to-ground (CG) lightning activities and disasters in Xinjiang were statistically analyzed. The results show that the CG lightning in Xinjiang is mainly the negative one, accounting for 79.7% of the total lightning. In 2017, the distribution of positive, negative and total the CG lightning months mainly focuses on June to August, and the main occurrence period is from 14 to 23 hours. The intensity of total the CG lightning and negative the CG lightning mainly distributes from 20 to 40 kA, and the peak value appears in 30 kA. The CG lightning intensity is mainly distributed in 30 - 70 kA. The distribution of the CG lightning density in Xinjiang is larger in the north than in the south and larger in the west than in the east. Lightning disasters mainly occur from May to August, accounting for 93.2 percent of the total, with the largest number in June. From 2005 to 2017, 44.6% of lightning accidents occurred in farming and pastoral areas, followed by civil electronic equipment damage. In addition, electrical equipment, buildings and factory equipment are damaged by lightning strikes to varying degrees.
基金support from the National Natural Science Foundation of China(22371058,21961006,32172459,22371057,22071036)the National Key Research and Development Program of China(2022YFD1700300)+3 种基金the Science and Technology Department of Guizhou Province(Qiankehejichu-ZK[2021]Key033)the Program of Introducing Talents of Discipline to Universities of China(111 Program,D20023)at Guizhou University,Frontiers Science Center for Asymmetric Synthesis and Medicinal MoleculesDepartment of Education,Guizhou Province[Qianjiaohe KY(2020)004]Guizhou University(China).
文摘Plant growth regulators(PGRs)are chemical substances that imitate the functions of phytohormones to enhance the crop yield and the harvest process.Phenylurea-derived plant growth regulators are known for their excellent efficacy in promoting fruit growth,particularly in kiwifruit,grapes,and melons.Phenylurea derivatives represent one class of the highly efficient and versatile PGRs.Specifically,forchlorfenuron(CPPU,N-(2-chloro-4-pyridinyl)-N0-phenylurea)exhibits similar growth-regulating efficacy to cytokinins and has a significant impact on the plant growth and the crop yield.As a result,there is growing interest in exploring the incorporation of various phenylurea moieties into agrochemicals to enhance their regulatory properties on crops.This review aims to provide a comprehensive overview on representative synthetic approaches for phenylurea derived PGRs.Additionally,we provide our perspective on the future development in this active researchfield.
基金funded by the China National Science Foundation(Nos.82022048 and 82373121)the Science and Technology Planning Project of Guangzhou(No.202206080013)the National Key Research&Development Programme(No.2022YFC2505100).
文摘To the Editor:Immunotherapy has overtaken chemotherapy(Chemo)as the frontline mode of treatment for advanced non-small cell lung cancer(NSCLC).The efficacy of immunotherapies such as immune checkpoint inhibitors(ICIs)can be further increased by combining them with Chemo and/or anti-angiogenic therapy.However,these combination treatments are associated with more adverse events,which need to be carefully managed.Although previous meta-analyses have shown that ICI use increased gastrointestinal and skin toxicities,the association between ICIs and hematological toxicity has not been adequately assessed.A study by Kramer et al[1]found that 0.6%of the 7626 ICI-treated patients experienced hematological adverse events;however,only 16%of this group of patients received ICIs+Chemo.Thus,the risks associated with combining ICIs and Chemo may not be fully appreciated.The present study reviewed data from phase III trials of ICIs used in combination with Chemo and/or anti-angiogenic agents to evaluate the hematological toxicity in advanced NSCLC.
