Electronic skin(e-skin),capable of perceiving various external stimuli,has emerged as a ubiquitous technology in the field of flexible electronics,finding diverse applications in healthcare systems,prosthetics,and sof...Electronic skin(e-skin),capable of perceiving various external stimuli,has emerged as a ubiquitous technology in the field of flexible electronics,finding diverse applications in healthcare systems,prosthetics,and soft robotics.Particularly,anisotropic e-skins have garnered extensive research attention due to their unique directional properties.Nevertheless,the continuous interference from diverse stimuli and intricate environments,along with low sensitivity,have hindered the further widespread application of anisotropic e-skin.Here,we present a transparent e-skin exhibiting remarkable anisotropic strain sensing performance,along with exceptional resilience against interference from other stimuli and harsh environments.Benefiting from the synergistic coexistence of aligned silver nanowires wrinkles and cracks,the e-skin achieves outstanding anisotropy showcasing maximum strain gauge factors(GFs)difference of 2825 and 0.69 along two perpendicular directions,exceeding a difference of more than 4000 times.Furthermore,the e-skin displays superior anti-interference capability,evidenced by a resistance change of less than 6%when subjected to high pressure(663 kPa),torsion(540°),or bending(180°),and exhibits negligible performance degradation even after exposure to harsh environments.Finally,our e-skin is successfully applied to undisturbed predicting crack propagation and precise control of dual-mode soft robots,highlighting its immense potential in structural damage warning and intelligent robotics.展开更多
Background： Overexpression and constitutive activation of signal transducer and activator of transcription （STAT） 3 have been suggested in the tumorigenesis of many human cancers, including multiple carcinomas, mel...Background： Overexpression and constitutive activation of signal transducer and activator of transcription （STAT） 3 have been suggested in the tumorigenesis of many human cancers, including multiple carcinomas, melanoma, and lymphoma. The diagnosis ofhepatocellular carcinoma （HCC） in lobectomy specimens is usually straightforward, but distinguishing cirrhosis from well-differentiated HCC can be challenging in core biopsies. Our aims were to investigate the expression level of STAT3 and phosphorylated STAT3 （pSTAT3） in HCC and cirrhosis, and the application of STAT3 in the differential diagnosis of HCC and cirrhosis. Methods： Sixty cases were divided into three groups： patients with HCC only （Group 1）, HCC and cirrhosis （Group 2）, and cirrhosis only （Group 3）. Formalin-fixed and paraffin-embedded tissue sections were stained immunohistochemically for STAT3, pSTAT3, and CD163. The values obtained from the tissue sections of each group were compared in statistical analysis. Results： STAT3 showed a high level in HCC and was a significant marker for differentiating HCC from cirrhosis （P 〈 0.0001 ）. The odds ratio between HCC and cirrhosis increased 34.4 times when the intensity of STAT3 increased by 1 level. Spearman＇s correlation and Chi-square tests also demonstrated that expression level of STAT3 did not correlate with age, gender, or the presence of a cirrhotic background. Conclusions： STAT3 staining differs significantly in HCC and cirrhosis. The findings reinforce the role of STAT3 in the tumorigenesis of HCC and provide a useful marker to differentiate HCC from cirrhosis in challenging liver biopsies.展开更多
基金supported by the National Natural Science Foundation of China(No.22175164)Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0450402)。
文摘Electronic skin(e-skin),capable of perceiving various external stimuli,has emerged as a ubiquitous technology in the field of flexible electronics,finding diverse applications in healthcare systems,prosthetics,and soft robotics.Particularly,anisotropic e-skins have garnered extensive research attention due to their unique directional properties.Nevertheless,the continuous interference from diverse stimuli and intricate environments,along with low sensitivity,have hindered the further widespread application of anisotropic e-skin.Here,we present a transparent e-skin exhibiting remarkable anisotropic strain sensing performance,along with exceptional resilience against interference from other stimuli and harsh environments.Benefiting from the synergistic coexistence of aligned silver nanowires wrinkles and cracks,the e-skin achieves outstanding anisotropy showcasing maximum strain gauge factors(GFs)difference of 2825 and 0.69 along two perpendicular directions,exceeding a difference of more than 4000 times.Furthermore,the e-skin displays superior anti-interference capability,evidenced by a resistance change of less than 6%when subjected to high pressure(663 kPa),torsion(540°),or bending(180°),and exhibits negligible performance degradation even after exposure to harsh environments.Finally,our e-skin is successfully applied to undisturbed predicting crack propagation and precise control of dual-mode soft robots,highlighting its immense potential in structural damage warning and intelligent robotics.
文摘Background： Overexpression and constitutive activation of signal transducer and activator of transcription （STAT） 3 have been suggested in the tumorigenesis of many human cancers, including multiple carcinomas, melanoma, and lymphoma. The diagnosis ofhepatocellular carcinoma （HCC） in lobectomy specimens is usually straightforward, but distinguishing cirrhosis from well-differentiated HCC can be challenging in core biopsies. Our aims were to investigate the expression level of STAT3 and phosphorylated STAT3 （pSTAT3） in HCC and cirrhosis, and the application of STAT3 in the differential diagnosis of HCC and cirrhosis. Methods： Sixty cases were divided into three groups： patients with HCC only （Group 1）, HCC and cirrhosis （Group 2）, and cirrhosis only （Group 3）. Formalin-fixed and paraffin-embedded tissue sections were stained immunohistochemically for STAT3, pSTAT3, and CD163. The values obtained from the tissue sections of each group were compared in statistical analysis. Results： STAT3 showed a high level in HCC and was a significant marker for differentiating HCC from cirrhosis （P 〈 0.0001 ）. The odds ratio between HCC and cirrhosis increased 34.4 times when the intensity of STAT3 increased by 1 level. Spearman＇s correlation and Chi-square tests also demonstrated that expression level of STAT3 did not correlate with age, gender, or the presence of a cirrhotic background. Conclusions： STAT3 staining differs significantly in HCC and cirrhosis. The findings reinforce the role of STAT3 in the tumorigenesis of HCC and provide a useful marker to differentiate HCC from cirrhosis in challenging liver biopsies.
