The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers.The penis consists of the glans penis and penile shaft,which differ considerably in both histology and innervati...The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers.The penis consists of the glans penis and penile shaft,which differ considerably in both histology and innervation.This paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of it.The thresholds,latencies,and amplitudes of somatosensory evoked potentials(SSEPs)were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory areas.The thresholds,latencies,and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different(all P<0.0001).The latency of the glans penis or penile shaft was shorter than average(indicating hypersensitivity)in 141(48.6%)cases,of which 50(35.5%)cases were sensitive in both the glans penis and penile shaft,14(9.9%)cases were sensitive in the glans penis only,and 77(54.6%)cases were sensitive in the penile shaft only(P<0.0001).There are statistical differences in the signals perceived through the glans penis and the penile shaft.Penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive.We classify penile hypersensitivity into three categories,namely,glans penis,penile shaft,and whole-penis hypersensitivity,and we propose the new concept of penile hypersensitive zone.展开更多
The two-dimensional(2D) materials with nodal line band crossing have been attracting great research interest. However, it remains a challenge to find high-stable nodal line structure in 2D systems. Herein, based on th...The two-dimensional(2D) materials with nodal line band crossing have been attracting great research interest. However, it remains a challenge to find high-stable nodal line structure in 2D systems. Herein, based on the first-principles calculations and theoretical analysis, we propose that monolayer B_(6)O possesses symmetry protected Dirac nodal line(DNL)state, with its Fermi velocity of 10^(6)m/s in the same order of magnitude as that of graphene. The origin of DNL fermions is induced by coexistence of time-reversal symmetry and inversion symmetry. A two-band tight-binding model is further given to understand the mechanism of DNL. Considering its robustness against spin–orbit coupling(SOC) and high structural stability, these results suggest monolayer B_(6)O as a new platform for realizing future high-speed low-dissipation devices.展开更多
Dear editor,Chronic myeloid leukemia(CML)is a malignant myeloproliferative disorder arising from hematopoietic stem cells and accounts for 15%of newly diagnosed cases of leukemia in adults.Central to the pathogenesis ...Dear editor,Chronic myeloid leukemia(CML)is a malignant myeloproliferative disorder arising from hematopoietic stem cells and accounts for 15%of newly diagnosed cases of leukemia in adults.Central to the pathogenesis of CML is the presence of the BCR-ABL fusion gene resulting from the chromosome translocation t(9;22)(q34;q11)[1].The chimeric oncoprotein encoded by BCR-ABL exhibits aberrant tyrosine kinase activity and drives oncogenic processes by dysregulating or reprogramming multiple downstream signaling pathways involved in cell proliferation,differentiation,and survival[2].Recently,emerging evidences have demonstrated that fusion genes can not only encode oncoprotein but also generate circular RNAs(circRNAs)involved in tumor progression[3].展开更多
文摘The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers.The penis consists of the glans penis and penile shaft,which differ considerably in both histology and innervation.This paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of it.The thresholds,latencies,and amplitudes of somatosensory evoked potentials(SSEPs)were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory areas.The thresholds,latencies,and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different(all P<0.0001).The latency of the glans penis or penile shaft was shorter than average(indicating hypersensitivity)in 141(48.6%)cases,of which 50(35.5%)cases were sensitive in both the glans penis and penile shaft,14(9.9%)cases were sensitive in the glans penis only,and 77(54.6%)cases were sensitive in the penile shaft only(P<0.0001).There are statistical differences in the signals perceived through the glans penis and the penile shaft.Penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive.We classify penile hypersensitivity into three categories,namely,glans penis,penile shaft,and whole-penis hypersensitivity,and we propose the new concept of penile hypersensitive zone.
基金Project supported by Taishan Scholar Program of Shandong Province, China (Grant No. ts20190939)Independent Cultivation Program of Innovation Team of Jinan City (Grant No. 2021GXRC043)the National Natural Science Foundation of China (Grant Nos. 52173283 and 62071200)。
文摘The two-dimensional(2D) materials with nodal line band crossing have been attracting great research interest. However, it remains a challenge to find high-stable nodal line structure in 2D systems. Herein, based on the first-principles calculations and theoretical analysis, we propose that monolayer B_(6)O possesses symmetry protected Dirac nodal line(DNL)state, with its Fermi velocity of 10^(6)m/s in the same order of magnitude as that of graphene. The origin of DNL fermions is induced by coexistence of time-reversal symmetry and inversion symmetry. A two-band tight-binding model is further given to understand the mechanism of DNL. Considering its robustness against spin–orbit coupling(SOC) and high structural stability, these results suggest monolayer B_(6)O as a new platform for realizing future high-speed low-dissipation devices.
基金This work is supported by grants from the National Natural Science Foundation of China(81900156),the China Post-doctoral Science Foundation(2018M640927)the Post-Doctor Research Project,West China Hospital,Sichuan University(2018HXBH022).
文摘Dear editor,Chronic myeloid leukemia(CML)is a malignant myeloproliferative disorder arising from hematopoietic stem cells and accounts for 15%of newly diagnosed cases of leukemia in adults.Central to the pathogenesis of CML is the presence of the BCR-ABL fusion gene resulting from the chromosome translocation t(9;22)(q34;q11)[1].The chimeric oncoprotein encoded by BCR-ABL exhibits aberrant tyrosine kinase activity and drives oncogenic processes by dysregulating or reprogramming multiple downstream signaling pathways involved in cell proliferation,differentiation,and survival[2].Recently,emerging evidences have demonstrated that fusion genes can not only encode oncoprotein but also generate circular RNAs(circRNAs)involved in tumor progression[3].
