Objective:Early predicting response before neoadjuvant chemotherapy(NAC)is crucial for personalized treatment plans for locally advanced breast cancer patients.We aim to develop a multi-task model using multiscale who...Objective:Early predicting response before neoadjuvant chemotherapy(NAC)is crucial for personalized treatment plans for locally advanced breast cancer patients.We aim to develop a multi-task model using multiscale whole slide images(WSIs)features to predict the response to breast cancer NAC more finely.Methods:This work collected 1,670 whole slide images for training and validation sets,internal testing sets,external testing sets,and prospective testing sets of the weakly-supervised deep learning-based multi-task model(DLMM)in predicting treatment response and pCR to NAC.Our approach models two-by-two feature interactions across scales by employing concatenate fusion of single-scale feature representations,and controls the expressiveness of each representation via a gating-based attention mechanism.Results:In the retrospective analysis,DLMM exhibited excellent predictive performance for the prediction of treatment response,with area under the receiver operating characteristic curves(AUCs)of 0.869[95%confidence interval(95%CI):0.806−0.933]in the internal testing set and 0.841(95%CI:0.814−0.867)in the external testing sets.For the pCR prediction task,DLMM reached AUCs of 0.865(95%CI:0.763−0.964)in the internal testing and 0.821(95%CI:0.763−0.878)in the pooled external testing set.In the prospective testing study,DLMM also demonstrated favorable predictive performance,with AUCs of 0.829(95%CI:0.754−0.903)and 0.821(95%CI:0.692−0.949)in treatment response and pCR prediction,respectively.DLMM significantly outperformed the baseline models in all testing sets(P<0.05).Heatmaps were employed to interpret the decision-making basis of the model.Furthermore,it was discovered that high DLMM scores were associated with immune-related pathways and cells in the microenvironment during biological basis exploration.Conclusions:The DLMM represents a valuable tool that aids clinicians in selecting personalized treatment strategies for breast cancer patients.展开更多
Yaks are well-adapted to the harsh environment of the Tibetan Plateau,and they emit less enteric methane(CH_(4))and digest poor-quality forage better than cattle.To examine the potential of yak rumen inoculum to mitig...Yaks are well-adapted to the harsh environment of the Tibetan Plateau,and they emit less enteric methane(CH_(4))and digest poor-quality forage better than cattle.To examine the potential of yak rumen inoculum to mitigate CH_(4)production and improve digestibility in cattle,we incubated substrate with rumen inoculum from yak(YRI)and cattle(CRI)in vitro in five ratios(YRI:CRI):(1)0:100(control),(2)25:75,(3)50:50,(4)75:25 and(5)100:0 for 72 h.The YRI:CRI ratios of 50:50,75:25 and 100:0 produced less total gas and CH_(4)and accumulated less hydrogen(H_(2))than0:100(control)at most time points.From 12 h onwards,there was a linear decrease(P<0.05)in carbon dioxide(CO_(2))production with increasing YRI:CRI ratio.At 72 h,the ratios of 50:50 and 75:25 had higher dry matter(+7.71%and+4.11%,respectively),as well as higher acid detergent fiber digestibility(+15.5%and+7.61%,respectively),when compared to the 0:100 ratio(P<0.05).Increasing the proportion of YRI generally increased total VFA concentrations,and,concomitantly,decreased the proportion of metabolic hydrogen([2H])incorporated into CH_(4),and decreased the recovery of[2H].The lower[2H]recovery indicates unknown[2H]sinks in the culture.Estimated Gibbs free energy changes(ΔG)for reductive acetogenesis were negative,indicating the thermodynamic feasibility of this process.It would be beneficial to identify:1)the alternative[2H]sinks,which could help mitigate CH_(4)emission,and 2)core microbes involved in fiber digestion.This experiment supported lower CH_(4)emission and greater nutrient digestibility of yaks compared to cattle.Multi-omics combined with microbial culture technologies developed in recent years could help to better understand fermentation differences among species.展开更多
Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,envir...Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and biomedicine.There-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be analyzed.Based on the presented studies of CF and its composite materials,the types and structures of the crystal are summarized.In addition,the current application technologies and theoretical mechanisms with various properties in different fields are elucidated.Moreover,the various preparation methods of CF and its composite materials are elaborated in detail.Most importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are identified.Furthermore,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.展开更多
A novel Eu^(3+)-doped fluorapatite red phosphor Ca_(2)Y_(8)(BO_(4))_(2)(SiO_(4))_(4)F_(2)Eu^(3+)with pure phase was synthesized in this study.Density functional theory(DFT)calculation and diffuse reflection spectrum a...A novel Eu^(3+)-doped fluorapatite red phosphor Ca_(2)Y_(8)(BO_(4))_(2)(SiO_(4))_(4)F_(2)Eu^(3+)with pure phase was synthesized in this study.Density functional theory(DFT)calculation and diffuse reflection spectrum analysis reveal its potential as a matrix for phosphors excited by ultraviolet light.Eu^(3+)has a^(7)F_(0)→^(5)L_(6)transition at 394 nm,and the prepared phosphor exhibits a high emission intensity at 614 nm,which may be attributed to the^(5)D_(0)-^(7)F_(2)energy transition at the lower symmetry site of Eu^(3+).The optimal doping concentration of the phosphor is determined to be 11 mol%,with concentration quenching attributed to the exchange interaction mechanism.The overall color purity of the phosphor is up to 99.88%,with an internal quantum efficiency as high as 91.15%.Notably,Ca_(2)Y_(8)(BO_(4))_(2)(SiO_(4))_(4)F_(2):11 mol%Eu^(3+)(CYBSF:11 mol%Eu^(3+))phosphors exhibit good thermal stability,with a thermal quenching temperature(T1/2)of 552 K and the intensity of emission at 423 K still at 88.89%of that at 298 K.The activation energy of the phosphor is up to 0.30287 eV.Its comprehensive luminescence performance surpasses that of commercial red phosphor,making it suitable for near ultraviolet excited warm white light emitting diode(NUV-WLED)with a high color rendering index(Ra=82)and a correlated color temperature(CCT)of 4339 K.Moreover,the phosphor achieves latent fingerprint visualization and anti-counterfeiting ink on different material surfaces:glass,aluminum foil,plastic and paper.Overall,the fluorapatite CYBSF:11 mol%Eu^(3+)phosphor holds great potential for multimodal applications due to its high quantum efficiency and good thermal stability.展开更多
The activation of CO_(2)molecules is a fundamental step for their effective utilization.Constructing highdensity oxygen vacancies on the surface of reducible oxides is pivotal for the activation of CO_(2).In this work...The activation of CO_(2)molecules is a fundamental step for their effective utilization.Constructing highdensity oxygen vacancies on the surface of reducible oxides is pivotal for the activation of CO_(2).In this work,we prepared a series of 0.5PtxCe/Al_(2)O_(3)(x=1,5,10,or 20)catalysts with varying Ce loading and 0.5 wt%of Pt for the reverse water gas shift(RWGS)reaction.The size of CeO_(2)particle increases with Ce loading.Remarkably,the 0.5Pt5Ce/Al_(2)O_(3) catalyst with an average CeO_(2)particle size of 5.5 nm exhibits a very high CO_(2)conversion rate(116.4×10^(-5)mol_(CO_(2))/(g_(cat)·s))and CO selectivity(96.1%)at 600℃.Our experimental findings reveal that the small-size CeO_(2)in 0.5Pt5Ce/Al_(2)O_(3) possesses a greater capacity to generate reactive oxygen vacancies,promoting the adsorption and activation of CO_(2).In addition,the oxygen vacancies are cyclically generated and consumed during the reaction,which contributes to the elevated catalytic performance of the catalyst.This work provides a general strategy to construct rich oxygen vacancies on CeO_(2)for designing high-performance catalysts in C_(1) chemistry.展开更多
Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various sources.To evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabi...Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various sources.To evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabidopsis thaliana was exposed to bisphenol A(BPA),BPB,BPE,BPF,and BPS at 1,3,10 mg/L for a duration of 14 days,and their growth status were monitored.At day 14,roots and leaves were collected for internal BPs exposure concentration detection,RNA-seq(only roots),and morphological observations.As shown in the results,exposure to BPs significantly disturbed root elongation,exhibiting a trend of stimulation at low concentration and inhibition at high concentration.Additionally,BPs exhibited pronounced generation of reactive oxygen species,while none of the pollutants caused significant changes in root morphology.Internal exposure concentration analysis indicated that BPs tended to accumulate in the roots,with BPS exhibiting the highest level of accumulation.The results of RNA-seq indicated that the shared 211 differently expressed genes(DEGs)of these 5 exposure groups were enriched in defense response,generation of precursormetabolites,response to organic substance,response to oxygen-containing,response to hormone,oxidation-reduction process and so on.Regarding unique DEGs in each group,BPS wasmainly associated with the redox pathway,BPB primarily influenced seed germination,and BPA,BPE and BPF were primarily involved in metabolic signaling pathways.Our results provide newinsights for BPs induced adverse effects on Arabidopsis thaliana and suggest that the ecological risks associated with BPA alternatives cannot be ignored.展开更多
The rigorous operating condition of proton exchange membrane fuel cells(PEMFCs)poses a substantial hurdle for the long-term stability of Pt-based alloy catalysts;thus,the development of Pt-alloy catalysts with unique ...The rigorous operating condition of proton exchange membrane fuel cells(PEMFCs)poses a substantial hurdle for the long-term stability of Pt-based alloy catalysts;thus,the development of Pt-alloy catalysts with unique morphologies is crucial for enhancing the stability of PEMFCs.In this study,we synthesized a novel PtCu nano-dendrite(PtCuND)catalyst through a facile,one-step solvothermal process.The sub-nanometer particles and nanopores within this catalyst facilitate enhanced mass transport.In PEM single-cell tests,the PtCuND catalyst displays high activity and robust stability,achieving a mass activity of 0.65 A mgPt^(–1).Notably,after accelerated durability tests,the mass activity and the voltage at 0.8 A cm^(–2)of PtCuND exhibits only minimal decreases of 18.5%and 9 mV,respectively.The combined experimental results and theoretical calculations conclusively illustrate the optimized adsorption of oxygen species and the impact of compressive strain on the catalyst surface.The enhanced durability can be attributed to the maintained nano-dendritic morphology and the strengthened interaction within the Pt-Cu bonds.This work not only enhances the stability of PEMFCs but also provides a robust foundation for the future scaling up of catalyst production,paving the way for widespread application in sustainable energy systems.展开更多
Humic acid(HA),a principal constituent of natural organic matter(NOM),manifests ubiquitously across diverse ecosystems and can significantly influence the environmental behaviors of Cd(II)in aquatic systems.Previous s...Humic acid(HA),a principal constituent of natural organic matter(NOM),manifests ubiquitously across diverse ecosystems and can significantly influence the environmental behaviors of Cd(II)in aquatic systems.Previous studies on NOM-Cd(II)interactions have primarily focused on the immobilization of Cd(II)solids,but little is known about the colloidal stability of organically complexed Cd(II)particles in the environment.In this study,we investigated the formation of HA-Cd(II)colloids and quantified their aggregation,stability,and transport behaviors in a saturated porous media representative of typical subsurface conditions.Results from batch experiments indicated that the relative quantity of HA-Cd(II)colloids increased with increasing C/Cd molar ratio and that the carboxyl functional groups of HA dominated the stability of HA-Cd(II)colloids.The results of correlation analysis between particle size,critical aggregation concentration(CCC),and zeta potential indicated that both Derjaguin-Landau-Verwey-Overbeek(DLVO)and non-DLVO interactions contributed to the enhanced colloidal stability of HA-Cd(II)colloids.Column results further confirmed that the stable HA-Cd(II)colloid can transport fast in a saturated media composed of clean sand.Together,this study provides newknowledge of the colloidal behaviors of NOM-Cd(II)nanoparticles,which is important for better understanding the ultimate cycling of Cd(II)in aquatic systems.展开更多
Cultural filtering is deeply embedded in cross-cultural literary exchange and exerts a lasting influence on both the transmission and interpretation of literary works.This article examines the English translation of B...Cultural filtering is deeply embedded in cross-cultural literary exchange and exerts a lasting influence on both the transmission and interpretation of literary works.This article examines the English translation of Ba Jin’s The Family by Sidney Shapiro,focusing on the manifestations and underlying causes of cultural filtering in the translated text.The translator adopts a range of strategies-including the addition of cultural annotations,selective omission,and abridged translation of certain content-to implement various forms of cultural filtering.These choices are shaped by multiple filtering processes,such as the translator’s cultural identity and his understanding of traditional Chinese culture.While cultural filtering in cross-cultural translation is inevitable and may result in partial loss of meaning,it can also breathe new life into the source text and facilitate mutual understanding and dialogue between different cultural systems.展开更多
Mycotoxins are the most widely existing pollutants in both dietary provisions and livestock feed,and they pose a series of hazards for humans and animals.Deoxynivalenol(DON)is a prevalent mycotoxin that is primarily p...Mycotoxins are the most widely existing pollutants in both dietary provisions and livestock feed,and they pose a series of hazards for humans and animals.Deoxynivalenol(DON)is a prevalent mycotoxin that is primarily produced by Fusarium spp.and commonly found in various cereal products.Feeding swine diets contaminated with trichothecene DON can lead to major adverse effects,including reduced feed intake,diminished weight gains,and compromised immune function.Among all animal species,swine are the most sensitive to DON.Here we explore the disruption of gut health by DON,considering aspects such as intestinal histomorphology,epithelial barrier functions,immune system,microflora,and short-chain fatty acid production in the intestines.Numerous additives have been documented for their potential in the detoxification of DON.These additives can alleviate the toxic effects of DON on pigs by modulating the Nrf2-Keap1,mitogen-activated protein kinases(MAPKs)and Nuclear factor kappa-B(NF-κB)signaling pathways.Additionally,there are additives capable of mitigating the toxicity of DON through adsorption or biotransformation.This update has novel potential for advancing our comprehension of the mechanisms linked to DON intestinal toxicity and facilitating the formulation of innovative strategies to mitigate the impact of DON.展开更多
Background: Clostridium perfringens is the main etiological agent of necrotic enteritis. Lactobacil i show beneficial effects on intestinal health in infectious disease, but the protective functions of lactobacil i in...Background: Clostridium perfringens is the main etiological agent of necrotic enteritis. Lactobacil i show beneficial effects on intestinal health in infectious disease, but the protective functions of lactobacil i in C. perfringens-infected chickens are scarcely described. This study examined the effects of Lactobacil us acidophilus(L. acidophilus) on the growth performance and intestinal health of broiler chickens chal enged with Clostridium perfringens(C. perfringens) over a 28-day period. Using a 2 × 2 factorial arrangement of treatments, a total of 308 1-day-old male Arbor Acres broiler chicks were included to investigate the effects of Lactobacil us acidophilus(L. acidophilus) on the growth performance and intestinal health of broiler chickens chal enged with Clostridium perfringens(C. perfringens) during a 28-day trial.Results: During infection(d 14–21), C. perfringens challenge decreased the average daily gain(P < 0.05), and increased feed conversion ratio and the mortality rate(P < 0.05). However, dietary supplementation with L. acidophilus increased the body weight of C. perfringens-infected broilers on d 21(P < 0.05), and tended to decrease the mortality(P = 0.061).C. perfringens challenge decreased the villus height(P < 0.05), the ratio of villus height to crypt depth(P < 0.05) and OCLN(occludin) m RNA expression(P < 0.05), and increased the pro-inflammatory cytokine expression in the spleen and jejunum, the intestinal populations of C. perfringens and Escherichia(P < 0.05), and the serum content of endotoxin(P < 0.05), regardless of L. acidophilus supplementation. In contrast, dietary L. acidophilus reducedthe intestinal lesion score of challenged broilers(P < 0.05), the m RNA expression of pro-inflammatory cytokines, ileal populations of Escherichia and serum endotoxin content(P < 0.05), but increased the intestinal Lactobacillus populations(P < 0.05),irrespective of C. perfringens challenge.Conclusion: Dietary addition of L. acidophilus could improve the intestinal health and reduce the mortality of broilers suffering from necrotic enteritis.展开更多
Background： Necrotic enteritis caused by Clostfidium perffingens infection leads to serious economic losses in the global poultry production. In the present study, we investigated the protective effects of essential ...Background： Necrotic enteritis caused by Clostfidium perffingens infection leads to serious economic losses in the global poultry production. In the present study, we investigated the protective effects of essential oils （EO, which contained 25 % thymol and 25 % carvacrol as active components） supplementation on growth performance, gut lesions, intestinal morphology, and immune responses of the broiler chickens infected with C. perfringens. A total of 448 1-day-old male broiler chicks were allocated into eight treatment groups following a 4 x 2 factorial arrangement with four dietary EO dosages （0, 60, 120, or 240 mg/kg） and two infection status （with or without C. perfringens challenge from d 14 to 20）. Results： The challenge did not impair the growth performance of birds, but induced gut lesions and increased crypt depth in the ileum （P ≤ 0.05）. It also down-regulated the claudin-1 and occludin mRNA expression （P ≤0.05）, up-regulated the mRNA expression of interleukin-113 （P≤ 0.05）, tended to increase the toll-like receptor （TLR） 2 mRNA expression （P 〈 0.10） in the ileum, and enhanced the mucosal secretory IgA production （P 〈 0.05）. In the challenged birds, dietary EO supplementation linearly alleviated the gut lesions and improved the ratio of villus height to crypt depth （P ≤0.05）, and the supplementation of 120 and 240 mg/kg EO increased the serum antibody titers against Newcastle disease virus （P≤ 0.05）. Regardless of challenge, the EO supplementation showed a tendency to linearly elevate the feed conversion efficiency between 14 and 28 d of age as well as the occludin mRNA expression （P〈 0.10）, and linearly inhibited the mRNA expression of TLR2 and tumor necrotic factor-o in the ileum （P≤ 0.05）. Conclusions： The dietary supplementation of EO could alleviate the intestinal injury by improving intestinal integrity and modulating immune responses in the C. perffingens-challenged broiler chickens.展开更多
Copper-based catalysts for CO2 hydrogenation to methanol are supported on ZrO2 and CeO2,respectively.Reaction results at 3.0 MPa and temperatures between 200 and 300°C reveal that Cu catalysts supported on ZrO2 a...Copper-based catalysts for CO2 hydrogenation to methanol are supported on ZrO2 and CeO2,respectively.Reaction results at 3.0 MPa and temperatures between 200 and 300°C reveal that Cu catalysts supported on ZrO2 and CeO2 exhibit better activity and selectivity than pure Cu catalyst due to Cu-support(ZrO2 and CeO2)interaction.Combining the structural characterizations with in-situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS),Cu/CeO2 shows the higher methanol selectivity due to the formation of main carbonates intermediates,which are closely related with the oxygen vacancies over Cu/CeO2.In contrast,bicarbonate and carboxyl species are observed on Cu/ZrO2,which originates from the hydroxyl groups presented on catalyst surfaces.Difference in CO2 adsorption intermediates results in the distinct methanol selectivity over the two catalysts.展开更多
基金supported by the National Natural Science Foundation of China(No.82371933)the National Natural Science Foundation of Shandong Province of China(No.ZR2021MH120)+1 种基金the Taishan Scholars Project(No.tsqn202211378)the Shandong Provincial Natural Science Foundation for Excellent Young Scholars(No.ZR2024YQ075).
文摘Objective:Early predicting response before neoadjuvant chemotherapy(NAC)is crucial for personalized treatment plans for locally advanced breast cancer patients.We aim to develop a multi-task model using multiscale whole slide images(WSIs)features to predict the response to breast cancer NAC more finely.Methods:This work collected 1,670 whole slide images for training and validation sets,internal testing sets,external testing sets,and prospective testing sets of the weakly-supervised deep learning-based multi-task model(DLMM)in predicting treatment response and pCR to NAC.Our approach models two-by-two feature interactions across scales by employing concatenate fusion of single-scale feature representations,and controls the expressiveness of each representation via a gating-based attention mechanism.Results:In the retrospective analysis,DLMM exhibited excellent predictive performance for the prediction of treatment response,with area under the receiver operating characteristic curves(AUCs)of 0.869[95%confidence interval(95%CI):0.806−0.933]in the internal testing set and 0.841(95%CI:0.814−0.867)in the external testing sets.For the pCR prediction task,DLMM reached AUCs of 0.865(95%CI:0.763−0.964)in the internal testing and 0.821(95%CI:0.763−0.878)in the pooled external testing set.In the prospective testing study,DLMM also demonstrated favorable predictive performance,with AUCs of 0.829(95%CI:0.754−0.903)and 0.821(95%CI:0.692−0.949)in treatment response and pCR prediction,respectively.DLMM significantly outperformed the baseline models in all testing sets(P<0.05).Heatmaps were employed to interpret the decision-making basis of the model.Furthermore,it was discovered that high DLMM scores were associated with immune-related pathways and cells in the microenvironment during biological basis exploration.Conclusions:The DLMM represents a valuable tool that aids clinicians in selecting personalized treatment strategies for breast cancer patients.
基金supported by the National Natural Science Foundation of China(32072757 and U21A20250)。
文摘Yaks are well-adapted to the harsh environment of the Tibetan Plateau,and they emit less enteric methane(CH_(4))and digest poor-quality forage better than cattle.To examine the potential of yak rumen inoculum to mitigate CH_(4)production and improve digestibility in cattle,we incubated substrate with rumen inoculum from yak(YRI)and cattle(CRI)in vitro in five ratios(YRI:CRI):(1)0:100(control),(2)25:75,(3)50:50,(4)75:25 and(5)100:0 for 72 h.The YRI:CRI ratios of 50:50,75:25 and 100:0 produced less total gas and CH_(4)and accumulated less hydrogen(H_(2))than0:100(control)at most time points.From 12 h onwards,there was a linear decrease(P<0.05)in carbon dioxide(CO_(2))production with increasing YRI:CRI ratio.At 72 h,the ratios of 50:50 and 75:25 had higher dry matter(+7.71%and+4.11%,respectively),as well as higher acid detergent fiber digestibility(+15.5%and+7.61%,respectively),when compared to the 0:100 ratio(P<0.05).Increasing the proportion of YRI generally increased total VFA concentrations,and,concomitantly,decreased the proportion of metabolic hydrogen([2H])incorporated into CH_(4),and decreased the recovery of[2H].The lower[2H]recovery indicates unknown[2H]sinks in the culture.Estimated Gibbs free energy changes(ΔG)for reductive acetogenesis were negative,indicating the thermodynamic feasibility of this process.It would be beneficial to identify:1)the alternative[2H]sinks,which could help mitigate CH_(4)emission,and 2)core microbes involved in fiber digestion.This experiment supported lower CH_(4)emission and greater nutrient digestibility of yaks compared to cattle.Multi-omics combined with microbial culture technologies developed in recent years could help to better understand fermentation differences among species.
基金supported by the National Natural Science Foundation of China(No.51574105)the Science and Technology Program of Hebei Province,China(No.23564101D)+2 种基金the Natural Science Foundation of Hebei Province,China(No.E2021209147)the Key Research Project of North China University of Science and Technology(No.ZD-ST-202308)the Postgraduate Innovation Funding Project of Hebei Province,China(No.CXZZBS2024135).
文摘Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and biomedicine.There-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be analyzed.Based on the presented studies of CF and its composite materials,the types and structures of the crystal are summarized.In addition,the current application technologies and theoretical mechanisms with various properties in different fields are elucidated.Moreover,the various preparation methods of CF and its composite materials are elaborated in detail.Most importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are identified.Furthermore,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.
基金supported by the National Natural Science Foundation of China(52372013)Natural Science Foundation of Shanghai(22ZR1460600)。
文摘A novel Eu^(3+)-doped fluorapatite red phosphor Ca_(2)Y_(8)(BO_(4))_(2)(SiO_(4))_(4)F_(2)Eu^(3+)with pure phase was synthesized in this study.Density functional theory(DFT)calculation and diffuse reflection spectrum analysis reveal its potential as a matrix for phosphors excited by ultraviolet light.Eu^(3+)has a^(7)F_(0)→^(5)L_(6)transition at 394 nm,and the prepared phosphor exhibits a high emission intensity at 614 nm,which may be attributed to the^(5)D_(0)-^(7)F_(2)energy transition at the lower symmetry site of Eu^(3+).The optimal doping concentration of the phosphor is determined to be 11 mol%,with concentration quenching attributed to the exchange interaction mechanism.The overall color purity of the phosphor is up to 99.88%,with an internal quantum efficiency as high as 91.15%.Notably,Ca_(2)Y_(8)(BO_(4))_(2)(SiO_(4))_(4)F_(2):11 mol%Eu^(3+)(CYBSF:11 mol%Eu^(3+))phosphors exhibit good thermal stability,with a thermal quenching temperature(T1/2)of 552 K and the intensity of emission at 423 K still at 88.89%of that at 298 K.The activation energy of the phosphor is up to 0.30287 eV.Its comprehensive luminescence performance surpasses that of commercial red phosphor,making it suitable for near ultraviolet excited warm white light emitting diode(NUV-WLED)with a high color rendering index(Ra=82)and a correlated color temperature(CCT)of 4339 K.Moreover,the phosphor achieves latent fingerprint visualization and anti-counterfeiting ink on different material surfaces:glass,aluminum foil,plastic and paper.Overall,the fluorapatite CYBSF:11 mol%Eu^(3+)phosphor holds great potential for multimodal applications due to its high quantum efficiency and good thermal stability.
基金Project supported by the National Science Fund for Distinguished Young Scholars of China(22225110)the National Key Research and Development Program of China(2021YFA1501103)+1 种基金the National Science Foundation of China(22075166,22271177)the Young Scholars Program of Shandong University。
文摘The activation of CO_(2)molecules is a fundamental step for their effective utilization.Constructing highdensity oxygen vacancies on the surface of reducible oxides is pivotal for the activation of CO_(2).In this work,we prepared a series of 0.5PtxCe/Al_(2)O_(3)(x=1,5,10,or 20)catalysts with varying Ce loading and 0.5 wt%of Pt for the reverse water gas shift(RWGS)reaction.The size of CeO_(2)particle increases with Ce loading.Remarkably,the 0.5Pt5Ce/Al_(2)O_(3) catalyst with an average CeO_(2)particle size of 5.5 nm exhibits a very high CO_(2)conversion rate(116.4×10^(-5)mol_(CO_(2))/(g_(cat)·s))and CO selectivity(96.1%)at 600℃.Our experimental findings reveal that the small-size CeO_(2)in 0.5Pt5Ce/Al_(2)O_(3) possesses a greater capacity to generate reactive oxygen vacancies,promoting the adsorption and activation of CO_(2).In addition,the oxygen vacancies are cyclically generated and consumed during the reaction,which contributes to the elevated catalytic performance of the catalyst.This work provides a general strategy to construct rich oxygen vacancies on CeO_(2)for designing high-performance catalysts in C_(1) chemistry.
基金supported by the National Science Foundation of China (No.22106098)the Youth Science and Technology Research Foundation of Shanxi Province (No.20210302124298)+2 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (Nos.2020L0174,and 2020L0025)the Startup Foundation for Doctors of Shanxi Province (No.SD1917)the Startup Foundation for Doctors of Shanxi Medical University (No.XD1917).
文摘Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various sources.To evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabidopsis thaliana was exposed to bisphenol A(BPA),BPB,BPE,BPF,and BPS at 1,3,10 mg/L for a duration of 14 days,and their growth status were monitored.At day 14,roots and leaves were collected for internal BPs exposure concentration detection,RNA-seq(only roots),and morphological observations.As shown in the results,exposure to BPs significantly disturbed root elongation,exhibiting a trend of stimulation at low concentration and inhibition at high concentration.Additionally,BPs exhibited pronounced generation of reactive oxygen species,while none of the pollutants caused significant changes in root morphology.Internal exposure concentration analysis indicated that BPs tended to accumulate in the roots,with BPS exhibiting the highest level of accumulation.The results of RNA-seq indicated that the shared 211 differently expressed genes(DEGs)of these 5 exposure groups were enriched in defense response,generation of precursormetabolites,response to organic substance,response to oxygen-containing,response to hormone,oxidation-reduction process and so on.Regarding unique DEGs in each group,BPS wasmainly associated with the redox pathway,BPB primarily influenced seed germination,and BPA,BPE and BPF were primarily involved in metabolic signaling pathways.Our results provide newinsights for BPs induced adverse effects on Arabidopsis thaliana and suggest that the ecological risks associated with BPA alternatives cannot be ignored.
文摘The rigorous operating condition of proton exchange membrane fuel cells(PEMFCs)poses a substantial hurdle for the long-term stability of Pt-based alloy catalysts;thus,the development of Pt-alloy catalysts with unique morphologies is crucial for enhancing the stability of PEMFCs.In this study,we synthesized a novel PtCu nano-dendrite(PtCuND)catalyst through a facile,one-step solvothermal process.The sub-nanometer particles and nanopores within this catalyst facilitate enhanced mass transport.In PEM single-cell tests,the PtCuND catalyst displays high activity and robust stability,achieving a mass activity of 0.65 A mgPt^(–1).Notably,after accelerated durability tests,the mass activity and the voltage at 0.8 A cm^(–2)of PtCuND exhibits only minimal decreases of 18.5%and 9 mV,respectively.The combined experimental results and theoretical calculations conclusively illustrate the optimized adsorption of oxygen species and the impact of compressive strain on the catalyst surface.The enhanced durability can be attributed to the maintained nano-dendritic morphology and the strengthened interaction within the Pt-Cu bonds.This work not only enhances the stability of PEMFCs but also provides a robust foundation for the future scaling up of catalyst production,paving the way for widespread application in sustainable energy systems.
基金supported by Guizhou Science Cooperation Platform Talents(No.GCC[2023]045)the National Natural Science Foundation of China(Nos.42267030 and 42177237)+2 种基金the Innovation and Entrepreneurship Talents of Guizhou Province(No.GZQ202208091)the Science and Technology Planning Project of Guizhou Province(Qian Ke He Zhi Cheng,2022-217)the Science and Technology Planning Project of Guizhou Province(Qian Ke He Cheng Guo,2023-006).
文摘Humic acid(HA),a principal constituent of natural organic matter(NOM),manifests ubiquitously across diverse ecosystems and can significantly influence the environmental behaviors of Cd(II)in aquatic systems.Previous studies on NOM-Cd(II)interactions have primarily focused on the immobilization of Cd(II)solids,but little is known about the colloidal stability of organically complexed Cd(II)particles in the environment.In this study,we investigated the formation of HA-Cd(II)colloids and quantified their aggregation,stability,and transport behaviors in a saturated porous media representative of typical subsurface conditions.Results from batch experiments indicated that the relative quantity of HA-Cd(II)colloids increased with increasing C/Cd molar ratio and that the carboxyl functional groups of HA dominated the stability of HA-Cd(II)colloids.The results of correlation analysis between particle size,critical aggregation concentration(CCC),and zeta potential indicated that both Derjaguin-Landau-Verwey-Overbeek(DLVO)and non-DLVO interactions contributed to the enhanced colloidal stability of HA-Cd(II)colloids.Column results further confirmed that the stable HA-Cd(II)colloid can transport fast in a saturated media composed of clean sand.Together,this study provides newknowledge of the colloidal behaviors of NOM-Cd(II)nanoparticles,which is important for better understanding the ultimate cycling of Cd(II)in aquatic systems.
文摘Cultural filtering is deeply embedded in cross-cultural literary exchange and exerts a lasting influence on both the transmission and interpretation of literary works.This article examines the English translation of Ba Jin’s The Family by Sidney Shapiro,focusing on the manifestations and underlying causes of cultural filtering in the translated text.The translator adopts a range of strategies-including the addition of cultural annotations,selective omission,and abridged translation of certain content-to implement various forms of cultural filtering.These choices are shaped by multiple filtering processes,such as the translator’s cultural identity and his understanding of traditional Chinese culture.While cultural filtering in cross-cultural translation is inevitable and may result in partial loss of meaning,it can also breathe new life into the source text and facilitate mutual understanding and dialogue between different cultural systems.
基金supported by the National Key Research and Development Program of China(2021YFD1301003)the Beijing University of Agriculture Science and Technology Innovation“Spark Action”Support Program,China(BUA-HHXD2022011)the key research and development Program of Shaanxi Province,China(2022NY-095)。
文摘Mycotoxins are the most widely existing pollutants in both dietary provisions and livestock feed,and they pose a series of hazards for humans and animals.Deoxynivalenol(DON)is a prevalent mycotoxin that is primarily produced by Fusarium spp.and commonly found in various cereal products.Feeding swine diets contaminated with trichothecene DON can lead to major adverse effects,including reduced feed intake,diminished weight gains,and compromised immune function.Among all animal species,swine are the most sensitive to DON.Here we explore the disruption of gut health by DON,considering aspects such as intestinal histomorphology,epithelial barrier functions,immune system,microflora,and short-chain fatty acid production in the intestines.Numerous additives have been documented for their potential in the detoxification of DON.These additives can alleviate the toxic effects of DON on pigs by modulating the Nrf2-Keap1,mitogen-activated protein kinases(MAPKs)and Nuclear factor kappa-B(NF-κB)signaling pathways.Additionally,there are additives capable of mitigating the toxicity of DON through adsorption or biotransformation.This update has novel potential for advancing our comprehension of the mechanisms linked to DON intestinal toxicity and facilitating the formulation of innovative strategies to mitigate the impact of DON.
基金supported by Natural Science Foundation of China(No.3140130343)
文摘Background: Clostridium perfringens is the main etiological agent of necrotic enteritis. Lactobacil i show beneficial effects on intestinal health in infectious disease, but the protective functions of lactobacil i in C. perfringens-infected chickens are scarcely described. This study examined the effects of Lactobacil us acidophilus(L. acidophilus) on the growth performance and intestinal health of broiler chickens chal enged with Clostridium perfringens(C. perfringens) over a 28-day period. Using a 2 × 2 factorial arrangement of treatments, a total of 308 1-day-old male Arbor Acres broiler chicks were included to investigate the effects of Lactobacil us acidophilus(L. acidophilus) on the growth performance and intestinal health of broiler chickens chal enged with Clostridium perfringens(C. perfringens) during a 28-day trial.Results: During infection(d 14–21), C. perfringens challenge decreased the average daily gain(P < 0.05), and increased feed conversion ratio and the mortality rate(P < 0.05). However, dietary supplementation with L. acidophilus increased the body weight of C. perfringens-infected broilers on d 21(P < 0.05), and tended to decrease the mortality(P = 0.061).C. perfringens challenge decreased the villus height(P < 0.05), the ratio of villus height to crypt depth(P < 0.05) and OCLN(occludin) m RNA expression(P < 0.05), and increased the pro-inflammatory cytokine expression in the spleen and jejunum, the intestinal populations of C. perfringens and Escherichia(P < 0.05), and the serum content of endotoxin(P < 0.05), regardless of L. acidophilus supplementation. In contrast, dietary L. acidophilus reducedthe intestinal lesion score of challenged broilers(P < 0.05), the m RNA expression of pro-inflammatory cytokines, ileal populations of Escherichia and serum endotoxin content(P < 0.05), but increased the intestinal Lactobacillus populations(P < 0.05),irrespective of C. perfringens challenge.Conclusion: Dietary addition of L. acidophilus could improve the intestinal health and reduce the mortality of broilers suffering from necrotic enteritis.
基金supported by Novus International Company (Missouri, USA)the earmarked fund for China Agricultural Research Systems (CARS-42)
文摘Background： Necrotic enteritis caused by Clostfidium perffingens infection leads to serious economic losses in the global poultry production. In the present study, we investigated the protective effects of essential oils （EO, which contained 25 % thymol and 25 % carvacrol as active components） supplementation on growth performance, gut lesions, intestinal morphology, and immune responses of the broiler chickens infected with C. perfringens. A total of 448 1-day-old male broiler chicks were allocated into eight treatment groups following a 4 x 2 factorial arrangement with four dietary EO dosages （0, 60, 120, or 240 mg/kg） and two infection status （with or without C. perfringens challenge from d 14 to 20）. Results： The challenge did not impair the growth performance of birds, but induced gut lesions and increased crypt depth in the ileum （P ≤ 0.05）. It also down-regulated the claudin-1 and occludin mRNA expression （P ≤0.05）, up-regulated the mRNA expression of interleukin-113 （P≤ 0.05）, tended to increase the toll-like receptor （TLR） 2 mRNA expression （P 〈 0.10） in the ileum, and enhanced the mucosal secretory IgA production （P 〈 0.05）. In the challenged birds, dietary EO supplementation linearly alleviated the gut lesions and improved the ratio of villus height to crypt depth （P ≤0.05）, and the supplementation of 120 and 240 mg/kg EO increased the serum antibody titers against Newcastle disease virus （P≤ 0.05）. Regardless of challenge, the EO supplementation showed a tendency to linearly elevate the feed conversion efficiency between 14 and 28 d of age as well as the occludin mRNA expression （P〈 0.10）, and linearly inhibited the mRNA expression of TLR2 and tumor necrotic factor-o in the ileum （P≤ 0.05）. Conclusions： The dietary supplementation of EO could alleviate the intestinal injury by improving intestinal integrity and modulating immune responses in the C. perffingens-challenged broiler chickens.
基金financially supported by the National Natural Science Foundation of China (21577014, 21876019, 21825203, 21688102)Programme of Introducing Talents of Discipline to Universities (B13012)the fund of the State Key Laboratory of Catalysis in DICP (Y401010502)
文摘Copper-based catalysts for CO2 hydrogenation to methanol are supported on ZrO2 and CeO2,respectively.Reaction results at 3.0 MPa and temperatures between 200 and 300°C reveal that Cu catalysts supported on ZrO2 and CeO2 exhibit better activity and selectivity than pure Cu catalyst due to Cu-support(ZrO2 and CeO2)interaction.Combining the structural characterizations with in-situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS),Cu/CeO2 shows the higher methanol selectivity due to the formation of main carbonates intermediates,which are closely related with the oxygen vacancies over Cu/CeO2.In contrast,bicarbonate and carboxyl species are observed on Cu/ZrO2,which originates from the hydroxyl groups presented on catalyst surfaces.Difference in CO2 adsorption intermediates results in the distinct methanol selectivity over the two catalysts.
