Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Ta...Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Targeting mitosis is an effective method for cancer treatment.This review summarizes several natural products with anti-tumor effects related to mitosis,focusing on targeting microtubulin,inducing DNA damage,and modulating mitosis-associated kinases.Furthermore,the main disadvantages of several typical compounds,including drug resistance,toxicity to non-tumor tissues,and poor aqueous solubility and pharmacokinetic properties,are also discussed,together with strategies to address them.Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.展开更多
This paper proposes a V-shaped permanent magnet vernier(V-PMV)motor for potential applications in direct drive system.By designing suitable pole slot ratio and adopting the V-shaped PM topology and dummy slots in roto...This paper proposes a V-shaped permanent magnet vernier(V-PMV)motor for potential applications in direct drive system.By designing suitable pole slot ratio and adopting the V-shaped PM topology and dummy slots in rotor,the flux leakage can be avoided effectively.Meanwhile,the high-order harmonics with large amplitude in the airgap magnetic field are fully utilized and served as the effective working harmonics,which aim at enhancing the output torque and reducing the torque ripple.Moreover,to extensively explore the performance advantages of the V-PMV motor,a multi-objective optimization study is carried out.And,the electromagnetic performances of the V-PMV motors are analyzed and compared in detail.Finally,a prototype machine is built and tested.Both theoretical analysis and experimental results verify the validity of the motor and multi-objective optimization design approach.展开更多
Malignant tumor has become a major threat affecting human health,and is one of the main causes of human death.Recent studies have shown that many traditional Chinese medicines(TCM)have good anti-tumor activity,which m...Malignant tumor has become a major threat affecting human health,and is one of the main causes of human death.Recent studies have shown that many traditional Chinese medicines(TCM)have good anti-tumor activity,which may improve the therapeutic effect of routine treatment and quality of life with lower toxicity.However,the efficacy of TCM alone for the treatment of tumors is limited.Metal ions are essential substances for maintaining normal physiological activities.This article summarized the multiple mechanisms in which metal ions are involved in the prevention and treatment of tumors in TCM.展开更多
Objective:Alveolar macrophages(AMs)are involved in the development and progression of a variety of lung diseases.It is of great significance to explore the pathogenesis of diseases and evaluate the efficacy of drugs.H...Objective:Alveolar macrophages(AMs)are involved in the development and progression of a variety of lung diseases.It is of great significance to explore the pathogenesis of diseases and evaluate the efficacy of drugs.However,there is no standard process for extracting primary AM.Nitidine chloride(NC)is an alkaloid extracted from Zanthoxylum nitidum(Roxb.)DC.,which has an antitumour pharmacological effect.However,there is no evidence that NC has a direct effect on colorectal cancer cell lung metastasis.The purpose of this study was to establish a standard for the extraction of primary AM from mice and to investigate the pharmacodynamics of NC in mice with lung metastases to colorectal cancer.Methods:The standard for the extraction of mouse primary AM by lavage was established.Western blot and polymerase chain reaction were used to detect the regulatory mechanism of NC in the treatment of lung metastasis in mice by macrophage phenotype and glycolysis level.Results:The results showed that sufficient quantity and quality of primary AM could be obtained by optimizing extraction steps,and AM obtained by this method could accurately reflect disease progression.At the same time,NC can effectively reduce colorectal cancer lung metastasis in mice.From the mechanism,NC can inhibit the expression of M2 macrophage markers and the levels of mRNA and proteins of the glycolysis-limiting enzyme.Conclusions:Our results show that primary AM that accurately reflects disease and assesses pharmacological effects can be obtained using our established criteria.The inhibitory effect of NC on colorectal cancer lung metastasis may be attributed to its regulation of macrophage phenotype and glycolysis.展开更多
基金This study was jointly supported by the National Key R&D Program of China(Grant No.2021YFE0203100)the National Natural Science Foundation of China(No.82274154)the Technology Project of Haihe Laboratory of Modern Chinese Medicine(HH2022X1008).
基金This work was supported by the National Key Research and Development Program of China(Grant No:2021YFE0203100)National Natural Science Foundation of China(Grant Nos:81873089,81603253 and 81973570)+1 种基金Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No:ZYYCXTD-C-202009)Innovation Team and Talents Cultivation Program ofNational Administration ofTraditional Chinese Medicine(Grant No:ZYYCXTD-D-202002).
文摘Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Targeting mitosis is an effective method for cancer treatment.This review summarizes several natural products with anti-tumor effects related to mitosis,focusing on targeting microtubulin,inducing DNA damage,and modulating mitosis-associated kinases.Furthermore,the main disadvantages of several typical compounds,including drug resistance,toxicity to non-tumor tissues,and poor aqueous solubility and pharmacokinetic properties,are also discussed,together with strategies to address them.Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.
基金supported in part by the Natural Science Foundation of China under Grant 52177046,51991385,51807081 and 51937006in part by the China Postdoctoral Science Foundation under Project 2020T130256 and 2018M642178。
文摘This paper proposes a V-shaped permanent magnet vernier(V-PMV)motor for potential applications in direct drive system.By designing suitable pole slot ratio and adopting the V-shaped PM topology and dummy slots in rotor,the flux leakage can be avoided effectively.Meanwhile,the high-order harmonics with large amplitude in the airgap magnetic field are fully utilized and served as the effective working harmonics,which aim at enhancing the output torque and reducing the torque ripple.Moreover,to extensively explore the performance advantages of the V-PMV motor,a multi-objective optimization study is carried out.And,the electromagnetic performances of the V-PMV motors are analyzed and compared in detail.Finally,a prototype machine is built and tested.Both theoretical analysis and experimental results verify the validity of the motor and multi-objective optimization design approach.
文摘Malignant tumor has become a major threat affecting human health,and is one of the main causes of human death.Recent studies have shown that many traditional Chinese medicines(TCM)have good anti-tumor activity,which may improve the therapeutic effect of routine treatment and quality of life with lower toxicity.However,the efficacy of TCM alone for the treatment of tumors is limited.Metal ions are essential substances for maintaining normal physiological activities.This article summarized the multiple mechanisms in which metal ions are involved in the prevention and treatment of tumors in TCM.
基金China Postdoctoral Science Foundation(No.2023M732627 and No.2024T170657)Natural Science Foundation of Tianjin Municipality(No:23JCZXJC00150 and 23JCJQJC00040)supported this work。
文摘Objective:Alveolar macrophages(AMs)are involved in the development and progression of a variety of lung diseases.It is of great significance to explore the pathogenesis of diseases and evaluate the efficacy of drugs.However,there is no standard process for extracting primary AM.Nitidine chloride(NC)is an alkaloid extracted from Zanthoxylum nitidum(Roxb.)DC.,which has an antitumour pharmacological effect.However,there is no evidence that NC has a direct effect on colorectal cancer cell lung metastasis.The purpose of this study was to establish a standard for the extraction of primary AM from mice and to investigate the pharmacodynamics of NC in mice with lung metastases to colorectal cancer.Methods:The standard for the extraction of mouse primary AM by lavage was established.Western blot and polymerase chain reaction were used to detect the regulatory mechanism of NC in the treatment of lung metastasis in mice by macrophage phenotype and glycolysis level.Results:The results showed that sufficient quantity and quality of primary AM could be obtained by optimizing extraction steps,and AM obtained by this method could accurately reflect disease progression.At the same time,NC can effectively reduce colorectal cancer lung metastasis in mice.From the mechanism,NC can inhibit the expression of M2 macrophage markers and the levels of mRNA and proteins of the glycolysis-limiting enzyme.Conclusions:Our results show that primary AM that accurately reflects disease and assesses pharmacological effects can be obtained using our established criteria.The inhibitory effect of NC on colorectal cancer lung metastasis may be attributed to its regulation of macrophage phenotype and glycolysis.
