Selective laser melting(SLM)is an advanced additive manufacturing technique that enables the fabrication of complex metal components with high density,precision,and design flexibility.A novel Sc-free Al-4.58Mg-1.17Mn-...Selective laser melting(SLM)is an advanced additive manufacturing technique that enables the fabrication of complex metal components with high density,precision,and design flexibility.A novel Sc-free Al-4.58Mg-1.17Mn-1.59Zr-1.45Ti alloy was successfully fabricated via SLM,achieving a relative density of~99.89%.The microstructure of the as-fabricated alloy was characterized by scanning electron microscopy and transmission electron microscopy,which revealed refined equiaxed grains,a high density of low-angle grain boundaries and dislocation structures,as well as Mg segregation along grain boundaries.Additionally,a variety of dispersed precipitates were identified,including Mg-containing oxides,L1_(2)-Al_(3)(Ti_(x),Zr_(1−x)),and Al_(3)Zr particles.Room-temperature tensile tests showed that the alloy exhibits an excellent combination of strength and ductility,with a yield strength of 453.2±12 MPa,an ultimate tensile strength of 515.1±8 MPa,and an elongation of 22.5%±0.3%.The high strength was attributed to the combined effects of grain boundary strengthening,solid solution strengthening,precipitation strengthening,and dislocation strengthening.The developed Sc-free Al-Mg-Mn-Zr-Ti alloy demonstrates significant potential as an economical high-strength lightweight material for SLM-based manufacturing applications.展开更多
This paper reports on the time and frequency standard system for the Five-hundred meter Aperture Spherical radio Telescope(FAST),including the system design,stability measurements and pulsar timing observations.The st...This paper reports on the time and frequency standard system for the Five-hundred meter Aperture Spherical radio Telescope(FAST),including the system design,stability measurements and pulsar timing observations.The stability and drift rate of the frequency standard are calculated using 1-year monitoring data.The UTC-NIM Disciplined Oscillator(NIMDO)system improves the system time accuracy and stability to the level of 5 ns.Pulsar timing observations were carried out for several months.The weighted RMS of timing residuals reaches the level of less than 3.0μs.展开更多
AIM: To implement high-throughput 16S rDNA sequencing to study microbial diversity in the fecal matter of rats with acute lung injury/acute respiratory distress syndrome (ALI/ARDS).
As the most sensitive single-dish radio telescope,the Five-hundred Aperture Spherical radio Telescope(FAST)is very susceptive to radio frequency interference(RFI)from active radio services.Moreover,due to the rapid de...As the most sensitive single-dish radio telescope,the Five-hundred Aperture Spherical radio Telescope(FAST)is very susceptive to radio frequency interference(RFI)from active radio services.Moreover,due to the rapid development of space applications and research,satellite interference has become one of the main RFI sources for FAST,particularly at the L band.Therefore,we have developed several measures to mitigate satellite RFI.On the one hand,an antenna with 4.5-meter diameter has been constructed and installed at the FAST site to detect the satellite interference in the frequency band between 1 to 5 GHz.Meanwhile,we have developed a satellite RFI database based on the FAST sky coverage,the observing frequency bands,and known satellite systems.By combining the satellite RFI monitoring antenna and the database,we have established a satellite RFI mitigation system.With this system,we can not only track satellites to collect their characteristics and update the database but also help the observer to program the observing plan by predicting satellite interference.During the practical observation of FAST at the L band,the feasibility of this system to mitigate satellite RFI has been proved.In particular,the system effectively avoids strong satellite interference from entering the main beam of the telescope and causing receiver saturation.展开更多
Silicon(Si)particles were functionalized using carbon dots(CDs)to enhance the interaction between the Si particles and the binders.First,CDs rich in polar groups were synthesized using a simple hydrothermal method.The...Silicon(Si)particles were functionalized using carbon dots(CDs)to enhance the interaction between the Si particles and the binders.First,CDs rich in polar groups were synthesized using a simple hydrothermal method.Then,CDs were loaded on the Si surface by impregnation to obtain the functionalized Si particles(Si/CDs).The phases and microstructures of the Si/CDs were observed using Fourier-transform infrared reflection,X-ray diffraction,scanning electron microscopy,and high-resolution transmission electron microscopy.Si/CDs were used as the active material of the anode for electrochemical performance experiments.The electrochemical performance of the Si/CD electrode was assessed using cyclic voltammetry,electrochemical impedance spectroscopy,and constant current charge and discharge experiment.The electrodes prepared with Si/CDs showed good mechanical structure stability and electrochemical performance.After 150 cycles at 0.2 C,the capacity retention rate of the Si/CD electrode was 64.0%,which is twice as much as that of pure Si electrode under the same test conditions.展开更多
We report the properties of more than 800 bursts detected from the repeating fast radio burst(FRB)source FRB20201124A with the Five-hundred-meter Aperture Spherical radio Telescope(FAST)during an extremely active epis...We report the properties of more than 800 bursts detected from the repeating fast radio burst(FRB)source FRB20201124A with the Five-hundred-meter Aperture Spherical radio Telescope(FAST)during an extremely active episode on UTC 2021 September 25–28 in a series of four papers.In this second paper of the series,we study the energy distribution of 881 bursts(defined as significant signals separated by dips down to the noise level)detected in the first four days of our 19 hr observational campaign spanning 17 days.The event rate initially increased exponentially but the source activity stopped within 24 hr after the 4th day.The detection of 542 bursts in one hour during the fourth day marked the highest event rate detected from one single FRB source so far.The bursts have complex structures in the time-frequency space.We find a double-peak distribution of the waiting time,which can be modeled with two log-normal functions peaking at 51.22 ms and 10.05 s,respectively.Compared with the emission from a previous active episode of the source detected with FAST,the second distribution peak time is smaller,suggesting that this peak is defined by the activity level of the source.We calculate the isotropic energy of the bursts using both a partial bandwidth and a full bandwidth and find that the energy distribution is not significantly changed.We find that an exponentially connected broken-power law function can fit the cumulative burst energy distribution well,with the lower and higher-energy indices being-1.22±0.01 and-4.27±0.23,respectively.Assuming a radio radiative efficiency ofη_(r)=10^(-4),the total isotropic energy of the bursts released during the four days when the source was active is already 3.9×10^(46)erg,exceeding~23%of the available magnetar dipolar magnetic energy.This challenges the magnetar models which invoke an inefficient radio emission(e.g.,synchrotron maser models).展开更多
We report the properties of more than 800 bursts detected from the repeating fast radio burst(FRB)source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio Telescope during an extremely active episode ...We report the properties of more than 800 bursts detected from the repeating fast radio burst(FRB)source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio Telescope during an extremely active episode on UTC 2021 September 25th-28th in a series of four papers.In this fourth paper of the series,we present a systematic search of the spin period and linear acceleration of the source object from both 996 individual pulse peaks and the dedispersed time series.No credible spin period was found from this data set.We rule out the presence of significant periodicity in the range between 1 ms and 100 s with a pulse duty cycle<0.49±0.08(when the profile is defined by a von-Mises function,not a boxcar function)and linear acceleration up to 300 m s^(-2)in each of the four one-hour observing sessions,and up to 0.6 m s^(-2)in all 4 days.These searches contest theoretical scenarios involving a 1 ms–100 s isolated magnetar/pulsar with surface magnetic field<10^(15)G and a small duty cycle(such as in a polar-cap emission mode)or a pulsar with a companion star or black hole up to 100 M_(⊙)and P_(b)>10 hr.We also perform a periodicity search of the fine structures and identify 53 unrelated millisecond-timescale“periods”in multicomponents with the highest significance of 3.9σ.The“periods”recovered from the fine structures are neither consistent nor harmonically related.Thus they are not likely to come from a spin period.We caution against claiming spin periodicity with significance below~4σwith multi-components from one-off FRBs.We discuss the implications of our results and the possible connections between FRB multi-components and pulsar microstructures.展开更多
3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomi...3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomic layer deposition technique was used to deposit nanometer-thick zinc oxide(ZnO)layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores.The effect of ZnO thin film on the in vitro degradation behavior,antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated.The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds.The thickness of ZnO thin film could be easily controlled by the deposition cycles.The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus,while did not significantly affect cytocompatibility and could also promote cell adhesion.展开更多
The evolution of microstructure,texture,and magnetic properties with random texture,near-copper texture,weak near-cube texture,and strong λ fiber(<001>/ND(normal direction))before rolling of non-oriented electr...The evolution of microstructure,texture,and magnetic properties with random texture,near-copper texture,weak near-cube texture,and strong λ fiber(<001>/ND(normal direction))before rolling of non-oriented electrical steel was studied.Three recrystallized hot bands with different textures but similar grain sizes were prepared by pre-annealing at low-temperature and high-temperature normalization annealing.It was observed that the final annealed products exhibited similar recrystallized microstructures.By contrast,the final annealed product with more 2 fiber before rolling exhibited a stronger cube texture.With the fiber before rolling becoming stronger,the proportion of(111)<110>deformed matrices became larger,which could be observed in the early recrystallization stage.The overwhelmingly dominant 2 orientation nuclei are formed in the(111)<110>deformed matrix and become the dominant texture.Eventually,the best magnetic properties are obtained in the products with strong 2 fiber before rolling,corresponding to the strong cube texture and low anisotropyparameter.展开更多
We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polar...We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polarization profile of this millisecond pulsar(MSP) using the Five-hundred-meter Aperture Spherical radio Telescope(FAST), the Green Bank Telescope(GBT), and the Parkes Telescope. For the first time from such a system, an oscillatory polarization angle change was observed from a particular eclipse egress with partial depolarization, indicating 10-milliGauss-level reciprocating magnetic fields oscillating in a length scale of 5 ×10^(3)km(assuming an orbital inclination angle of 90°) outside the companion's magnetosphere. The dispersion measure variation observed during the ingresses and egresses shows the rapid raising of the electron density in the shock boundary between the companion's magnetosphere and the surrounding pulsar wind. We suggest that the observed oscillatory magnetic fields originate from the pulsar wind outside the companion's magnetosphere.展开更多
We present Arecibo 327 MHz confirmation and follow-up studies of seven new pulsars discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST).These pulsars are discovered in a pilot program of the C...We present Arecibo 327 MHz confirmation and follow-up studies of seven new pulsars discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST).These pulsars are discovered in a pilot program of the Commensal Radio Astronomy FAST Survey(CRAFTS)with the ultra-widebandwidth commissioning receiver.Five of them are normal pulsars and two are extreme nulling slow pulsars.PSR J2111+2132’s dispersion measure(DM:78.5 pc cm^(-3))is above the upper limits of the two Galactic free electron density models,NE2001 and YMW16,and PSR J2057+2133’s position is out of the Scutum-Crux Arm,making them uniquely useful for improving the Galactic free electron density model in their directions.We present a detailed single pulse analysis for the slow nulling pulsars.We show evidence that PSR J2323+1214’s main pulse component follows a non-Poisson distribution and marginal evidence for a sub-pulse-drift or recurrent period of 32.3±0.4 rotations from PSR J0539+0013.We discuss the implication of our finding to the pulsar radiation mechanism.展开更多
Radio frequency interference(RFI)is an important challenge in radio astronomy.RFI comes from various sources and increasingly impacts astronomical observation as telescopes become more sensitive.In this study,we propo...Radio frequency interference(RFI)is an important challenge in radio astronomy.RFI comes from various sources and increasingly impacts astronomical observation as telescopes become more sensitive.In this study,we propose a fast and effective method for removing RFI in pulsar data.We use pseudo-inverse learning to train a single hidden layer auto-encoder(AE).We demonstrate that the AE can quickly learn the RFI signatures and then remove them from fast-sampled spectra,leaving real pulsar signals.This method has the advantage over traditional threshold-based filter method in that it does not completely remove contaminated channels,which could also contain useful astronomical information.展开更多
The precipitation behavior of FeTiP in interstitial free high strength（IFHS）steels has been studied by using a transmission electron microscope（TEM）.The results show that the TiC particles,appearing at earlier sta...The precipitation behavior of FeTiP in interstitial free high strength（IFHS）steels has been studied by using a transmission electron microscope（TEM）.The results show that the TiC particles,appearing at earlier stage,are more stable than the FeTiP ones during recrystallization annealing at the two given temperatures（810℃ and 840℃）.Therefore,the FeTiP particles can only be observed in the steels with sufficient amount of Ti.There is a critical forming time for the FeTiP,which is between 90-120 sat 810 ℃ and 60-90 sat 840 ℃.The precipitation of FeTiP involves two steps,i.e.the formation of FeTi precursors and the diffusion of P.The former step determines the reliance of Ti content for the precipitation of FeTiP,whereas the latter step leads to the difference in the critical annealing time.展开更多
As the third paper in the multiple-part series,we report the statistical properties of radio bursts detected from the repeating fast radio burst(FRB)source FRB 20201124A with the Five-hundred-meter Aperture Spherical ...As the third paper in the multiple-part series,we report the statistical properties of radio bursts detected from the repeating fast radio burst(FRB)source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio Telescope during an extremely active episode between the 25th and 28th of September 2021(UT).We focus on the polarization properties of536 bright bursts with S/N>50.We found that the Faraday rotation measures(RMs)monotonically dropped from-579to-605 rad m^(-2)in the 4 day window.The RM values were compatible with the values(-300 to-900 rad m^(-2))reported 4 months ago.However,the RM evolution rate in the current observation window was at least an order of magnitude smaller than the one(~500 rad m^(-2)day^(-1))previously reported during the rapid RM-variation phase,but is still higher than the one(≤1 rad m^(-2)day^(-1))during the later RM no-evolution phase.The bursts of FRB 20201124A were highly polarized with the total degree of polarization(circular plus linear)greater than 90%for more than 90%of all bursts.The distribution of linear polarization position angles(PAs),degree of linear polarization(L/I)and degree of circular polarization(V/I)can be characterized with unimodal distribution functions.During the observation window,the distributions became wider with time,i.e.,with larger scatter,but the centroids of the distribution functions remained nearly constant.For individual bursts,significant PA variations(confidence level 5σ)were observed in 33%of all bursts.The polarization of single pulses seems to follow certain complex trajectories on the Poincarésphere,which may shed light on the radiation mechanism at the source or the plasma properties along the path of FRB propagation.展开更多
Fast radio bursts(FRBs) are extremely strong radio flares lasting several milliseconds,most of which come from unidentified objects at a cosmological distance.They can be apparently repeating or not.In this paper,we a...Fast radio bursts(FRBs) are extremely strong radio flares lasting several milliseconds,most of which come from unidentified objects at a cosmological distance.They can be apparently repeating or not.In this paper,we analyzed 18 repeaters and 12 non-repeating FRBs observed in the frequency bands of 400–800 MHz from Canadian Hydrogen Intensity Mapping Experiment(CHIME).We investigated the distributions of FRB isotropic-equivalent radio luminosity,considering the K correction.Statistically,the luminosity distribution can be better fitted by Gaussian form than by power-law.Based on the above results,together with the observed FRB event rate,pulse duration,and radio luminosity,FRB origin models are evaluated and constrained such that the gamma-ray bursts(GRBs) may be excluded for the non-repeaters while magnetars or neutron stars(NSs) emitting the supergiant pulses are preferred for the repeaters.We also found the necessity of a small FRB emission beaming solid angle(about 0.1 sr) from magnetars that should be considered,and/or the FRB association with soft gamma-ray repeaters(SGRs) may lie at a low probability of about 10%.Finally,we discussed the uncertainty of FRB luminosity caused by the estimation of the distance that is inferred by the simple relation between the redshift and dispersion measure(DM).展开更多
In this paper,we present the Five-hundred-meter Aperture Spherical radio Telescope(FAST)observations of PSRs B1929+10 and B1842+14.Through analysis of the pulsars’scintillation pattern,we detected the known scintilla...In this paper,we present the Five-hundred-meter Aperture Spherical radio Telescope(FAST)observations of PSRs B1929+10 and B1842+14.Through analysis of the pulsars’scintillation pattern,we detected the known scintillation arc from PSR B1929+10 and two previously undetected scintillation arcs from B1842+14.We find that the B1929+10 arc’s curvature scales with observing frequency asη-∝ν-2.1±0.1 andη+∝ν-1.8±0.2,consistent with Arecibo results and the theoretical expectations ofη∝ν-2.From the arc curvature,we infer the scattering screen to be located at 0.20±0.02 kpc from the Earth,close to what was measured by RadioAstron at 324 MHz.From B1842+14,we find two scintillation arcs for the first time.The arcs’curvatures imply that they are caused by two scattering screens located at a distance of 0.3±0.2 kpc and 1.6±0.6 kpc from the Earth,respectively.The screen distance uncertainties mainly come from the uncertainty in pulsar’s dispersion measure(DM)-derived distance.We present these FAST scintillation observations and discuss the future prospect of FAST pulsar scintillation study.展开更多
Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, ...Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope(FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected for any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided. The dataset is available in Science Data Bank, with the link https://www.doi.org/10.57760/sciencedb.j00113.00076.展开更多
Precise measurements of neutron star(NS)velocities provide critical clues in regard to the supernova physics and evolution of binary systems.Based on Gaia Data Release 2(DR2),we selected a sample of 24 young(<3 Myr...Precise measurements of neutron star(NS)velocities provide critical clues in regard to the supernova physics and evolution of binary systems.Based on Gaia Data Release 2(DR2),we selected a sample of 24 young(<3 Myr)pulsars with precise parallax measurements and measured the velocity of their local standard of rest(LSR)and the velocity dispersion among their respective local stellar groups.The median velocity difference between thus calculated LSRs and the Galactic rotation model is~7.6 km s^(-1),small compared to the typical velocity dispersion of~27.5 km s^(-1).For pulsars off the Galactic plane,such differences grow significantly to as large as~40 km s^(-1).More importantly,the velocity dispersion of stars in the local group of low-velocity pulsars can be comparable to their transverse velocities,suggesting that the intrinsic velocities of NS progenitors should be taken into account when we consider their natal kicks and binary evolution.We also examined the double NS system J0737-3039 A/B,and measured its transverse velocity to be 26-13+18 km s^(-1)assuming nearby Gaia sources are representative of their birth environment.This work demonstrated the feasibility and importance of using Gaia data to study the velocity of individual systems and velocity distribution of NSs.展开更多
BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotio...BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and behavior.AIM To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective treatments.METHODS This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same period.The expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance spectroscopy.The recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive function.The correlation between GABA receptor subunit downregulation and schizophrenia was also analyzed.RESULTS Significant differences in GABA receptor subunit levels were found between the case and control groups(P<0.05).A significant difference was also found between the case and control groups in terms of cognitive function measures,including attention/alertness and learning ability(P<0.05).Specifically,as the expression levels of GABRA1(α1 subunit gene),GABRB2(β2 subunit gene),GABRD(δsubunit),and GABRE(εsubunit)decreased,the severity of the patients’condition increased gradually,indicating a positive correlation between the downregulation of these 4 receptor subunits and schizophrenia(P<0.05).However,the expression levels of GABRA5(α5 subunit gene)and GABRA6(α6 subunit gene)showed no significant correlation with schizophrenia(P>0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with schizophrenia.In other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.展开更多
基金supported by the Jilin Scientific and Technological Development Program(No.20240302108GX)the National Natural Science Foundation of China(Nos.51974032,52174355,51874043,and 51604034).
文摘Selective laser melting(SLM)is an advanced additive manufacturing technique that enables the fabrication of complex metal components with high density,precision,and design flexibility.A novel Sc-free Al-4.58Mg-1.17Mn-1.59Zr-1.45Ti alloy was successfully fabricated via SLM,achieving a relative density of~99.89%.The microstructure of the as-fabricated alloy was characterized by scanning electron microscopy and transmission electron microscopy,which revealed refined equiaxed grains,a high density of low-angle grain boundaries and dislocation structures,as well as Mg segregation along grain boundaries.Additionally,a variety of dispersed precipitates were identified,including Mg-containing oxides,L1_(2)-Al_(3)(Ti_(x),Zr_(1−x)),and Al_(3)Zr particles.Room-temperature tensile tests showed that the alloy exhibits an excellent combination of strength and ductility,with a yield strength of 453.2±12 MPa,an ultimate tensile strength of 515.1±8 MPa,and an elongation of 22.5%±0.3%.The high strength was attributed to the combined effects of grain boundary strengthening,solid solution strengthening,precipitation strengthening,and dislocation strengthening.The developed Sc-free Al-Mg-Mn-Zr-Ti alloy demonstrates significant potential as an economical high-strength lightweight material for SLM-based manufacturing applications.
基金supported by the Joint Research Fund in Astronomy(Grant Nos.U1931129,U1631115 and U1831117)under cooperative agreement between NSFC and Chinese Academy of Sciences(CAS)NSFC-STINT Grant 11611130023(CH2015-6360)the National Natural Science Foundation of China(NSFC,Grant No.11403054)
文摘This paper reports on the time and frequency standard system for the Five-hundred meter Aperture Spherical radio Telescope(FAST),including the system design,stability measurements and pulsar timing observations.The stability and drift rate of the frequency standard are calculated using 1-year monitoring data.The UTC-NIM Disciplined Oscillator(NIMDO)system improves the system time accuracy and stability to the level of 5 ns.Pulsar timing observations were carried out for several months.The weighted RMS of timing residuals reaches the level of less than 3.0μs.
基金Grants from the Science and Technology Development Plan of Shandong Province and Taishan Scholar project of Shandong Province
文摘AIM: To implement high-throughput 16S rDNA sequencing to study microbial diversity in the fecal matter of rats with acute lung injury/acute respiratory distress syndrome (ALI/ARDS).
基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23000000)the National Key Research and Development Program(No.2019YFB1312704)+2 种基金the National Natural Science Foundation of China(Program No.U1831128)the International Partnership Program of Chinese Academy of Sciences(Program No.114A11KYSB20160008)supported by the National Development and Reform Commission,the Key Laboratory of FAST of CAS。
文摘As the most sensitive single-dish radio telescope,the Five-hundred Aperture Spherical radio Telescope(FAST)is very susceptive to radio frequency interference(RFI)from active radio services.Moreover,due to the rapid development of space applications and research,satellite interference has become one of the main RFI sources for FAST,particularly at the L band.Therefore,we have developed several measures to mitigate satellite RFI.On the one hand,an antenna with 4.5-meter diameter has been constructed and installed at the FAST site to detect the satellite interference in the frequency band between 1 to 5 GHz.Meanwhile,we have developed a satellite RFI database based on the FAST sky coverage,the observing frequency bands,and known satellite systems.By combining the satellite RFI monitoring antenna and the database,we have established a satellite RFI mitigation system.With this system,we can not only track satellites to collect their characteristics and update the database but also help the observer to program the observing plan by predicting satellite interference.During the practical observation of FAST at the L band,the feasibility of this system to mitigate satellite RFI has been proved.In particular,the system effectively avoids strong satellite interference from entering the main beam of the telescope and causing receiver saturation.
基金financially supported by the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,China(No.2019R01006)the National Key R&D Program of China(Grant No.2018YFB0104300).
文摘Silicon(Si)particles were functionalized using carbon dots(CDs)to enhance the interaction between the Si particles and the binders.First,CDs rich in polar groups were synthesized using a simple hydrothermal method.Then,CDs were loaded on the Si surface by impregnation to obtain the functionalized Si particles(Si/CDs).The phases and microstructures of the Si/CDs were observed using Fourier-transform infrared reflection,X-ray diffraction,scanning electron microscopy,and high-resolution transmission electron microscopy.Si/CDs were used as the active material of the anode for electrochemical performance experiments.The electrochemical performance of the Si/CD electrode was assessed using cyclic voltammetry,electrochemical impedance spectroscopy,and constant current charge and discharge experiment.The electrodes prepared with Si/CDs showed good mechanical structure stability and electrochemical performance.After 150 cycles at 0.2 C,the capacity retention rate of the Si/CD electrode was 64.0%,which is twice as much as that of pure Si electrode under the same test conditions.
基金supported by the National Natural Science Foundation of China(NSFC,Grant Nos.11988101 and 11725313)supported by the Open Project Program of the Key Laboratory of FAST,Chinese Academy of Sciences+11 种基金support from the National Natural Science Foundation of China(NSFC,Grant No.U2031117)the Youth Innovation Promotion Association CAS(id.2021055)CAS Project for Young Scientists in Basic Research(grant YSBR-006)the Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CASsupported by the Key Research Project of Zhejiang Lab No.2021PE0AC0supported by the National Natural Science Foundation of China(NSFC,Grant Nos.11988101 and 11833009)the Key Research Program of the Chinese Academy of Sciences(Grant No.QYZDJ-SSWSLH021)supported by the Cultivation Project for the FAST scientific Payoff and Research Achievement of CAMSCASsupported by National SKA Program of China 2020SKA0120200National Natural Science Foundation of China(NSFC,Grant No.12041303)the CAS-MPG LEGACY projectfunding from the MaxPlanck Partner Group。
文摘We report the properties of more than 800 bursts detected from the repeating fast radio burst(FRB)source FRB20201124A with the Five-hundred-meter Aperture Spherical radio Telescope(FAST)during an extremely active episode on UTC 2021 September 25–28 in a series of four papers.In this second paper of the series,we study the energy distribution of 881 bursts(defined as significant signals separated by dips down to the noise level)detected in the first four days of our 19 hr observational campaign spanning 17 days.The event rate initially increased exponentially but the source activity stopped within 24 hr after the 4th day.The detection of 542 bursts in one hour during the fourth day marked the highest event rate detected from one single FRB source so far.The bursts have complex structures in the time-frequency space.We find a double-peak distribution of the waiting time,which can be modeled with two log-normal functions peaking at 51.22 ms and 10.05 s,respectively.Compared with the emission from a previous active episode of the source detected with FAST,the second distribution peak time is smaller,suggesting that this peak is defined by the activity level of the source.We calculate the isotropic energy of the bursts using both a partial bandwidth and a full bandwidth and find that the energy distribution is not significantly changed.We find that an exponentially connected broken-power law function can fit the cumulative burst energy distribution well,with the lower and higher-energy indices being-1.22±0.01 and-4.27±0.23,respectively.Assuming a radio radiative efficiency ofη_(r)=10^(-4),the total isotropic energy of the bursts released during the four days when the source was active is already 3.9×10^(46)erg,exceeding~23%of the available magnetar dipolar magnetic energy.This challenges the magnetar models which invoke an inefficient radio emission(e.g.,synchrotron maser models).
基金supported by the National SKA Program of China(Nos.2020SKA0120200 and 2020SKA0120100)the National Natural Science Foundation of China(Grant Nos.12041303,11873067 and 12041304)+4 种基金the National Key R&D Program of China(Nos.2017YFA0402600,2021YFA0718500 and 2017YFA0402602)the CAS-MPG LEGACY project,the Max-Planck Partner Group,the Key Research Project of Zhejiang Lab(No.2021PE0AC0)supported by the National Natural Science Foundation of China(NSFC,Nos.11988101 and 11833009)the Key Research Program of the Chinese Academy of Sciences(Grant No.QYZDJ-SSWSLH021)supported by the Cultivation Project for the FAST scientific Payoff and Research Achievement of CAMS-CAS。
文摘We report the properties of more than 800 bursts detected from the repeating fast radio burst(FRB)source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio Telescope during an extremely active episode on UTC 2021 September 25th-28th in a series of four papers.In this fourth paper of the series,we present a systematic search of the spin period and linear acceleration of the source object from both 996 individual pulse peaks and the dedispersed time series.No credible spin period was found from this data set.We rule out the presence of significant periodicity in the range between 1 ms and 100 s with a pulse duty cycle<0.49±0.08(when the profile is defined by a von-Mises function,not a boxcar function)and linear acceleration up to 300 m s^(-2)in each of the four one-hour observing sessions,and up to 0.6 m s^(-2)in all 4 days.These searches contest theoretical scenarios involving a 1 ms–100 s isolated magnetar/pulsar with surface magnetic field<10^(15)G and a small duty cycle(such as in a polar-cap emission mode)or a pulsar with a companion star or black hole up to 100 M_(⊙)and P_(b)>10 hr.We also perform a periodicity search of the fine structures and identify 53 unrelated millisecond-timescale“periods”in multicomponents with the highest significance of 3.9σ.The“periods”recovered from the fine structures are neither consistent nor harmonically related.Thus they are not likely to come from a spin period.We caution against claiming spin periodicity with significance below~4σwith multi-components from one-off FRBs.We discuss the implications of our results and the possible connections between FRB multi-components and pulsar microstructures.
基金This work was financially supported by the Natural Science Foundation of Guangdong(No.2019A1515011755)China.The authors acknowledge the assistance of SUSTech Core Research Facilities that receives support from Presidential Fund and Development and Reform Commission of Shenzhen Municipality.
文摘3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomic layer deposition technique was used to deposit nanometer-thick zinc oxide(ZnO)layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores.The effect of ZnO thin film on the in vitro degradation behavior,antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated.The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds.The thickness of ZnO thin film could be easily controlled by the deposition cycles.The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus,while did not significantly affect cytocompatibility and could also promote cell adhesion.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.52174355,51701021,51974032,and 51604034)the China Postdoctoral Science Foundation funded project(Grant Nos.2022T150074 and 2021M693904)the Science and Technology Development Program of Jilin Province(Grant No.20230201149GX).
文摘The evolution of microstructure,texture,and magnetic properties with random texture,near-copper texture,weak near-cube texture,and strong λ fiber(<001>/ND(normal direction))before rolling of non-oriented electrical steel was studied.Three recrystallized hot bands with different textures but similar grain sizes were prepared by pre-annealing at low-temperature and high-temperature normalization annealing.It was observed that the final annealed products exhibited similar recrystallized microstructures.By contrast,the final annealed product with more 2 fiber before rolling exhibited a stronger cube texture.With the fiber before rolling becoming stronger,the proportion of(111)<110>deformed matrices became larger,which could be observed in the early recrystallization stage.The overwhelmingly dominant 2 orientation nuclei are formed in the(111)<110>deformed matrix and become the dominant texture.Eventually,the best magnetic properties are obtained in the products with strong 2 fiber before rolling,corresponding to the strong cube texture and low anisotropyparameter.
基金The Parkes Radio Telescope (Murriyang) is part of the Australia Telescope National Facility, which is funded by the Australian Government for operation as a National Facility managed by CSIROsupported by the National Natural Science Foundation of China (NSFC) grant Nos. 12041303, 12041304, 11873067, 12133004, 12203045, 12203070, 12203072, 12103013, U2031117 and T2241020+11 种基金the CAS-MPG LEGACY project and the National SKA Program of China No. 2020SKA0120200the Foundation of Science and Technology of Guizhou Province No. ((2021)023)the Foundation of Guizhou Provincial Education Department (No.KY(2021)303)the National Key Research and Development Program of China Nos. 2022YFC2205202 and 2022YFC2205203the Major Science and Technology Program of Xinjiang Uygur Autonomous Region Nos. 2022A03013-1, 2022A03013-3 and 2022A03013-4the National Key Research and Development Program of China No. 2022YFC2205203the 2021 project Xinjiang Uygur autonomous region of China for Tianshan elites and the Youth Innovation Promotion Association of CAS under No. 2023069support from the Youth Innovation Promotion Association CAS (id. 2021055)CAS Project for Young Scientists in Basic Research (grant YSBR-006)the Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CASsupport from Zhejiang Provincial Natural Science Foundation of China under grant No. LY23A030001supported by the NSF Physics Frontiers Center award number 2020265。
文摘We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polarization profile of this millisecond pulsar(MSP) using the Five-hundred-meter Aperture Spherical radio Telescope(FAST), the Green Bank Telescope(GBT), and the Parkes Telescope. For the first time from such a system, an oscillatory polarization angle change was observed from a particular eclipse egress with partial depolarization, indicating 10-milliGauss-level reciprocating magnetic fields oscillating in a length scale of 5 ×10^(3)km(assuming an orbital inclination angle of 90°) outside the companion's magnetosphere. The dispersion measure variation observed during the ingresses and egresses shows the rapid raising of the electron density in the shock boundary between the companion's magnetosphere and the surrounding pulsar wind. We suggest that the observed oscillatory magnetic fields originate from the pulsar wind outside the companion's magnetosphere.
基金supported by the National Natural Science Foundation of China(Grant Nos.11988101,U2031117,11725313,12041303,11873067,U1831131 and U1631132)the China Scholarship Council(No.201704910686)+4 种基金the CASMPG LEGACY projectthe Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23000000)the National SKA Program of China(No.2020SKA0120200)the Foundation of Guizhou Provincial Education Department(No.KY(2020)003)the Cultivation Project for FAST Scientific Payoff and the Research Achievement of CAMS-CAS。
文摘We present Arecibo 327 MHz confirmation and follow-up studies of seven new pulsars discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST).These pulsars are discovered in a pilot program of the Commensal Radio Astronomy FAST Survey(CRAFTS)with the ultra-widebandwidth commissioning receiver.Five of them are normal pulsars and two are extreme nulling slow pulsars.PSR J2111+2132’s dispersion measure(DM:78.5 pc cm^(-3))is above the upper limits of the two Galactic free electron density models,NE2001 and YMW16,and PSR J2057+2133’s position is out of the Scutum-Crux Arm,making them uniquely useful for improving the Galactic free electron density model in their directions.We present a detailed single pulse analysis for the slow nulling pulsars.We show evidence that PSR J2323+1214’s main pulse component follows a non-Poisson distribution and marginal evidence for a sub-pulse-drift or recurrent period of 32.3±0.4 rotations from PSR J0539+0013.We discuss the implication of our finding to the pulsar radiation mechanism.
基金the National Natural Science Foundation of China(NSFC,Grant Nos.11988101,61472043,11743002,11873067,11690024,11673005 and 11725313)the Outstanding Youth Fund Project of Natural Science Fund of Shandong Province(Grant No.ZR2019YQ03)+1 种基金supported by the Joint Research Fund in Astronomy(U1531242)under cooperative agreement between the NSFC and the Chinese Academy of Sciences(CAS)supported by the Chinese Academy of Science Pioneer Hundred Talents Programthe Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23000000)。
文摘Radio frequency interference(RFI)is an important challenge in radio astronomy.RFI comes from various sources and increasingly impacts astronomical observation as telescopes become more sensitive.In this study,we propose a fast and effective method for removing RFI in pulsar data.We use pseudo-inverse learning to train a single hidden layer auto-encoder(AE).We demonstrate that the AE can quickly learn the RFI signatures and then remove them from fast-sampled spectra,leaving real pulsar signals.This method has the advantage over traditional threshold-based filter method in that it does not completely remove contaminated channels,which could also contain useful astronomical information.
基金Item Sponsored by National Natural Science Foundation of China(50901054,51101114)
文摘The precipitation behavior of FeTiP in interstitial free high strength（IFHS）steels has been studied by using a transmission electron microscope（TEM）.The results show that the TiC particles,appearing at earlier stage,are more stable than the FeTiP ones during recrystallization annealing at the two given temperatures（810℃ and 840℃）.Therefore,the FeTiP particles can only be observed in the steels with sufficient amount of Ti.There is a critical forming time for the FeTiP,which is between 90-120 sat 810 ℃ and 60-90 sat 840 ℃.The precipitation of FeTiP involves two steps,i.e.the formation of FeTi precursors and the diffusion of P.The former step determines the reliance of Ti content for the precipitation of FeTiP,whereas the latter step leads to the difference in the critical annealing time.
基金supported by the National SKA Program of China(2020SKA0120100,2020SKA0120200)the National Key R&D Program of China(2017YFA0402602)+7 种基金the National Natural Science Foundation of China(NSFC,Grant No.12041303)the CAS-MPG LEGACY project and funding from the Max-Planck Partner Groupsupported by the National Natural Science Foundation of China(NSFC,Grant Nos.11988101 and 11833009)the Key Research Program of the Chinese Academy of Sciences(Grant No.QYZDJ-SSW-SLH021supported by the Cultivation Project for the FAST scientific Payoff and Research Achievement of CAMS-CASsupported by the Key Research Project of Zhejiang Lab no.2021PE0AC0supported by National Natural Science Foundation of China(Grant No.12003028)the China Manned Spaced Project(CMS-CSST-2021-B11)。
文摘As the third paper in the multiple-part series,we report the statistical properties of radio bursts detected from the repeating fast radio burst(FRB)source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio Telescope during an extremely active episode between the 25th and 28th of September 2021(UT).We focus on the polarization properties of536 bright bursts with S/N>50.We found that the Faraday rotation measures(RMs)monotonically dropped from-579to-605 rad m^(-2)in the 4 day window.The RM values were compatible with the values(-300 to-900 rad m^(-2))reported 4 months ago.However,the RM evolution rate in the current observation window was at least an order of magnitude smaller than the one(~500 rad m^(-2)day^(-1))previously reported during the rapid RM-variation phase,but is still higher than the one(≤1 rad m^(-2)day^(-1))during the later RM no-evolution phase.The bursts of FRB 20201124A were highly polarized with the total degree of polarization(circular plus linear)greater than 90%for more than 90%of all bursts.The distribution of linear polarization position angles(PAs),degree of linear polarization(L/I)and degree of circular polarization(V/I)can be characterized with unimodal distribution functions.During the observation window,the distributions became wider with time,i.e.,with larger scatter,but the centroids of the distribution functions remained nearly constant.For individual bursts,significant PA variations(confidence level 5σ)were observed in 33%of all bursts.The polarization of single pulses seems to follow certain complex trajectories on the Poincarésphere,which may shed light on the radiation mechanism at the source or the plasma properties along the path of FRB propagation.
基金supported by the National Natural Science Foundation of China (Grant Nos.11988101,U1938117,U1731238,11703003 and 11725313)the International Partnership Program of Chinese Academy of Sciences (Grant No.114A11KYSB20160008)+1 种基金the National Key R&D Program of China (No.2016YFA0400702)the Guizhou Provincial Science and Technology Foundation (Grant No.[2020]1Y019)。
文摘Fast radio bursts(FRBs) are extremely strong radio flares lasting several milliseconds,most of which come from unidentified objects at a cosmological distance.They can be apparently repeating or not.In this paper,we analyzed 18 repeaters and 12 non-repeating FRBs observed in the frequency bands of 400–800 MHz from Canadian Hydrogen Intensity Mapping Experiment(CHIME).We investigated the distributions of FRB isotropic-equivalent radio luminosity,considering the K correction.Statistically,the luminosity distribution can be better fitted by Gaussian form than by power-law.Based on the above results,together with the observed FRB event rate,pulse duration,and radio luminosity,FRB origin models are evaluated and constrained such that the gamma-ray bursts(GRBs) may be excluded for the non-repeaters while magnetars or neutron stars(NSs) emitting the supergiant pulses are preferred for the repeaters.We also found the necessity of a small FRB emission beaming solid angle(about 0.1 sr) from magnetars that should be considered,and/or the FRB association with soft gamma-ray repeaters(SGRs) may lie at a low probability of about 10%.Finally,we discussed the uncertainty of FRB luminosity caused by the estimation of the distance that is inferred by the simple relation between the redshift and dispersion measure(DM).
基金supported by the CAS“Light of West China”Program 2017-XBQNXZ-B-022the“Tianchi Doctoral Program 2017”+4 种基金the CAS International Partnership Program(No.114A11KYSB20160008)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23000000)supported by the National Natural Science Foundation of China(Grant Nos.61472043,11743002,11873067,11690024,11725313 and U1831104)supported by the Chinese Academy of Science Pioneer Hundred Talents Programsupported by Special Funding for Advanced Users,budgeted and administrated by Center for Astronomical MegaScience,Chinese Academy of Sciences(CAMS)
文摘In this paper,we present the Five-hundred-meter Aperture Spherical radio Telescope(FAST)observations of PSRs B1929+10 and B1842+14.Through analysis of the pulsars’scintillation pattern,we detected the known scintillation arc from PSR B1929+10 and two previously undetected scintillation arcs from B1842+14.We find that the B1929+10 arc’s curvature scales with observing frequency asη-∝ν-2.1±0.1 andη+∝ν-1.8±0.2,consistent with Arecibo results and the theoretical expectations ofη∝ν-2.From the arc curvature,we infer the scattering screen to be located at 0.20±0.02 kpc from the Earth,close to what was measured by RadioAstron at 324 MHz.From B1842+14,we find two scintillation arcs for the first time.The arcs’curvatures imply that they are caused by two scattering screens located at a distance of 0.3±0.2 kpc and 1.6±0.6 kpc from the Earth,respectively.The screen distance uncertainties mainly come from the uncertainty in pulsar’s dispersion measure(DM)-derived distance.We present these FAST scintillation observations and discuss the future prospect of FAST pulsar scintillation study.
基金supported by the National SKA Program of China (Grant Nos. 2020SKA0120100 and 2020SKA0120200)the National Natural Science Foundation of China (Grant Nos. 12041304, 11873067, 11988101, 12041303, 11725313, 11725314, 11833003, 12003028, 12041306, 12103089, U2031209, U2038105, and U1831207)+8 种基金the National Key Research and Development Program of China (Grant Nos. 2019YFA0405100, 2017YFA0402602, 2018YFA0404204, and 2016YFA0400801)Key Research Program of the Chinese Academy of Sciences (Grant No. QYZDJ-SSW-SLH021)Natural Science Foundation of Jiangsu Province (Grant No. BK20211000)Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CAS, the Strategic Priority Research Program on Space Science, the Western Light Youth Project of Chinese Academy of Sciences (Grant Nos. XDA15360000, XDA15052700, and XDB23040400)funding from the MaxPlanck Partner Group, the science research grants from the China Manned Space Project (Grant Nos. CMS-CSST2021-B11 and CMS-CSST-2021-A11)PKU development (Grant No. 7101502590)support from the XPLORER PRIZEsupported by Fundamental Research Funds for the Central Universities (Grant No. 14380046)the Program for Innovative Talents, Entrepreneur in Jiangsu。
文摘Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope(FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected for any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided. The dataset is available in Science Data Bank, with the link https://www.doi.org/10.57760/sciencedb.j00113.00076.
基金supported by the National Natural Science Foundation of China(Grant Nos.11988101,11725313 and U2031121)Funding for the DPAC has been provided by national institutions,in particular the institutions participating in the Gaia Multilateral AgreementS.D.is the recipient of an Australian Research Council Discovery Early Career Award(DE210101738)funded by the Australian Government。
文摘Precise measurements of neutron star(NS)velocities provide critical clues in regard to the supernova physics and evolution of binary systems.Based on Gaia Data Release 2(DR2),we selected a sample of 24 young(<3 Myr)pulsars with precise parallax measurements and measured the velocity of their local standard of rest(LSR)and the velocity dispersion among their respective local stellar groups.The median velocity difference between thus calculated LSRs and the Galactic rotation model is~7.6 km s^(-1),small compared to the typical velocity dispersion of~27.5 km s^(-1).For pulsars off the Galactic plane,such differences grow significantly to as large as~40 km s^(-1).More importantly,the velocity dispersion of stars in the local group of low-velocity pulsars can be comparable to their transverse velocities,suggesting that the intrinsic velocities of NS progenitors should be taken into account when we consider their natal kicks and binary evolution.We also examined the double NS system J0737-3039 A/B,and measured its transverse velocity to be 26-13+18 km s^(-1)assuming nearby Gaia sources are representative of their birth environment.This work demonstrated the feasibility and importance of using Gaia data to study the velocity of individual systems and velocity distribution of NSs.
文摘BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and behavior.AIM To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective treatments.METHODS This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same period.The expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance spectroscopy.The recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive function.The correlation between GABA receptor subunit downregulation and schizophrenia was also analyzed.RESULTS Significant differences in GABA receptor subunit levels were found between the case and control groups(P<0.05).A significant difference was also found between the case and control groups in terms of cognitive function measures,including attention/alertness and learning ability(P<0.05).Specifically,as the expression levels of GABRA1(α1 subunit gene),GABRB2(β2 subunit gene),GABRD(δsubunit),and GABRE(εsubunit)decreased,the severity of the patients’condition increased gradually,indicating a positive correlation between the downregulation of these 4 receptor subunits and schizophrenia(P<0.05).However,the expression levels of GABRA5(α5 subunit gene)and GABRA6(α6 subunit gene)showed no significant correlation with schizophrenia(P>0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with schizophrenia.In other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.
