This study investigates the relationship between the detection rates of MgⅡabsorption lines and the asymmetries of[OⅢ]emission lines.We first select 21,364 quasars from the Sloan Digital Sky Survey DR12Q exhibiting ...This study investigates the relationship between the detection rates of MgⅡabsorption lines and the asymmetries of[OⅢ]emission lines.We first select 21,364 quasars from the Sloan Digital Sky Survey DR12Q exhibiting prominent[OⅢ]emission lines,of which 351 quasars have Category 1 MgⅡabsorption lines(4365≤υ_(r)≤10,000 km s^(-)1)and 518 quasars have Category 2 MgⅡabsorption lines(610≤υ_(r)≤4365 km s-1).Subsequently,we quantify the asymmetries of[OⅢ]emission lines using the velocity offsetδv,and find that the detection rates of Category 1 MgⅡabsorption lines(predominantly intervening absorbers)show no correlation with the blueshifted asymmetries of[OⅢ]emission lines,whereas the detection rates of Category 2 MgⅡabsorption lines(primarily outflow and intervening absorbers)increase with risingδ_(v).Finally,we discuss the results from two perspectives:quasar evolutionary stages and acceleration mechanisms driven by radiation pressure.展开更多
Using the 1.26 m National Astronomical Observatory-Guangzhou University Infrared/Optical Telescope(NGT),we monitor one BL Lac object,OJ 287.For this source,we obtain 15094 gri observations(4900 at g band,5184 at r ban...Using the 1.26 m National Astronomical Observatory-Guangzhou University Infrared/Optical Telescope(NGT),we monitor one BL Lac object,OJ 287.For this source,we obtain 15094 gri observations(4900 at g band,5184 at r band and 5010 at i band)in 155 nights from 2014 December 13 to 2019 March15.Based on the upper observations,we obtain the following results.(1)The total variation amplitude is~2.3 mag.(2)There are intra-day variabilities(IDVs).The IDV timescales(△T)are in the range from 7.69 min(Δm=0.06±0.02 mag)to 371.09 min(Δm=0.26±0.04 mag).(3)There are strong correlations betweenΔT andΔm,△m=(2.91±0.66)×10^(-4)ΔT+(0.08±0.009),with r=0.52,p=5.33×10^(-5).(4)There are intra-day periods in this source,with the period P≈94 min on 2017 December 10.When we supplement the observations from the literature,we can obtain that the long-term period is about 12.02±0.41 yr.(5)The spectral properties of OJ 287 show the bluer-when-brighter behavior,whatever state the source is at.展开更多
Objective:To understand the latent categories of perceived stress in colorectal cancer patients and analyze the characteristics of different categories of patients.Methods:A total of 255 colorectal cancer patients rec...Objective:To understand the latent categories of perceived stress in colorectal cancer patients and analyze the characteristics of different categories of patients.Methods:A total of 255 colorectal cancer patients receiving treatment in the gastrointestinal surgery and oncology depar tments of a ter tiary Grade A hospital in Sichuan Province,from January 2023 to June 2023,were selected as the study subjects.General information questionnaire,Chinese version of the Perceived Stress Scale(CPSS),and Comprehensive Score Table for Patient-Repor ted Outcome Measures of Economic Toxicity(COST-PROM)were used for data collection.Results:Perceived stress in colorectal cancer patients was classified into 3 latent categories:C1“Low stress-stable type”(19.2%),C2“Moderate stress-uncontrolled type”(23.9%),and C3“High stress-anxious type”(56.9%).The average score of perceived stress was(34.07±5.08).Compared with C1 type,patients with a monthly household income of≤3000 RMB were more likely to belong to the C2 and C3 types(P<0.05),and patients without a stoma were less likely to belong to C3 type(P<0.05).Compared with C2 type,male patients were more likely to belong to C3 type(P<0.05),and patients without a stoma were less likely to belong to C3 type(P<0.05).Compared with C3 type,patients with higher economic toxicity scores were more likely to be classified into C1 and C2 types(P<0.05).Conclusions:Perceived stress in colorectal cancer patients exhibits distinct categorical features.Male gender,lower income,presence of a stoma,and higher economic toxicity are associated with higher levels of perceived stress in colorectal cancer patients.展开更多
Background and Aims:Although activation of hepatic stellate cells(HSCs)plays a central role in the development of liver fibrosis,the mechanism underlying the activation of HSCs remains unclear.Keratin 17(KRT17),a memb...Background and Aims:Although activation of hepatic stellate cells(HSCs)plays a central role in the development of liver fibrosis,the mechanism underlying the activation of HSCs remains unclear.Keratin 17(KRT17),a member of the intermediate filament family,can regulate tumor cell proliferation and migration.The current study aimed to elucidate the role of KRT17 in the activation of HSCs and the mechanisms underlying liver fibrosis.Methods:The expression of KRT17 was determined using immunohistochemistry in tissue microarray.Western blotting and qRT-PCR assays were used to determine the KRT17 expression in fibrotic liver tissues obtained from human subjects and mice.LX-2 cells were treated with TGF-β1 recombinant protein and adipocyte differentiation mixture(MDI)mix to induce and reverse LX-2 cell activation,respectively,in order to explore the correlation between KRT17 and HSC activation.Additionally,cell proliferation and migration abilities of LX-2 cells transfected with KRT17-overexpressing plasmid or small interfering RNA were determined using CCK-8,flow cytometry,Transwell,and wound healing assays.Finally,rescue assay was used to explore the role of KRT17 in HSC activation and epithelial-mesenchymal transition(EMT).Results:The expression of KRT17 was higher in the hu-man and mouse fibrotic liver tissues than in healthy liver tissues,and it was positively correlated with HSC activa-tion.Upregulated KRT17 enhanced proliferation,migration,HSC activation and EMT in LX-2 cells,while knockdown of KRT17 reversed these effects.TGF-β1 recombinant protein accelerated KRT17-mediated EMT,HSC activation and proliferation,while TGF-β1 inhibitor counteracted the effect of KRT17 in vitro.Conclusions:KRT17 promoted HSC activation,proliferation and EMT in hepatic fibrosis probably via TGF-β1 signaling,and KRT17 might serve as a therapeutic target for the treatment of liver fibrosis.展开更多
基金supported by the Scientific Research Project of Guangxi Minzu University(2023KJQD07)Guangxi Natural Science Foundation(2025GXNSFBA069287)+2 种基金the Guangxi Natural Science Foundation(2024GXNSFDA010069,2019GXNSFFA245008)the National Natural Science Foundation of China(12073007)the Scientific Research Project of Guangxi University for Nationalities(2018KJQD01)。
文摘This study investigates the relationship between the detection rates of MgⅡabsorption lines and the asymmetries of[OⅢ]emission lines.We first select 21,364 quasars from the Sloan Digital Sky Survey DR12Q exhibiting prominent[OⅢ]emission lines,of which 351 quasars have Category 1 MgⅡabsorption lines(4365≤υ_(r)≤10,000 km s^(-)1)and 518 quasars have Category 2 MgⅡabsorption lines(610≤υ_(r)≤4365 km s-1).Subsequently,we quantify the asymmetries of[OⅢ]emission lines using the velocity offsetδv,and find that the detection rates of Category 1 MgⅡabsorption lines(predominantly intervening absorbers)show no correlation with the blueshifted asymmetries of[OⅢ]emission lines,whereas the detection rates of Category 2 MgⅡabsorption lines(primarily outflow and intervening absorbers)increase with risingδ_(v).Finally,we discuss the results from two perspectives:quasar evolutionary stages and acceleration mechanisms driven by radiation pressure.
基金partially supported by the National Natural Science Foundation of China(Grant Nos.U1831119,U1531245,U1431112,11733006,11503004 and 11403006)Science and Technology Program of Guangzhou(201707010401)。
文摘Using the 1.26 m National Astronomical Observatory-Guangzhou University Infrared/Optical Telescope(NGT),we monitor one BL Lac object,OJ 287.For this source,we obtain 15094 gri observations(4900 at g band,5184 at r band and 5010 at i band)in 155 nights from 2014 December 13 to 2019 March15.Based on the upper observations,we obtain the following results.(1)The total variation amplitude is~2.3 mag.(2)There are intra-day variabilities(IDVs).The IDV timescales(△T)are in the range from 7.69 min(Δm=0.06±0.02 mag)to 371.09 min(Δm=0.26±0.04 mag).(3)There are strong correlations betweenΔT andΔm,△m=(2.91±0.66)×10^(-4)ΔT+(0.08±0.009),with r=0.52,p=5.33×10^(-5).(4)There are intra-day periods in this source,with the period P≈94 min on 2017 December 10.When we supplement the observations from the literature,we can obtain that the long-term period is about 12.02±0.41 yr.(5)The spectral properties of OJ 287 show the bluer-when-brighter behavior,whatever state the source is at.
基金supported by the Health and Humanities Research Center Project of Zigong City Key Research Base of Philosophy and Social Sciences(No.JKRWY22-26)。
文摘Objective:To understand the latent categories of perceived stress in colorectal cancer patients and analyze the characteristics of different categories of patients.Methods:A total of 255 colorectal cancer patients receiving treatment in the gastrointestinal surgery and oncology depar tments of a ter tiary Grade A hospital in Sichuan Province,from January 2023 to June 2023,were selected as the study subjects.General information questionnaire,Chinese version of the Perceived Stress Scale(CPSS),and Comprehensive Score Table for Patient-Repor ted Outcome Measures of Economic Toxicity(COST-PROM)were used for data collection.Results:Perceived stress in colorectal cancer patients was classified into 3 latent categories:C1“Low stress-stable type”(19.2%),C2“Moderate stress-uncontrolled type”(23.9%),and C3“High stress-anxious type”(56.9%).The average score of perceived stress was(34.07±5.08).Compared with C1 type,patients with a monthly household income of≤3000 RMB were more likely to belong to the C2 and C3 types(P<0.05),and patients without a stoma were less likely to belong to C3 type(P<0.05).Compared with C2 type,male patients were more likely to belong to C3 type(P<0.05),and patients without a stoma were less likely to belong to C3 type(P<0.05).Compared with C3 type,patients with higher economic toxicity scores were more likely to be classified into C1 and C2 types(P<0.05).Conclusions:Perceived stress in colorectal cancer patients exhibits distinct categorical features.Male gender,lower income,presence of a stoma,and higher economic toxicity are associated with higher levels of perceived stress in colorectal cancer patients.
基金supported by the National Natural Science Foundation of China,General Project(No.82070624)Health Commission of Jiangsu Province,Key Project(No.ZDB2020006)+1 种基金Tianqing Liver Disease Research Foundation of China Hepatitis Prevention Foundation(No.TQGB20210029)Social Development Foundation of Nantong City(No.JC2019032).
文摘Background and Aims:Although activation of hepatic stellate cells(HSCs)plays a central role in the development of liver fibrosis,the mechanism underlying the activation of HSCs remains unclear.Keratin 17(KRT17),a member of the intermediate filament family,can regulate tumor cell proliferation and migration.The current study aimed to elucidate the role of KRT17 in the activation of HSCs and the mechanisms underlying liver fibrosis.Methods:The expression of KRT17 was determined using immunohistochemistry in tissue microarray.Western blotting and qRT-PCR assays were used to determine the KRT17 expression in fibrotic liver tissues obtained from human subjects and mice.LX-2 cells were treated with TGF-β1 recombinant protein and adipocyte differentiation mixture(MDI)mix to induce and reverse LX-2 cell activation,respectively,in order to explore the correlation between KRT17 and HSC activation.Additionally,cell proliferation and migration abilities of LX-2 cells transfected with KRT17-overexpressing plasmid or small interfering RNA were determined using CCK-8,flow cytometry,Transwell,and wound healing assays.Finally,rescue assay was used to explore the role of KRT17 in HSC activation and epithelial-mesenchymal transition(EMT).Results:The expression of KRT17 was higher in the hu-man and mouse fibrotic liver tissues than in healthy liver tissues,and it was positively correlated with HSC activa-tion.Upregulated KRT17 enhanced proliferation,migration,HSC activation and EMT in LX-2 cells,while knockdown of KRT17 reversed these effects.TGF-β1 recombinant protein accelerated KRT17-mediated EMT,HSC activation and proliferation,while TGF-β1 inhibitor counteracted the effect of KRT17 in vitro.Conclusions:KRT17 promoted HSC activation,proliferation and EMT in hepatic fibrosis probably via TGF-β1 signaling,and KRT17 might serve as a therapeutic target for the treatment of liver fibrosis.
