Gastrointestinal endoscopy is a common examination for digestive system.The stimulation of endoscope often causes cough,nausea and vomiting,increased heart rate and blood pressure,arrhythmia,and even cardiovascular an...Gastrointestinal endoscopy is a common examination for digestive system.The stimulation of endoscope often causes cough,nausea and vomiting,increased heart rate and blood pressure,arrhythmia,and even cardiovascular and cerebrovascular accidents,thus makes people fear of this procedure.Sedation or anesthesia can effectively improve the safety,comfort and quality of gastrointestinal endoscopy.A small dose of opioids is a good adjuvant to sedatives.In this narrative review,we summarized the main roles of opioid analgesics in gastrointestinal endoscopy,including reducing visceral pain,throat irritation and the dose of sedatives.Moreover,the frequently used and novel opioids are reviewed.Classic fentanyl,sufentanil and dezocine are preferable by anesthesiologists.Newly approved oliceridine is promising to render ideal analgesic effects for gastrointestinal endoscopy.Clinical studies on oliceridine in endoscopic procedures are urgently needed.展开更多
BACKGROUND Stereoelectroencephalography(SEEG)is a minimally invasive preoperative evaluation of drug-resistant focal epilepsies.Increasing preclinical data show that SEEG has tremendous diagnostic and therapeutic valu...BACKGROUND Stereoelectroencephalography(SEEG)is a minimally invasive preoperative evaluation of drug-resistant focal epilepsies.Increasing preclinical data show that SEEG has tremendous diagnostic and therapeutic value for epilepsy.There are currently many studies on SEEG.AIM To summarize the development and application of SEEG.METHODS We conducted a bibliometric analysis of research on SEEG from 2019 to 2023.We obtained publications on SEEG from the Web of Science Core Collection(WoSCC)database.Excel,VOSviewer,and CiteSpace were responsible for the analyses.A variety of bibliographic elements were collected,including annual publications,authors,countries/regions,journals,keywords,etc.RESULTS A total of 691 publications were included in this study.Professor Fabrice Bartolomei of Timone Hospital in France was the most productive and influential author in the field of SEEG,whereas the authors from the United States were the leaders in general.In addition,we found that deep learning and source localization in SEEG have been popular in recent years.CONCLUSION This study provides a comprehensive analysis of SEEG research and highlights the growing interest in SEEG and its deep learning and source localization.展开更多
BACKGROUND The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has produced a global pandemic of coronavirus disease 2019(COVID-19),resulting in modifications to public health policies on a u...BACKGROUND The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has produced a global pandemic of coronavirus disease 2019(COVID-19),resulting in modifications to public health policies on a universal scale.SARSCoV-2 vaccine has evolved as the most effective and secure way for protecting healthy individuals against COVID-19.Patients with cancer were excluded from clinical trials due to their increased COVID-19 risk and current immunosuppressing therapy.Safety and effectiveness evidence is insufficient for SARS-CoV-2 vaccination in cancer patients.AIM To assess the efficacy and safety of two-dose SARS-CoV-2 vaccines in cancer patients.METHODS A multicenter observational study was performed at ten Chinese hospitals between January 1,2021 and December 31,2021.Each participant in the research received two doses of vaccination.A total of 215 healthy people were screened and 132 eligible patients with cancer were recruited.In order to verify the safety of the second dose of the vaccine,a side-effect report was compiled.Two weeks following the second vaccination dose,subjects underwent an analogous questionnaire survey.Utilizing a magnetic particle-based chemiluminescence immunoassay,serum levels of anti-SARS-CoV-2 immunoglobulin G(IgG)antibodies were measured to determine the effectiveness of vaccination.IgG levels≥10 AU/mL were considered seropositive.RESULTS All the 347 eligible patients completed the follow-up,and anti-SARS-CoV-2 IgG antibodies were detected.Local pain at the injection location was the most common side effect mentioned by all responders,with an increased incidence in cancer patients than the healthy people after the second dose vaccine(17.2%vs 9.1%;P=0.035).There was no significant difference in headache,urticaria,or other adverse reactions between patients with cancer and healthy people.In the group of cancer patients,the seropositivity incidence was 83.3%,while it was 96.3%in the group of healthy people.In the group of cancer patients,the seropositivity incidence and antibody levels were significantly lower(P<0.001).This analysis showed a poorer response rate in patients on active immunosuppressive treatment and elderly cancer patients.CONCLUSION Two-dose Chinese vaccines are effective and safe in cancer patients.However,further research is required on the efficacy in elderly cancer patients and those on active immunosuppressive treatment.展开更多
BACKGROUND Low back pain has become a global problem.Since many traditional Chinese therapies are helpful for low back pain,the current status of low back pain in China may provide some insights to this issue.AIM To d...BACKGROUND Low back pain has become a global problem.Since many traditional Chinese therapies are helpful for low back pain,the current status of low back pain in China may provide some insights to this issue.AIM To demonstrate the disease burden of low back pain in China and the response of Chinese scholars to this issue.METHODS The burden of low back pain in China was estimated using the Global Burden of Disease Study 2021 released by the American Institute for Health Metrics and Evaluation.The incidence,prevalence and disability-adjusted life years were analyzed.We also performed a bibliometric analysis to analyzed the publication trend,changes of cooperation models and research topics on low back pain.RESULTS Prevalence of low back pain increased from 69.61 million in 1990 to 102.96 million in 2021.New cases increased by a stunning 44.50 million in 2021.Low back pain led to an increase of 4.16 per 1000000 population in terms of disability-adjusted life years from 1990 to 2021.But the increase in China was slower than that of world average.As a response,publications of low back pain published by Chinese scholars were stably raised.From 1990 to 2023,domestic cooperation significantly increased,while international cooperation and no cooperation decreased.However,domestic cooperation decreased between 2021 and 2023.The number of studies on prevention and treatment of low back pain reduced from 1990 to 2023,while the mechanism,etiology and other aspects of low back pain augmented.CONCLUSION The burden of low back pain in China is heavy.Together with the government,Chinese institutions of medical science should do more in declining the impacts of low back pain.展开更多
基金Supported by Wu Jieping Foundation,No.320.6750.2024-05-55.
文摘Gastrointestinal endoscopy is a common examination for digestive system.The stimulation of endoscope often causes cough,nausea and vomiting,increased heart rate and blood pressure,arrhythmia,and even cardiovascular and cerebrovascular accidents,thus makes people fear of this procedure.Sedation or anesthesia can effectively improve the safety,comfort and quality of gastrointestinal endoscopy.A small dose of opioids is a good adjuvant to sedatives.In this narrative review,we summarized the main roles of opioid analgesics in gastrointestinal endoscopy,including reducing visceral pain,throat irritation and the dose of sedatives.Moreover,the frequently used and novel opioids are reviewed.Classic fentanyl,sufentanil and dezocine are preferable by anesthesiologists.Newly approved oliceridine is promising to render ideal analgesic effects for gastrointestinal endoscopy.Clinical studies on oliceridine in endoscopic procedures are urgently needed.
文摘BACKGROUND Stereoelectroencephalography(SEEG)is a minimally invasive preoperative evaluation of drug-resistant focal epilepsies.Increasing preclinical data show that SEEG has tremendous diagnostic and therapeutic value for epilepsy.There are currently many studies on SEEG.AIM To summarize the development and application of SEEG.METHODS We conducted a bibliometric analysis of research on SEEG from 2019 to 2023.We obtained publications on SEEG from the Web of Science Core Collection(WoSCC)database.Excel,VOSviewer,and CiteSpace were responsible for the analyses.A variety of bibliographic elements were collected,including annual publications,authors,countries/regions,journals,keywords,etc.RESULTS A total of 691 publications were included in this study.Professor Fabrice Bartolomei of Timone Hospital in France was the most productive and influential author in the field of SEEG,whereas the authors from the United States were the leaders in general.In addition,we found that deep learning and source localization in SEEG have been popular in recent years.CONCLUSION This study provides a comprehensive analysis of SEEG research and highlights the growing interest in SEEG and its deep learning and source localization.
文摘BACKGROUND The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has produced a global pandemic of coronavirus disease 2019(COVID-19),resulting in modifications to public health policies on a universal scale.SARSCoV-2 vaccine has evolved as the most effective and secure way for protecting healthy individuals against COVID-19.Patients with cancer were excluded from clinical trials due to their increased COVID-19 risk and current immunosuppressing therapy.Safety and effectiveness evidence is insufficient for SARS-CoV-2 vaccination in cancer patients.AIM To assess the efficacy and safety of two-dose SARS-CoV-2 vaccines in cancer patients.METHODS A multicenter observational study was performed at ten Chinese hospitals between January 1,2021 and December 31,2021.Each participant in the research received two doses of vaccination.A total of 215 healthy people were screened and 132 eligible patients with cancer were recruited.In order to verify the safety of the second dose of the vaccine,a side-effect report was compiled.Two weeks following the second vaccination dose,subjects underwent an analogous questionnaire survey.Utilizing a magnetic particle-based chemiluminescence immunoassay,serum levels of anti-SARS-CoV-2 immunoglobulin G(IgG)antibodies were measured to determine the effectiveness of vaccination.IgG levels≥10 AU/mL were considered seropositive.RESULTS All the 347 eligible patients completed the follow-up,and anti-SARS-CoV-2 IgG antibodies were detected.Local pain at the injection location was the most common side effect mentioned by all responders,with an increased incidence in cancer patients than the healthy people after the second dose vaccine(17.2%vs 9.1%;P=0.035).There was no significant difference in headache,urticaria,or other adverse reactions between patients with cancer and healthy people.In the group of cancer patients,the seropositivity incidence was 83.3%,while it was 96.3%in the group of healthy people.In the group of cancer patients,the seropositivity incidence and antibody levels were significantly lower(P<0.001).This analysis showed a poorer response rate in patients on active immunosuppressive treatment and elderly cancer patients.CONCLUSION Two-dose Chinese vaccines are effective and safe in cancer patients.However,further research is required on the efficacy in elderly cancer patients and those on active immunosuppressive treatment.
文摘BACKGROUND Low back pain has become a global problem.Since many traditional Chinese therapies are helpful for low back pain,the current status of low back pain in China may provide some insights to this issue.AIM To demonstrate the disease burden of low back pain in China and the response of Chinese scholars to this issue.METHODS The burden of low back pain in China was estimated using the Global Burden of Disease Study 2021 released by the American Institute for Health Metrics and Evaluation.The incidence,prevalence and disability-adjusted life years were analyzed.We also performed a bibliometric analysis to analyzed the publication trend,changes of cooperation models and research topics on low back pain.RESULTS Prevalence of low back pain increased from 69.61 million in 1990 to 102.96 million in 2021.New cases increased by a stunning 44.50 million in 2021.Low back pain led to an increase of 4.16 per 1000000 population in terms of disability-adjusted life years from 1990 to 2021.But the increase in China was slower than that of world average.As a response,publications of low back pain published by Chinese scholars were stably raised.From 1990 to 2023,domestic cooperation significantly increased,while international cooperation and no cooperation decreased.However,domestic cooperation decreased between 2021 and 2023.The number of studies on prevention and treatment of low back pain reduced from 1990 to 2023,while the mechanism,etiology and other aspects of low back pain augmented.CONCLUSION The burden of low back pain in China is heavy.Together with the government,Chinese institutions of medical science should do more in declining the impacts of low back pain.
