Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term foll...Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term follow-up and preliminarily explore the relationship between maternal body weight and human milk composition,including macronutrients,leptin,and adiponectin.Methods:The study included a longitudinal cohort(122 mothers),and a cross-sectional cohort(37 mothers).The human milk,maternal weight,and dietary surveys were collected in the longitudinal cohort at different follow-up time points(1-14 days postpartum,2-4 months postpartum,5-7 months postpartum,and 12-17 months postpartum).The maternal body weight was analyzed using the responses in the survey questionnaires.A milk analyzer based on the mid-infrared spectroscopy(MIRS)was used to determine milk composition,and nutrition analysis software evaluated dietary intakes.In the cross-sectional cohort,participating mothers were asked to provide blood and human milk samples and pertinent information related to maternal body composition.Maternal body composition was measured by bioelectrical impedance analysis(BIA),while ELISA analyzed leptin and adiponectin in milk and serum.Results:At 5-7 months postpartum,the PPWR of breastfeeding mothers was(2.46±3.59)kg.At 12-17 months postpartum,the PPWR was(0.98±4.06)kg.PPWR was found to be negatively correlated with milk fat content within 14 days postpartum and positively correlated at 2-4 months postpartum.In addition,the maternal weight and body muscle mass were positively correlated with leptin and adiponectin in milk.Plasma leptin was positively correlated with the mother’s body weight,body mass index(BMI),FAT percentage,and body fat mass,while plasma adiponectin did not correlate with any parameter.The results also indicate that the PPWR did not correlate with leptin and adiponectin in plasma or milk.Conclusions:Breastfeeding mothers may retain considerable weight gain one year after delivery.Human milk composition may be related to changes in maternal body weight.Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition.This study supports the notion that maternal nutritional status may affect offspring health through lactation,and future research should focus on exploring weight management of postpartum mothers.展开更多
Semi-heterogeneous photocatalysis has emerged as a powerful and productive platform in organic chemistry,which provides mild and eco-friendly conditions for a diverse range of bond-forming reactions.The synergy of hom...Semi-heterogeneous photocatalysis has emerged as a powerful and productive platform in organic chemistry,which provides mild and eco-friendly conditions for a diverse range of bond-forming reactions.The synergy of homogeneous catalysts and heterogeneous catalysts inherits their main advantages,such as higher activities,easy separation and superior recyclability.In this review,we summarize the recent advances in recyclable semi-heterogenous protocols for the light promoted bond-forming reactions and identify directions for future research according to the different photocatalysts/metal/redox catalysts involved.Notably,this review is not a comprehensive description of reported literature but aim to highlight and illustrate key concepts,strategies,reaction model,reaction conditions and mechanisms.展开更多
Four-dimensional(4D)printing represents a groundbreaking advancement in manufacturing,yet a persistent challenge is the limited number of stable configurations achievable through spontaneous shape reconstruction.Herei...Four-dimensional(4D)printing represents a groundbreaking advancement in manufacturing,yet a persistent challenge is the limited number of stable configurations achievable through spontaneous shape reconstruction.Herein,we present a novel 4D printing mechanism that utilizes self-adjustable gas pressure to facilitate a wide range of spontaneous and stable multi-shape transformations.The gas is precisely released at designated spatial locations through strategic temperature-controlled degradation of a solid material,which is printed and distributed as needed at the voxel level within a specially designed multi-material structure,consisting of a low degradation temperature material(LDTM),a high degradation temperature soft material(HDTSM),and a high degradation temperature hard material(HDTHM).Each shape configuration is determined and locked in by the maximum temperature experienced during its thermal history.Notably,this shape retains its form robustly,independently of subsequent temperature changes,until a higher temperature threshold is reached,at which point a new shape configuration is triggered.These shapes exhibit a remarkable temperature memory effect,permanently recording the peak temperature reached in their thermal history.Our study comprehensively investigates the underlying principles and key parameters that influence deformation.We present a series of examples demonstrating complex multi-shape transformations modulated by temperature,supported by finite element simulations.This advance in 4D printing has the potential to significantly enhance its functional capabilities,performance,and applicability,opening up new horizons in additive manufacturing and design.展开更多
Polycyclic compounds are widely found in natural products and drug molecules with important biological activities,which attracted the attention of many chemists.Phosphine-catalyzed nucleophilic addition is one of the ...Polycyclic compounds are widely found in natural products and drug molecules with important biological activities,which attracted the attention of many chemists.Phosphine-catalyzed nucleophilic addition is one of the most powerful tools for the construction of various cyclic compounds with the advantages of atom economy,mild reaction conditions and simplicity of operation.Allenolates,Morita−Baylis−Hillman(MBH)alcohols and their derivatives(MBHADs),electron-deficient olefins and alkynes are very efficient substrates in phosphine mediated annulations,which formed many phosphonium species such asβ-phosphonium enolates,β-phosphonium dienolates and vinyl phosphonium ylides as intermediates.This review describes the reactivities of these phosphonium zwitterions and summarizes the synthesis of polycycle compounds through phosphine-mediated intramolecular and intermolecular sequential annulations.Thus,a systematic summary of the research process based on the phosphine-mediated sequential annulations of allenolates,MBH alcohols and MBHADs,electron-deficient olefins and alkynes are presented in Chapters 2-6,respectively.展开更多
In order to reduce the occurrence of traffic accidents and assist drivers to avoid dangerous driving. This paper presents a smart in-vehicle safety system that utilises the Yolov5 algorithm. Yolov5 algorithm is used t...In order to reduce the occurrence of traffic accidents and assist drivers to avoid dangerous driving. This paper presents a smart in-vehicle safety system that utilises the Yolov5 algorithm. Yolov5 algorithm is used to anticipate driver fatigue and distraction behaviours, and remind drivers to pay attention to safe driving in time. The system continuously splits the frames and analyses the frame content through the video feedback from the front camera, compared to the traditional machine learning, Yolov5’s mosaic data is enhanced, resulting in a batch size enhancement of 92.3%, and it also uses the Drop Block mechanism to prevent overfitting. The hardware of this system uses STM32 microcontroller and uses system DMA interrupt control and buzzer alarm device to warn about dangerous driving behaviour.展开更多
Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and mortality.It is mainly characterized by cholestasis in chi...Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and mortality.It is mainly characterized by cholestasis in children and steatohepatitis in adults.Unfortunately,there is no effective approach to prevent or reverse the disease.Regulated cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver diseases.Nowadays cell death is reclassified into several types,based on the mechanisms and morphological phenotypes.Emerging evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver diseases.Recent studies have shown that different modes of RCD are present in animal models and patients with IFALD.Understanding the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in IFALD.In this review,we discuss the current knowledge on how RCD may link to the pathogenesis of IFALD.We highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.展开更多
Background:Glioma-induced refractory epilepsy can be alleviated through conventional exercise,providing a potential therapeutic approach to manage this condition.This study aims to investigate the underlying mechanism...Background:Glioma-induced refractory epilepsy can be alleviated through conventional exercise,providing a potential therapeutic approach to manage this condition.This study aims to investigate the underlying mechanisms.Methods:Bioinformatics methodologies were employed to scrutinize gene expression data from public repositories such as GEO,with a specific focus on mobility-related genes in epilepsy.Through differential and enrichment analyses,differentially expressed genes(DEGs)were identified,while protein-protein interaction networks elucidated pivotal hub genes.Results:Our analysis revealed 32 DEGs,comprising 23 upregulated and 9 downregulated genes.Enrichment analysis underscored significant alterations in immune pathways in epilepsy.Two central hub genes,haptoglobin(HP)and prostaglandin-endoperoxide synthase 2(PTGS2),were found to be modulated by Arginase 1(ARG1)and Chemokine(C-X-C motif)ligand 8(CXCL8).GSVA analysis associated elevated PTGS2 expression with metabolic pathways,while increased HP expression was correlated with angiogenesis and inflammation.Subsequent experiments validated HP’s role in tumor cell proliferation,emphasizing its potential as a therapeutic target.Conclusion:This study highlights the crucial involvement of HP and PTGS2 genes in the etiology of epilepsy,linked to discrepancies in the immune system.These findings offer fresh perspectives on the management of epilepsy,emphasizing the neuroprotective possibilities of targeting specific gene pathway.展开更多
Recently,Mg_(3)Sb_(2)-xBixalloys have attracted intensive attention,with the aim of maximizing the electrical transport performance via donor element doping,increasing the grain size,as well as electronic band structu...Recently,Mg_(3)Sb_(2)-xBixalloys have attracted intensive attention,with the aim of maximizing the electrical transport performance via donor element doping,increasing the grain size,as well as electronic band structure engineering.However,less attention has been paid to other significant factors,like how these intrinsic point defects and accompanied secondary phases influence thermoelectric properties.In this study,the microstructure and thermoelectric transport properties of Mg_(3.2)Sb_(0.5)Bi_(1.495-x)Te_(0.005)(x=0~0.2)compounds were systematically investigated,where tuning the Bi content shows the counter-intuitive impact on the thermoelectric properties.It was found that the Bipoor environment associated with Bi impurities facilitated the increment of cation vacancy formation energy and then increased the carrier concentration,leading to the enhancement of power factor.Simultaneously,the reduction of Bi-rich second phase content weakened the carrier scattering by grain boundaries whereas high carrier mobility was maintained.Moreover,the bipolar thermal conductivity decreased obviously due to the increased majority carrier concentration to suppress the intrinsic excitation.The synergistic optimization pushes the average ZT value(300-573 K)up to 0.95 in the Mg_(3.2)Sb_(0.5)Bi_(1.295)Te_(0.005)sample.Moreover,the calculated single-leg conversion efficiency is increased up to 9.7%with the hot-side temperature of 573 K,as the record-high value in this system.展开更多
AIM: To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-κB expression in multiple org...AIM: To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-κB expression in multiple organs of SAP rats as well as the mechanisms involved. METHODS: Ninety Sprague-Dawley (SD) rats with SAP were randomly divided into the model group (n = 45) and dexamethasone treatment group (n = 45), and another 45 rats were selected for the sham operation group. All groups were randomly subdivided into the 3 h, 6 h and 12 h groups, each group containing 15 rats. The survival of all groups and pathological changes of multiple organs (liver, kidney and lung) were observed at different time points after the operation. The pathologicalscore of multiple organs was carried out, followed by the determination of amylase, endotoxin and TNF-α contents in blood. The tissue microarray was used to detect the expression levels of NF-κB p65 protein in multiple organs. RESULTS: There was no marked difference between the model group and treatment group in the survival rate. The amylase content of the treatment group was significantly lower compared to the model group at 12 h (P < 0.01, 7791.00 vs 9195.00). Moreover, the endotoxin and TNF-α levels of the treatment group were significantly lower than that of the model group at 6 h and 12 h (P < 0.01, 0.040 vs 0.055, 0.042 vs 0.059 and P < 0.05, 58.30 vs 77.54, 38.70 vs 67.30, respectively). Regarding the changes in liver NF-κB expression, the model group significantly exceeded the sham operation group at 3 h (P < 0.01, 1.00 vs 0.00), and the treatment group significantly exceeded the sham operation group at 12 h (P < 0.01, 1.00 vs 0.00), whereas no marked difference was observed between the model group and treatment group at all time points. The kidney NF-κB expression level in the treatment group significantly exceeded the model group (P < 0.05, 2.00 vs 0.00) and the sham operation group (P < 0.01, 2.00 vs 0.00) at 12 h. No NF-κB expression in the lung was found in any group. CONCLUSION: Dexamethasone can lower the amylase, endotoxin and TNF-α levels as well as mortality of SAP rats. NF-κB plays an important role in multiple organ injury. Further studies should be conducted to determine whether dexamethasone can ameliorate the pathological changes of multiple organs by reducing the NF-κB expression in the liver and kidney. The advantages of tissue microarrays in pancreatitis pathological examination include time- and energy- saving, and are highly efficient and representative. The restriction of tissue microarrays on the representation of tissues to various extents due to small diameter may lead to the deviation of analysis.展开更多
Blockchain with these characteristics of decentralized structure, transparent and credible, time-series and immutability, has been considering as a promising technology. Consensus algorithm as one of the core techniqu...Blockchain with these characteristics of decentralized structure, transparent and credible, time-series and immutability, has been considering as a promising technology. Consensus algorithm as one of the core techniques of blockchain directly affects the scalability of blockchain systems. Existing probabilistic finality blockchain consensus algorithms such as PoW, PoS, suffer from power consumptions and low efficiency;while absolute finality blockchain consensus algorithms such as PBFT, HoneyBadgerBFT, could not meet the scalability requirement in a largescale network. In this paper, we propose a novel optimized practical Byzantine fault tolerance consensus algorithm based on EigenTrust model, namely T-PBFT, which is a multi-stage consensus algorithm. It evaluates node trust by the transactions between nodes so that the high quality of nodes in the network will be selected to construct a consensus group. To reduce the probability of view change, we propose to replace a single primary node with a primary group. By group signature and mutual supervision, we can enhance the robustness of the primary group further. Finally, we analyze T-PBFT and compare it with the other Byzantine fault tolerant consensus algorithms. Theoretical analysis shows that our T-PBFT can optimize the Byzantine fault-tolerant rate,reduce the probability of view change and communication complexity.展开更多
AIM: To investigate the disruptions of interstitial cells of Cajal (ICC) in the remaining bowel in rats after massive small bowel resection (mSBR). METHODS: Thirty male Sprague-Dawley rats fitting entry criteria were ...AIM: To investigate the disruptions of interstitial cells of Cajal (ICC) in the remaining bowel in rats after massive small bowel resection (mSBR). METHODS: Thirty male Sprague-Dawley rats fitting entry criteria were divided randomly into three experimental groups (n = 10 each): Group A rats underwent bowel transection and re-anastomosis (sham) and tissue samples were harvested at day 7 post-surgery. Group B and C rats underwent 80% small bowel resection with tissue harvested from Group B rats at day 7 post-surgery, and from Group C rats at day 14 postsurgery. The distribution of ICC at the site of the resid-ual small bowel was evaluated by immunohistochemical analysis of small intestine samples. The ultrastructural changes of ICC in the remnant ileum of model rats 7 and 14 d after mSBR were analyzed by transmission electron microscopy. Intracellular recordings of slow wave oscillations were used to evaluate electrical pacemaking. The protein expression of c-kit, ICC phenotypic markers, and membrane-bound stem cell factor (mSCF) in intestinal smooth muscle of each group were detected by Western blotting. RESULTS: After mSBR, immunohistochemical analysis indicated that the number of c-kit-positive cells was dramatically decreased in Group B rats compared with sham tissues. Significant ultrastructural changes in ICC with associated smooth muscle hypertrophy were also observed. Disordered spontaneous rhythmic contractions with reduced amplitude (8.5 ± 1.4 mV vs 24.8 ± 1.3 mV, P = 0.037) and increased slow wave frequency (39.5 ± 2.1 cycles/min vs 33.0 ± 1.3 cycles/min, P = 0.044) were found in the residual intestinal smooth muscle 7 d post mSBR. The contractile function and electrical activity of intestinal circular smooth muscle returned to normal levels at 14 d post mSBR (amplitude, 14.9 ± 1.6 mV vs 24.8 ± 1.3 mV; frequency, 30.7 ± 1.7 cycles/min vs 33.0 ± 1.3 cycles/min). The expression of Mscf and c-kit protein was decreased at 7 d (P = 0.026), but gradually returned to normal levels at 14 d. The ICC and associated neural networks were disrupted, which was associated with the phenotype alterations of ICC. CONCLUSION: Massive small bowel resection in rats triggered damage to ICC networks and decreased the number of ICC leading to disordered intestinal rhythmicity. The mSCF/c-kit signaling pathway plays a role in the regulation and maintenance of ICC phenotypes.展开更多
BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatiti...BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.展开更多
TiO2 supports doped with different amounts of Si were prepared by a sol-gel method, and 1 wt% vanadia （V2O5） loaded on Si-doped TiO2 was obtained by an impregnation method. The mole ratio of Si/Ti was 0.2, NOx conve...TiO2 supports doped with different amounts of Si were prepared by a sol-gel method, and 1 wt% vanadia （V2O5） loaded on Si-doped TiO2 was obtained by an impregnation method. The mole ratio of Si/Ti was 0.2, NOx conversion exceeds 94% at 300℃ and GHSV of 41,324 hr-1 , which is about 20% higher than pure V2O5/TiO2 . The catalysts were characterized by XRD, BET, TEM, FT-IR, NH3-TPD, XPS, H2-TPR, Raman and in situ DRIFTS. The results of FT-IR and XPS indicated that Si was doped into the TiO2 lattice successfully and a solid solution was obtained. V2O5 active component could be dispersed well on the support with the increasing of surface area of the catalyst, which was confirmed by Raman and XRD results. Above all, the numbers of acid sites （especially the Br nsted-acid） and oxidation properties were enhanced for Si-doped V2O5/TiO2 catalysts, which improved the deNOx catalytic activity.展开更多
AIM. To establish a kind of standardization of the clinical chemotherapeutic prototypes for unresectable hepatocellular carcinomas （HCC）. METHODS： 10-Hydroxycamptothecin （HCPT） was applied through transcatheter a...AIM. To establish a kind of standardization of the clinical chemotherapeutic prototypes for unresectable hepatocellular carcinomas （HCC）. METHODS： 10-Hydroxycamptothecin （HCPT） was applied through transcatheter arterial embolization （TAE） to HCC patients who were categorized into three groups： （1） test group： treatment with HCPT twice （HCPT dl and 14） through TAE and portal venous embolization. （2） Control Ⅰ： treatment with anticancer drugs without HCPT. （3） Control Ⅱ： treatment with HCPT as a major component in anticancer drugs once （HCPT dl）. A set of comparisons between test groups and control Ⅰ and Ⅱ groups were performed before and after the treatment to study the effectiveness of each treatment, in terms of tumor volumes, dynamic variations in serum alpha-fetoprotein （AFP）, gamma-glutamyl transferase hepatoma-specific band （GGT-Ⅱ）, patient survival and adverse events. RESULTS： The general effectiveness rate of the test group reached 62.1% （72/116）, remarkably higher than that of control Ⅰ （32.1%, 40/124） and control Ⅱ （54.7%, 47/56）, （P〈0.01 and P〈0.05, respectively）. Especially, the reduction rate or disappearance of the portal vein tumor emboli was as high as 88.4% （61/69） in the test group, in contrast with 13.9% （10/72） in control Ⅰ and 35.9% （18/51） in control Ⅱ （P〈0.01 and P〈0.01, respectively）. After treatment, AFP decreased or turned to negative levels at 52.3% （34/65） in control Ⅰ, 67.3% （35/52） in control Ⅱ, and 96.8% （60/62） in the test group. Also GGT-Ⅱ declined or became negative at 37.8% （28/74） in control Ⅰ, 69.5% （57/82） in control Ⅱ, and 94.7% （89/94） in test group （P〈0.01 and P〈0.05, respectively）. CONCLUSION： We have designed a good protocol （test group） to treat HCC with excellent advantages of high efficiency, low cost, low toxicity and low adverse events and easy application. It could be recommended as one of the standardizations for HCC treatment in clinical practice.展开更多
Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater ...Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater diameter with concrete strength is different from that of shaped charge penetration into normal strength concrete(NSC).The crater diameter of RPC is smaller than that of NSC penetrated by the shaped charge.The jet particles are strongly disturbed and hardly reach the crater bottom because they pass through the narrow channel formed by jet penetration into the RPC.The effects of radial drift velocity and gap effects of jet particles for a shaped charge penetration into RFC target are discussed.Moreover,a theoretical model is presented to describe the penetration of shaped charge into RPC target.As the concrete strength increases,the penetration resistance increases and the entrance crater diameter decreases.Given the drift velocity and narrow crater channel,the low-velocity jet particles can hardly reach the crater bottom to increase the penetration depth.Moreover,the narrow channel has a stronger interference to the jet particles with increasing concrete strength;hence,the gap effects must be considered.The drift velocity and gap effects,which are the same as penetration resistance,also have significant effects during the process of shaped charge penetration into ultrahigh-strength concrete,The crater profiles are calculated through a theoretical model,and the results are in good agreement with the experiments.展开更多
基金supported by grants from the Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition(17dz2272000)Foundation of Shanghai Municipal Health Commission(Key weak discipline construction project 2019ZB0101)the Scientific research fund of China Nutrition Society(CNSHPNK2021-16)。
文摘Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term follow-up and preliminarily explore the relationship between maternal body weight and human milk composition,including macronutrients,leptin,and adiponectin.Methods:The study included a longitudinal cohort(122 mothers),and a cross-sectional cohort(37 mothers).The human milk,maternal weight,and dietary surveys were collected in the longitudinal cohort at different follow-up time points(1-14 days postpartum,2-4 months postpartum,5-7 months postpartum,and 12-17 months postpartum).The maternal body weight was analyzed using the responses in the survey questionnaires.A milk analyzer based on the mid-infrared spectroscopy(MIRS)was used to determine milk composition,and nutrition analysis software evaluated dietary intakes.In the cross-sectional cohort,participating mothers were asked to provide blood and human milk samples and pertinent information related to maternal body composition.Maternal body composition was measured by bioelectrical impedance analysis(BIA),while ELISA analyzed leptin and adiponectin in milk and serum.Results:At 5-7 months postpartum,the PPWR of breastfeeding mothers was(2.46±3.59)kg.At 12-17 months postpartum,the PPWR was(0.98±4.06)kg.PPWR was found to be negatively correlated with milk fat content within 14 days postpartum and positively correlated at 2-4 months postpartum.In addition,the maternal weight and body muscle mass were positively correlated with leptin and adiponectin in milk.Plasma leptin was positively correlated with the mother’s body weight,body mass index(BMI),FAT percentage,and body fat mass,while plasma adiponectin did not correlate with any parameter.The results also indicate that the PPWR did not correlate with leptin and adiponectin in plasma or milk.Conclusions:Breastfeeding mothers may retain considerable weight gain one year after delivery.Human milk composition may be related to changes in maternal body weight.Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition.This study supports the notion that maternal nutritional status may affect offspring health through lactation,and future research should focus on exploring weight management of postpartum mothers.
文摘Semi-heterogeneous photocatalysis has emerged as a powerful and productive platform in organic chemistry,which provides mild and eco-friendly conditions for a diverse range of bond-forming reactions.The synergy of homogeneous catalysts and heterogeneous catalysts inherits their main advantages,such as higher activities,easy separation and superior recyclability.In this review,we summarize the recent advances in recyclable semi-heterogenous protocols for the light promoted bond-forming reactions and identify directions for future research according to the different photocatalysts/metal/redox catalysts involved.Notably,this review is not a comprehensive description of reported literature but aim to highlight and illustrate key concepts,strategies,reaction model,reaction conditions and mechanisms.
基金support from the Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20200109115439775 and JCYJ20230807140459034)Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A1515012645)National Natural Science Foundation of China(Grant No.11872369).
文摘Four-dimensional(4D)printing represents a groundbreaking advancement in manufacturing,yet a persistent challenge is the limited number of stable configurations achievable through spontaneous shape reconstruction.Herein,we present a novel 4D printing mechanism that utilizes self-adjustable gas pressure to facilitate a wide range of spontaneous and stable multi-shape transformations.The gas is precisely released at designated spatial locations through strategic temperature-controlled degradation of a solid material,which is printed and distributed as needed at the voxel level within a specially designed multi-material structure,consisting of a low degradation temperature material(LDTM),a high degradation temperature soft material(HDTSM),and a high degradation temperature hard material(HDTHM).Each shape configuration is determined and locked in by the maximum temperature experienced during its thermal history.Notably,this shape retains its form robustly,independently of subsequent temperature changes,until a higher temperature threshold is reached,at which point a new shape configuration is triggered.These shapes exhibit a remarkable temperature memory effect,permanently recording the peak temperature reached in their thermal history.Our study comprehensively investigates the underlying principles and key parameters that influence deformation.We present a series of examples demonstrating complex multi-shape transformations modulated by temperature,supported by finite element simulations.This advance in 4D printing has the potential to significantly enhance its functional capabilities,performance,and applicability,opening up new horizons in additive manufacturing and design.
基金the National Natural Science Foundation of China(Nos.22171147 and 21871148)for the financial support。
文摘Polycyclic compounds are widely found in natural products and drug molecules with important biological activities,which attracted the attention of many chemists.Phosphine-catalyzed nucleophilic addition is one of the most powerful tools for the construction of various cyclic compounds with the advantages of atom economy,mild reaction conditions and simplicity of operation.Allenolates,Morita−Baylis−Hillman(MBH)alcohols and their derivatives(MBHADs),electron-deficient olefins and alkynes are very efficient substrates in phosphine mediated annulations,which formed many phosphonium species such asβ-phosphonium enolates,β-phosphonium dienolates and vinyl phosphonium ylides as intermediates.This review describes the reactivities of these phosphonium zwitterions and summarizes the synthesis of polycycle compounds through phosphine-mediated intramolecular and intermolecular sequential annulations.Thus,a systematic summary of the research process based on the phosphine-mediated sequential annulations of allenolates,MBH alcohols and MBHADs,electron-deficient olefins and alkynes are presented in Chapters 2-6,respectively.
文摘In order to reduce the occurrence of traffic accidents and assist drivers to avoid dangerous driving. This paper presents a smart in-vehicle safety system that utilises the Yolov5 algorithm. Yolov5 algorithm is used to anticipate driver fatigue and distraction behaviours, and remind drivers to pay attention to safe driving in time. The system continuously splits the frames and analyses the frame content through the video feedback from the front camera, compared to the traditional machine learning, Yolov5’s mosaic data is enhanced, resulting in a batch size enhancement of 92.3%, and it also uses the Drop Block mechanism to prevent overfitting. The hardware of this system uses STM32 microcontroller and uses system DMA interrupt control and buzzer alarm device to warn about dangerous driving behaviour.
基金This work was supported by grants from the National Natural Science Foundation of China(82100950,81974066)Foundation of Shanghai Municipal Health Commission(shslczdzk05702).
文摘Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and mortality.It is mainly characterized by cholestasis in children and steatohepatitis in adults.Unfortunately,there is no effective approach to prevent or reverse the disease.Regulated cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver diseases.Nowadays cell death is reclassified into several types,based on the mechanisms and morphological phenotypes.Emerging evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver diseases.Recent studies have shown that different modes of RCD are present in animal models and patients with IFALD.Understanding the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in IFALD.In this review,we discuss the current knowledge on how RCD may link to the pathogenesis of IFALD.We highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.
基金supported by the Ningxia Natural Science Foundation(Grant No.2022AAC03741)the Ningxia Medical University Scientific Research Fund(Grant No.XZ2021025).
文摘Background:Glioma-induced refractory epilepsy can be alleviated through conventional exercise,providing a potential therapeutic approach to manage this condition.This study aims to investigate the underlying mechanisms.Methods:Bioinformatics methodologies were employed to scrutinize gene expression data from public repositories such as GEO,with a specific focus on mobility-related genes in epilepsy.Through differential and enrichment analyses,differentially expressed genes(DEGs)were identified,while protein-protein interaction networks elucidated pivotal hub genes.Results:Our analysis revealed 32 DEGs,comprising 23 upregulated and 9 downregulated genes.Enrichment analysis underscored significant alterations in immune pathways in epilepsy.Two central hub genes,haptoglobin(HP)and prostaglandin-endoperoxide synthase 2(PTGS2),were found to be modulated by Arginase 1(ARG1)and Chemokine(C-X-C motif)ligand 8(CXCL8).GSVA analysis associated elevated PTGS2 expression with metabolic pathways,while increased HP expression was correlated with angiogenesis and inflammation.Subsequent experiments validated HP’s role in tumor cell proliferation,emphasizing its potential as a therapeutic target.Conclusion:This study highlights the crucial involvement of HP and PTGS2 genes in the etiology of epilepsy,linked to discrepancies in the immune system.These findings offer fresh perspectives on the management of epilepsy,emphasizing the neuroprotective possibilities of targeting specific gene pathway.
基金National Natural Science Foundation of China(Nos.52130106)Heilongjiang Touyan Innovation Team ProgramFundamental Research Funds for the Central Universities(FRFCU5710053021 and HIT.OCEF.2021014)。
文摘Recently,Mg_(3)Sb_(2)-xBixalloys have attracted intensive attention,with the aim of maximizing the electrical transport performance via donor element doping,increasing the grain size,as well as electronic band structure engineering.However,less attention has been paid to other significant factors,like how these intrinsic point defects and accompanied secondary phases influence thermoelectric properties.In this study,the microstructure and thermoelectric transport properties of Mg_(3.2)Sb_(0.5)Bi_(1.495-x)Te_(0.005)(x=0~0.2)compounds were systematically investigated,where tuning the Bi content shows the counter-intuitive impact on the thermoelectric properties.It was found that the Bipoor environment associated with Bi impurities facilitated the increment of cation vacancy formation energy and then increased the carrier concentration,leading to the enhancement of power factor.Simultaneously,the reduction of Bi-rich second phase content weakened the carrier scattering by grain boundaries whereas high carrier mobility was maintained.Moreover,the bipolar thermal conductivity decreased obviously due to the increased majority carrier concentration to suppress the intrinsic excitation.The synergistic optimization pushes the average ZT value(300-573 K)up to 0.95 in the Mg_(3.2)Sb_(0.5)Bi_(1.295)Te_(0.005)sample.Moreover,the calculated single-leg conversion efficiency is increased up to 9.7%with the hot-side temperature of 573 K,as the record-high value in this system.
基金the financial supports from the National Natural Science Foundation of China(Nos.11772332,11790292,11727803,11988102)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB22040501)the Opening Fund of State Key Laboratory of Nonlinear Mechanics,China。
基金Technological Foundation Project of Traditional Chinese Medicine Science of Zhejiang Province, NO. 2003C130 and NO. 2004C142 Foundation Project for Medical Science and Technology of Zhejiang province, No. 2003B134+3 种基金 Grave Foundation Project for Technological and Development of Hangzhou, No. 2003123B19 Intensive Foundation Project for Technology of Hangzhou, NO. 2004Z006 Foundation Project for Medical Science and Technology of Hangzhou, No. 2003A004 and Foundation Project for Technology of Hangzhou, No. 2005224
文摘AIM: To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-κB expression in multiple organs of SAP rats as well as the mechanisms involved. METHODS: Ninety Sprague-Dawley (SD) rats with SAP were randomly divided into the model group (n = 45) and dexamethasone treatment group (n = 45), and another 45 rats were selected for the sham operation group. All groups were randomly subdivided into the 3 h, 6 h and 12 h groups, each group containing 15 rats. The survival of all groups and pathological changes of multiple organs (liver, kidney and lung) were observed at different time points after the operation. The pathologicalscore of multiple organs was carried out, followed by the determination of amylase, endotoxin and TNF-α contents in blood. The tissue microarray was used to detect the expression levels of NF-κB p65 protein in multiple organs. RESULTS: There was no marked difference between the model group and treatment group in the survival rate. The amylase content of the treatment group was significantly lower compared to the model group at 12 h (P < 0.01, 7791.00 vs 9195.00). Moreover, the endotoxin and TNF-α levels of the treatment group were significantly lower than that of the model group at 6 h and 12 h (P < 0.01, 0.040 vs 0.055, 0.042 vs 0.059 and P < 0.05, 58.30 vs 77.54, 38.70 vs 67.30, respectively). Regarding the changes in liver NF-κB expression, the model group significantly exceeded the sham operation group at 3 h (P < 0.01, 1.00 vs 0.00), and the treatment group significantly exceeded the sham operation group at 12 h (P < 0.01, 1.00 vs 0.00), whereas no marked difference was observed between the model group and treatment group at all time points. The kidney NF-κB expression level in the treatment group significantly exceeded the model group (P < 0.05, 2.00 vs 0.00) and the sham operation group (P < 0.01, 2.00 vs 0.00) at 12 h. No NF-κB expression in the lung was found in any group. CONCLUSION: Dexamethasone can lower the amylase, endotoxin and TNF-α levels as well as mortality of SAP rats. NF-κB plays an important role in multiple organ injury. Further studies should be conducted to determine whether dexamethasone can ameliorate the pathological changes of multiple organs by reducing the NF-κB expression in the liver and kidney. The advantages of tissue microarrays in pancreatitis pathological examination include time- and energy- saving, and are highly efficient and representative. The restriction of tissue microarrays on the representation of tissues to various extents due to small diameter may lead to the deviation of analysis.
基金supported by Nature Key Research and Development Program of China (2017YFB1400700)the National Natural Science Foundation of China (61602537, U1509214)+1 种基金the Central University of Finance and Economics Funds for the Youth Talent Support Plan (QYP1808)First-Class Discipline Construction in 2019,open fund of Key Laboratory of Grain Information Processing and Control (KFJJ-2018-202)
文摘Blockchain with these characteristics of decentralized structure, transparent and credible, time-series and immutability, has been considering as a promising technology. Consensus algorithm as one of the core techniques of blockchain directly affects the scalability of blockchain systems. Existing probabilistic finality blockchain consensus algorithms such as PoW, PoS, suffer from power consumptions and low efficiency;while absolute finality blockchain consensus algorithms such as PBFT, HoneyBadgerBFT, could not meet the scalability requirement in a largescale network. In this paper, we propose a novel optimized practical Byzantine fault tolerance consensus algorithm based on EigenTrust model, namely T-PBFT, which is a multi-stage consensus algorithm. It evaluates node trust by the transactions between nodes so that the high quality of nodes in the network will be selected to construct a consensus group. To reduce the probability of view change, we propose to replace a single primary node with a primary group. By group signature and mutual supervision, we can enhance the robustness of the primary group further. Finally, we analyze T-PBFT and compare it with the other Byzantine fault tolerant consensus algorithms. Theoretical analysis shows that our T-PBFT can optimize the Byzantine fault-tolerant rate,reduce the probability of view change and communication complexity.
基金Supported by Grants from the Program for Innovative Research Team of Shanghai Municipal Education Commission and Special Foundation of Shanghai Municipal Public Health Bureau, LJ06021the National Natural Science Foundation of China, No. 30772270, 30972427the Scientific Foundation of Nantong University, No. 10Z046
文摘AIM: To investigate the disruptions of interstitial cells of Cajal (ICC) in the remaining bowel in rats after massive small bowel resection (mSBR). METHODS: Thirty male Sprague-Dawley rats fitting entry criteria were divided randomly into three experimental groups (n = 10 each): Group A rats underwent bowel transection and re-anastomosis (sham) and tissue samples were harvested at day 7 post-surgery. Group B and C rats underwent 80% small bowel resection with tissue harvested from Group B rats at day 7 post-surgery, and from Group C rats at day 14 postsurgery. The distribution of ICC at the site of the resid-ual small bowel was evaluated by immunohistochemical analysis of small intestine samples. The ultrastructural changes of ICC in the remnant ileum of model rats 7 and 14 d after mSBR were analyzed by transmission electron microscopy. Intracellular recordings of slow wave oscillations were used to evaluate electrical pacemaking. The protein expression of c-kit, ICC phenotypic markers, and membrane-bound stem cell factor (mSCF) in intestinal smooth muscle of each group were detected by Western blotting. RESULTS: After mSBR, immunohistochemical analysis indicated that the number of c-kit-positive cells was dramatically decreased in Group B rats compared with sham tissues. Significant ultrastructural changes in ICC with associated smooth muscle hypertrophy were also observed. Disordered spontaneous rhythmic contractions with reduced amplitude (8.5 ± 1.4 mV vs 24.8 ± 1.3 mV, P = 0.037) and increased slow wave frequency (39.5 ± 2.1 cycles/min vs 33.0 ± 1.3 cycles/min, P = 0.044) were found in the residual intestinal smooth muscle 7 d post mSBR. The contractile function and electrical activity of intestinal circular smooth muscle returned to normal levels at 14 d post mSBR (amplitude, 14.9 ± 1.6 mV vs 24.8 ± 1.3 mV; frequency, 30.7 ± 1.7 cycles/min vs 33.0 ± 1.3 cycles/min). The expression of Mscf and c-kit protein was decreased at 7 d (P = 0.026), but gradually returned to normal levels at 14 d. The ICC and associated neural networks were disrupted, which was associated with the phenotype alterations of ICC. CONCLUSION: Massive small bowel resection in rats triggered damage to ICC networks and decreased the number of ICC leading to disordered intestinal rhythmicity. The mSCF/c-kit signaling pathway plays a role in the regulation and maintenance of ICC phenotypes.
基金Supported by the National Natural Science Foundation of China,No.81570535 and No.81770587Key Projects in the National Science and Technology Pillar Program during the Thirteenth Five-year Plan Period,No.2017ZX10203201-008,No.2018ZX09206005-003,and 2017ZX10202202-005-004+4 种基金the Shanghai Three-Year Plan of the Clinical Skills and Innovations,No.16CR1002Athe Shanghai Municipal Key Clinical Specialty,No.shslczdzk01103the Shanghai Three-Year Plan of the Key Subjects Construction in Public Health-Infectious Diseases and Pathogenic Microorganism,No.15GWZK0102the Suzhou Expert Team of Clinical Medicine,No.SZYJTD201717the Joint Research Initiative-Shanghai Jiao Tong University School of Medicine,No.YW20190002
文摘BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.
基金supported by the National Natural Science Foundation of China (No. 51078185, U1162119)the research fund of Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province (No. AE201001)the research fund for the Doctoral Program of Higher Education of China (No.20113219110009)
文摘TiO2 supports doped with different amounts of Si were prepared by a sol-gel method, and 1 wt% vanadia （V2O5） loaded on Si-doped TiO2 was obtained by an impregnation method. The mole ratio of Si/Ti was 0.2, NOx conversion exceeds 94% at 300℃ and GHSV of 41,324 hr-1 , which is about 20% higher than pure V2O5/TiO2 . The catalysts were characterized by XRD, BET, TEM, FT-IR, NH3-TPD, XPS, H2-TPR, Raman and in situ DRIFTS. The results of FT-IR and XPS indicated that Si was doped into the TiO2 lattice successfully and a solid solution was obtained. V2O5 active component could be dispersed well on the support with the increasing of surface area of the catalyst, which was confirmed by Raman and XRD results. Above all, the numbers of acid sites （especially the Br nsted-acid） and oxidation properties were enhanced for Si-doped V2O5/TiO2 catalysts, which improved the deNOx catalytic activity.
文摘AIM. To establish a kind of standardization of the clinical chemotherapeutic prototypes for unresectable hepatocellular carcinomas （HCC）. METHODS： 10-Hydroxycamptothecin （HCPT） was applied through transcatheter arterial embolization （TAE） to HCC patients who were categorized into three groups： （1） test group： treatment with HCPT twice （HCPT dl and 14） through TAE and portal venous embolization. （2） Control Ⅰ： treatment with anticancer drugs without HCPT. （3） Control Ⅱ： treatment with HCPT as a major component in anticancer drugs once （HCPT dl）. A set of comparisons between test groups and control Ⅰ and Ⅱ groups were performed before and after the treatment to study the effectiveness of each treatment, in terms of tumor volumes, dynamic variations in serum alpha-fetoprotein （AFP）, gamma-glutamyl transferase hepatoma-specific band （GGT-Ⅱ）, patient survival and adverse events. RESULTS： The general effectiveness rate of the test group reached 62.1% （72/116）, remarkably higher than that of control Ⅰ （32.1%, 40/124） and control Ⅱ （54.7%, 47/56）, （P〈0.01 and P〈0.05, respectively）. Especially, the reduction rate or disappearance of the portal vein tumor emboli was as high as 88.4% （61/69） in the test group, in contrast with 13.9% （10/72） in control Ⅰ and 35.9% （18/51） in control Ⅱ （P〈0.01 and P〈0.01, respectively）. After treatment, AFP decreased or turned to negative levels at 52.3% （34/65） in control Ⅰ, 67.3% （35/52） in control Ⅱ, and 96.8% （60/62） in the test group. Also GGT-Ⅱ declined or became negative at 37.8% （28/74） in control Ⅰ, 69.5% （57/82） in control Ⅱ, and 94.7% （89/94） in test group （P〈0.01 and P〈0.05, respectively）. CONCLUSION： We have designed a good protocol （test group） to treat HCC with excellent advantages of high efficiency, low cost, low toxicity and low adverse events and easy application. It could be recommended as one of the standardizations for HCC treatment in clinical practice.
基金supported by the Natural Science Foundation of China through Grant No.11702144。
文摘Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater diameter with concrete strength is different from that of shaped charge penetration into normal strength concrete(NSC).The crater diameter of RPC is smaller than that of NSC penetrated by the shaped charge.The jet particles are strongly disturbed and hardly reach the crater bottom because they pass through the narrow channel formed by jet penetration into the RPC.The effects of radial drift velocity and gap effects of jet particles for a shaped charge penetration into RFC target are discussed.Moreover,a theoretical model is presented to describe the penetration of shaped charge into RPC target.As the concrete strength increases,the penetration resistance increases and the entrance crater diameter decreases.Given the drift velocity and narrow crater channel,the low-velocity jet particles can hardly reach the crater bottom to increase the penetration depth.Moreover,the narrow channel has a stronger interference to the jet particles with increasing concrete strength;hence,the gap effects must be considered.The drift velocity and gap effects,which are the same as penetration resistance,also have significant effects during the process of shaped charge penetration into ultrahigh-strength concrete,The crater profiles are calculated through a theoretical model,and the results are in good agreement with the experiments.
