Rechargeable aqueous zinc-ion batteries(AZIBs)exhibit appreciable potential in the domain of electrochemical energy storage.However,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evo...Rechargeable aqueous zinc-ion batteries(AZIBs)exhibit appreciable potential in the domain of electrochemical energy storage.However,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction(HER),and corrosion side reactions.Herein,we propose a surface engineering modification strategy for coating the montmorillonite(MMT)layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable AZIBs.The results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc ions.Density functional theory(DFT)calculations and water contact angle(CA)tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn^(2+)and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling stability.Moreover,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm^(-2)and 0.125 m A h cm^(-2),even exceeding 1800 h long cycling under harsh conditions of 5 m A cm^(-2)and 1.25 m A h cm^(-2).The MMT@Zn||V_(2)O_(5)full cell reaches over 3000 cycles at 2 A g^(-1)with excellent rate capability.Therefore,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.展开更多
The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastroi...The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system,focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system.展开更多
At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,f...At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,fruit juice processing and health products.Therefore,vigorously developing the grape and cherry industries in Shandong Province and carrying out development and innovation are important parts of Shandong Province in responding to the strategy of national new and old kinetic energy conversion.However,currently the germplasm resources preserved in the fruit tree resources banks in China are only 45%of those in the US and 27.2%of those in the EU.Moreover,the development of fruit trees resources banks in Shandong is relatively backward in China,and there is still no banks related with grape and cherry germplasm resources in Shandong.Therefore,importance can be attached to the agriculture,forestry,and animal husbandry to build germplasm resources banks for grape and cherry industries in Shandong Province.Building the national-level grape and cherry germplasm resources bank in Shandong Province can also promote the utilization of wild and farm germplasm resources in the future;advance the research on the genes related to disease resistance,stress resistance and quality of grapes and cherries;push forward the construction and development of cherry and grape mutants banks.It is conducive to the research on the agronomic traits of grapes and cherries,and can provide the parents resources for planting innovation and improving the quality of grapes and cherries,as well as promote the development and application of molecular markers of grapes and cherries,including the identification of lines and crossbreeding.Thereby,it cannot only promote the industry development,but also achieve the development of cultivation,breeding and basic research in an all-round way and the development of"production,study and research"going side by side.展开更多
Rechargeable aqueous zinc ion batteries(AZIBs)have attracted considerable attention.However,issues such as zinc dendrite growth and harmful parasitic reactions adversely affect their cycling stability.This work propos...Rechargeable aqueous zinc ion batteries(AZIBs)have attracted considerable attention.However,issues such as zinc dendrite growth and harmful parasitic reactions adversely affect their cycling stability.This work proposes a novel and simple strategy to coat organic montmorillonite(MDS),where the interlayers are expanded through didodecyldimethylammonium bromide,on the zinc surface to achieve excellent cycling stability.The mechanisms for suppressing zinc dendrite growth and hindering harmful reactions are elucidated.The results revealthat the MDS coating on the zinc anode surface provides a pathway for Zn^(2+)transport,facilitating the regulation of the(002)crystal plane and isolating the electrolyte from direct contact with the zinc plate.Density functional theory calculations indicate that the MDS possesses higher adsorption energy for Zn^(2+),H_(2)O,and SO_(4)^(2−),thereby suppressing the harmful parasitic reactions.The MDS@Zn symmetric cell demonstrates an excellent cycle life of over 3620 h(1 mAh cm^(−2),2 mA cm^(−2)).The MDS@Zn||Cu cell achieves an impressive coulombic efficiency of 99.5%over 3,600 h(1 mA cm^(−2),1 mAh cm^(−2)).Further,the MDS@Zn||VO_(2)full cell retained 95.5%capacity(200 mAh g^(−1))after 1300 cycles at 2.5 A g^(−1).This work offers new insights into surface engineering strategies to achieve high-performance AZIBs.展开更多
The intake of sugars,especially glucose and fructose,has significantly increased with the change of lifestyle.Excessive intake of sugar has been proven to be associated with tumors and inflammatory diseases.Fructose d...The intake of sugars,especially glucose and fructose,has significantly increased with the change of lifestyle.Excessive intake of sugar has been proven to be associated with tumors and inflammatory diseases.Fructose directly mediates innate immune responses;however,whether it can directly regulate T-cell immunity remains unknown.We show that high fructose consumption accelerates the development of inflammatory bowel disease(IBD)by promoting the generation of T helper 1(Th1)and T helper 17(Th17)cells.It was demonstrated that fructose promotes the differentiation of Th1 and Th17 cells directly by enhancing mechanistic target of rapamycin complex 1(mTORC1)activation through the glutamine metabolism-dependent pathway.Reactive oxygen species(ROS)-induced activation of transforming growth factor-β(TGF-β)is also involved in fructose-induced Th17 cell generation.Moreover,metformin can reverse Th1 and Th17 cell generation induced by fructose by suppressing mTORC1 activation and reducing ROS-mediated TGF-βactivation.Finally,we identified metformin as an in vivo therapeutic drug for relieving high fructose consumption-induced T-cell inflammation and colitis aggravation.Our study revealed a previously unknown adverse effect of high fructose consumption in disrupting immune homeostasis and exacerbating IBD by directly promoting T-cell immunity,and showed metformin is a potential therapeutic for reversing the T cell immune imbalance caused by long-term high fructose consumption.展开更多
Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of ...Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus.展开更多
The construction of chiral quaternary carbon stereocenters is a significant challenge in asymmetric synthesis.Catalytic synthesis of these structures with trisubstituted allylic alcohols is highly important. However, ...The construction of chiral quaternary carbon stereocenters is a significant challenge in asymmetric synthesis.Catalytic synthesis of these structures with trisubstituted allylic alcohols is highly important. However, most ofthe reported methodologies required noble transition-metals. Herein we reported the first highly asymmetricstereoselective synthesis of cyclopentanes bearing chiral quaternary carbon stereocenters of trisubstituted allylicsiloxanes by reductive cyclization of all carbon 1,6-alkynones with the non-noble nickel catalysis of Ni(cod)2 withP-chiral monophosphine ligand (S)-BIDIME. Various multi-substituted functionalized cyclopentanes were obtained in high yields (up to 96%), excellent enantioselectivities (up to >99% ee) and perfect stereoselectivities(>99:1 E/Z). Thirty-two examples were successfully established for this method. Clarified mechanism studieswere investigated first time by React-IR and DFT calculations to understand and explain the ligand-control ofexcellent enantio-stereoselectivity. Gram-scale reaction and control experiments were carried out. A new reactiondesign was proposed for further application of this type of catalysis.展开更多
基金National Natural Science Foundation of China(Grant No.22005318,22379152)Western Young Scholars Foundations of Chinese Academy of Sciences+4 种基金Lanzhou Youth Science and Technology Talent Innovation Project(Grant No.2023-NQ-86,No.2023-QN-96)Lanzhou Chengguan District Science and Technology Plan Project(Grant No.2023-rc-4,2022-rc-4)Collaborative Innovation Alliance Fund for Young Science and Technology Worker(Grant No.HZJJ23-7)National Nature Science Foundations of Gansu Province(Grant No.21JR11RA020)Fundamental Research Funds for the Central Universities(Grant No.31920220073,31920230128)。
文摘Rechargeable aqueous zinc-ion batteries(AZIBs)exhibit appreciable potential in the domain of electrochemical energy storage.However,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction(HER),and corrosion side reactions.Herein,we propose a surface engineering modification strategy for coating the montmorillonite(MMT)layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable AZIBs.The results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc ions.Density functional theory(DFT)calculations and water contact angle(CA)tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn^(2+)and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling stability.Moreover,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm^(-2)and 0.125 m A h cm^(-2),even exceeding 1800 h long cycling under harsh conditions of 5 m A cm^(-2)and 1.25 m A h cm^(-2).The MMT@Zn||V_(2)O_(5)full cell reaches over 3000 cycles at 2 A g^(-1)with excellent rate capability.Therefore,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.
基金supported by the Intramural Research Program of the National Institutes of HealthNational Institute of Dental and Craniofacial Research, USA+1 种基金supported by grant 2012DFA31370 from the International S&T Cooperation Program of Chinathe National Nature Science Foundation of China (81321002)
文摘The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system,focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system.
基金supported by the Agricultural scientific and technological innovation project of Shandong Academy of Agricultural Sciences(CXGC2016D01)Agricultural scientific and technological innovation project of Shandong Academy of Agricultural Sciences-cultivating project for National Natural Science Foundation of China in 2018"identification and function research of Vitis vinifera and Vitis amurensis cold stress response-related micro RNAs"+2 种基金Major Agricultural Application Technology Innovation Project of Shandong Province"Research and Application of Precision Control of Maturation and Product Innovation of Featured Brewing Grape"Major Agricultural Application Technology Innovation Project of Shandong Province"Development of Landmark Wines and Integrated Application of Key Technologies in Shandong Province"Fruit innovation team of modern agricultural industry technology system in Shandong Province-Jinan comprehensive test station(SDAIT-06-21)
文摘At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,fruit juice processing and health products.Therefore,vigorously developing the grape and cherry industries in Shandong Province and carrying out development and innovation are important parts of Shandong Province in responding to the strategy of national new and old kinetic energy conversion.However,currently the germplasm resources preserved in the fruit tree resources banks in China are only 45%of those in the US and 27.2%of those in the EU.Moreover,the development of fruit trees resources banks in Shandong is relatively backward in China,and there is still no banks related with grape and cherry germplasm resources in Shandong.Therefore,importance can be attached to the agriculture,forestry,and animal husbandry to build germplasm resources banks for grape and cherry industries in Shandong Province.Building the national-level grape and cherry germplasm resources bank in Shandong Province can also promote the utilization of wild and farm germplasm resources in the future;advance the research on the genes related to disease resistance,stress resistance and quality of grapes and cherries;push forward the construction and development of cherry and grape mutants banks.It is conducive to the research on the agronomic traits of grapes and cherries,and can provide the parents resources for planting innovation and improving the quality of grapes and cherries,as well as promote the development and application of molecular markers of grapes and cherries,including the identification of lines and crossbreeding.Thereby,it cannot only promote the industry development,but also achieve the development of cultivation,breeding and basic research in an all-round way and the development of"production,study and research"going side by side.
基金supported by the National Natural Science Foundation of China(grant nos.22379152,22005318,and 44469020)the Science and Technology Plan Foundations of Gansu Province(grant no.25JRRA470)+2 种基金the Western Young Scholars Foundations of the Chinese Academy of Sciences,the Lanzhou Chengguan District Science and Technology Plan Project(grant nos.2023-rc-4 and 2024RCCX0002)the Gansu Provincial Key R&D Program Project(grant no.24YFGA010)the Lanzhou Youth Science and Technology Talent Innovation Project(grant no.2024-QN-1).
文摘Rechargeable aqueous zinc ion batteries(AZIBs)have attracted considerable attention.However,issues such as zinc dendrite growth and harmful parasitic reactions adversely affect their cycling stability.This work proposes a novel and simple strategy to coat organic montmorillonite(MDS),where the interlayers are expanded through didodecyldimethylammonium bromide,on the zinc surface to achieve excellent cycling stability.The mechanisms for suppressing zinc dendrite growth and hindering harmful reactions are elucidated.The results revealthat the MDS coating on the zinc anode surface provides a pathway for Zn^(2+)transport,facilitating the regulation of the(002)crystal plane and isolating the electrolyte from direct contact with the zinc plate.Density functional theory calculations indicate that the MDS possesses higher adsorption energy for Zn^(2+),H_(2)O,and SO_(4)^(2−),thereby suppressing the harmful parasitic reactions.The MDS@Zn symmetric cell demonstrates an excellent cycle life of over 3620 h(1 mAh cm^(−2),2 mA cm^(−2)).The MDS@Zn||Cu cell achieves an impressive coulombic efficiency of 99.5%over 3,600 h(1 mA cm^(−2),1 mAh cm^(−2)).Further,the MDS@Zn||VO_(2)full cell retained 95.5%capacity(200 mAh g^(−1))after 1300 cycles at 2.5 A g^(−1).This work offers new insights into surface engineering strategies to achieve high-performance AZIBs.
基金supported by the National Natural Science Foundation of China(NO.82171829)the Key Project of the Science and Technology Department of Sichuan Province(NO.2025YFHZ0205)+2 种基金the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(NO.ZYYC25010)supported by the Intramural Research Program of the U.S.National Institutes of Health(NIH)National Institute of Dental and Craniofacial Research(NIDCR).
文摘The intake of sugars,especially glucose and fructose,has significantly increased with the change of lifestyle.Excessive intake of sugar has been proven to be associated with tumors and inflammatory diseases.Fructose directly mediates innate immune responses;however,whether it can directly regulate T-cell immunity remains unknown.We show that high fructose consumption accelerates the development of inflammatory bowel disease(IBD)by promoting the generation of T helper 1(Th1)and T helper 17(Th17)cells.It was demonstrated that fructose promotes the differentiation of Th1 and Th17 cells directly by enhancing mechanistic target of rapamycin complex 1(mTORC1)activation through the glutamine metabolism-dependent pathway.Reactive oxygen species(ROS)-induced activation of transforming growth factor-β(TGF-β)is also involved in fructose-induced Th17 cell generation.Moreover,metformin can reverse Th1 and Th17 cell generation induced by fructose by suppressing mTORC1 activation and reducing ROS-mediated TGF-βactivation.Finally,we identified metformin as an in vivo therapeutic drug for relieving high fructose consumption-induced T-cell inflammation and colitis aggravation.Our study revealed a previously unknown adverse effect of high fructose consumption in disrupting immune homeostasis and exacerbating IBD by directly promoting T-cell immunity,and showed metformin is a potential therapeutic for reversing the T cell immune imbalance caused by long-term high fructose consumption.
基金by the Major International(Regional)Joint Research Project(No.81720108020)National Natural Science Foundation of China(No.81373199,81501347 and 81370730,81273304)+2 种基金National Natural Science Foundation of Jiangsu(BK20150098)Jiangsu Province Major Research and Development Program(BE2015602)Jiangsu Province 333 Talant Grant(BRA2016001).
文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus.
基金financial support provided by the National Natural Science Foundation of China(No.22061032)Natural Science Foundation of Inner Mongolia(Nos.2020MS02022,and 2022QN02005)+5 种基金Science and Technology Program of Inner Mongolia(No.2020GG0134)Opening-fund from State Key Laboratory of Bio-organic and Natural Products Chemistry of SIOC(No.21300-5206002)“JUN-MA”Highlevel Talents Program of Inner Mongolia University(No.21300-5185121)“Grassland Talents”Program of Inner Mongolia(No.12000-12102414)High-level Recruit Program of Inner Mongolia(No.12000-13000603)Key Project at Central Government Level:the ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302)is sincerely acknowledged。
文摘The construction of chiral quaternary carbon stereocenters is a significant challenge in asymmetric synthesis.Catalytic synthesis of these structures with trisubstituted allylic alcohols is highly important. However, most ofthe reported methodologies required noble transition-metals. Herein we reported the first highly asymmetricstereoselective synthesis of cyclopentanes bearing chiral quaternary carbon stereocenters of trisubstituted allylicsiloxanes by reductive cyclization of all carbon 1,6-alkynones with the non-noble nickel catalysis of Ni(cod)2 withP-chiral monophosphine ligand (S)-BIDIME. Various multi-substituted functionalized cyclopentanes were obtained in high yields (up to 96%), excellent enantioselectivities (up to >99% ee) and perfect stereoselectivities(>99:1 E/Z). Thirty-two examples were successfully established for this method. Clarified mechanism studieswere investigated first time by React-IR and DFT calculations to understand and explain the ligand-control ofexcellent enantio-stereoselectivity. Gram-scale reaction and control experiments were carried out. A new reactiondesign was proposed for further application of this type of catalysis.
