Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce....Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce. Fourteen patients were recruited from the Neuro-Rehabilitation Unit of Hangzhou Hospital of Zhejiang Armed Police Corps of China. Altogether, there were seven cases of unresponsive wakefulness syndrome（five males and two females, aged 45.7 ± 16.8 years） and seven cases of minimally conscious state（six males and one female, aged 42.3 ± 20.8 years）. Simultaneously, fourteen healthy controls（10 males and 4 females, aged 51.7 ± 9.7 years） also participated in this case-control experiment. Brain response to music, subjects＇ own name, and noise was monitored by quantitative electroencephalography（QEEG） in the resting state and with acoustic stimulation. Predictive QEEG values in various brain regions were investigated. Our results show that cerebral activation was high in subjects stimulated by their own name, especially in the temporal lobe in patients with disorders of consciousness, and the frontal lobe in the control group. Further, during resting and stimulation, QEEG index（δ ＋ θ/α ＋ β ratio） negatively correlated with the Coma Recovery Scale-Revised score in traumatic disorders of consciousness patients. Hence, we speculate that a subject＇s own name might be an effective awakening therapy for patients with disorders of consciousness. Moreover, QEEG index in specific stimulation states may be used as a prognostic indicator for disorders of consciousness patients（sensitivity, 75%; specificity, 50%）.展开更多
INTRODUCTION Traumatic brain injury （TBI）, one of the most common causes of death and disability worldwide, has become a public health crisis. TBI can be classified as primary injury or secondary injury. The leading...INTRODUCTION Traumatic brain injury （TBI）, one of the most common causes of death and disability worldwide, has become a public health crisis. TBI can be classified as primary injury or secondary injury. The leading causes of primary injury are falls, motor vehicle traffic, and struck.I^1 The delayed, secondary injury cascades with highly complex pathophysiological events occur following primary mechanical insults and are regarded as contributing factors influencing the recovery of TB Over the past few decades, a considerable number of clinical trials and animal experiments have sought to develop therapeutic strategies. The efforts to lower the risk of secondary injury and improve outcomes for TBI patients can be ascribed to the process of＂squeezing oxygenated blood through a swollen brain＂.展开更多
基金supported by grants from the General Project Plan of Zhejiang Medical Technology of China,No.2014RCA007the Medical Science and Technology Project Co-founded by Zhejiang Province and the Ministry of Health of China,No.2016152769
文摘Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce. Fourteen patients were recruited from the Neuro-Rehabilitation Unit of Hangzhou Hospital of Zhejiang Armed Police Corps of China. Altogether, there were seven cases of unresponsive wakefulness syndrome（five males and two females, aged 45.7 ± 16.8 years） and seven cases of minimally conscious state（six males and one female, aged 42.3 ± 20.8 years）. Simultaneously, fourteen healthy controls（10 males and 4 females, aged 51.7 ± 9.7 years） also participated in this case-control experiment. Brain response to music, subjects＇ own name, and noise was monitored by quantitative electroencephalography（QEEG） in the resting state and with acoustic stimulation. Predictive QEEG values in various brain regions were investigated. Our results show that cerebral activation was high in subjects stimulated by their own name, especially in the temporal lobe in patients with disorders of consciousness, and the frontal lobe in the control group. Further, during resting and stimulation, QEEG index（δ ＋ θ/α ＋ β ratio） negatively correlated with the Coma Recovery Scale-Revised score in traumatic disorders of consciousness patients. Hence, we speculate that a subject＇s own name might be an effective awakening therapy for patients with disorders of consciousness. Moreover, QEEG index in specific stimulation states may be used as a prognostic indicator for disorders of consciousness patients（sensitivity, 75%; specificity, 50%）.
文摘INTRODUCTION Traumatic brain injury （TBI）, one of the most common causes of death and disability worldwide, has become a public health crisis. TBI can be classified as primary injury or secondary injury. The leading causes of primary injury are falls, motor vehicle traffic, and struck.I^1 The delayed, secondary injury cascades with highly complex pathophysiological events occur following primary mechanical insults and are regarded as contributing factors influencing the recovery of TB Over the past few decades, a considerable number of clinical trials and animal experiments have sought to develop therapeutic strategies. The efforts to lower the risk of secondary injury and improve outcomes for TBI patients can be ascribed to the process of＂squeezing oxygenated blood through a swollen brain＂.
