Background Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world,especially in developing countries.We aimed to determine the prevalence of ABE based...Background Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world,especially in developing countries.We aimed to determine the prevalence of ABE based on the Johnson bilirubininduced neurologic dysfunction (BIND) score and to describe the discharge outcomes.Methods We prospectively studied all newborns ≥ 35 weeks with ABE by evaluating signs of mental sensorium,muscle tone,and cry patterns over 1 year.Results 12% (81 out of 674) of the newborns admitted for neonatal hyperbilirubinemia had a BIND score > 1.Their admission age was 6 ± 4.1 days;total serum bilirubin (TSB) was 31.2± 10 mg/dL (range 17.5-75.2).Of these newborns,40.7% and 21% had evidence of haemolysis and sepsis,respectively.Overall mortality was 9.9%;58% of the newborns showed signs of mild-to-moderate BIND at discharge,while 32.1% survived with an apparently normal outcome.Admission BIND score was significantly correlated with admission TSB (r=0.476,P < 0.001).Similarly,BIND score at discharge was correlated with admission TSB (r=0.442,P < 0.001) and admission BIND score (r =0.888,P < 0.001).The regression model showed that admission TSB (P < 0.001) and maternal illiteracy (P =0.034) were predictors of the BIND score at admission,while admission BIND score was the best indicator of the discharge score (P < 0.001).Conclusions ABE is still a major problem in our community.Admission TSB and maternal illiteracy are good predictors of bilirubin encephalopathy at admission and discharge.展开更多
Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders world-wide.Down syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live...Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders world-wide.Down syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live births.Turner syndrome results from X-chromosome monosomy and has an incidence of 1 in 2000 of live-born female infants.展开更多
文摘Background Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world,especially in developing countries.We aimed to determine the prevalence of ABE based on the Johnson bilirubininduced neurologic dysfunction (BIND) score and to describe the discharge outcomes.Methods We prospectively studied all newborns ≥ 35 weeks with ABE by evaluating signs of mental sensorium,muscle tone,and cry patterns over 1 year.Results 12% (81 out of 674) of the newborns admitted for neonatal hyperbilirubinemia had a BIND score > 1.Their admission age was 6 ± 4.1 days;total serum bilirubin (TSB) was 31.2± 10 mg/dL (range 17.5-75.2).Of these newborns,40.7% and 21% had evidence of haemolysis and sepsis,respectively.Overall mortality was 9.9%;58% of the newborns showed signs of mild-to-moderate BIND at discharge,while 32.1% survived with an apparently normal outcome.Admission BIND score was significantly correlated with admission TSB (r=0.476,P < 0.001).Similarly,BIND score at discharge was correlated with admission TSB (r=0.442,P < 0.001) and admission BIND score (r =0.888,P < 0.001).The regression model showed that admission TSB (P < 0.001) and maternal illiteracy (P =0.034) were predictors of the BIND score at admission,while admission BIND score was the best indicator of the discharge score (P < 0.001).Conclusions ABE is still a major problem in our community.Admission TSB and maternal illiteracy are good predictors of bilirubin encephalopathy at admission and discharge.
文摘Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders world-wide.Down syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live births.Turner syndrome results from X-chromosome monosomy and has an incidence of 1 in 2000 of live-born female infants.
