目的:分析轻度与中重度疼痛股骨头坏死(Osteonecrosis of Femoral Head,ONFH)患者血清Ⅰ型胶原羧基端肽β交联肽(β-CTx)水平与骨髓水肿分级的差异,探讨疼痛与β-CTx水平及骨髓水肿的相关性。方法:自2022年1月至2023年6月,将符合纳入标...目的:分析轻度与中重度疼痛股骨头坏死(Osteonecrosis of Femoral Head,ONFH)患者血清Ⅰ型胶原羧基端肽β交联肽(β-CTx)水平与骨髓水肿分级的差异,探讨疼痛与β-CTx水平及骨髓水肿的相关性。方法:自2022年1月至2023年6月,将符合纳入标准的99例股骨头坏死患者,根据入院时视觉模拟量表(VAS)评分高低分为两组。A组为轻度疼痛患者(VAS评分≤3分),47例;B组为中重度疼痛患者(VAS评分≥4分),52例。所有患者经保守治疗6个月后比较治疗前后患者血清β-CTx水平及骨髓水肿分级。结果:治疗前A组VAS评分为1.74±0.98,β-CTx水平为0.72±0.17;B组VAS评分为5.27±1.08,β-CTx水平为0.59±0.23。两组之间β-CTx水平差异有统计学意义(P<0.05);Pearson相关分析表明,VAS评分与β-CTx水平呈低度正相关(r=0.269,P=0.007)。治疗6个月后A组与B组患者VAS评分分别为1.47±0.90和3.87±1.52;β-CTx水平分别为0.38±0.18和0.42±0.23,治疗前后β-CTx水平差异有统计学意义(P<0.05)。骨髓水肿分级:治疗前A组1级18例,2级23例,3级6例;B组,1级7例,2级21例,3级24例。治疗后骨髓水肿分级:A组0级2例,1级33例,2级10例,3级2例;B组0级1例,1级16例,2级23例,3级12例。卡方检验结果表明,治疗前后患者疼痛程度与骨髓水肿分级有相关性,非参数检验表明各疼痛程度下骨髓水肿分级的平均秩次呈递增趋势。结论:股骨头坏死患者疼痛轻重与血清β-CTx水平及骨髓水肿分级呈正相关,中重度疼痛较轻度疼痛患者,其血清β-CTx水平及骨髓水肿分级均明显更高,提示坏死区域破骨细胞异常活跃所致的骨吸收及骨髓水肿所致的骨内高压可能是引起患者疼痛的重要因素。展开更多
In order to study the effect of electromagnetic compound treatment on the mechanical property, cutting performance and microstructure of cemented carbide, the samples were treated by a self-made electromagnetic compou...In order to study the effect of electromagnetic compound treatment on the mechanical property, cutting performance and microstructure of cemented carbide, the samples were treated by a self-made electromagnetic compound treatment device with different magnetic field strength(H=1, 1.25 and 1.5 T). The electromagnetic compound treatment method was proposed to couple pulsed magnetic field and pulsed current. The results show that after the pulsed magnetic field treatment, the values of the transverse rupture strength of the samples were respectively reduced by 21%, 20.6% and 20.1%;the cutting performance was decreased by about 4.5%, which means the tool life was decreased. After the electromagnetic compound treatment, the values of the transverse rupture strength of the rectangular samples were respectively increased by 8%, 8.6% and 9.5%, and the tool life was increased by 4.2%, 7% and 10.3%. After the electromagnetic compound treatment, the pulse current provided the driving force for dislocation motion. A strong pulse current driving force is more likely to make the dislocation multiply and slip. A high density dislocation cell is formed within the material, so the mechanical properties were significantly increased.展开更多
文摘目的:分析轻度与中重度疼痛股骨头坏死(Osteonecrosis of Femoral Head,ONFH)患者血清Ⅰ型胶原羧基端肽β交联肽(β-CTx)水平与骨髓水肿分级的差异,探讨疼痛与β-CTx水平及骨髓水肿的相关性。方法:自2022年1月至2023年6月,将符合纳入标准的99例股骨头坏死患者,根据入院时视觉模拟量表(VAS)评分高低分为两组。A组为轻度疼痛患者(VAS评分≤3分),47例;B组为中重度疼痛患者(VAS评分≥4分),52例。所有患者经保守治疗6个月后比较治疗前后患者血清β-CTx水平及骨髓水肿分级。结果:治疗前A组VAS评分为1.74±0.98,β-CTx水平为0.72±0.17;B组VAS评分为5.27±1.08,β-CTx水平为0.59±0.23。两组之间β-CTx水平差异有统计学意义(P<0.05);Pearson相关分析表明,VAS评分与β-CTx水平呈低度正相关(r=0.269,P=0.007)。治疗6个月后A组与B组患者VAS评分分别为1.47±0.90和3.87±1.52;β-CTx水平分别为0.38±0.18和0.42±0.23,治疗前后β-CTx水平差异有统计学意义(P<0.05)。骨髓水肿分级:治疗前A组1级18例,2级23例,3级6例;B组,1级7例,2级21例,3级24例。治疗后骨髓水肿分级:A组0级2例,1级33例,2级10例,3级2例;B组0级1例,1级16例,2级23例,3级12例。卡方检验结果表明,治疗前后患者疼痛程度与骨髓水肿分级有相关性,非参数检验表明各疼痛程度下骨髓水肿分级的平均秩次呈递增趋势。结论:股骨头坏死患者疼痛轻重与血清β-CTx水平及骨髓水肿分级呈正相关,中重度疼痛较轻度疼痛患者,其血清β-CTx水平及骨髓水肿分级均明显更高,提示坏死区域破骨细胞异常活跃所致的骨吸收及骨髓水肿所致的骨内高压可能是引起患者疼痛的重要因素。
基金Funded by the National Natural Science Foundation of China(Nos.51575369&51675357)
文摘In order to study the effect of electromagnetic compound treatment on the mechanical property, cutting performance and microstructure of cemented carbide, the samples were treated by a self-made electromagnetic compound treatment device with different magnetic field strength(H=1, 1.25 and 1.5 T). The electromagnetic compound treatment method was proposed to couple pulsed magnetic field and pulsed current. The results show that after the pulsed magnetic field treatment, the values of the transverse rupture strength of the samples were respectively reduced by 21%, 20.6% and 20.1%;the cutting performance was decreased by about 4.5%, which means the tool life was decreased. After the electromagnetic compound treatment, the values of the transverse rupture strength of the rectangular samples were respectively increased by 8%, 8.6% and 9.5%, and the tool life was increased by 4.2%, 7% and 10.3%. After the electromagnetic compound treatment, the pulse current provided the driving force for dislocation motion. A strong pulse current driving force is more likely to make the dislocation multiply and slip. A high density dislocation cell is formed within the material, so the mechanical properties were significantly increased.
