目的:通过Meta分析比较右美托咪定(dexmedetomidine,DEX)对手术患者围术期炎症和应激反应的影响。方法:我们分别检索了PubMed,METSTR,EMBASE和Web of Science四个数据库,共收录30篇评估术中持续泵注DEX对全麻手术患者围术期炎症和应激...目的:通过Meta分析比较右美托咪定(dexmedetomidine,DEX)对手术患者围术期炎症和应激反应的影响。方法:我们分别检索了PubMed,METSTR,EMBASE和Web of Science四个数据库,共收录30篇评估术中持续泵注DEX对全麻手术患者围术期炎症和应激反应影响的随机对照实验。结局指标包括肾上腺素、去甲肾上腺素、皮质醇、血糖、IL-6、TNF-α、CRP、IL-10、IL-1β和WBC水平。连续性变量采用标准均数差(standard mean difference,SMD)和95%置信区间(CI)作为合并统计量。结果:Meta分析结果显示,与对照组相比,DEX组肾上腺素、去甲肾上腺素、皮质醇、血糖、IL-6、TNF-α、IL-1β、WBC水平降低,且差异有统计学意义。CRP、IL-10水平在两组无统计学差异。结论:DEX作为一种麻醉辅助药,能显著降低全麻手术患者应激(肾上腺素、去甲肾上腺素、血浆皮质醇、血糖)和炎症(IL-6、TNF-α和IL-1β)反应水平,有助于改善患者的临床疗效。但CRP、IL-10水平在两组无统计学差异。展开更多
Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas sensors.Herein,we report a simple processing route of highly sensitive OSCs for high performan...Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas sensors.Herein,we report a simple processing route of highly sensitive OSCs for high performance OTFT based nitrogen dioxide(NO2)sensors,where the active OSC layer is based on ultraviolet-ozone(UVO)treated poly(3-hexylthiophene-2,5-diyl)(P3HT).Compared to conventional P3HT based OTFT sensors,the reported device exhibits a remarkable improvement of the gas response from 350%to 30000%.The studies in morphologies,chemical compositions and microstructures of the UVOtreated films reveal that a large number of carrier traps generated in the P3HT films is the decisive reason for the enhancement of sensing performance.Moreover,the optimized device shows great potential of practical applications on the stand points of sensitivity,selectivity,reusability and the ability of recovery,as well as limit of detection of~7.3 ppb.This simple method provides an innovative understanding for the role of the carrier traps in sensing performance and demonstrates a bright future for developing high performance OTFT gas sensors.展开更多
文摘目的:通过Meta分析比较右美托咪定(dexmedetomidine,DEX)对手术患者围术期炎症和应激反应的影响。方法:我们分别检索了PubMed,METSTR,EMBASE和Web of Science四个数据库,共收录30篇评估术中持续泵注DEX对全麻手术患者围术期炎症和应激反应影响的随机对照实验。结局指标包括肾上腺素、去甲肾上腺素、皮质醇、血糖、IL-6、TNF-α、CRP、IL-10、IL-1β和WBC水平。连续性变量采用标准均数差(standard mean difference,SMD)和95%置信区间(CI)作为合并统计量。结果:Meta分析结果显示,与对照组相比,DEX组肾上腺素、去甲肾上腺素、皮质醇、血糖、IL-6、TNF-α、IL-1β、WBC水平降低,且差异有统计学意义。CRP、IL-10水平在两组无统计学差异。结论:DEX作为一种麻醉辅助药,能显著降低全麻手术患者应激(肾上腺素、去甲肾上腺素、血浆皮质醇、血糖)和炎症(IL-6、TNF-α和IL-1β)反应水平,有助于改善患者的临床疗效。但CRP、IL-10水平在两组无统计学差异。
基金supported by the National Natural Science Foundation of China(Grant Nos.61421002,61675041,51703019&31771079)the National Key R&D Program of China(Grant No.2018YFB0407102)+2 种基金the Project of Science and Technology of Sichuan Province(Grant Nos.2020YFG0281,2019YFG0121&2020YFG0279)City University of Hong Kong(Grant No.9610423)sponsored by Sichuan Province Key Laboratory of Display Science and Technology。
文摘Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas sensors.Herein,we report a simple processing route of highly sensitive OSCs for high performance OTFT based nitrogen dioxide(NO2)sensors,where the active OSC layer is based on ultraviolet-ozone(UVO)treated poly(3-hexylthiophene-2,5-diyl)(P3HT).Compared to conventional P3HT based OTFT sensors,the reported device exhibits a remarkable improvement of the gas response from 350%to 30000%.The studies in morphologies,chemical compositions and microstructures of the UVOtreated films reveal that a large number of carrier traps generated in the P3HT films is the decisive reason for the enhancement of sensing performance.Moreover,the optimized device shows great potential of practical applications on the stand points of sensitivity,selectivity,reusability and the ability of recovery,as well as limit of detection of~7.3 ppb.This simple method provides an innovative understanding for the role of the carrier traps in sensing performance and demonstrates a bright future for developing high performance OTFT gas sensors.
