Imaging of surface-enhanced Raman scattering(SERS) nanoparticles(NPs) has been intensively studied for cancer detection due to its high sensitivity, unconstrained low signal-to-noise ratios, and multiplexing detection...Imaging of surface-enhanced Raman scattering(SERS) nanoparticles(NPs) has been intensively studied for cancer detection due to its high sensitivity, unconstrained low signal-to-noise ratios, and multiplexing detection capability. Furthermore, conjugating SERS NPs with various biomarkers is straightforward, resulting in numerous successful studies on cancer detection and diagnosis. However, Raman spectroscopy only provides spectral data from an imaging area without co-registered anatomic context.展开更多
基金National Science Foundation (1808436,1918074,2306708,2237142-CAREER)U.S.Department of Energy (234402)。
文摘Imaging of surface-enhanced Raman scattering(SERS) nanoparticles(NPs) has been intensively studied for cancer detection due to its high sensitivity, unconstrained low signal-to-noise ratios, and multiplexing detection capability. Furthermore, conjugating SERS NPs with various biomarkers is straightforward, resulting in numerous successful studies on cancer detection and diagnosis. However, Raman spectroscopy only provides spectral data from an imaging area without co-registered anatomic context.
