The Permanent Magnet Torque Motor(PMTM)is the key electro-mechanical conversion device in an Electro-Hydraulic Servo Valve(EHSV).In this work,a refined model of a PMTM is developed,considering the non-working air-gaps...The Permanent Magnet Torque Motor(PMTM)is the key electro-mechanical conversion device in an Electro-Hydraulic Servo Valve(EHSV).In this work,a refined model of a PMTM is developed,considering the non-working air-gaps between the upper or lower yoke and the armature,the fringing effect at the limiting holes,and the nonlinear permeability of soft magnetic material.Based on the refined model,the influences of various factors on the calculation accuracy of the magnetic flux at the pole surfaces of the armature and the output torque are investigated.For verifying the validity of the refined model,a Finite Element Analysis(FEA)of the PMTM is conducted,and a test platform is constructed.Compared with existing models,the refined model can better reveal the intrinsic mechanism of the PMTM,and its calculations are more consistent with the FEA results.The experimental results of the armature deflection displacement show that the refined model can accurately describe the output characteristics of the PMTM.展开更多
Background:Osteosarcoma is the most common primary bone malignancy,with a strong tendency towards local invasion and metastasis.The SRY-Box Transcription Factor 1(SOX1)gene,a member of the HMG-box family of DNA-bindin...Background:Osteosarcoma is the most common primary bone malignancy,with a strong tendency towards local invasion and metastasis.The SRY-Box Transcription Factor 1(SOX1)gene,a member of the HMG-box family of DNA-binding transcription factors,plays a crucial role in embryogenesis and tumorigenesis.However,its role in osteosarcoma,particularly in relation to metastatic potential,is not well understood.Methods:The GSE14359 dataset containing five samples of conventional osteosarcoma and four samples of lung metastatic osteosarcoma was obtained from the Gene Expression Omnibus(GEO)database and analyzed for differential gene expression using the R language.Gene expression was detected using qPCR and Western blotting.Transcriptional activity was assessed by Luciferase reporter gene assays,and cell metastatic ability was assessed by migration and invasion assays.Results:The study demonstrated that SOX1 binds to a specific response element within the Transmembrane 4 Superfamily Member 12(TSPAN12)promoter,upregulating TSPAN12 and its associated inflammatory pathways.Silencing TSPAN12 markedly reduces SOX1-mediated osteosarcoma cell invasion and inflammatory response,while TSPAN12 overexpression reverses these effects in SOX1-suppressed cells.Conclusion:In this study,our findings elucidate SOX1’s role in enhancing osteosarcoma metastasis via TSPAN12 upregulation,offering new insights into the molecular mechanisms of osteosarcoma progression.展开更多
We report a high-power,all-fiber Tm-doped laser system operating at 1908 nm,based on a master-oscillator power amplifier(MOPA)configuration.The oscillator utilizes two polarization-maintaining(PM)fiber Bragg gratings(...We report a high-power,all-fiber Tm-doped laser system operating at 1908 nm,based on a master-oscillator power amplifier(MOPA)configuration.The oscillator utilizes two polarization-maintaining(PM)fiber Bragg gratings(FBGs)with orthogonal principal axes to achieve single-polarization output.The system generates a linearly polarized output power of 12.6 W,with a slope efficiency of 40.6%.The power is subsequently scaled to 207.6 W through a primary amplifier,which uses a large mode area(LMA)fiber while maintaining single-mode operation.The amplifier achieves a beam quality factor(M^(2))of 1.36 and a polarization extinction ratio(PER)exceeding 18.3 d B.展开更多
Numerous strategies involving multiple cross-linking networks have been applied for fabricating robust hydrogels.Inspired by this,the development of mechanically strong and tough biological fibers by the incorporation...Numerous strategies involving multiple cross-linking networks have been applied for fabricating robust hydrogels.Inspired by this,the development of mechanically strong and tough biological fibers by the incorporation of intermolecular linking networks is becoming important.Herein,we present a versatile strategy for the fabrication of protein-saccharide composite fibers through protein-initiated double interacting networks.Three types of lysine-rich bioengineered proteins were introduced and the present multiple cross-linking interactions including electrostatic forces and covalent bonds significantly enhanced the mechanical properties of as-obtained composite fibers.In stark contrast to pristine saccharide or other polymer fibers,the as-obtained composite fibers exhibited outstanding mechanical performance,showing a breaking strength of~768 MPa,Young’s modulus of~24 GPa,and toughness of~69 MJ∙m^(–3),respectively.Thus,this established approach has great potentials to fabricate new generation renewable biological fibers with high performance.展开更多
基金co-supported by the National Natural Science Foundation of China(No.51975275)Primary Research&Development Plan of Jiangsu Province,China(No.BE2021034)Postgraduate Research&Practice Innovation Program of NUAA,China(No.xcxjh20210502).
文摘The Permanent Magnet Torque Motor(PMTM)is the key electro-mechanical conversion device in an Electro-Hydraulic Servo Valve(EHSV).In this work,a refined model of a PMTM is developed,considering the non-working air-gaps between the upper or lower yoke and the armature,the fringing effect at the limiting holes,and the nonlinear permeability of soft magnetic material.Based on the refined model,the influences of various factors on the calculation accuracy of the magnetic flux at the pole surfaces of the armature and the output torque are investigated.For verifying the validity of the refined model,a Finite Element Analysis(FEA)of the PMTM is conducted,and a test platform is constructed.Compared with existing models,the refined model can better reveal the intrinsic mechanism of the PMTM,and its calculations are more consistent with the FEA results.The experimental results of the armature deflection displacement show that the refined model can accurately describe the output characteristics of the PMTM.
文摘Background:Osteosarcoma is the most common primary bone malignancy,with a strong tendency towards local invasion and metastasis.The SRY-Box Transcription Factor 1(SOX1)gene,a member of the HMG-box family of DNA-binding transcription factors,plays a crucial role in embryogenesis and tumorigenesis.However,its role in osteosarcoma,particularly in relation to metastatic potential,is not well understood.Methods:The GSE14359 dataset containing five samples of conventional osteosarcoma and four samples of lung metastatic osteosarcoma was obtained from the Gene Expression Omnibus(GEO)database and analyzed for differential gene expression using the R language.Gene expression was detected using qPCR and Western blotting.Transcriptional activity was assessed by Luciferase reporter gene assays,and cell metastatic ability was assessed by migration and invasion assays.Results:The study demonstrated that SOX1 binds to a specific response element within the Transmembrane 4 Superfamily Member 12(TSPAN12)promoter,upregulating TSPAN12 and its associated inflammatory pathways.Silencing TSPAN12 markedly reduces SOX1-mediated osteosarcoma cell invasion and inflammatory response,while TSPAN12 overexpression reverses these effects in SOX1-suppressed cells.Conclusion:In this study,our findings elucidate SOX1’s role in enhancing osteosarcoma metastasis via TSPAN12 upregulation,offering new insights into the molecular mechanisms of osteosarcoma progression.
文摘We report a high-power,all-fiber Tm-doped laser system operating at 1908 nm,based on a master-oscillator power amplifier(MOPA)configuration.The oscillator utilizes two polarization-maintaining(PM)fiber Bragg gratings(FBGs)with orthogonal principal axes to achieve single-polarization output.The system generates a linearly polarized output power of 12.6 W,with a slope efficiency of 40.6%.The power is subsequently scaled to 207.6 W through a primary amplifier,which uses a large mode area(LMA)fiber while maintaining single-mode operation.The amplifier achieves a beam quality factor(M^(2))of 1.36 and a polarization extinction ratio(PER)exceeding 18.3 d B.
基金supported by the National Key Research and Development Program of China(Nos.2021YFB3502300,2020YFA0908900,and 2021YFF0701800)the National Natural Science Foundation of China(Nos.22125701,21877104,and 22020102003)+1 种基金Tsinghua University Spring Breeze Fund(Nos.2021Z99CFZ005)Grants from Natural Science Foundation of Guangdong Province,China(Nos.2021A1515010253 and 202102020523).
文摘Numerous strategies involving multiple cross-linking networks have been applied for fabricating robust hydrogels.Inspired by this,the development of mechanically strong and tough biological fibers by the incorporation of intermolecular linking networks is becoming important.Herein,we present a versatile strategy for the fabrication of protein-saccharide composite fibers through protein-initiated double interacting networks.Three types of lysine-rich bioengineered proteins were introduced and the present multiple cross-linking interactions including electrostatic forces and covalent bonds significantly enhanced the mechanical properties of as-obtained composite fibers.In stark contrast to pristine saccharide or other polymer fibers,the as-obtained composite fibers exhibited outstanding mechanical performance,showing a breaking strength of~768 MPa,Young’s modulus of~24 GPa,and toughness of~69 MJ∙m^(–3),respectively.Thus,this established approach has great potentials to fabricate new generation renewable biological fibers with high performance.
