Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity an...Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.展开更多
Guided by the fundamental principles of the whole petroleum system,the control of tectonism,sedimentation,and diagenesis on hydrocarbon accumulation in a rifted basin is studied using the data of petroleum geology and...Guided by the fundamental principles of the whole petroleum system,the control of tectonism,sedimentation,and diagenesis on hydrocarbon accumulation in a rifted basin is studied using the data of petroleum geology and exploration of the second member of the Paleogene Kongdian Formation(Kong-2 Member)in the Cangdong Sag,Bohai Bay Basin,China.It is clarified that the circle structure and circle effects are the marked features of a continental fault petroliferous basin,and they govern the orderly distribution of conventional and unconventional hydrocarbons in the whole petroleum systems of the rifted basin.Tectonic circle zones control sedimentary circle zones,while sedimentary circle zones and diagenetic circle zones control the spatial distribution of favorable reservoirs,thereby determining the orderly distribution of hydrocarbon accumulations in various circles.A model for the integrated,systematic accumulation of conventional and unconventional hydrocarbons under a multi-circle structure of the whole petroleum system of continental rifted basin has been developed.It reveals that each sag of the rifted basin is an independent whole petroleum system and circle system,which encompasses multiple orderly circles of conventional and unconventional hydrocarbons controlled by the same source kitchen.From the outer circle to the middle circle and then to the inner circle,there is an orderly transition from structural and stratigraphic reservoirs,to lithological and structural-lithological reservoirs,and finally to tight oil/gas and shale oil/gas enrichment zones.The significant feature of the whole petroleum system is the orderly control of hydrocarbons by multi-circle stratigraphic coupling,with the integrated,orderly distribution of conventional and unconventional reserves being the inevitable result of the multi-layered interaction within the whole petroleum system.This concept of multi-circle stratigraphic coupling for the orderly,integrated accumulation of conventional and unconventional hydrocarbons has guided significant breakthroughs in the overall,three-dimensional exploration and shale oil exploration in the Cangdong Sag.展开更多
The accelerated demand for engineering services has led to the extensive utilization of engineering blasting techniques.Blasting-induced changes in loess microstructure(e.g.particle breakage,pore structure change)dire...The accelerated demand for engineering services has led to the extensive utilization of engineering blasting techniques.Blasting-induced changes in loess microstructure(e.g.particle breakage,pore structure change)directly affect its macroscopic mechanical properties.However,there remains a notable lack of studies on the impact of explosions on loess microstructure and the quantificationof loess microstructure.This study employed micro-computed tomography(μ-CT)technology to examine loess samples extracted from the surrounding area of the explosion cavity,systematically investigating the volume,orientation,and morphological characteristics of particles and pores.The research findings indicated that the explosion caused a break for the particles with a diameter larger than 10μm,and the number of smaller particles increased.Blasting decreased the particle sphericity and orientation angle.The reduction in porosity was primarily attributed to a decrease in the volume of both macropores and mesopores,with a greater reduction in the volume of mesopores.Although the number of micropores increased,the volume change was insignificant.Furthermore,the explosion increased the pore fractal dimension and patch density,suggesting a more complex and fragmented pore structure.Moreover,the pore throat radius and channel length decreased with decreasing distance from the explosion cavity(D_(EC)),indicating that the pore's connectivity reduced.The radius of the blasting cavity was approximately 0.35 m.Additionally,the loess zone surrounding the blasting cavity was divided into failure,plastic,and elastic zones using the D_(EC)=0.2 m and 1.2 m as the boundaries.The impacts of the explosion on loess were mainly within the range of D_(EC)less than 1.20 m.The analysis of the traits,patterns,and mechanisms of explosions'impact on the loess's microstructure can provide microscopic insight into the macro-dynamic behavior,assess the impact of explosions on the surrounding loess,and identify the potential geological hazards triggered by blasting,which offers a theoretical foundation for the subsequent engineering design and security measures.展开更多
Rock-like specimens containing a joint with different inclination angles and roughness were prepared using 3D printing technology.Then,true triaxial compression loading experiments were conducted on those jointed spec...Rock-like specimens containing a joint with different inclination angles and roughness were prepared using 3D printing technology.Then,true triaxial compression loading experiments were conducted on those jointed specimens.The increase in roughness leads to an increase in the axial strength and peak strain.With the increasing inclination angle,the axial strength initially decreases from 30°to 60°and then increases from 60°to 90°.While the peak strain first rises from 30°to 45°and then declines from 45°to 90°.The variation in failure mode results from differences in lateral stress on the joints under different strike directions.Specimens with joint strike parallel to the intermediate principal stress predominantly showed matrix or matrix-joint mixed shear failure,whereas those parallel to the minimum principal stress exhibited matrix shear failure.The analysis results of acoustic emission signals indicate the crack number and shear crack percentage increase with the increasing roughness and first decrease(30°to 60°),then increase(60°to 90°)with the increasing inclination angle.The research results can provide some guidance for the design and support of underground engineering with jointed surrounding rock.展开更多
Objective: Pseudomonas aeruginosa bloodstream infection presents a severe challenge to hospitalized patients. To investigate the clinical characteristics, risk factors and drug resistance of Pseudomonas aeruginosa blo...Objective: Pseudomonas aeruginosa bloodstream infection presents a severe challenge to hospitalized patients. To investigate the clinical characteristics, risk factors and drug resistance of Pseudomonas aeruginosa bloodstream infection. Methods: Clinical data and laboratory results of patients with Pseudomonas aeruginosa bloodstream infection in the First Affiliated Hospital of Yangtze University from January 2019 to December 2022 were retrospectively analyzed. The factors associated with infection and death were analyzed by univariate analysis. Results: A total of 55 patients were enrolled in this study, The 28-day mortality rate was 14.5%. Univariate analysis showed that high procalcitonin, low albumin, ICU admission, central venous catheterization, indwelling catheter, and mechanical ventilation were associated with death. Multivariate Logistic regression analysis showed that hypoproteinemia and central venous catheters were independent risk factors for death in patients with Pseudomonas aeruginosa bloodstream infection. Conclusions: The drug resistance of P. aeruginosa bloodstream infection is not high, but the fatality rate is high. The combination of hypoalbuminemia after the onset of the disease and the use of central vein catheters can lead to increased mortality, suggesting that clinical identification of high-risk patients as early as possible, reducing the use of catheters, preventing the occurrence of P. aeruginosa bloodstream infection and improving the prognosis.展开更多
基金financially supported by the International Cooperation Program from the Ministry of Science and Technology of Hubei Province(No.2023EHA069)Shenzhen Science and Technology Program(No.JCYJ20230807143702005)National Foreign Experts Program(No.G2022027015L)。
文摘Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.
基金Supported by the National Science and Technology Major Project of China(2024ZD1400101)China National Key Research and Development Project(2022YFF0801204)Major Science and Technology Project of CNPC(2023ZZ15YJ01,2021DJ0702)。
文摘Guided by the fundamental principles of the whole petroleum system,the control of tectonism,sedimentation,and diagenesis on hydrocarbon accumulation in a rifted basin is studied using the data of petroleum geology and exploration of the second member of the Paleogene Kongdian Formation(Kong-2 Member)in the Cangdong Sag,Bohai Bay Basin,China.It is clarified that the circle structure and circle effects are the marked features of a continental fault petroliferous basin,and they govern the orderly distribution of conventional and unconventional hydrocarbons in the whole petroleum systems of the rifted basin.Tectonic circle zones control sedimentary circle zones,while sedimentary circle zones and diagenetic circle zones control the spatial distribution of favorable reservoirs,thereby determining the orderly distribution of hydrocarbon accumulations in various circles.A model for the integrated,systematic accumulation of conventional and unconventional hydrocarbons under a multi-circle structure of the whole petroleum system of continental rifted basin has been developed.It reveals that each sag of the rifted basin is an independent whole petroleum system and circle system,which encompasses multiple orderly circles of conventional and unconventional hydrocarbons controlled by the same source kitchen.From the outer circle to the middle circle and then to the inner circle,there is an orderly transition from structural and stratigraphic reservoirs,to lithological and structural-lithological reservoirs,and finally to tight oil/gas and shale oil/gas enrichment zones.The significant feature of the whole petroleum system is the orderly control of hydrocarbons by multi-circle stratigraphic coupling,with the integrated,orderly distribution of conventional and unconventional reserves being the inevitable result of the multi-layered interaction within the whole petroleum system.This concept of multi-circle stratigraphic coupling for the orderly,integrated accumulation of conventional and unconventional hydrocarbons has guided significant breakthroughs in the overall,three-dimensional exploration and shale oil exploration in the Cangdong Sag.
基金financiallysupported by the National Key&Program of China(Grant No.2022YFC3003403)the National Natural Science Foundation of China(Grant Nos.42472348 and 42220104005).
文摘The accelerated demand for engineering services has led to the extensive utilization of engineering blasting techniques.Blasting-induced changes in loess microstructure(e.g.particle breakage,pore structure change)directly affect its macroscopic mechanical properties.However,there remains a notable lack of studies on the impact of explosions on loess microstructure and the quantificationof loess microstructure.This study employed micro-computed tomography(μ-CT)technology to examine loess samples extracted from the surrounding area of the explosion cavity,systematically investigating the volume,orientation,and morphological characteristics of particles and pores.The research findings indicated that the explosion caused a break for the particles with a diameter larger than 10μm,and the number of smaller particles increased.Blasting decreased the particle sphericity and orientation angle.The reduction in porosity was primarily attributed to a decrease in the volume of both macropores and mesopores,with a greater reduction in the volume of mesopores.Although the number of micropores increased,the volume change was insignificant.Furthermore,the explosion increased the pore fractal dimension and patch density,suggesting a more complex and fragmented pore structure.Moreover,the pore throat radius and channel length decreased with decreasing distance from the explosion cavity(D_(EC)),indicating that the pore's connectivity reduced.The radius of the blasting cavity was approximately 0.35 m.Additionally,the loess zone surrounding the blasting cavity was divided into failure,plastic,and elastic zones using the D_(EC)=0.2 m and 1.2 m as the boundaries.The impacts of the explosion on loess were mainly within the range of D_(EC)less than 1.20 m.The analysis of the traits,patterns,and mechanisms of explosions'impact on the loess's microstructure can provide microscopic insight into the macro-dynamic behavior,assess the impact of explosions on the surrounding loess,and identify the potential geological hazards triggered by blasting,which offers a theoretical foundation for the subsequent engineering design and security measures.
基金Projects(52074259,52204132)supported by the National Natural Science Foundation of ChinaProject(104023002)supported by the Yunlong Lake Laboratory of Deep Underground Science and Engineering Project,China+2 种基金Project(BK20220157)supported by Natural Science Foundation of Jiangsu Province of ChinaProject(2023JJ40285)supported by Hunan Provincial Natural Science Foundation of ChinaProject(22B0469)supported by Scientific Research Foundation of Hunan Provincial Education Department,China。
文摘Rock-like specimens containing a joint with different inclination angles and roughness were prepared using 3D printing technology.Then,true triaxial compression loading experiments were conducted on those jointed specimens.The increase in roughness leads to an increase in the axial strength and peak strain.With the increasing inclination angle,the axial strength initially decreases from 30°to 60°and then increases from 60°to 90°.While the peak strain first rises from 30°to 45°and then declines from 45°to 90°.The variation in failure mode results from differences in lateral stress on the joints under different strike directions.Specimens with joint strike parallel to the intermediate principal stress predominantly showed matrix or matrix-joint mixed shear failure,whereas those parallel to the minimum principal stress exhibited matrix shear failure.The analysis results of acoustic emission signals indicate the crack number and shear crack percentage increase with the increasing roughness and first decrease(30°to 60°),then increase(60°to 90°)with the increasing inclination angle.The research results can provide some guidance for the design and support of underground engineering with jointed surrounding rock.
文摘Objective: Pseudomonas aeruginosa bloodstream infection presents a severe challenge to hospitalized patients. To investigate the clinical characteristics, risk factors and drug resistance of Pseudomonas aeruginosa bloodstream infection. Methods: Clinical data and laboratory results of patients with Pseudomonas aeruginosa bloodstream infection in the First Affiliated Hospital of Yangtze University from January 2019 to December 2022 were retrospectively analyzed. The factors associated with infection and death were analyzed by univariate analysis. Results: A total of 55 patients were enrolled in this study, The 28-day mortality rate was 14.5%. Univariate analysis showed that high procalcitonin, low albumin, ICU admission, central venous catheterization, indwelling catheter, and mechanical ventilation were associated with death. Multivariate Logistic regression analysis showed that hypoproteinemia and central venous catheters were independent risk factors for death in patients with Pseudomonas aeruginosa bloodstream infection. Conclusions: The drug resistance of P. aeruginosa bloodstream infection is not high, but the fatality rate is high. The combination of hypoalbuminemia after the onset of the disease and the use of central vein catheters can lead to increased mortality, suggesting that clinical identification of high-risk patients as early as possible, reducing the use of catheters, preventing the occurrence of P. aeruginosa bloodstream infection and improving the prognosis.
