Shallow-water seabed reverberation presents a critical disturbance in acoustic propagation,affecting the target detection performance of monostatic sonar.This paper proposes a novel seabed reverberation model integrat...Shallow-water seabed reverberation presents a critical disturbance in acoustic propagation,affecting the target detection performance of monostatic sonar.This paper proposes a novel seabed reverberation model integrating Gaussian beam tracing with seabed scattering physics.The model synthesizes time-domain reverberation signals by superimposing scattering signals received across multiple propagation paths.It accurately resolves scattering signals along distinct paths and enables simulation of reverberation under diverse shallow-water environments by adjusting the marine parameters.Furthermore,we model the seabed reverberation signals in the time domain and the space domain for a cylindrical transceiver array,and provide a detailed statistical characterization of the simulated seabed reverberation signals.Finally,shallow-water seabed reverberation experiments were conducted with a cylindrical transceiver array.Comparisons between shallow-water seabed reverberation measurements and simulation estimates at various sites and transceiver depths demonstrate that the proposed seabed reverberation model can efficiently simulate shallow-water seabed reverberation.展开更多
This paper is a review of recent developments in solid-state linear transformer driver(SSLTD)for applications to pulsed power generation.It summarizes the technological advances reported by previous publications and i...This paper is a review of recent developments in solid-state linear transformer driver(SSLTD)for applications to pulsed power generation.It summarizes the technological advances reported by previous publications and interprets the experimental progresses.The application of solid-state LTDs has been proved to be an attractive approach to make compact and repetitive pulsed power generators that have been sought by a variety of industrial applications and scientific researches.Their advantages and disadvantages compared with their alternatives are reported and analyzed in this paper.Future technical trends of solid-state LTDs are also discussed.展开更多
In this paper, a fractional multi-point boundary value problem is considered. By using the fixed point index theory and Krein-Rutman theorem, some results on existence are obtained.
To investigate the adverse reactions and efficacy of docetaxel combined with lobaplatin in adjuvant chemotherapy for triple-negative breast cancer in elderly patients.A total of 96 elderly triple-negative breast cance...To investigate the adverse reactions and efficacy of docetaxel combined with lobaplatin in adjuvant chemotherapy for triple-negative breast cancer in elderly patients.A total of 96 elderly triple-negative breast cancer patients admitted to our hospital from January 2008 to December 2011 were randomly divided into two groups.A group of 56 patients received docetaxel 75 mg·m^(-2),intravenous drip,d1;lobaplatin 30 mg·m^(-2),intravenous drip,d1;21 days repeat,a total of 6 cycles.A group of 40 patients received chemotherapy for 6 cycles with an anthracycline-containing(TEC)regimen.Comparison of adverse reactions and 5-year diseasefree survival in both groups.The incidence of thrombocytopenia was significantly higher in 56 patients with TL regimen than those with TCE-containing anthracyclines(P=0.005).But the incidence of cardiotoxicity was 32.5%in the TEC group.And the difference was statistically significant(P=0.008).The 5-year disease-free survival rate was 73.2%in the TL group and 67.5%in the TEC group.There was no statistical difference.Docetaxel combined with lobaplatin in the treatment of elderly triple-negative breast cancer has no significant difference in efficacy compared with traditional anthracycline-containing drugs,but it can avoid the cardiotoxicity caused by anthracyclines.It’s a new option for elderly TNBC adjuvant chemotherapy,suggesting to expand the sample content for further research.展开更多
A high-current pulse forming network (PFN) has been developed for applications to artificial solar-wind generation. It is switched by staticinduction thyristor (SIThy) and is capable of generating pulsed current of ~...A high-current pulse forming network (PFN) has been developed for applications to artificial solar-wind generation. It is switched by staticinduction thyristor (SIThy) and is capable of generating pulsed current of ~9.7 kA for a time duration of ~1 ms. The SIThy switch module ismade that it can be controlled by an optical signal and it can be operated at elevated electrical potential. The experiments reported in this paperused two switch modules connected in series for maximum operating voltage of 3.5 kV. The experimental results have demonstrated a pulsedhigh-current generator switched by semiconductor devices, as well as the control and operation of SIThy for pulsed power application.展开更多
Cholangiocarcinoma(CCA)is a fatal malignancy with steadily increasing incidence and poor prognosis.Since most CCA cases are diagnosed at an advanced stage,systemic therapies,including chemotherapy,radiotherapy,targete...Cholangiocarcinoma(CCA)is a fatal malignancy with steadily increasing incidence and poor prognosis.Since most CCA cases are diagnosed at an advanced stage,systemic therapies,including chemotherapy,radiotherapy,targeted therapy,and immunotherapy,play a crucial role in the management of unresectable CCA.The recent advances in targeted therapies and immunotherapies brought more options in the clinical management of unresectable CCA.This review depicts the advances of targeted therapies and immunotherapies for unresectable CCA,summarizes crucial clinical trials,and describes the efficacy and safety of different drugs,which may help further develop precision and individualization in the clinical treatment of unresectable CCA.展开更多
Certain problems concerning state constraints and control constraints can often be reduced to the study of positive invariance of some subsets of the state space of dynamical systems. The robust positive invariance of...Certain problems concerning state constraints and control constraints can often be reduced to the study of positive invariance of some subsets of the state space of dynamical systems. The robust positive invariance of given linear state constraint sets of uncertain discrete-time systems is studied by the mixed monotone decomposition method. Necessary and suffi-展开更多
Band 3 and glucose transport protein (GluTl) are two kinds of important proteins in the human erythro-cyte membranes. Bis(sulfosuccinimidyl)suberate (BS ), an impermeable cross-linker of band 3, inhibited NO2- transpo...Band 3 and glucose transport protein (GluTl) are two kinds of important proteins in the human erythro-cyte membranes. Bis(sulfosuccinimidyl)suberate (BS ), an impermeable cross-linker of band 3, inhibited NO2- transport, showing that anion exchange is affected by the association state of band 3 in the intact erythrocyte membranes. At the same time, the rates of glucose transport of both exit and entry declined. The amount of monomers of band 3 was decreased after treatment of the erythrocytes with BS3, but there was no change in GluTl according to the SDS-PAGE patterns. This demonstrates that band 3 and GluTl would be linkaged together in the erythrocyte membranes for the requirement of rapid and cooperative performance of physiological functions of the membrane proteins.展开更多
By the fxed point index theory, the existence of one, two and three positive solutions to(k, n-k) conjugate boundary value problems is obtained, where n 】 2, 1 ≤ k ≤ n-1, the nonlinear term may be noncontinuous and...By the fxed point index theory, the existence of one, two and three positive solutions to(k, n-k) conjugate boundary value problems is obtained, where n 】 2, 1 ≤ k ≤ n-1, the nonlinear term may be noncontinuous and singular at any point of [0,1]. Our results extend some of the existent results.展开更多
By the Schauder fixed point theory,this paper establishes the existence of positive solutions to a(k,n k)m-point boundary value problem.We show that there exists a positive constant b such that the problem has at leas...By the Schauder fixed point theory,this paper establishes the existence of positive solutions to a(k,n k)m-point boundary value problem.We show that there exists a positive constant b such that the problem has at least one positive solution when the homogeneous boundary parameter is smaller than b,and no positive solution when this parameter is greater than b.展开更多
To investigate the effect of heterogeneity on the global dynamics of two SIR epidemic models with general nonlinear incidence rate and infection delays, we formulate a multi- group model corresponding to the heterogen...To investigate the effect of heterogeneity on the global dynamics of two SIR epidemic models with general nonlinear incidence rate and infection delays, we formulate a multi- group model corresponding to the heterogeneity in the host population and a multi-stage model corresponding to heterogeneous stages of infection. Under biological!y motivated considerations, we establish that the global dynamics for each of the two models is determined completely by the corresponding basic reproduction number： if the basic reproduction number is less than or equal to one, then the disease-free equilibrium is globally asymptotically stable and the disease dies out in all groups or stages; if the basic reproduction number is larger than one, then the disease will persist in all groups or stages, and there is a unique endemic equilibrium which is globally asymptotically stable. Then we conclude that the heterogeneity does not change the global dynamics of the SIR model when the incidence rate is a general nonlinear function. Our results extend a class of previous results and can be applied to the other epidemiological models. The proofs of the main results use Lyapunov functional and graph-theoretic approach.展开更多
We consider a system of partial differential equations that describes the interaction of the sterile and fertile species undergoing the sterile insect release method （SIRM）. Unlike in the previous work [M. A. Lewis ...We consider a system of partial differential equations that describes the interaction of the sterile and fertile species undergoing the sterile insect release method （SIRM）. Unlike in the previous work [M. A. Lewis and P. van den Driessche, Waves of extinction from sterile insect release, Math. Biosci. 5 （1992） 221 247] where the habitat is assumed to be the one-dimensional whole space ~, we consider this system in a bounded one- dimensional domain （interval）. Our goal is to derive sufficient conditions for success of the SIRM. We show the existence of the fertile-free steady state and prove its stability. Using the releasing rate as the parameter, and by a saddle-node bifurcation analysis, we obtain conditions for existence of two co-persistence steady states, one stable and the other unstable. Biological implications of our mathematical results are that： （i） when the fertile population is at low level, the SIRM, even with small releasing rate, can successfully eradicate the fertile insects; （ii） when the fertile population is at a higher level, the SIRM can succeed as long as the strength of the sterile releasing is large enough, while the method may also fail if the releasing is not sufficient.展开更多
In this paper, two sunflower equations are considered. Using delay T as a parameter and applying the global Hopf bifurcation theorem, we investigate the existence of global Hopf bifurcation for the sunflower equation....In this paper, two sunflower equations are considered. Using delay T as a parameter and applying the global Hopf bifurcation theorem, we investigate the existence of global Hopf bifurcation for the sunflower equation. Furthermore, we analyze the local Hopf bifurcation of the modified equation with nonlinear relation about stem＇s increase, including the occurrence, the bifurcation direction, the stability and the approximation expression of the bifurcating periodic solution using the theory of normal form and center manifold. Finally, the obtained results of these two equations are compared, which finds that the result about the period of their bifurcating periodic solutions is obviously different, while the bifurcation direction and stability are identical.展开更多
基金The Youth Project of National Natural Science Foundation of China under contract No.12304507the Natural Science Foundation of Guangdong Province,China under contract No.2024A1515011512+2 种基金the Stable Supporting Fund of Acoustic Science and Technology Laboratory under contract No.JCKYS2025SSJS010the Fundamental Research Funds for the Central Universities under contract No.20720240108the Special Project for Marine Economy Development of Guangdong Province,China under contract No.GDNRC2023-47.
文摘Shallow-water seabed reverberation presents a critical disturbance in acoustic propagation,affecting the target detection performance of monostatic sonar.This paper proposes a novel seabed reverberation model integrating Gaussian beam tracing with seabed scattering physics.The model synthesizes time-domain reverberation signals by superimposing scattering signals received across multiple propagation paths.It accurately resolves scattering signals along distinct paths and enables simulation of reverberation under diverse shallow-water environments by adjusting the marine parameters.Furthermore,we model the seabed reverberation signals in the time domain and the space domain for a cylindrical transceiver array,and provide a detailed statistical characterization of the simulated seabed reverberation signals.Finally,shallow-water seabed reverberation experiments were conducted with a cylindrical transceiver array.Comparisons between shallow-water seabed reverberation measurements and simulation estimates at various sites and transceiver depths demonstrate that the proposed seabed reverberation model can efficiently simulate shallow-water seabed reverberation.
基金The development of solid-state LTD was supported by the National Natural Science Foundation of China under Grant 50837004by the Grants-in-Aid for Scientific Research Program of Japan Society for the Promotion of Science under Grant No.24360105.
文摘This paper is a review of recent developments in solid-state linear transformer driver(SSLTD)for applications to pulsed power generation.It summarizes the technological advances reported by previous publications and interprets the experimental progresses.The application of solid-state LTDs has been proved to be an attractive approach to make compact and repetitive pulsed power generators that have been sought by a variety of industrial applications and scientific researches.Their advantages and disadvantages compared with their alternatives are reported and analyzed in this paper.Future technical trends of solid-state LTDs are also discussed.
文摘In this paper, a fractional multi-point boundary value problem is considered. By using the fixed point index theory and Krein-Rutman theorem, some results on existence are obtained.
基金Natural Science Fund of Xinjiang Uygur Autonomous Region(2017D01C407)。
文摘To investigate the adverse reactions and efficacy of docetaxel combined with lobaplatin in adjuvant chemotherapy for triple-negative breast cancer in elderly patients.A total of 96 elderly triple-negative breast cancer patients admitted to our hospital from January 2008 to December 2011 were randomly divided into two groups.A group of 56 patients received docetaxel 75 mg·m^(-2),intravenous drip,d1;lobaplatin 30 mg·m^(-2),intravenous drip,d1;21 days repeat,a total of 6 cycles.A group of 40 patients received chemotherapy for 6 cycles with an anthracycline-containing(TEC)regimen.Comparison of adverse reactions and 5-year diseasefree survival in both groups.The incidence of thrombocytopenia was significantly higher in 56 patients with TL regimen than those with TCE-containing anthracyclines(P=0.005).But the incidence of cardiotoxicity was 32.5%in the TEC group.And the difference was statistically significant(P=0.008).The 5-year disease-free survival rate was 73.2%in the TL group and 67.5%in the TEC group.There was no statistical difference.Docetaxel combined with lobaplatin in the treatment of elderly triple-negative breast cancer has no significant difference in efficacy compared with traditional anthracycline-containing drugs,but it can avoid the cardiotoxicity caused by anthracyclines.It’s a new option for elderly TNBC adjuvant chemotherapy,suggesting to expand the sample content for further research.
文摘A high-current pulse forming network (PFN) has been developed for applications to artificial solar-wind generation. It is switched by staticinduction thyristor (SIThy) and is capable of generating pulsed current of ~9.7 kA for a time duration of ~1 ms. The SIThy switch module ismade that it can be controlled by an optical signal and it can be operated at elevated electrical potential. The experiments reported in this paperused two switch modules connected in series for maximum operating voltage of 3.5 kV. The experimental results have demonstrated a pulsedhigh-current generator switched by semiconductor devices, as well as the control and operation of SIThy for pulsed power application.
基金funded by grants from the National Natural Science Foundation of China(Nos.82171824,82272906,82103087,82002625,and 82373133)the Scientific and Technological Innovation Project of Science and Technology Commission of Shanghai Municipality(No.21JC1404300)+7 种基金the Innovation Group Project of Shanghai Municipal Health Commission(No.2019CXJQ03)the Shanghai Municipal Commission of Health and Family Planning(No.2018ZHYL0223)Shanghai Municipal Education Commission-Gao Feng Clinical Medicine Grant Support(No.20161312)Shanghai Key Clinical Specialty(Oncology),Shanghai Leading Talents Project,Clinical Research Plan of SHDC(No.SHDC2020CR1035B)Shanghai Sailing Program(No.20YF1446400)the National Key R&D Program of China(No.2019YFC1315900)Project from CSCO Clinical Oncology Research Foundation(No.Y-2019AZZD-0513)the Innovative Research Team of High-Level Local Universities in Shanghai(No.SHSMU-ZDCX20210802).
文摘Cholangiocarcinoma(CCA)is a fatal malignancy with steadily increasing incidence and poor prognosis.Since most CCA cases are diagnosed at an advanced stage,systemic therapies,including chemotherapy,radiotherapy,targeted therapy,and immunotherapy,play a crucial role in the management of unresectable CCA.The recent advances in targeted therapies and immunotherapies brought more options in the clinical management of unresectable CCA.This review depicts the advances of targeted therapies and immunotherapies for unresectable CCA,summarizes crucial clinical trials,and describes the efficacy and safety of different drugs,which may help further develop precision and individualization in the clinical treatment of unresectable CCA.
文摘Certain problems concerning state constraints and control constraints can often be reduced to the study of positive invariance of some subsets of the state space of dynamical systems. The robust positive invariance of given linear state constraint sets of uncertain discrete-time systems is studied by the mixed monotone decomposition method. Necessary and suffi-
基金This work was supported by the National Natural Science Foundation of China (Grant Nos. 30070205and 39730150)
文摘Band 3 and glucose transport protein (GluTl) are two kinds of important proteins in the human erythro-cyte membranes. Bis(sulfosuccinimidyl)suberate (BS ), an impermeable cross-linker of band 3, inhibited NO2- transport, showing that anion exchange is affected by the association state of band 3 in the intact erythrocyte membranes. At the same time, the rates of glucose transport of both exit and entry declined. The amount of monomers of band 3 was decreased after treatment of the erythrocytes with BS3, but there was no change in GluTl according to the SDS-PAGE patterns. This demonstrates that band 3 and GluTl would be linkaged together in the erythrocyte membranes for the requirement of rapid and cooperative performance of physiological functions of the membrane proteins.
基金supported by the National Natural Science Foundation of China(11171088)the Natural Science Foundation of Hebei Province(A2013208108)the Foundation of Hebei University of Science and Technology(XI2013060)
文摘By the fxed point index theory, the existence of one, two and three positive solutions to(k, n-k) conjugate boundary value problems is obtained, where n 】 2, 1 ≤ k ≤ n-1, the nonlinear term may be noncontinuous and singular at any point of [0,1]. Our results extend some of the existent results.
文摘By the Schauder fixed point theory,this paper establishes the existence of positive solutions to a(k,n k)m-point boundary value problem.We show that there exists a positive constant b such that the problem has at least one positive solution when the homogeneous boundary parameter is smaller than b,and no positive solution when this parameter is greater than b.
文摘To investigate the effect of heterogeneity on the global dynamics of two SIR epidemic models with general nonlinear incidence rate and infection delays, we formulate a multi- group model corresponding to the heterogeneity in the host population and a multi-stage model corresponding to heterogeneous stages of infection. Under biological!y motivated considerations, we establish that the global dynamics for each of the two models is determined completely by the corresponding basic reproduction number： if the basic reproduction number is less than or equal to one, then the disease-free equilibrium is globally asymptotically stable and the disease dies out in all groups or stages; if the basic reproduction number is larger than one, then the disease will persist in all groups or stages, and there is a unique endemic equilibrium which is globally asymptotically stable. Then we conclude that the heterogeneity does not change the global dynamics of the SIR model when the incidence rate is a general nonlinear function. Our results extend a class of previous results and can be applied to the other epidemiological models. The proofs of the main results use Lyapunov functional and graph-theoretic approach.
基金Part of this work was completed when the second author was visiting the Univer- sity of Western Ontario, and he would like to thank the staff in the Department of Applied Mathematics for their help and thank the University for its excellent facilities and support during his stay. The second author was supported by China Scholarship Council, partially sup- ported by NNSF of China （No. 11031002）, by the Heilongjiang Provincial Natural Science Foundation （No. A200806）, and by the Program of Excellent Team and the Science Research Foundation in Harbin Institute of Technology.
文摘We consider a system of partial differential equations that describes the interaction of the sterile and fertile species undergoing the sterile insect release method （SIRM）. Unlike in the previous work [M. A. Lewis and P. van den Driessche, Waves of extinction from sterile insect release, Math. Biosci. 5 （1992） 221 247] where the habitat is assumed to be the one-dimensional whole space ~, we consider this system in a bounded one- dimensional domain （interval）. Our goal is to derive sufficient conditions for success of the SIRM. We show the existence of the fertile-free steady state and prove its stability. Using the releasing rate as the parameter, and by a saddle-node bifurcation analysis, we obtain conditions for existence of two co-persistence steady states, one stable and the other unstable. Biological implications of our mathematical results are that： （i） when the fertile population is at low level, the SIRM, even with small releasing rate, can successfully eradicate the fertile insects; （ii） when the fertile population is at a higher level, the SIRM can succeed as long as the strength of the sterile releasing is large enough, while the method may also fail if the releasing is not sufficient.
文摘In this paper, two sunflower equations are considered. Using delay T as a parameter and applying the global Hopf bifurcation theorem, we investigate the existence of global Hopf bifurcation for the sunflower equation. Furthermore, we analyze the local Hopf bifurcation of the modified equation with nonlinear relation about stem＇s increase, including the occurrence, the bifurcation direction, the stability and the approximation expression of the bifurcating periodic solution using the theory of normal form and center manifold. Finally, the obtained results of these two equations are compared, which finds that the result about the period of their bifurcating periodic solutions is obviously different, while the bifurcation direction and stability are identical.
