Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myr...Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.展开更多
The present study is focused on a comparative evaluation of landslide disaster using analytical hierarchy process and information value method for hazard assessment in highly tectonic Chamba region in bosom of Himalay...The present study is focused on a comparative evaluation of landslide disaster using analytical hierarchy process and information value method for hazard assessment in highly tectonic Chamba region in bosom of Himalaya. During study, the information about the causative factors was generated and the landslide hazard zonation maps were delineated using Information Value Method(IV) and Analytical Hierarchy Process(AHP) using Arc GIS(ESRI). For this purpose, the study area was selected in a part of Ravi river catchment along one of the landslide prone Chamba to Bharmour road corridor of National Highway(NH^(-1)54 A) in Himachal Pradesh, India. A numeral landslide triggering geoenvironmental factors i.e. slope, aspect, relative relief, soil, curvature, land use and land cover(LULC), lithology, drainage density, and lineament density were selected for landslide hazard mapping based on landslide inventory. Landslide hazard zonation map was categorized namely "very high hazard, high hazard, medium hazard, low hazard, and very low hazard". The results from these two methods were validated using Area Under Curve(AUC) plots. It is found that hazard zonation map prepared using information value method and analytical hierarchy process methods possess the prediction rate of 78.87% and 75.42%, respectively. Hence, landslide hazardzonation map obtained using information value method is proposed to be more useful for the study area. These final hazard zonation maps can be used by various stakeholders like engineers and administrators for proper maintenance and smooth traffic flow between Chamba and Bharmour cities, which is the only route connecting these tourist places.展开更多
Cancer has a major impact on society across the world.There are different strategiessuch as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for treatingcarcinoma.Now-a-days,phytochemicals are gaining...Cancer has a major impact on society across the world.There are different strategiessuch as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for treatingcarcinoma.Now-a-days,phytochemicals are gaining a lot of interest for their chemopreventiveaction in treatment of carcinoma.Recent investigations demonstrated that extract/bioactivecompounds from A.comosus resulting in reduction of inflammatory cytokines release andproliferation of T-cell was also inhibited.Therefore in treatment of cancer nanoemulsion of A.comosus have ben proposed.On the basis of previous literature,we have postulated thatnanoemulsion of A.comosus may be beneficial because of its safety and efficacy profile.展开更多
Herbal compounds have enormous potential to enhance the efficacy of current cancer treatments.Several herbal compounds have been reported to enhance the effect of chemotherapy,hormonal therapy and gene therapy on tumo...Herbal compounds have enormous potential to enhance the efficacy of current cancer treatments.Several herbal compounds have been reported to enhance the effect of chemotherapy,hormonal therapy and gene therapy on tumor cells.Compared to synthetic formulations,natural products are considered safer and do not have toxic effects at therapeutic doses,thus increasing demand for them.These compounds can significantly effect on signal transduction pathways,reduce side effects,and even inhibit the efflux of anticancer drugs.This review will explain factors influencing herbal nanomedicines,targeting of nanomedicines,nanocarriers used for delivery,herbal nanomedicines in cancer,phytochemical based combinatorial nanomedicines,and challenges to the nanocarriers based cancer therapy.展开更多
Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in ...Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate behaviour.Objective and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug candidates.It encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s disease.Furthermore,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the brain.These derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s disease.This review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous system.The antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and disease.Conclusion:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological properties.In addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.展开更多
Malaria is one of the world's major public health concerns and numerous medicinal plants are commonly used for treating malaria.Traditional health care uses medicinal plants widely,but no scientific documentation ...Malaria is one of the world's major public health concerns and numerous medicinal plants are commonly used for treating malaria.Traditional health care uses medicinal plants widely,but no scientific documentation is available and,there is a growing risk of losing this knowledge.Thus,this study aims to document the traditional use of medicinal plants in treating malaria and related conditions.In this review,numerous herbal medicines for antimalarial potential are explained.The literature survey was done using keywords i.e.,malaria,herbal,herbal,traditional use,antimalarial,quinine,artemisinin,and traditional medicine by using PubMed,Science Direct,Google Scholar,and HINARI database.This review discusses the life cycle of the malarial parasite,what makes you attractive to mosquitoes,and the role of traditional herbal medicine in malaria.展开更多
The COVID-19 global health disaster has caused more than two million deaths globally.Although,a new therapeutic molecule has not been developed for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as of yet....The COVID-19 global health disaster has caused more than two million deaths globally.Although,a new therapeutic molecule has not been developed for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as of yet.As a result,some medications that had been previously authorized for use against SARS-CoV-2 could now be given to COVID-19 patients.The use of medications to treat COVID-19 is discussed in this publication.The report also discusses the lessons learned when using combination therapy,convalescent plasma therapy,immunotherapeutic molecules,and therapeutic molecules to treat COVID-19 patients.Several beneficial outcomes were noted with anti-viral therapy and immunotherapy.The COVID-19 medicine and vaccination have undergone 9,037 clinical trials since July 2022.It may be possible to provide COVID-19 patients with a successful outcome through the short-term repurposing of an existing drug.The evaluation of potential antiviral molecules can thus lead to more clinical trials being initiated.展开更多
Cancer has a major impact on society across the world.There are different strategies such as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for treating carcinoma.Nowadays,phytochemicals are gaining...Cancer has a major impact on society across the world.There are different strategies such as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for treating carcinoma.Nowadays,phytochemicals are gaining a lot of interest for their chemopreventive action in the treatment of carcinoma.Recent investigations demonstrated that extract/bioactive compounds from Ananas comosus(A.comosus)resulting in the reduction of inflammatory cytokines release and proliferation of T-cell was also inhibited.Therefore,A.comosus nanoemulsion have been proposed in the treatment of cancer.Based on previous literature,we have postulated that nanoemulsion of A.comosus may be beneficial because of its safety and efficacy profile.展开更多
Women are more likely than men to develop cancer of the breast.Most breast cancer drugs are highly toxic,and treatment can cause side effects.It is imperative to find safe alternative medicines in the pursuit of a cur...Women are more likely than men to develop cancer of the breast.Most breast cancer drugs are highly toxic,and treatment can cause side effects.It is imperative to find safe alternative medicines in the pursuit of a cure for breast cancer.An extract of pineapple contains cysteine proteases known as bromelains.In general,pineapples are regarded as safe foods.From the fruit,stem,and of pineapples,bromelain is produced by multiple endopeptidases.As well as reducing the growth of tumors locally,bromelain severely impaired the cytotoxicity of monocytes in the immune system in the fight against cancer.Specifically,we investigated pineapple’s possible mechanisms of action and its bioactive compounds in breast cancer.展开更多
A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the rise.Although we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and th...A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the rise.Although we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and therapies available for those disorders have not progressed historically.Supplements to existing therapies are made from traditional natural derivatives and herbal medicines.Natural compounds such as these are capable of acting as the basis for developing new drugs and related treatments.Plants possess bioactive compounds that have distinct advantages over allopathic medicines because chemotherapy roots severe adverse effects rather than providing limited benefits.As a result of better effects and fewer adverse effects,herbal bioactive is a promising approach for treating respiratory disorders,resulting in a better quality of life and longer life expectancy for patients.Asthma,pulmonary fibrosis,lung cancer,and chronic obstructive pulmonary disease are among the pulmonary disorders addressed in the present article and approaches based on clinical trials.展开更多
Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark.This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells and rapidly multiplying cancerous cel...Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark.This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells and rapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxic anticancer agents.As an essential tool in nanotechnology,nanoemulsions have therapeutic and clinical applications.Currently,nanoemulsions are considered to be one of the most feasible nano-carriers for delivering lipophilic antineoplastic agents with targeted delivery.In addition to solving water-solubilization issues,these formulations deliver specific targeting to cancer cells and might even be developed to overcome multi-drug resistance.Nanoemulsions overcome the problems associated with conventional drug delivery systems,such as low bioavailability and noncompliance.A review of nanoemulsion in cancer therapeutics is presented here to shed light on the current position of this technology.展开更多
Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskeri...Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.展开更多
Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of...Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin.展开更多
文摘Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.
文摘The present study is focused on a comparative evaluation of landslide disaster using analytical hierarchy process and information value method for hazard assessment in highly tectonic Chamba region in bosom of Himalaya. During study, the information about the causative factors was generated and the landslide hazard zonation maps were delineated using Information Value Method(IV) and Analytical Hierarchy Process(AHP) using Arc GIS(ESRI). For this purpose, the study area was selected in a part of Ravi river catchment along one of the landslide prone Chamba to Bharmour road corridor of National Highway(NH^(-1)54 A) in Himachal Pradesh, India. A numeral landslide triggering geoenvironmental factors i.e. slope, aspect, relative relief, soil, curvature, land use and land cover(LULC), lithology, drainage density, and lineament density were selected for landslide hazard mapping based on landslide inventory. Landslide hazard zonation map was categorized namely "very high hazard, high hazard, medium hazard, low hazard, and very low hazard". The results from these two methods were validated using Area Under Curve(AUC) plots. It is found that hazard zonation map prepared using information value method and analytical hierarchy process methods possess the prediction rate of 78.87% and 75.42%, respectively. Hence, landslide hazardzonation map obtained using information value method is proposed to be more useful for the study area. These final hazard zonation maps can be used by various stakeholders like engineers and administrators for proper maintenance and smooth traffic flow between Chamba and Bharmour cities, which is the only route connecting these tourist places.
文摘Cancer has a major impact on society across the world.There are different strategiessuch as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for treatingcarcinoma.Now-a-days,phytochemicals are gaining a lot of interest for their chemopreventiveaction in treatment of carcinoma.Recent investigations demonstrated that extract/bioactivecompounds from A.comosus resulting in reduction of inflammatory cytokines release andproliferation of T-cell was also inhibited.Therefore in treatment of cancer nanoemulsion of A.comosus have ben proposed.On the basis of previous literature,we have postulated thatnanoemulsion of A.comosus may be beneficial because of its safety and efficacy profile.
文摘Herbal compounds have enormous potential to enhance the efficacy of current cancer treatments.Several herbal compounds have been reported to enhance the effect of chemotherapy,hormonal therapy and gene therapy on tumor cells.Compared to synthetic formulations,natural products are considered safer and do not have toxic effects at therapeutic doses,thus increasing demand for them.These compounds can significantly effect on signal transduction pathways,reduce side effects,and even inhibit the efflux of anticancer drugs.This review will explain factors influencing herbal nanomedicines,targeting of nanomedicines,nanocarriers used for delivery,herbal nanomedicines in cancer,phytochemical based combinatorial nanomedicines,and challenges to the nanocarriers based cancer therapy.
文摘Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate behaviour.Objective and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug candidates.It encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s disease.Furthermore,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the brain.These derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s disease.This review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous system.The antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and disease.Conclusion:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological properties.In addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.
文摘Malaria is one of the world's major public health concerns and numerous medicinal plants are commonly used for treating malaria.Traditional health care uses medicinal plants widely,but no scientific documentation is available and,there is a growing risk of losing this knowledge.Thus,this study aims to document the traditional use of medicinal plants in treating malaria and related conditions.In this review,numerous herbal medicines for antimalarial potential are explained.The literature survey was done using keywords i.e.,malaria,herbal,herbal,traditional use,antimalarial,quinine,artemisinin,and traditional medicine by using PubMed,Science Direct,Google Scholar,and HINARI database.This review discusses the life cycle of the malarial parasite,what makes you attractive to mosquitoes,and the role of traditional herbal medicine in malaria.
文摘The COVID-19 global health disaster has caused more than two million deaths globally.Although,a new therapeutic molecule has not been developed for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as of yet.As a result,some medications that had been previously authorized for use against SARS-CoV-2 could now be given to COVID-19 patients.The use of medications to treat COVID-19 is discussed in this publication.The report also discusses the lessons learned when using combination therapy,convalescent plasma therapy,immunotherapeutic molecules,and therapeutic molecules to treat COVID-19 patients.Several beneficial outcomes were noted with anti-viral therapy and immunotherapy.The COVID-19 medicine and vaccination have undergone 9,037 clinical trials since July 2022.It may be possible to provide COVID-19 patients with a successful outcome through the short-term repurposing of an existing drug.The evaluation of potential antiviral molecules can thus lead to more clinical trials being initiated.
文摘Cancer has a major impact on society across the world.There are different strategies such as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for treating carcinoma.Nowadays,phytochemicals are gaining a lot of interest for their chemopreventive action in the treatment of carcinoma.Recent investigations demonstrated that extract/bioactive compounds from Ananas comosus(A.comosus)resulting in the reduction of inflammatory cytokines release and proliferation of T-cell was also inhibited.Therefore,A.comosus nanoemulsion have been proposed in the treatment of cancer.Based on previous literature,we have postulated that nanoemulsion of A.comosus may be beneficial because of its safety and efficacy profile.
文摘Women are more likely than men to develop cancer of the breast.Most breast cancer drugs are highly toxic,and treatment can cause side effects.It is imperative to find safe alternative medicines in the pursuit of a cure for breast cancer.An extract of pineapple contains cysteine proteases known as bromelains.In general,pineapples are regarded as safe foods.From the fruit,stem,and of pineapples,bromelain is produced by multiple endopeptidases.As well as reducing the growth of tumors locally,bromelain severely impaired the cytotoxicity of monocytes in the immune system in the fight against cancer.Specifically,we investigated pineapple’s possible mechanisms of action and its bioactive compounds in breast cancer.
文摘A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the rise.Although we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and therapies available for those disorders have not progressed historically.Supplements to existing therapies are made from traditional natural derivatives and herbal medicines.Natural compounds such as these are capable of acting as the basis for developing new drugs and related treatments.Plants possess bioactive compounds that have distinct advantages over allopathic medicines because chemotherapy roots severe adverse effects rather than providing limited benefits.As a result of better effects and fewer adverse effects,herbal bioactive is a promising approach for treating respiratory disorders,resulting in a better quality of life and longer life expectancy for patients.Asthma,pulmonary fibrosis,lung cancer,and chronic obstructive pulmonary disease are among the pulmonary disorders addressed in the present article and approaches based on clinical trials.
文摘Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark.This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells and rapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxic anticancer agents.As an essential tool in nanotechnology,nanoemulsions have therapeutic and clinical applications.Currently,nanoemulsions are considered to be one of the most feasible nano-carriers for delivering lipophilic antineoplastic agents with targeted delivery.In addition to solving water-solubilization issues,these formulations deliver specific targeting to cancer cells and might even be developed to overcome multi-drug resistance.Nanoemulsions overcome the problems associated with conventional drug delivery systems,such as low bioavailability and noncompliance.A review of nanoemulsion in cancer therapeutics is presented here to shed light on the current position of this technology.
文摘Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.
文摘Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin.
