In spite of tremendous progresses in surgical and chemo-radiotherapeutic regimens, rectal cancer still suffers from high relapse and mortality rates, and metastatic disease is incurable. Here we assess some of the mos...In spite of tremendous progresses in surgical and chemo-radiotherapeutic regimens, rectal cancer still suffers from high relapse and mortality rates, and metastatic disease is incurable. Here we assess some of the most recent and validated biomarkers and potential targets studied in rectal cancer, and provide comments to a recent monographic topic covering several aspects of colorectal cancer, published in Current Cancer Drug Targets .展开更多
A patient presented with an acute abdomen at the Emergency Department.The patient,a 69-year-old man,was admitted and underwent surgery with a provisional diagnosis of acute appendicitis.During surgery,omental torsion ...A patient presented with an acute abdomen at the Emergency Department.The patient,a 69-year-old man,was admitted and underwent surgery with a provisional diagnosis of acute appendicitis.During surgery,omental torsion was diagnosed and the involved omentum was removed.The patient had no previous surgical history.Omental torsion is a rare cause of acute abdomen in children and adults who may present with various signs and symptoms;a preoperative diagnosis may therefore be difficult and can usually only be established during surgery.展开更多
Neoadjuvant chemoradiation is the standard treatment for advanced rectal tumor,providing better local control of disease and potentially increasing sphincter preservation surgery.Neoadjuvant radiation may affect the n...Neoadjuvant chemoradiation is the standard treatment for advanced rectal tumor,providing better local control of disease and potentially increasing sphincter preservation surgery.Neoadjuvant radiation may affect the number of lymph nodes harvested after resection or alter their prognostic value.Over the past 10 years,standards for lymph node harvests in colorectal cancer have been proposed.Several studies have recommend examination of at least 12 lymph nodes(LNs) in the specimen and this number is now used as a reflection of surgical quality.Nevertheless,recent reports have identified significantly decreased LN harvests in patients treated with neoadjuvant radiation.And preoperative chemoradiation has a significant effect on the number of nodes harvested in rectal specimens and this should be considered in staging of the tumor.In the near future,the total number of nodes will be less important than specific biologic markers in detecting high-risk patients and improving their prognosis with adjuvant therapy tailored.展开更多
文摘In spite of tremendous progresses in surgical and chemo-radiotherapeutic regimens, rectal cancer still suffers from high relapse and mortality rates, and metastatic disease is incurable. Here we assess some of the most recent and validated biomarkers and potential targets studied in rectal cancer, and provide comments to a recent monographic topic covering several aspects of colorectal cancer, published in Current Cancer Drug Targets .
文摘A patient presented with an acute abdomen at the Emergency Department.The patient,a 69-year-old man,was admitted and underwent surgery with a provisional diagnosis of acute appendicitis.During surgery,omental torsion was diagnosed and the involved omentum was removed.The patient had no previous surgical history.Omental torsion is a rare cause of acute abdomen in children and adults who may present with various signs and symptoms;a preoperative diagnosis may therefore be difficult and can usually only be established during surgery.
文摘Neoadjuvant chemoradiation is the standard treatment for advanced rectal tumor,providing better local control of disease and potentially increasing sphincter preservation surgery.Neoadjuvant radiation may affect the number of lymph nodes harvested after resection or alter their prognostic value.Over the past 10 years,standards for lymph node harvests in colorectal cancer have been proposed.Several studies have recommend examination of at least 12 lymph nodes(LNs) in the specimen and this number is now used as a reflection of surgical quality.Nevertheless,recent reports have identified significantly decreased LN harvests in patients treated with neoadjuvant radiation.And preoperative chemoradiation has a significant effect on the number of nodes harvested in rectal specimens and this should be considered in staging of the tumor.In the near future,the total number of nodes will be less important than specific biologic markers in detecting high-risk patients and improving their prognosis with adjuvant therapy tailored.
