BACKGROUND Bile duct cancer constitutes gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICA),and extrahepatic cholangiocarcinoma(ECA).These three entities show morphological and immunohistochemical resemblance...BACKGROUND Bile duct cancer constitutes gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICA),and extrahepatic cholangiocarcinoma(ECA).These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC,which sometimes becomes a point of discussion in clinical practice.Although these cancers demonstrate significant differences in their mutational landscape,several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary cancers.CASE SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2(ERBB2)activating mutation on next-generation sequencing(NGS)-based genomic testing.One year later,a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological diagnosis.The histological findings of the hepatic lesion were similar to those of the primary lesion.Additionally,using NGS panel testing,the hepatic lesion was found to have ERBB2 activating mutation,which is the identical mutation detected in the sequencing result of the primary site.ERBB2 activating mutation occurs more frequently in GBC than ICA and ECA.Therefore,in the present case,we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic recurrence.Additionally,this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical benefit.CONCLUSION This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC.展开更多
The present paper focuses on the effect of air jets through a perforated thin plate on the characteristics of an acoustic absorption coefficient. We measured the flow rate, internal pressure, acoustic pressure, and tr...The present paper focuses on the effect of air jets through a perforated thin plate on the characteristics of an acoustic absorption coefficient. We measured the flow rate, internal pressure, acoustic pressure, and transfer function by using an improved acoustic impedance tube. The normal incidence absorption coefficient was calculated from the measured transfer function using transfer function methods. As a result, the frequency characteristics of the acoustic absorption coefficient against the frequency showed a maximum value at the local frequency. The peak frequency of the acoustic absorption coefficient depended on the thickness of the background air space and the thickness of the perforated plate. As the flow rate increased through the micropores, the peak level of the acoustic absorption coefficient also increased until a flow rate of 80?l /min. As the flow rate further increased, the peak level of the acoustic absorption coefficient decreased and that of the high frequency band increased.展开更多
文摘BACKGROUND Bile duct cancer constitutes gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICA),and extrahepatic cholangiocarcinoma(ECA).These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC,which sometimes becomes a point of discussion in clinical practice.Although these cancers demonstrate significant differences in their mutational landscape,several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary cancers.CASE SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2(ERBB2)activating mutation on next-generation sequencing(NGS)-based genomic testing.One year later,a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological diagnosis.The histological findings of the hepatic lesion were similar to those of the primary lesion.Additionally,using NGS panel testing,the hepatic lesion was found to have ERBB2 activating mutation,which is the identical mutation detected in the sequencing result of the primary site.ERBB2 activating mutation occurs more frequently in GBC than ICA and ECA.Therefore,in the present case,we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic recurrence.Additionally,this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical benefit.CONCLUSION This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC.
文摘The present paper focuses on the effect of air jets through a perforated thin plate on the characteristics of an acoustic absorption coefficient. We measured the flow rate, internal pressure, acoustic pressure, and transfer function by using an improved acoustic impedance tube. The normal incidence absorption coefficient was calculated from the measured transfer function using transfer function methods. As a result, the frequency characteristics of the acoustic absorption coefficient against the frequency showed a maximum value at the local frequency. The peak frequency of the acoustic absorption coefficient depended on the thickness of the background air space and the thickness of the perforated plate. As the flow rate increased through the micropores, the peak level of the acoustic absorption coefficient also increased until a flow rate of 80?l /min. As the flow rate further increased, the peak level of the acoustic absorption coefficient decreased and that of the high frequency band increased.
