The transition metal iron exerts essential roles in the central nervous system（CNS）for oxygen transport,myelin formation,and synthesis of neurotransmitters.Being redox active,iron switches between ferrous and ferric...The transition metal iron exerts essential roles in the central nervous system（CNS）for oxygen transport,myelin formation,and synthesis of neurotransmitters.Being redox active,iron switches between ferrous and ferric states.Switching between oxygen states also makes iron an important inducer of reactive oxygen species through the Fenton and Haber-Weiss reactions.展开更多
Studies conducted on neurodegenerative diseases diversely report on changes in the cerebral microvasculature:Fundamental hallmarks of prevalent neurodegenerative diseases,such as Alzheimer’s disease(AD),dementia with...Studies conducted on neurodegenerative diseases diversely report on changes in the cerebral microvasculature:Fundamental hallmarks of prevalent neurodegenerative diseases,such as Alzheimer’s disease(AD),dementia with Lewy bodies,Parkinson’s disease,Huntington’s disease,include region-specific neuronal loss and neuroinflammation eventually leading to brain atrophy.Numerous studies have also demonstrated that neurodegeneration and changes in the microvasculature are interconnected.For example,in AD,changes in vessel density have been reported to vary-increasing,remaining unchanged,or decreasing-in brain regions most affected by neurodegeneration.展开更多
文摘The transition metal iron exerts essential roles in the central nervous system（CNS）for oxygen transport,myelin formation,and synthesis of neurotransmitters.Being redox active,iron switches between ferrous and ferric states.Switching between oxygen states also makes iron an important inducer of reactive oxygen species through the Fenton and Haber-Weiss reactions.
文摘Studies conducted on neurodegenerative diseases diversely report on changes in the cerebral microvasculature:Fundamental hallmarks of prevalent neurodegenerative diseases,such as Alzheimer’s disease(AD),dementia with Lewy bodies,Parkinson’s disease,Huntington’s disease,include region-specific neuronal loss and neuroinflammation eventually leading to brain atrophy.Numerous studies have also demonstrated that neurodegeneration and changes in the microvasculature are interconnected.For example,in AD,changes in vessel density have been reported to vary-increasing,remaining unchanged,or decreasing-in brain regions most affected by neurodegeneration.
