Parkinson’s disease(PD)is a neurological disorder characterized by rigidity,tremor,bradykinesia,and postural instability.Gait disturbance is one of cardinal symptoms of PD and affects the activities of daily living a...Parkinson’s disease(PD)is a neurological disorder characterized by rigidity,tremor,bradykinesia,and postural instability.Gait disturbance is one of cardinal symptoms of PD and affects the activities of daily living and quality of life.This symptom in advanced PD patients is usually refractory to medication and surgical intervention such as deep brain stimulation(Morishita et al.,2016).展开更多
Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure ...Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,展开更多
文摘Parkinson’s disease(PD)is a neurological disorder characterized by rigidity,tremor,bradykinesia,and postural instability.Gait disturbance is one of cardinal symptoms of PD and affects the activities of daily living and quality of life.This symptom in advanced PD patients is usually refractory to medication and surgical intervention such as deep brain stimulation(Morishita et al.,2016).
基金supported by Japan Society for the Promotion of Science(JSPS)Grant-in-Aid for young scientists(B)15K19984JSPS Fujita Memorial Fund for Medical Research,Takeda Science Foundation+1 种基金Uehara Memorial FoundationCentral Research Institute of Fukuoka University(No.161042)
文摘Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,
