High quality gallium oxide(Ga_2O_3) thin films are deposited by remote plasma-enhanced atomic layer deposition(RPEALD) with trimethylgallium(TMG) and oxygen plasma as precursors. By introducing in-situ NH3 plasma pret...High quality gallium oxide(Ga_2O_3) thin films are deposited by remote plasma-enhanced atomic layer deposition(RPEALD) with trimethylgallium(TMG) and oxygen plasma as precursors. By introducing in-situ NH3 plasma pretreatment on the substrates, the deposition rate of Ga_2O_3 films on Si and GaN are remarkably enhanced, reached to 0.53 and 0.46 ?/cycle at 250 °C,respectively. The increasing of deposition rate is attributed to more hydroxyls(–OH) generated on the substrate surfaces after NH3 pretreatment, which has no effect on the stoichiometry and surface morphology of the oxide films, but only modifies the surface states of substrates by enhancing reactive site density. Ga_2O_3 film deposited on GaN wafer is crystallized at 250 °C, with an epitaxial interface between Ga_2O_3 and GaN clearly observed. This is potentially very important for reducing the interface state density through high quality passivation.展开更多
The prevalence of type 2 diabetes mellitus(T2DM)is rising,with hypertension as a common comorbidity that significantly increases cardiovascular and microva-scular risks.Accurate prediction of hypertension in T2DM is e...The prevalence of type 2 diabetes mellitus(T2DM)is rising,with hypertension as a common comorbidity that significantly increases cardiovascular and microva-scular risks.Accurate prediction of hypertension in T2DM is essential for early intervention and personalized management.In this editorial,we comment on a recent retrospective study by Zhao et al,which developed a nomogram model using a large cohort of 26850 patients to predict hypertension risk in patients with T2DM.The model incorporated key independent risk factors,including age,body mass index,duration of diabetes,low-density lipoprotein cholesterol and urine protein levels,demonstrating promising discriminative power and predictive accuracy in internal validation.However,its external applicability requires fur-ther confirmation.This editorial discusses the clinical value and limitations of the predictive model,highlighting the unfavorable impact of hypertension on T2DM patients.Future research should evaluate the potential contribution of other risk factors to enhance risk prediction and improve the management of T2DM co-morbidities.展开更多
0 INTRODUCTION The Haidewula uranium deposit is located in the Haidewula volcanic basin,which hosts a suite of basic,intermediate to felsic volcanic and subvolcanic rocks,including basalt,trachyte,trachyandesite.Previ...0 INTRODUCTION The Haidewula uranium deposit is located in the Haidewula volcanic basin,which hosts a suite of basic,intermediate to felsic volcanic and subvolcanic rocks,including basalt,trachyte,trachyandesite.Previous geochronological studies of the intrusions within this volcanic basin suggest that they primarily formed during the Silurian and Triassic periods(Dai et al.,2025;Sun et al.,2024;Wang et al.,2024;Zhu et al.,2022;Lei et al.,2021).展开更多
BACKGROUND Heart failure with preserved ejection fraction(HFpEF)following acute myocardial infarction(AMI)carries substantial morbidity and mortality,yet reliable prognostic markers beyond conventional cardiovascular ...BACKGROUND Heart failure with preserved ejection fraction(HFpEF)following acute myocardial infarction(AMI)carries substantial morbidity and mortality,yet reliable prognostic markers beyond conventional cardiovascular factors remain limited.Frailty,reflecting diminished physiological reserve,has emerged as a potential determinant of adverse outcomes in this high-risk population.Therefore,the aim of this study was to address a critical knowledge gap and to provide evidence that may guide frailty-adapted management strategies to improve prognosis and quality of life in this high-risk population.METHODS We conducted a multicenter retrospective cohort study including 4507 patients with HFpEF discharged after AMI across 82 hospitals in China(from January 2010 to March 2024).Frailty was assessed using the Hospital Frailty Risk Score(HFRS),with HFRS<5 defined as non-frail and HFRS≥5 as frail.Multivariable Cox proportional hazards models,adjusted for demographics,comorbidities,left ventricular ejection fraction,and therapies,were applied to evaluate associations between frailty and clinical outcomes.The primary endpoints were all-cause death and major adverse cardiovascular events(MACE),which defined as the composite of cardiovascular death and heart failure rehospitalization.Secondary endpoints included net adverse clinical events(NACE),which defined as the composite of all-cause death,stroke,recurrent myocardial infarction,revascularization,and major bleeding,as well as the individual components of MACE.RESULTS Frailty was independently associated with a higher risk of all-cause death[adjusted hazard ratio(aHR)=1.52,95%CI:1.31–2.03,P=0.005]and NACE(aHR=1.20,95%CI:1.02–1.41,P=0.026).At one year,frail patients had higher unadjusted rates of all-cause death(9.0%vs.2.9%)and NACE(19.8%vs.13.7%)compared with non-frail patients.For cardiovascular death,the association did not reach statistical significance(aHR=1.42,95%CI:0.99–2.03,P=0.053).No significant associations were found for MACE(aHR=1.05,95%CI:0.86–1.28,P=0.636)or heart failure rehospitalization(aHR=0.94,95%CI:0.75–1.19,P=0.616).CONCLUSIONS Frailty,as measured by the HFRS,is an independent predictor of one-year mortality and composite adverse events in post-AMI HFpEF patients.These findings support the use of HFRS at discharge to identify high-risk population who may benefit from closer follow-up,optimization of medical therapy,and targeted frailty-focused interventions.展开更多
Chronic pain affects over 30%of the global adult population,significantly impairing quality of life,physical function,and psychological well-being,while imposing a substantial personal and economic burden[1].As the gl...Chronic pain affects over 30%of the global adult population,significantly impairing quality of life,physical function,and psychological well-being,while imposing a substantial personal and economic burden[1].As the global population continues to age,there is an urgent and unmet need to effectively prevent,assess,and manage chronic pain in older adults.Although age-related changes in pain perception,processing,and coping mechanisms have been increasingly recognized over recent decades,many aspects of the relationship between aging and pain remain poorly understood.In addition,aging is associated with increased susceptibility to chronic pain conditions,particularly following peripheral nerve injury[2,3].However,the incomplete understanding of the mechanisms underlying pain in the aged population represents a major barrier to the development of effective medical treatment is often insufficient to provide complete pain relief[4,5].Targeted interventions for geriatric pain management are needed.Therefore,elucidating the impact of aging on the pathogenesis of chronic pain is urgently needed.展开更多
Coronary thrombosis remains a critical event in the pathophysiology of acute coronary syndromes,including myocardial infarction.The prompt and effective removal of coronary thrombi is essential to restore blood flow,m...Coronary thrombosis remains a critical event in the pathophysiology of acute coronary syndromes,including myocardial infarction.The prompt and effective removal of coronary thrombi is essential to restore blood flow,minimize myocardial damage,and improve clinical outcomes.The reperfusion treatment of acute myocardial infarction(AMI)patients with large thrombus burden has been keeping challenging.Over the past decade,significant advancements have been made in the techniques and technologies available for thrombus removal.展开更多
The nascent polypeptide-associated complex(NAC)plays crucial roles in various biological functions in eukaryotes and has been extensively studied in animals and plants;however,its role in the biocontrol mechanisms of ...The nascent polypeptide-associated complex(NAC)plays crucial roles in various biological functions in eukaryotes and has been extensively studied in animals and plants;however,its role in the biocontrol mechanisms of microorganisms requires further investigation.This study examined the function of TbNACα,a NAC subunit,in the biocontrol activity of Trichoderma breve T069 against Sclerotium rolfsii.Following deletion of the TbNACα gene from T.breve T069,the ΔTbNACα mutant exhibited significantly reduced mycelial growth,spore production,and spore germination.While volatile substances from ΔTbNACα showed no significant effect on S.rolfsii,non-volatile substances demonstrated significant inhibition of S.rolfsii growth.Transcriptome sequencing analysis revealed 3,398 differentially expressed genes in the ΔTbNACα mutant compared to wild-type T069,primarily regulating genes associated with secondary metabolite biosynthetic enzymes,hydrolases,and membrane transport proteins.Untargeted metabolomics identified 50 upregulated metabolites(27 in positive ion mode and 23 in negative ion mode)in crude extracts from ΔTbNACα mutant metabolite broth.Among these metabolic substances,ethyl caffeate demonstrated the strongest activity against S.rolfsii,with an EC_(50) of 107.15μg mL^(-1).Quantitative real-time PCR(qPCR)analysis indicated significant upregulation of genes involved in the ethyl caffeate synthesis pathway in ΔTbNACα strains.This research establishes the negative regulation of ethyl caffeate synthesis and elucidates the antagonistic inhibition mechanism of TbNACα in T.breve T069.展开更多
BACKGROUND The beneficial effects of sodium-glucose co-transporter-2 inhibitors(SGLT2i)on adverse cardiac outcomes in diabetic patients are well-established.However,the effects of SGLT2i against cancer therapy-related...BACKGROUND The beneficial effects of sodium-glucose co-transporter-2 inhibitors(SGLT2i)on adverse cardiac outcomes in diabetic patients are well-established.However,the effects of SGLT2i against cancer therapy-related cardiotoxicity remain understudied.We investigated the association between SGLT2i and cardiac outcomes in cancer patients.METHODS PubMed,Embase,and the Cochrane Library were searched from their inception until September 30,2024 for studies evaluating the effects of SGLT2i in patients with cancer.The primary outcomes included incident heart failure(HF),HF exacerbation,HF hospitalization,atrial fibrillation/atrial flutter(AF/AFL),myocardial infarction,and all-cause mortality.The secondary outcomes included acute kidney injury and sepsis.Odds ratio(OR)with 95%CI was pooled.RESULTS Thirteen studies with 85,596 patients were included.Compared to non-SGLT2i use,SGLT2i treatment was associated with lower risks of incident HF(OR=0.51,95%CI:0.32-0.79,P=0.003),HF exacerbation(OR=0.74,95%CI:0.63-0.87,P<0.001),AF/AFL(OR=0.67,95%CI:0.55-0.82,P<0.001),myocardial infarction(OR=0.61,95%CI:0.41-0.90,P=0.01),and all-cause mortality(OR=0.44,95%CI:0.28-0.69,P<0.001),but not for HF hospitalization(OR=0.58,95%CI:0.22-1.55,P=0.28).As for safety outcomes,SGLT2i use was associated with lower risks of acute kidney injury(OR=0.68,95%CI:0.57-0.81,P<0.001)and sepsis(OR=0.32,95%CI:0.23-0.44,P<0.001).CONCLUSIONS SGLT2i were associated with lower risks of incident HF,HF exacerbation,AF/AFL,myocardial infarction,allcause mortality,acute kidney injury,and sepsis in cancer patients.展开更多
Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellula...Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellular carcinoma.It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD.Triggering receptor expressed on myeloid cells 2(TREM2)can sense tissue injury and mediate immune remodeling,thereby inducing phagocytosis,lipid metabolism,and metabolic transfer,promoting cell survival and combating inflammatory activation.NAFLD might develop as a result of TREM2's regulatory role.We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD.Moreover,we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2.展开更多
With the rapid advancement and widespread adoption of new artificial intelligence(AI)technologies,personalized medicine and more accurate diagnosis using medical imaging are now possible.Among its many applications,AI...With the rapid advancement and widespread adoption of new artificial intelligence(AI)technologies,personalized medicine and more accurate diagnosis using medical imaging are now possible.Among its many applications,AI has shown remarkable potential in the analysis of electrocardiograms(ECGs),which provide essential insights into the electrical activity of the heart and allowing early detection of ischemic heart disease(IHD).Notably,single-lead ECG(SLECG)analysis has emerged as a key focus in recent research due to its potential for widespread and efficient screening.This editorial focuses on the latest research progress of AI-enabled SLECG utilized in the diagnosis of IHD.展开更多
Ferrate[Fe(Ⅵ)]has demonstrated its efficacy as a potent oxidizing agent in the treatment of wastewater,showcasing its potential for application in environmental remediation.The self-decomposition of Fe(Ⅵ)results in ...Ferrate[Fe(Ⅵ)]has demonstrated its efficacy as a potent oxidizing agent in the treatment of wastewater,showcasing its potential for application in environmental remediation.The self-decomposition of Fe(Ⅵ)results in the formation of Fe(Ⅳ)/Fe(V),which exhibits remarkable reactivity and selectivity towards the degradation of electron-rich micro-pollutants.Here we presented a comprehensive review on the removal of micro-pollutants in Fe(Ⅵ)/carbon materials(CMs)systems,encompassing an analysis of the oxidation mechanism and mutual activation,thereby providing guidance for the efficient elimination of recalcitrant micro-pollutants.The combnation of Fe(Ⅵ)and CMs can significantly enhanced the removal efficiency of various pollutants,with an increase ranges from 30%to 70%.The rate constants for pseudo-first order reactions were increased ranging from 3 to 14 times,while the total organic carbon(TOC)removal rate was effectively doubled.The presence of active species,including hydroxyl radicals,superoxide radical and Fe(Ⅳ)/Fe(V)generated by Fe(Ⅵ)and CMs,can significantly enhance the oxidation efficiency of micro-pollutants which are not easily degraded solely by Fe(Ⅵ)or CMs.Furthermore,Fe(Ⅵ)can enhance the surface area and void volume of CMs,thereby reinforcing the adsorption capacity towards micropollutants.展开更多
Myocardial infarction(MI)is characterized by focal necrosis resulting from prolonged myocardial ischemia due to coronary artery obstruction.Vascular reconstruction following MI is crucial for improving cardiac functio...Myocardial infarction(MI)is characterized by focal necrosis resulting from prolonged myocardial ischemia due to coronary artery obstruction.Vascular reconstruction following MI is crucial for improving cardiac function and preventing recurrent infarction.This study investigates the interaction between macrophages and endothelial cells in angiogenesis mediated by nicotinamide mononucleotide(NMN)-induced secretion of macrophage-derived exosomes.We focus on the role of U2 small nuclear RNA auxiliary factor 1(U2af1)gene,a member of the splicing factor serine and arginine(SR)gene family,in the regulation of angiogenesis.Through cardiac ultrasound,Masson staining,2,3,5-triphenyltetrazolium chloride(TTC)staining,Microfil vascular perfusion,and platelet and endothelial cell adhesion molecule 1(CD31)immunofluorescence staining,extracellular vesicles from NMN-stimulated macrophages were shown to exert a protective effect in MI,with proteomic analysis identifying U2AF1 as a candidate protein involved in MI protection.Plasma U2AF1 levels were measured in 70 MI patients,revealing significantly lower levels in individuals with poor coronary collateral vessel(CCV;Rentrop scores 0–1)than in those with good CCV(Rentrop scores 2–3).In both myocardial and hindlimb ischemia mouse models,overexpression of endothelial cell-specific adenoviral overexpression U2AF1 promoted angiogenesis in the heart and hindlimbs and improved cardiac function after MI.Mechanistic studies demonstrated that U2AF1 regulates the alternative splicing(AS)of Yes1-associated transcriptional regulator(Yap1)gene,influencing post-MI angiogenesis and cardiac function recovery.Collectively,our clinical findings suggest that U2AF1 may serve as a therapeutic target for coronary collateral angiogenesis following MI.Given the low immunogenicity and high biosafety of exosomes,this study provides a foundational basis and translational potential for exosome-based therapies in MI treatment.展开更多
N6-methyladenosine(m6A)plays a key role in mammalian early embryonic development and cell lineage differentiation.However,the role and mechanisms of 18S ribosomal RNA(rRNA)m6A methyltransferase METTL5 in early embryon...N6-methyladenosine(m6A)plays a key role in mammalian early embryonic development and cell lineage differentiation.However,the role and mechanisms of 18S ribosomal RNA(rRNA)m6A methyltransferase METTL5 in early embryonic development remain unclear.Here,we found that 18S rRNA m6A methyltransferase METTL5 plays an important role in porcine early embryonic development.METTL5 knockdown and overexpression significantly reduced the developmental efficiency of porcine early embryos and impaired cell lineage allocation.METTL5 knockdown apparently decreased the global translation efficiency in blastocyst,while METTL5 overexpression increased the global translation efficiency.Furthermore,METTL5 knockdown did not affect the abundance of CDX2 mRNA,but resulted in a significant reduction in CDX2 protein levels.Moreover,the low developmental efficiency and abnormal lineage distribution of METTL5 knockdown embryos could be rescued by CDX2 overexpression.Collectively,our results demonstrated that 18S rRNA methyltransferase METTL5 regulates porcine early embryonic development via modulating the translation of CDX2.展开更多
BACKGROUND:Circulating biomarkers for sepsis are lacking,and research on circular RNAs(circR NAs)as potential biomarkers of pneumonia-induced sepsis is limited.This study aims to investigate the diagnostic and prognos...BACKGROUND:Circulating biomarkers for sepsis are lacking,and research on circular RNAs(circR NAs)as potential biomarkers of pneumonia-induced sepsis is limited.This study aims to investigate the diagnostic and prognostic potential of circRNAs in patients with pneumonia-induced sepsis.METHODS:This prospective cohort study included 40 healthy individuals,60 patients with pneumonia,and 80 patients with pneumonia-induced sepsis.CircRNAs identified through RNA-sequencing were validated using quantitative real-time polymerase chain reaction(qRT-PCR).Spearman correlation analysis was used to evaluate the associations between circRNAs,inflammatory markers,Sequential Organ Failure Assessment(SOFA)scores,and Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)scores.Receiver operating characteristic(ROC)curves analysis were used to assess the diagnostic performance of circRNAs,while ROC curves and Kaplan-Meier survival analysis were used to evaluate their prognostic value of 28-day mortality.RESULTS:qRT-PCR confirmed the significant upregulation of Circ-CTD-2281E23.2 and downregulation of Circ-0075723 and Circ-0008679 in sepsis patients.Spearman correlation analysis showed that Circ-CTD-2281E23.2 was positively correlated with inflammatory markers and severity scores,whereas Circ-0075723 and Circ-0008679 were negatively correlated with these parameters.The area under the curve(AUC)values for Circ-CTD-2281E23.2,Circ-0075723,and Circ-0008679 in diagnosing pneumonia-induced sepsis were 0.728,0.706,and 0.793,respectively.The combination of these circRNAs(AUC=0.846)and the combination with other clinical indicators(AUC=0.990)demostrated enhanced AUC values.The AUC values for Circ-CTD-2281E23.2 and Circ-0075723 in predicting 28-day mortality were 0.664 and 0.765,respectively.CONCLUSION:This study suggest the additional diagnostic and prognostic value of circRNAs in pneumonia-induced sepsis.Circ-CTD-2281E23.2,Circ-0075723,and Circ-0008679 exhibit diagnostic potential,with Circ-CTD-2281E23.2 and Circ-0075723 showing positive prognostic value for 28-day mortality in sepsis patients.展开更多
In recent years,environmental DNA(e DNA)has garnered significant attention as a novel tool in biodiversity monitoring,recognized for its efficiency,convenience,and non-invasiveness.Despite its extensive application in...In recent years,environmental DNA(e DNA)has garnered significant attention as a novel tool in biodiversity monitoring,recognized for its efficiency,convenience,and non-invasiveness.Despite its extensive application in various ecological studies,such as conservation,invasion biology,biomonitoring and biodiversity survey assessment,its use in avian monitoring remains in its infancy.This review critically examines the potential and limitations of e DNA technology for avian monitoring,focusing on current advancements and ongoing challenges in this emerging field.Water and air are the primary environmental media for collecting avian e DNA,although other sources like spider webs and plant flowers have been explored as well.Notably,airborne e DNA has been reported to capture the highest diversity of avian species.While avian e DNA technology has shown promise for monitoring rare and endangered species and assessing avian diversity,significant challenges remain,particularly in sampling strategies,DNA extraction methodology,primer selection,and ascertain abundance.Additionally,we discussed the factors influencing the production,transportation,and degradation of avian e DNA in the environment.Finally,we suggested future research directions,including optimizing sampling strategies,developing avian-specific universal primers,expanding avian DNA barcode databases,enhancing e DNA detectability,and integrating environmental RNA(e RNA)and e DNA approaches.展开更多
Global framework for nature management requires identifying areas of high priority for biodiversity conservation and restoration.The unique environments of Qinghai-Xizang Plateau(QXP) provide irreplaceable habitats fo...Global framework for nature management requires identifying areas of high priority for biodiversity conservation and restoration.The unique environments of Qinghai-Xizang Plateau(QXP) provide irreplaceable habitats for biodiversity which is prominent under future climate change.Despite the recent increase in research interest on conservation priorities,there is a lack of comprehensive and targeted protection strategies for pandemic species under climate change.Here,we compiled an exhaustive dataset with the variables of extinction risk and occurrence records of ectothermic lizards to investigate the conservation priorities in the QXP.We assessed the conservation status of the QXP lizards and identified the priority protected areas within the QXP under future climate scenarios using phylogenetic generalized least squares and ensemble species distribution models.Our analyses suggested nine lizard species to be prioritized for protection,with the most critical priority species being Dopasia gracilis,D.harti,and Phrynocephalus putjatai.Moreover,the priority protected areas covered~4.7%area of the QXP,mostly in the southern QXP and southeastern Hengduan Mountains.Protecting these regions would achieve a conservation effectiveness of≥95%for species richness,phylogenetic and functionaldiversity under climate change.Our findings provide realistic guidance for improving the conservation effectiveness of specific-lizard and-regions in the QXP under climate change.Our“bottom-up”approach could help the conservation efforts of other regions and species as an alternative to“top-down”global maps.展开更多
The effects of combined microwave and hydrogen peroxide(H_(2)O_(2))oxidation on the flotation separation of molybdenite and chalcopyrite,as well as the underlying mechanism were investigated via microflotation,zeta po...The effects of combined microwave and hydrogen peroxide(H_(2)O_(2))oxidation on the flotation separation of molybdenite and chalcopyrite,as well as the underlying mechanism were investigated via microflotation,zeta potential,contact angle,X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM)and atomic force microscopy(AFM)analyses.The microflotation experiments showed that the effective inhibition of chalcopyrite can be obtained through combined oxidation pretreatments with low microwave power and H_(2)O_(2)consumption.The zeta potential,contact angle and XPS analyses indicated that the surface hydrophobicity of molybdenite changed minimally after different treatments,whereas significant amounts of hydrophilic oxidation species were formed on the surface of chalcopyrite,thus decreasing its surface hydrophobicity and floatability.Moreover,the SEM and AFM analyses indicated that more uniform oxidative products were formed on the chalcopyrite surface,further significantly increasing the surface roughness.展开更多
In this article,we comment on the article by Zheng et al.This case report shed light on concomitant cerebrocardiac ischemic(CCI)in a 27-year-old male patient,which is defined as a concurrent acute ischemic stroke(AIS)...In this article,we comment on the article by Zheng et al.This case report shed light on concomitant cerebrocardiac ischemic(CCI)in a 27-year-old male patient,which is defined as a concurrent acute ischemic stroke(AIS)and acute myocardial infarction event.The patient received urgent systemic thrombolysis at the sta-ndard dose for AIS and then planned percutaneous coronary intervention was successfully conducted for ST-segment elevation myocardial infarction treatment.Considering the rarity of the comorbidity,the narrow time window for treatment of both AIS and acute myocardial infarction,as well as the complexity and severity of the condition,there are still no guidelines or consensus that have systematically recommended optimal treatment strategies.The successful treat-ment of this 27-year-old man suggests that urgent thrombolysis followed by planned percutaneous coronary intervention might be an alternative treatment options in the management of concomitant CCI.However,emergency treatment plans need to be developed according to the specific situation of the patients.A number of factors should be considered when making decision,including the location of occlusion of heart and brain,the hemodynamic instability,the ongoing ischemic symptoms,the presence of contraindications to thrombolysis,and the speed of response of cardiologists or neurointerventionists.Future,further res-earch involving multidisciplinary experts,including neurologist,cardiologist,and specialists in critical care medicine is needed to improve the understanding and management of concomitant CCI.展开更多
The regulation of the interfacial electric field plays a pivotal role in magnifying the electromagnetic en-ergy attenuation capability during the design and synthesis of efficient and tunable absorbers for elec-tromag...The regulation of the interfacial electric field plays a pivotal role in magnifying the electromagnetic en-ergy attenuation capability during the design and synthesis of efficient and tunable absorbers for elec-tromagnetic waves(EMW).Herein,a rational and universally applicable two-step hydrothermal method strategy was proposed to effectively control the electronic structure of Mott-Schottky EMW absorbing materials derived from Co-MOF.The as-synthesized Co_(3)S_(4)@MoS_(2)/NC ensures efficient electron transfer,while the change redistribution leads to the emergence of additional electric dipoles under an external EMM field.In addition,the hierarchical Co_(3)S_(4)@MoS_(2)/NC nano-architecture with a hierarchical arrange-ment in 2D and 3D offers more polarization sites,thereby extending the path for EMW transmission through multiple reflections and scattering.The potential to enhance the EMW absorption performance of Co_(3)S_(4)@MoS_(2)/NC lies in its unique microstructure and substantial surface area,which optimize impedance matching properties through a synergistic effect of dipole and interfacial polarization induced by Mott-Schottky heterointerfaces.As anticipated,the Co_(3)S_(4)@MoS_(2)/NC exhibits a maximum EMW absorption ca-pacity with an RLmin value of-41.97 dB and a broad EAB of 4.24 GHz at a thickness of 2.0 mm.This study provides insights for designing highly efficient Mott-Schottky EMW absorbing materials at the molecular level rationally.展开更多
基金supported jointly by the National Natural Science Foundation of China(Nos.61674165,61604167,61574160,61704183,61404159,11604366)the Natural Science Foundation of Jiangsu Province(Nos.BK20170432,BK20160397,BK20140394)+2 种基金the National Key R&D Program of China(No.2016YFB0401803)the Strategic Priority Re-search Program of the Chinese Academy of Science(No.XDA09020401)the support at the Platform for Characterization&Test,Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO),Chinese Academy of Sciences
文摘High quality gallium oxide(Ga_2O_3) thin films are deposited by remote plasma-enhanced atomic layer deposition(RPEALD) with trimethylgallium(TMG) and oxygen plasma as precursors. By introducing in-situ NH3 plasma pretreatment on the substrates, the deposition rate of Ga_2O_3 films on Si and GaN are remarkably enhanced, reached to 0.53 and 0.46 ?/cycle at 250 °C,respectively. The increasing of deposition rate is attributed to more hydroxyls(–OH) generated on the substrate surfaces after NH3 pretreatment, which has no effect on the stoichiometry and surface morphology of the oxide films, but only modifies the surface states of substrates by enhancing reactive site density. Ga_2O_3 film deposited on GaN wafer is crystallized at 250 °C, with an epitaxial interface between Ga_2O_3 and GaN clearly observed. This is potentially very important for reducing the interface state density through high quality passivation.
基金Supported by National Natural Science Foundation of China,No.82170327 and No.82370332Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-029A.
文摘The prevalence of type 2 diabetes mellitus(T2DM)is rising,with hypertension as a common comorbidity that significantly increases cardiovascular and microva-scular risks.Accurate prediction of hypertension in T2DM is essential for early intervention and personalized management.In this editorial,we comment on a recent retrospective study by Zhao et al,which developed a nomogram model using a large cohort of 26850 patients to predict hypertension risk in patients with T2DM.The model incorporated key independent risk factors,including age,body mass index,duration of diabetes,low-density lipoprotein cholesterol and urine protein levels,demonstrating promising discriminative power and predictive accuracy in internal validation.However,its external applicability requires fur-ther confirmation.This editorial discusses the clinical value and limitations of the predictive model,highlighting the unfavorable impact of hypertension on T2DM patients.Future research should evaluate the potential contribution of other risk factors to enhance risk prediction and improve the management of T2DM co-morbidities.
基金financially supported by projects from the National Natural Science Foundation of China(No.42321001)the Qinghai Provincial Department of Science and Technology Key R&D Project(No.2025-SF-141)+1 种基金the Qinghai“Kunlun Talent”Program(Qing RC Talent Zi(2024)No.1)the Academician Zhao Pengda Innovation Center in Qinghai Geological Bureau of Nuclear Industry。
文摘0 INTRODUCTION The Haidewula uranium deposit is located in the Haidewula volcanic basin,which hosts a suite of basic,intermediate to felsic volcanic and subvolcanic rocks,including basalt,trachyte,trachyandesite.Previous geochronological studies of the intrusions within this volcanic basin suggest that they primarily formed during the Silurian and Triassic periods(Dai et al.,2025;Sun et al.,2024;Wang et al.,2024;Zhu et al.,2022;Lei et al.,2021).
基金supported by the Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-029A)the Key Project of Tianjin Natural Science Foundation(21JCZDJC01080)the Tianjin Fourth Central Hospital Outstanding Young Talent Fund(tjdszxyy20230008).
文摘BACKGROUND Heart failure with preserved ejection fraction(HFpEF)following acute myocardial infarction(AMI)carries substantial morbidity and mortality,yet reliable prognostic markers beyond conventional cardiovascular factors remain limited.Frailty,reflecting diminished physiological reserve,has emerged as a potential determinant of adverse outcomes in this high-risk population.Therefore,the aim of this study was to address a critical knowledge gap and to provide evidence that may guide frailty-adapted management strategies to improve prognosis and quality of life in this high-risk population.METHODS We conducted a multicenter retrospective cohort study including 4507 patients with HFpEF discharged after AMI across 82 hospitals in China(from January 2010 to March 2024).Frailty was assessed using the Hospital Frailty Risk Score(HFRS),with HFRS<5 defined as non-frail and HFRS≥5 as frail.Multivariable Cox proportional hazards models,adjusted for demographics,comorbidities,left ventricular ejection fraction,and therapies,were applied to evaluate associations between frailty and clinical outcomes.The primary endpoints were all-cause death and major adverse cardiovascular events(MACE),which defined as the composite of cardiovascular death and heart failure rehospitalization.Secondary endpoints included net adverse clinical events(NACE),which defined as the composite of all-cause death,stroke,recurrent myocardial infarction,revascularization,and major bleeding,as well as the individual components of MACE.RESULTS Frailty was independently associated with a higher risk of all-cause death[adjusted hazard ratio(aHR)=1.52,95%CI:1.31–2.03,P=0.005]and NACE(aHR=1.20,95%CI:1.02–1.41,P=0.026).At one year,frail patients had higher unadjusted rates of all-cause death(9.0%vs.2.9%)and NACE(19.8%vs.13.7%)compared with non-frail patients.For cardiovascular death,the association did not reach statistical significance(aHR=1.42,95%CI:0.99–2.03,P=0.053).No significant associations were found for MACE(aHR=1.05,95%CI:0.86–1.28,P=0.636)or heart failure rehospitalization(aHR=0.94,95%CI:0.75–1.19,P=0.616).CONCLUSIONS Frailty,as measured by the HFRS,is an independent predictor of one-year mortality and composite adverse events in post-AMI HFpEF patients.These findings support the use of HFRS at discharge to identify high-risk population who may benefit from closer follow-up,optimization of medical therapy,and targeted frailty-focused interventions.
基金supported by the National Natural Science Foundation of China(82171229 and 82471232).
文摘Chronic pain affects over 30%of the global adult population,significantly impairing quality of life,physical function,and psychological well-being,while imposing a substantial personal and economic burden[1].As the global population continues to age,there is an urgent and unmet need to effectively prevent,assess,and manage chronic pain in older adults.Although age-related changes in pain perception,processing,and coping mechanisms have been increasingly recognized over recent decades,many aspects of the relationship between aging and pain remain poorly understood.In addition,aging is associated with increased susceptibility to chronic pain conditions,particularly following peripheral nerve injury[2,3].However,the incomplete understanding of the mechanisms underlying pain in the aged population represents a major barrier to the development of effective medical treatment is often insufficient to provide complete pain relief[4,5].Targeted interventions for geriatric pain management are needed.Therefore,elucidating the impact of aging on the pathogenesis of chronic pain is urgently needed.
基金supported by the Tianjin Natural Science Foundation(No.21JCYBJC01460)the Science Foundation of the Tianjin Education Commission(No.2024ZD028)+1 种基金the Clinical Medical Research Project of the Second Hospital of Tianjin Medical University(No.2023LC04)the Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-029A).
文摘Coronary thrombosis remains a critical event in the pathophysiology of acute coronary syndromes,including myocardial infarction.The prompt and effective removal of coronary thrombi is essential to restore blood flow,minimize myocardial damage,and improve clinical outcomes.The reperfusion treatment of acute myocardial infarction(AMI)patients with large thrombus burden has been keeping challenging.Over the past decade,significant advancements have been made in the techniques and technologies available for thrombus removal.
基金supported by the National Natural Science Foundation of China(32060589).
文摘The nascent polypeptide-associated complex(NAC)plays crucial roles in various biological functions in eukaryotes and has been extensively studied in animals and plants;however,its role in the biocontrol mechanisms of microorganisms requires further investigation.This study examined the function of TbNACα,a NAC subunit,in the biocontrol activity of Trichoderma breve T069 against Sclerotium rolfsii.Following deletion of the TbNACα gene from T.breve T069,the ΔTbNACα mutant exhibited significantly reduced mycelial growth,spore production,and spore germination.While volatile substances from ΔTbNACα showed no significant effect on S.rolfsii,non-volatile substances demonstrated significant inhibition of S.rolfsii growth.Transcriptome sequencing analysis revealed 3,398 differentially expressed genes in the ΔTbNACα mutant compared to wild-type T069,primarily regulating genes associated with secondary metabolite biosynthetic enzymes,hydrolases,and membrane transport proteins.Untargeted metabolomics identified 50 upregulated metabolites(27 in positive ion mode and 23 in negative ion mode)in crude extracts from ΔTbNACα mutant metabolite broth.Among these metabolic substances,ethyl caffeate demonstrated the strongest activity against S.rolfsii,with an EC_(50) of 107.15μg mL^(-1).Quantitative real-time PCR(qPCR)analysis indicated significant upregulation of genes involved in the ethyl caffeate synthesis pathway in ΔTbNACα strains.This research establishes the negative regulation of ethyl caffeate synthesis and elucidates the antagonistic inhibition mechanism of TbNACα in T.breve T069.
基金supported by the National Natural Science Foundation of China(No.82170327&No.82370332)the Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-029A).
文摘BACKGROUND The beneficial effects of sodium-glucose co-transporter-2 inhibitors(SGLT2i)on adverse cardiac outcomes in diabetic patients are well-established.However,the effects of SGLT2i against cancer therapy-related cardiotoxicity remain understudied.We investigated the association between SGLT2i and cardiac outcomes in cancer patients.METHODS PubMed,Embase,and the Cochrane Library were searched from their inception until September 30,2024 for studies evaluating the effects of SGLT2i in patients with cancer.The primary outcomes included incident heart failure(HF),HF exacerbation,HF hospitalization,atrial fibrillation/atrial flutter(AF/AFL),myocardial infarction,and all-cause mortality.The secondary outcomes included acute kidney injury and sepsis.Odds ratio(OR)with 95%CI was pooled.RESULTS Thirteen studies with 85,596 patients were included.Compared to non-SGLT2i use,SGLT2i treatment was associated with lower risks of incident HF(OR=0.51,95%CI:0.32-0.79,P=0.003),HF exacerbation(OR=0.74,95%CI:0.63-0.87,P<0.001),AF/AFL(OR=0.67,95%CI:0.55-0.82,P<0.001),myocardial infarction(OR=0.61,95%CI:0.41-0.90,P=0.01),and all-cause mortality(OR=0.44,95%CI:0.28-0.69,P<0.001),but not for HF hospitalization(OR=0.58,95%CI:0.22-1.55,P=0.28).As for safety outcomes,SGLT2i use was associated with lower risks of acute kidney injury(OR=0.68,95%CI:0.57-0.81,P<0.001)and sepsis(OR=0.32,95%CI:0.23-0.44,P<0.001).CONCLUSIONS SGLT2i were associated with lower risks of incident HF,HF exacerbation,AF/AFL,myocardial infarction,allcause mortality,acute kidney injury,and sepsis in cancer patients.
基金Supported by Henan Province's"Double First-Class"Creation of Scientific Research in Traditional Chinese Medicine,No.HSRPDFCTCM-2023-7-23 and No.STG-ZYX02-202117National Traditional Chinese Medicine Clinical Research Base Scientific Research Special Project,No.2022JDZX098 and No.2022JDZX114+1 种基金National Natural Science Foundation of China,No.82205086The 9th China Association for Science and Technology Young Talent Support Project,No.2023QNRC001.
文摘Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellular carcinoma.It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD.Triggering receptor expressed on myeloid cells 2(TREM2)can sense tissue injury and mediate immune remodeling,thereby inducing phagocytosis,lipid metabolism,and metabolic transfer,promoting cell survival and combating inflammatory activation.NAFLD might develop as a result of TREM2's regulatory role.We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD.Moreover,we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2.
基金Supported by National Natural Science Foundation of China,No.82170327 and No.82370332Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-029A.
文摘With the rapid advancement and widespread adoption of new artificial intelligence(AI)technologies,personalized medicine and more accurate diagnosis using medical imaging are now possible.Among its many applications,AI has shown remarkable potential in the analysis of electrocardiograms(ECGs),which provide essential insights into the electrical activity of the heart and allowing early detection of ischemic heart disease(IHD).Notably,single-lead ECG(SLECG)analysis has emerged as a key focus in recent research due to its potential for widespread and efficient screening.This editorial focuses on the latest research progress of AI-enabled SLECG utilized in the diagnosis of IHD.
基金supported by the National Natural Science Foundation of China(Nos.52170044 and 52070133)。
文摘Ferrate[Fe(Ⅵ)]has demonstrated its efficacy as a potent oxidizing agent in the treatment of wastewater,showcasing its potential for application in environmental remediation.The self-decomposition of Fe(Ⅵ)results in the formation of Fe(Ⅳ)/Fe(V),which exhibits remarkable reactivity and selectivity towards the degradation of electron-rich micro-pollutants.Here we presented a comprehensive review on the removal of micro-pollutants in Fe(Ⅵ)/carbon materials(CMs)systems,encompassing an analysis of the oxidation mechanism and mutual activation,thereby providing guidance for the efficient elimination of recalcitrant micro-pollutants.The combnation of Fe(Ⅵ)and CMs can significantly enhanced the removal efficiency of various pollutants,with an increase ranges from 30%to 70%.The rate constants for pseudo-first order reactions were increased ranging from 3 to 14 times,while the total organic carbon(TOC)removal rate was effectively doubled.The presence of active species,including hydroxyl radicals,superoxide radical and Fe(Ⅳ)/Fe(V)generated by Fe(Ⅵ)and CMs,can significantly enhance the oxidation efficiency of micro-pollutants which are not easily degraded solely by Fe(Ⅵ)or CMs.Furthermore,Fe(Ⅵ)can enhance the surface area and void volume of CMs,thereby reinforcing the adsorption capacity towards micropollutants.
基金supported by the National Natural Science Founda-tion of China(82370417,82330011,and U21A20339)the Science Fund for Distinguished Young Scholars of Heilongjiang Province(JQ2024H001)the Heilongjiang Provincial Postdoctoral Science Foundation(LBH-Z23212).
文摘Myocardial infarction(MI)is characterized by focal necrosis resulting from prolonged myocardial ischemia due to coronary artery obstruction.Vascular reconstruction following MI is crucial for improving cardiac function and preventing recurrent infarction.This study investigates the interaction between macrophages and endothelial cells in angiogenesis mediated by nicotinamide mononucleotide(NMN)-induced secretion of macrophage-derived exosomes.We focus on the role of U2 small nuclear RNA auxiliary factor 1(U2af1)gene,a member of the splicing factor serine and arginine(SR)gene family,in the regulation of angiogenesis.Through cardiac ultrasound,Masson staining,2,3,5-triphenyltetrazolium chloride(TTC)staining,Microfil vascular perfusion,and platelet and endothelial cell adhesion molecule 1(CD31)immunofluorescence staining,extracellular vesicles from NMN-stimulated macrophages were shown to exert a protective effect in MI,with proteomic analysis identifying U2AF1 as a candidate protein involved in MI protection.Plasma U2AF1 levels were measured in 70 MI patients,revealing significantly lower levels in individuals with poor coronary collateral vessel(CCV;Rentrop scores 0–1)than in those with good CCV(Rentrop scores 2–3).In both myocardial and hindlimb ischemia mouse models,overexpression of endothelial cell-specific adenoviral overexpression U2AF1 promoted angiogenesis in the heart and hindlimbs and improved cardiac function after MI.Mechanistic studies demonstrated that U2AF1 regulates the alternative splicing(AS)of Yes1-associated transcriptional regulator(Yap1)gene,influencing post-MI angiogenesis and cardiac function recovery.Collectively,our clinical findings suggest that U2AF1 may serve as a therapeutic target for coronary collateral angiogenesis following MI.Given the low immunogenicity and high biosafety of exosomes,this study provides a foundational basis and translational potential for exosome-based therapies in MI treatment.
基金supported by grants from the Sub-project of National Key Research and Development Program of China(2021YFA0805905-1)the Special Fund for Anhui Agriculture Research System,China(AHCYJSTX-04)+2 种基金the Joint Research Project on the Anhui Local Pigs Breeding and Utilization,China(340000211260001000431)the Open Project of Key Laboratory of Embryo Development and Reproductive Regulation of Anhui Province,China(FSKFKT004)the Major Special Science And Technology Project of Anhui Province,China(202103a06020013)。
文摘N6-methyladenosine(m6A)plays a key role in mammalian early embryonic development and cell lineage differentiation.However,the role and mechanisms of 18S ribosomal RNA(rRNA)m6A methyltransferase METTL5 in early embryonic development remain unclear.Here,we found that 18S rRNA m6A methyltransferase METTL5 plays an important role in porcine early embryonic development.METTL5 knockdown and overexpression significantly reduced the developmental efficiency of porcine early embryos and impaired cell lineage allocation.METTL5 knockdown apparently decreased the global translation efficiency in blastocyst,while METTL5 overexpression increased the global translation efficiency.Furthermore,METTL5 knockdown did not affect the abundance of CDX2 mRNA,but resulted in a significant reduction in CDX2 protein levels.Moreover,the low developmental efficiency and abnormal lineage distribution of METTL5 knockdown embryos could be rescued by CDX2 overexpression.Collectively,our results demonstrated that 18S rRNA methyltransferase METTL5 regulates porcine early embryonic development via modulating the translation of CDX2.
基金supported by grants from the municipal Natural Science Foundation of Shanghai Scientific Committee of China(22ZR1451000 to TL)the peak supporting clinical discipline of Shanghai Health Bureau(2023ZDFC0104 to TL)+3 种基金the key clinical discipline of Shanghai Pudong Health Bureau(PWZxk2022-17 to TL)the clinical peak discipline of Shanghai Pudong Heath Bureau(PWYgf2021-03)the top-notch innovative medical talents of Shanghai Pudong Health Bureau(2025PDWSYCBJ-03 to TL)the leading medical talent project of Shanghai Pudong Heath Bureau(PWR12020-07 to LS)。
文摘BACKGROUND:Circulating biomarkers for sepsis are lacking,and research on circular RNAs(circR NAs)as potential biomarkers of pneumonia-induced sepsis is limited.This study aims to investigate the diagnostic and prognostic potential of circRNAs in patients with pneumonia-induced sepsis.METHODS:This prospective cohort study included 40 healthy individuals,60 patients with pneumonia,and 80 patients with pneumonia-induced sepsis.CircRNAs identified through RNA-sequencing were validated using quantitative real-time polymerase chain reaction(qRT-PCR).Spearman correlation analysis was used to evaluate the associations between circRNAs,inflammatory markers,Sequential Organ Failure Assessment(SOFA)scores,and Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)scores.Receiver operating characteristic(ROC)curves analysis were used to assess the diagnostic performance of circRNAs,while ROC curves and Kaplan-Meier survival analysis were used to evaluate their prognostic value of 28-day mortality.RESULTS:qRT-PCR confirmed the significant upregulation of Circ-CTD-2281E23.2 and downregulation of Circ-0075723 and Circ-0008679 in sepsis patients.Spearman correlation analysis showed that Circ-CTD-2281E23.2 was positively correlated with inflammatory markers and severity scores,whereas Circ-0075723 and Circ-0008679 were negatively correlated with these parameters.The area under the curve(AUC)values for Circ-CTD-2281E23.2,Circ-0075723,and Circ-0008679 in diagnosing pneumonia-induced sepsis were 0.728,0.706,and 0.793,respectively.The combination of these circRNAs(AUC=0.846)and the combination with other clinical indicators(AUC=0.990)demostrated enhanced AUC values.The AUC values for Circ-CTD-2281E23.2 and Circ-0075723 in predicting 28-day mortality were 0.664 and 0.765,respectively.CONCLUSION:This study suggest the additional diagnostic and prognostic value of circRNAs in pneumonia-induced sepsis.Circ-CTD-2281E23.2,Circ-0075723,and Circ-0008679 exhibit diagnostic potential,with Circ-CTD-2281E23.2 and Circ-0075723 showing positive prognostic value for 28-day mortality in sepsis patients.
基金supported by the Key Research and Development Project of Tianjin,China(23YFZCSN00040)。
文摘In recent years,environmental DNA(e DNA)has garnered significant attention as a novel tool in biodiversity monitoring,recognized for its efficiency,convenience,and non-invasiveness.Despite its extensive application in various ecological studies,such as conservation,invasion biology,biomonitoring and biodiversity survey assessment,its use in avian monitoring remains in its infancy.This review critically examines the potential and limitations of e DNA technology for avian monitoring,focusing on current advancements and ongoing challenges in this emerging field.Water and air are the primary environmental media for collecting avian e DNA,although other sources like spider webs and plant flowers have been explored as well.Notably,airborne e DNA has been reported to capture the highest diversity of avian species.While avian e DNA technology has shown promise for monitoring rare and endangered species and assessing avian diversity,significant challenges remain,particularly in sampling strategies,DNA extraction methodology,primer selection,and ascertain abundance.Additionally,we discussed the factors influencing the production,transportation,and degradation of avian e DNA in the environment.Finally,we suggested future research directions,including optimizing sampling strategies,developing avian-specific universal primers,expanding avian DNA barcode databases,enhancing e DNA detectability,and integrating environmental RNA(e RNA)and e DNA approaches.
基金supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA20050201)the National Natural Science Foundation of China (31861143023,31872250 and 31872252)。
文摘Global framework for nature management requires identifying areas of high priority for biodiversity conservation and restoration.The unique environments of Qinghai-Xizang Plateau(QXP) provide irreplaceable habitats for biodiversity which is prominent under future climate change.Despite the recent increase in research interest on conservation priorities,there is a lack of comprehensive and targeted protection strategies for pandemic species under climate change.Here,we compiled an exhaustive dataset with the variables of extinction risk and occurrence records of ectothermic lizards to investigate the conservation priorities in the QXP.We assessed the conservation status of the QXP lizards and identified the priority protected areas within the QXP under future climate scenarios using phylogenetic generalized least squares and ensemble species distribution models.Our analyses suggested nine lizard species to be prioritized for protection,with the most critical priority species being Dopasia gracilis,D.harti,and Phrynocephalus putjatai.Moreover,the priority protected areas covered~4.7%area of the QXP,mostly in the southern QXP and southeastern Hengduan Mountains.Protecting these regions would achieve a conservation effectiveness of≥95%for species richness,phylogenetic and functionaldiversity under climate change.Our findings provide realistic guidance for improving the conservation effectiveness of specific-lizard and-regions in the QXP under climate change.Our“bottom-up”approach could help the conservation efforts of other regions and species as an alternative to“top-down”global maps.
基金support by the National Natural Science Foundation of China(Nos.52104266,52074206,52374278)Key Research and Development Project of Shaanxi Province,China(No.2023GXLH-054).
文摘The effects of combined microwave and hydrogen peroxide(H_(2)O_(2))oxidation on the flotation separation of molybdenite and chalcopyrite,as well as the underlying mechanism were investigated via microflotation,zeta potential,contact angle,X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM)and atomic force microscopy(AFM)analyses.The microflotation experiments showed that the effective inhibition of chalcopyrite can be obtained through combined oxidation pretreatments with low microwave power and H_(2)O_(2)consumption.The zeta potential,contact angle and XPS analyses indicated that the surface hydrophobicity of molybdenite changed minimally after different treatments,whereas significant amounts of hydrophilic oxidation species were formed on the surface of chalcopyrite,thus decreasing its surface hydrophobicity and floatability.Moreover,the SEM and AFM analyses indicated that more uniform oxidative products were formed on the chalcopyrite surface,further significantly increasing the surface roughness.
基金Supported by the National Natural Science Foundation of China,No.82170327 and No.82370332Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-029A.
文摘In this article,we comment on the article by Zheng et al.This case report shed light on concomitant cerebrocardiac ischemic(CCI)in a 27-year-old male patient,which is defined as a concurrent acute ischemic stroke(AIS)and acute myocardial infarction event.The patient received urgent systemic thrombolysis at the sta-ndard dose for AIS and then planned percutaneous coronary intervention was successfully conducted for ST-segment elevation myocardial infarction treatment.Considering the rarity of the comorbidity,the narrow time window for treatment of both AIS and acute myocardial infarction,as well as the complexity and severity of the condition,there are still no guidelines or consensus that have systematically recommended optimal treatment strategies.The successful treat-ment of this 27-year-old man suggests that urgent thrombolysis followed by planned percutaneous coronary intervention might be an alternative treatment options in the management of concomitant CCI.However,emergency treatment plans need to be developed according to the specific situation of the patients.A number of factors should be considered when making decision,including the location of occlusion of heart and brain,the hemodynamic instability,the ongoing ischemic symptoms,the presence of contraindications to thrombolysis,and the speed of response of cardiologists or neurointerventionists.Future,further res-earch involving multidisciplinary experts,including neurologist,cardiologist,and specialists in critical care medicine is needed to improve the understanding and management of concomitant CCI.
基金supported by the National Natural Science Foundation of China(Nos.22271178,22301239)Science and Technology New Star in Shaanxi Province(No.2023KJXX-045)+3 种基金the Youth Talent Promotion Project of Science and Technology Association of Universities of Shaanxi Province(No.20240601)Shaanxi Provincial Department of Education service local special project,industrialization cultivation project(No.23JC007)the Research Program of the Shaanxi Provincial Department of Education(Nos.23JK0596,23JP135)the Open Foundation of Xi’an Key Laboratory of Functional Supramolecular Structure and Materials(No.CFZKFKT23003).
文摘The regulation of the interfacial electric field plays a pivotal role in magnifying the electromagnetic en-ergy attenuation capability during the design and synthesis of efficient and tunable absorbers for elec-tromagnetic waves(EMW).Herein,a rational and universally applicable two-step hydrothermal method strategy was proposed to effectively control the electronic structure of Mott-Schottky EMW absorbing materials derived from Co-MOF.The as-synthesized Co_(3)S_(4)@MoS_(2)/NC ensures efficient electron transfer,while the change redistribution leads to the emergence of additional electric dipoles under an external EMM field.In addition,the hierarchical Co_(3)S_(4)@MoS_(2)/NC nano-architecture with a hierarchical arrange-ment in 2D and 3D offers more polarization sites,thereby extending the path for EMW transmission through multiple reflections and scattering.The potential to enhance the EMW absorption performance of Co_(3)S_(4)@MoS_(2)/NC lies in its unique microstructure and substantial surface area,which optimize impedance matching properties through a synergistic effect of dipole and interfacial polarization induced by Mott-Schottky heterointerfaces.As anticipated,the Co_(3)S_(4)@MoS_(2)/NC exhibits a maximum EMW absorption ca-pacity with an RLmin value of-41.97 dB and a broad EAB of 4.24 GHz at a thickness of 2.0 mm.This study provides insights for designing highly efficient Mott-Schottky EMW absorbing materials at the molecular level rationally.
