IR64 is an elite Xian/indica variety developed by International Rice Research Institute(IRRl)in 1985,which has been the most widely grown variety and core breeding parent in South/Southeast Asia(Mackill and Khush,2018...IR64 is an elite Xian/indica variety developed by International Rice Research Institute(IRRl)in 1985,which has been the most widely grown variety and core breeding parent in South/Southeast Asia(Mackill and Khush,2018).IR64 has been utilized to develop stress-tolerant(such as drought-adapted and submergenceresistant)near-isogenic lines,underscoring its great potential in agricultural genomics(Tanaka et al.,2020).展开更多
Recent genomic research on plant populations has revealed abundant structural variations(SVs)of>50 bp within and among genotypes of major crop species,but the application of SVs as a unique type of molecular marker...Recent genomic research on plant populations has revealed abundant structural variations(SVs)of>50 bp within and among genotypes of major crop species,but the application of SVs as a unique type of molecular marker in genetic research and breeding remains limited.In this study,we used a panel of 305 rice accessions from the 3000 Rice Genome Project to compare 26,000+SVs(>90%deletions and translocations)and 180,000+high-quality SNPs in predicting the field performance of 20 traits using nine commonly used genomic selection models.We demonstrated that SVs had slightly lower prediction accuracies(PA)across 20 different traits than SNPs,but saved 53.8%–77.8%of computation time to achieve reasonably high PA.The major advantage of SVs as valuable markers in obtaining reliable genomic estimated breeding values(GEBVs)in GS experiments resulted primarily from their greater phenotypic effects on high heritability traits.Our results suggested that P0.01 was an appropriate threshold for marker filtering of both SVs and SNPs to achieve high PA in genomic selection experiments.A dataset containing all identified SVs from this study has been deposited at the China National Center for Bioinformation under BioProject:PRJCA038102,a publicly accessible molecular marker resource,enabling broad applications in rice research including gene/QTL discovery,allelic mining,and genomic selection experiments.展开更多
Airborne transmission is among the most frequent types of nosocomial infection.Recent years have witnessed frequent outbreaks of airborne diseases,such as severe acute respiratory syndrome(SARS)in 2002,Middle East res...Airborne transmission is among the most frequent types of nosocomial infection.Recent years have witnessed frequent outbreaks of airborne diseases,such as severe acute respiratory syndrome(SARS)in 2002,Middle East respiratory syndrome(MERS)in 2012,and coronavirus disease 2019(COVID-19),with the latter being on the rampage since the end of 2019 and bringing the effect of aerosols on health back to the fore(Gralton et al.,2011;Wang et al.,2021).An increasing number of studies have shown that certain highly transmissible pathogens can maintain long-term stability and efficiently spread through aerosols(Leung,2021;Lv et al.,2021).As reported previously,influenza viruses that can spread efficiently through aerosols remain stable for a longer period compared to those that cannot.The World Health Organization(WHO)has stated that aerosol-generating procedures(AGPs)play an important role in aerosol transmission in hospitals(Calderwood et al.,2021).AGPs,referring to medical procedures that produce aerosols,including dental procedures,endotracheal intubation,sputum aspiration,and laparoscopic surgeries,have been reported to be significantly associated with an increased risk of nosocomial infection among medical personnel(Hamilton,2021).展开更多
Dear Editor,Although traditional breeding methods,such as phenotypebased and marker-assisted selection,remain valuable,genomic selection(GS)has emerged as a promising new approach.To address limitations of GS,particul...Dear Editor,Although traditional breeding methods,such as phenotypebased and marker-assisted selection,remain valuable,genomic selection(GS)has emerged as a promising new approach.To address limitations of GS,particularly the time and cost involved in developing training populations,we developed Rice3KGS,a web-based tool that provides access to diverse datasets and integrates analytical functions to support crop breeding efforts.展开更多
基金supported by the Natural Science Foundation of Anhui Province(2408085MC058 and 2308085QC91)National Natural Science Foundation of China(32301783and U21A20214)+5 种基金Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS CSIAF-202303)Nanfan special project,CAAS(YYLH2309,YBXM2322,YYLH2401)Scientific Innovation 2030 Project(2022ZD0401703)CAAS Innovative Team Award,Science and Technology of Innovative research program of Anhui Province(202423m1005002)National Key Research and Development Program of China(2023YFD1200900)the Natural Science Foundation General Program of Hebei Province(C2024204242).
文摘IR64 is an elite Xian/indica variety developed by International Rice Research Institute(IRRl)in 1985,which has been the most widely grown variety and core breeding parent in South/Southeast Asia(Mackill and Khush,2018).IR64 has been utilized to develop stress-tolerant(such as drought-adapted and submergenceresistant)near-isogenic lines,underscoring its great potential in agricultural genomics(Tanaka et al.,2020).
基金supported by the Natural Science Foundation of Anhui Province(2408085MC058 and 2308085QC91)National Natural Science Foundation of China(32301783 and U21A20214)+4 种基金the Biological Breeding-National Science and Technology Major Project(2022ZD04017)Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS CSIAF-202303)Nanfan Special Project,CAAS(YYLH2401)the Scientific Innovation 2030 Project(2022ZD0401703)the CAAS Innovative Team Award.
文摘Recent genomic research on plant populations has revealed abundant structural variations(SVs)of>50 bp within and among genotypes of major crop species,but the application of SVs as a unique type of molecular marker in genetic research and breeding remains limited.In this study,we used a panel of 305 rice accessions from the 3000 Rice Genome Project to compare 26,000+SVs(>90%deletions and translocations)and 180,000+high-quality SNPs in predicting the field performance of 20 traits using nine commonly used genomic selection models.We demonstrated that SVs had slightly lower prediction accuracies(PA)across 20 different traits than SNPs,but saved 53.8%–77.8%of computation time to achieve reasonably high PA.The major advantage of SVs as valuable markers in obtaining reliable genomic estimated breeding values(GEBVs)in GS experiments resulted primarily from their greater phenotypic effects on high heritability traits.Our results suggested that P0.01 was an appropriate threshold for marker filtering of both SVs and SNPs to achieve high PA in genomic selection experiments.A dataset containing all identified SVs from this study has been deposited at the China National Center for Bioinformation under BioProject:PRJCA038102,a publicly accessible molecular marker resource,enabling broad applications in rice research including gene/QTL discovery,allelic mining,and genomic selection experiments.
基金supported by the Medicine and Health Care in Zhejiang Province Science and Technology Plan Projects(Nos.2020KY552 and 2021PY006)the Commonweal Project of Science and Technology Department of Zhejiang Province(No.LGF21H030007),China.
文摘Airborne transmission is among the most frequent types of nosocomial infection.Recent years have witnessed frequent outbreaks of airborne diseases,such as severe acute respiratory syndrome(SARS)in 2002,Middle East respiratory syndrome(MERS)in 2012,and coronavirus disease 2019(COVID-19),with the latter being on the rampage since the end of 2019 and bringing the effect of aerosols on health back to the fore(Gralton et al.,2011;Wang et al.,2021).An increasing number of studies have shown that certain highly transmissible pathogens can maintain long-term stability and efficiently spread through aerosols(Leung,2021;Lv et al.,2021).As reported previously,influenza viruses that can spread efficiently through aerosols remain stable for a longer period compared to those that cannot.The World Health Organization(WHO)has stated that aerosol-generating procedures(AGPs)play an important role in aerosol transmission in hospitals(Calderwood et al.,2021).AGPs,referring to medical procedures that produce aerosols,including dental procedures,endotracheal intubation,sputum aspiration,and laparoscopic surgeries,have been reported to be significantly associated with an increased risk of nosocomial infection among medical personnel(Hamilton,2021).
基金supported by the National Natural Science Foundation of China(32301783 and U21A20214)the Natural Science Foundation of Anhui Province(2308085QC91 and 2408085MC058)+3 种基金the Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS-CSIAF202303)the Nanfan special project,CAAS(YYLH2309,YBXM2322,YYLH2401)the Scientific Innovation 2030 Project(2022ZD0401703)the CAAS Innovative Team Award.
文摘Dear Editor,Although traditional breeding methods,such as phenotypebased and marker-assisted selection,remain valuable,genomic selection(GS)has emerged as a promising new approach.To address limitations of GS,particularly the time and cost involved in developing training populations,we developed Rice3KGS,a web-based tool that provides access to diverse datasets and integrates analytical functions to support crop breeding efforts.
