Curriculum ideological and political teaching is an important way to realize the fundamental task of strengthening moral education and cultivating people in today's colleges and universities.Urban Garden Green Spa...Curriculum ideological and political teaching is an important way to realize the fundamental task of strengthening moral education and cultivating people in today's colleges and universities.Urban Garden Green Space Planning is one of core courses of landscape major.In this paper,taking the ideological and political construction of the course as an opportunity,starting from the course characteristics,the ideological and political elements contained in the course were excavated and refined,and their connotations were integrated into the theoretical teaching and practical training process.During imparting knowledge,the ideological and political awareness and professional quality of students can be improved,so as to achieve the educational goal of strengthening moral education and cultivating people,and provides reference for the teaching reform of integrating ideological and political education into other landscape courses.展开更多
Background:Tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies in combination provide survival benefits for patients with unresectable hepatocellular carcinoma(uHCC).However,the tool used to determine which patie...Background:Tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies in combination provide survival benefits for patients with unresectable hepatocellular carcinoma(uHCC).However,the tool used to determine which patients likely benefit most from this treatment strategy has not been reported.We sought to develop a prognostic scoring system based on tumor burden score(TBS)and alpha-fetoprotein(AFP)to predict the long-term prognosis of uHCC treated with TKIs and anti-PD-1 antibodies.Methods:Data on patients with uHCC treated with TKIs and anti-PD-1 antibodies from multiple centers were collected.The prognostic accuracy of TBS,AFP,Barcelona Clinic Liver Cancer(BCLC),and CTA(Combined TBS and AFP)for 2-year progression-free survival(PFS)and overall survival(OS)was evaluated.Results:Overall,278 patients with uHCC treated with TKIs and anti-PD-1 antibodies were enrolled,including 48 BCLC-B and 230 BCLC-C HCC patients.CTA(AUC?0.721 and 0.683)outperformed TBS(AUC?0.680 and 0.621),AFP(AUC?0.606 and 0.594),and BCLC staging(AUC?0.551 and 0.555)in predicting PFS and OS.The 2-year PFS and OS for low CTA(low TBS/low AFP)were 65.7%and 94.4%,respectively,which were significantly higher than 21.6%and 44.9%(p<0.001 and p?0.002),respectively,for intermediate CTA(low TBS/high AFP or high TBS/low AFP)and 8.7%and 12.1%(both p<0.001),respectively,for high CTA(high TBS/high AFP).Multivariable Cox regression analysis indicated that CTA grading was an independent prognostic factor for PFS and OS(referent:low CTA;intermediate CTA,HR 2.87 and 7.17;high CTA,HR 5.52 and 10.31,respectively).Conclusions:CTA grading is an accurate tool for stratifying the prognosis of uHCC treated with TKIs and anti-PD-1 antibodies and may help determine which patients may benefit more from this treatment strategy.展开更多
Dear Editor,Hepatocellular carcinoma(HCC)is highly aggressive and ranks among the leading causes of cancer-related deaths worldwide.The evaluation of treatment options and outcomes for patients with advanced HCC remai...Dear Editor,Hepatocellular carcinoma(HCC)is highly aggressive and ranks among the leading causes of cancer-related deaths worldwide.The evaluation of treatment options and outcomes for patients with advanced HCC remains a major focus in both clinical practice and research.Significant progress has been made in the treatment of advanced HCC with the introduction of various systemic therapies,including lenvatinib and regimens based on immune checkpoint inhibitors.However,a critical question remains:How to compare the relative effectiveness of immunotherapy versus multi-target tyrosine kinase inhibitors in real-world populations,thereby providing evidence for personalized first-line treatment decisions across different etiologies and patient subgroups.展开更多
基金Supported by the Project of Landscape Characteristic Specialty Construction in Colleges and Universities of Guangdong Province[Yuejiaogaohan(2020)19]Education and Teaching Reform Project of Lingnan Normal University[Lingshijiaowu(2020)240]Curriculum Ideological and Political Demonstration Major of Lingnan Normal University[Lingshijiaowu(2021)124].
文摘Curriculum ideological and political teaching is an important way to realize the fundamental task of strengthening moral education and cultivating people in today's colleges and universities.Urban Garden Green Space Planning is one of core courses of landscape major.In this paper,taking the ideological and political construction of the course as an opportunity,starting from the course characteristics,the ideological and political elements contained in the course were excavated and refined,and their connotations were integrated into the theoretical teaching and practical training process.During imparting knowledge,the ideological and political awareness and professional quality of students can be improved,so as to achieve the educational goal of strengthening moral education and cultivating people,and provides reference for the teaching reform of integrating ideological and political education into other landscape courses.
基金supported by the National Natural Science Foundation of China(No.62275050)the Major Research Projects for Young and Middle-aged Talent of Fujian Provincial Health Commission(No.2021ZQNZD013)+1 种基金Fujian Provincial Clinical Research Center for Hepatobiliary and Pancreatic Tumors(Grant number:2020Y2013)the Scientific Foundation of Fuzhou Municipal Health Commission(Grant number:2021-S-wp1).
文摘Background:Tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies in combination provide survival benefits for patients with unresectable hepatocellular carcinoma(uHCC).However,the tool used to determine which patients likely benefit most from this treatment strategy has not been reported.We sought to develop a prognostic scoring system based on tumor burden score(TBS)and alpha-fetoprotein(AFP)to predict the long-term prognosis of uHCC treated with TKIs and anti-PD-1 antibodies.Methods:Data on patients with uHCC treated with TKIs and anti-PD-1 antibodies from multiple centers were collected.The prognostic accuracy of TBS,AFP,Barcelona Clinic Liver Cancer(BCLC),and CTA(Combined TBS and AFP)for 2-year progression-free survival(PFS)and overall survival(OS)was evaluated.Results:Overall,278 patients with uHCC treated with TKIs and anti-PD-1 antibodies were enrolled,including 48 BCLC-B and 230 BCLC-C HCC patients.CTA(AUC?0.721 and 0.683)outperformed TBS(AUC?0.680 and 0.621),AFP(AUC?0.606 and 0.594),and BCLC staging(AUC?0.551 and 0.555)in predicting PFS and OS.The 2-year PFS and OS for low CTA(low TBS/low AFP)were 65.7%and 94.4%,respectively,which were significantly higher than 21.6%and 44.9%(p<0.001 and p?0.002),respectively,for intermediate CTA(low TBS/high AFP or high TBS/low AFP)and 8.7%and 12.1%(both p<0.001),respectively,for high CTA(high TBS/high AFP).Multivariable Cox regression analysis indicated that CTA grading was an independent prognostic factor for PFS and OS(referent:low CTA;intermediate CTA,HR 2.87 and 7.17;high CTA,HR 5.52 and 10.31,respectively).Conclusions:CTA grading is an accurate tool for stratifying the prognosis of uHCC treated with TKIs and anti-PD-1 antibodies and may help determine which patients may benefit more from this treatment strategy.
基金supported by the National Natural Science Foundation of China(Grant number:82503833).
文摘Dear Editor,Hepatocellular carcinoma(HCC)is highly aggressive and ranks among the leading causes of cancer-related deaths worldwide.The evaluation of treatment options and outcomes for patients with advanced HCC remains a major focus in both clinical practice and research.Significant progress has been made in the treatment of advanced HCC with the introduction of various systemic therapies,including lenvatinib and regimens based on immune checkpoint inhibitors.However,a critical question remains:How to compare the relative effectiveness of immunotherapy versus multi-target tyrosine kinase inhibitors in real-world populations,thereby providing evidence for personalized first-line treatment decisions across different etiologies and patient subgroups.
