Remaining largely under-appreciated, a majority of metal ion sorbents are limited in their target selectivity. In this work, a 3D sulfide intercalated NiFe-layered double hydroxide (NFL-S) hierarchical sorbent has bee...Remaining largely under-appreciated, a majority of metal ion sorbents are limited in their target selectivity. In this work, a 3D sulfide intercalated NiFe-layered double hydroxide (NFL-S) hierarchical sorbent has been synthesized for selective heavy metal removal. The intercalation of sulfurated groups in the interlayer of the layered double hydroxide (LDH) nanosheets endows NFL-S as a selective heavy metal ion filter;the selectivity of NFL-S for heavy metals is in the order of Pb^2+> Cu^2+≥ Zn^2+> Cd^2+> Mn^2+, and NFL-S has high kd values for Pb2+(~10^6 mL/g) and Cu2+(~10^5 mL/g). Scanning electron microscopy. X-ray photoelectron spectroscopy and powder X-ray diffraction were used to analyze the composition of the as-prepared nanoadsorbent. The selective adsorption behavior was systematically studied using batch experiments, and the performance was evaluated through kinetic and isotherm studies. Moreover, the adsorption mechanism of heavy metals by NFL-S through surface complexation was also investigated, which shows great potential for water decontamination.展开更多
The integral practical and aesthetic design teaching of architecture and site environment is expected to deal with the junior-grade design teaching in architecture major with a current situation that the insufficient ...The integral practical and aesthetic design teaching of architecture and site environment is expected to deal with the junior-grade design teaching in architecture major with a current situation that the insufficient consideration of the site environment and the chaotic city image, which caused by long-term emphasis on single function and personality performance of architecture. The key to the integral practicability and aesthetics is the emphasis on the integrality of spatial logical order of those two factors, which contains the integral harmony of function attributes, scale, logics, and modal relationships and so on. Combine with the teaching of kindergarten architecture design, using architecture and site logic model teaching methodology, through the extraction cognitive teaching approach of the site environment order logics, the cognitive teaching approach of kindergarten architecture spatial logics, the strategic teaching approach of the congruent design of the integral order of architecture and site environment logics, module and model congruent counterpoint design teaching approach of architecture and large site environment order logics, organization and construction integrated design teaching approach of architecture and small site environment spatial logics, and result design teaching approach of architectures integrated into the landscape of large site environment and their surrounding small site environment and other teaching procedures to complete die teaching tasks of the integral practical and aesthetic design of kindergarten architecture and site environment.展开更多
With the extensive rise of BIM technology, universities at home and abroad have carried out BIM teaching. There is no effective teaching model in China, because the curriculum is independent or requires higher teachin...With the extensive rise of BIM technology, universities at home and abroad have carried out BIM teaching. There is no effective teaching model in China, because the curriculum is independent or requires higher teaching conditions. Foreign teaching carried out a long time, has more experienced experience. The main teaching models are: BIM teaching in a single course, BIM teaching in a series of courses, and BIM teaching in integrated design studio. We draw lessons from the advanced experience of foreign countries, and put forward three suggestions for the teaching method of BIM course to universities in our country: design course teaching Integrating BIM information flow, multi-professional integrated teaching and life cycle simulation teaching.展开更多
Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed...Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed conditions and environmental pollution for crop and agrofood prompt us to take immediate action to develop a whole-new-era agrofood system from the perspective of sustainability[1].展开更多
Hybrid composite materials with hierarchical structures have attracted continuing attention for their enhanced features and various applications.The new hybrid composites XW_(9)@PDA(XW_(9) means Na_(8)H[α-PW_(9)O_(34...Hybrid composite materials with hierarchical structures have attracted continuing attention for their enhanced features and various applications.The new hybrid composites XW_(9)@PDA(XW_(9) means Na_(8)H[α-PW_(9)O_(34)],Na_(10)[α-SiW_(9)O_(34)]and Na_(10)[α-GeW_(9)O_(34)];PDA means polydopamine)have been synthesized for potential sensing applications.The effect of polyoxometalates on the formation of the hybrid composites was investigated.Scanning electron microscopy(SEM)supported the obtained XW_(9)@PDA were hierarchical microsphere.By monitoring the reaction of classical peroxidase substrate o-phenylenediamine(OPD)to form yellow 2,3-diaminophenazine(DAB)in the presence of H_(2)O_(2),the peroxidase-like activity of XW_(9)@PDA was calculated.The results showed that XW_(9)@PDA still keep the peroxidase-like activity and have 505.98%,208.58%and 582.78%enhancement in intrinsic catalytic activity for PW_(9)@PDA,SiW_(9)@PDA and GeW_(9)@PDA.Among the three composites,PW_(9)@PDA showed the highest peroxidase-like activity.Therefore,PW_(9)@PDA was applicable to the colorimetric and electrochemical sensing for H_(2)O_(2).展开更多
The increasing accumulation of toxic mercury species in water environment has posed a serious health threat worldwide, making it inevitable to develop the versatile materials to achieve efficient prevention and remedi...The increasing accumulation of toxic mercury species in water environment has posed a serious health threat worldwide, making it inevitable to develop the versatile materials to achieve efficient prevention and remediation of mercury pollution. Guided by the solvent-assisted ligand exchange (SALE) approach, this work rationally constructed a mixed-ligand NH2-UiO-66-SH (NSU66) with hierarchical-pore structure by incorporating the thiol-rich ligands (H2DMBD) into the water-stable NH2-UiO-66 (NU66) precursor to act as a smart adsorbent equipped with sensitive detector for simultaneous sensing and removal of Hg2+. Unlike the traditional adsorbents, the as-prepared NSU66 not only exhibits a remarkable removal ability with fast capture rate (within 60.0 min), large uptake capacity (265.29 mg/g), and qualified selectivity, but also possesses satisfactory sensing capability, accompanied by low detection limit (3.50 × 10−2 µM), wide linear range (1.00–99.7 µM), high specificity, and strong anti-interference capability. The detection function plays a vital role in indicating the removal behavior and the pre-enrichment effect of adsorption process correspondingly improves the sensitivity of indicator. Notably, the sensing and trapping capabilities of NSU66 are significantly improved compared to the NU66, which stems from the delicate design of the mixed-ligand and hierarchical-pore structure. Furthermore, proven excellent stability and recyclability emphasize the feasibility of NSU66 in practical applications. These results suggest that the smart NSU66 adsorbent can serve as a favorable platform for early warning and guided removal of toxic Hg2+ in water.展开更多
Background:Bacterial infection,tissue hypoxia and inflammatory response can hinder infected wound repair.This study aimed to develop a multifunctional specific therapeutic photo activated release nanosystem[HMPB@MB@Au...Background:Bacterial infection,tissue hypoxia and inflammatory response can hinder infected wound repair.This study aimed to develop a multifunctional specific therapeutic photo activated release nanosystem[HMPB@MB@AuNPs@PMB@HA(HMAPH)]by loading photosen sitizer methylene blue(MB)into hollow mesoporous Prussian blue nanostructures and modifying the surface with gold particles,polymyxin B(PMB)and hydrophilic hyaluronic acid.Methods:The HMAPH was characterized using transmission electron microscopy,UV-vis,Fourier transform infrared spectroscopy,X-ray diffraction and X-ray photon spectroscopy.The photother mal performance,iron ion release and free radical generation of the HMAPH were measured under different conditions to investigate its thermo-responsive cascade reaction.The antibacterial ability of HMAPH was investigated using live/dead fluorescence tests.The morphology and membrane integrity of Pseudomonas aeruginosa(P.aeruginosa)were investigated using transmission electron microscopy.The anti-biofilm activity of HMAPH was evaluated using crystal violet and SYBR Green I staining.Finally,we established a mouse model of a skin wound infected by P.aeruginosa to confirm the in vivo effectiveness of HMAPH.We used immunofluorescent staining,hematoxylin-eosin staining,Masson staining and enzyme-linked immunosorbent assay to examine whether HMAPH promoted wound healing and reduced inflammatory damage.Results:In this study,hyaluronic acid was decomposed under the action of hyaluronidase.Also,the exposed nanomaterials specifically bound to the outer membrane of P.aeruginosa through PMB to increase the membrane sensitivity to photodynamic treatment.Under dual-light irradiation,a large amount of iron ions released by HMAPH underwent a Fenton reaction with H_(2)O_(2)in bacteria to generate hydroxyl radicals(·OH),enabling direct killing of cells by hyperthermia.Additionally,the photodynamic activity of MB released by photo-induced activation led to the generation of reactive oxygen species,achieving synergistic and effective inhibition of P.aeruginosa.HMAPH also inhibited biofilm formation and downregulated the expression of virulence factors.In vivo experiments revealed that HMAPH accelerated the healing of P.aeruginosa-infected wounds by promoting angiogenesis and skin regeneration,inhibiting the inflammatory response and promoting M1 to M2 polarization.Conclusions:Our study proposed a strategy against bacteria and biofilms through a synergistic photothermal-photodynamic-Fenton reaction,opening up new prospects for combating biofilmassociated infections.展开更多
Considering the increasing abundance of antibiotic-resistant bacteria,novel antimicrobial approaches need to be investigated.Photothermal therapy(PTT),an innovative noninvasive therapeutic technique,has demonstrated s...Considering the increasing abundance of antibiotic-resistant bacteria,novel antimicrobial approaches need to be investigated.Photothermal therapy(PTT),an innovative noninvasive therapeutic technique,has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms.However,when used in isolation,PTT requires higher-temperature conditions to effectively eradicate bacteria,thereby potentially harming healthy tissues and inducing new inflammation.This study aims to present a comprehensive review of nanomaterials with intrinsic antimicrobial properties,antimicrobial materials relying on photothermal action,and nanomaterials using drug delivery antimicrobial action,along with their applications in antimicrobials.Additionally,the synergistic mechanisms of these antimicrobial approaches are elucidated.The review provides a reference for developing multifunctional photothermal nanoplatforms for treating bacterially infected wounds.展开更多
基金financially supported by the National Natural Science Foundation of China (No. 21675127)the Shaanxi Provincial Science Fund for Distinguished Young Scholars (No. 2018JC-011)
文摘Remaining largely under-appreciated, a majority of metal ion sorbents are limited in their target selectivity. In this work, a 3D sulfide intercalated NiFe-layered double hydroxide (NFL-S) hierarchical sorbent has been synthesized for selective heavy metal removal. The intercalation of sulfurated groups in the interlayer of the layered double hydroxide (LDH) nanosheets endows NFL-S as a selective heavy metal ion filter;the selectivity of NFL-S for heavy metals is in the order of Pb^2+> Cu^2+≥ Zn^2+> Cd^2+> Mn^2+, and NFL-S has high kd values for Pb2+(~10^6 mL/g) and Cu2+(~10^5 mL/g). Scanning electron microscopy. X-ray photoelectron spectroscopy and powder X-ray diffraction were used to analyze the composition of the as-prepared nanoadsorbent. The selective adsorption behavior was systematically studied using batch experiments, and the performance was evaluated through kinetic and isotherm studies. Moreover, the adsorption mechanism of heavy metals by NFL-S through surface complexation was also investigated, which shows great potential for water decontamination.
文摘The integral practical and aesthetic design teaching of architecture and site environment is expected to deal with the junior-grade design teaching in architecture major with a current situation that the insufficient consideration of the site environment and the chaotic city image, which caused by long-term emphasis on single function and personality performance of architecture. The key to the integral practicability and aesthetics is the emphasis on the integrality of spatial logical order of those two factors, which contains the integral harmony of function attributes, scale, logics, and modal relationships and so on. Combine with the teaching of kindergarten architecture design, using architecture and site logic model teaching methodology, through the extraction cognitive teaching approach of the site environment order logics, the cognitive teaching approach of kindergarten architecture spatial logics, the strategic teaching approach of the congruent design of the integral order of architecture and site environment logics, module and model congruent counterpoint design teaching approach of architecture and large site environment order logics, organization and construction integrated design teaching approach of architecture and small site environment spatial logics, and result design teaching approach of architectures integrated into the landscape of large site environment and their surrounding small site environment and other teaching procedures to complete die teaching tasks of the integral practical and aesthetic design of kindergarten architecture and site environment.
文摘With the extensive rise of BIM technology, universities at home and abroad have carried out BIM teaching. There is no effective teaching model in China, because the curriculum is independent or requires higher teaching conditions. Foreign teaching carried out a long time, has more experienced experience. The main teaching models are: BIM teaching in a single course, BIM teaching in a series of courses, and BIM teaching in integrated design studio. We draw lessons from the advanced experience of foreign countries, and put forward three suggestions for the teaching method of BIM course to universities in our country: design course teaching Integrating BIM information flow, multi-professional integrated teaching and life cycle simulation teaching.
基金supported by the National Key Research and Development Program of China(2018YFE0127000)the National Natural Science Foundation of China(21675127 and 31972150)+3 种基金Shaanxi Provincial Science and Technology Innovation Team(2023-CX-TD-55)the Key Industries Innovation Chain Project of Shaanxi Province(2019ZDLSF07-08)the Natural Science Foundation Project in Guangdong Province(2020A1515010778)Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resource(2020-ZJ-T05).
文摘Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed conditions and environmental pollution for crop and agrofood prompt us to take immediate action to develop a whole-new-era agrofood system from the perspective of sustainability[1].
基金financially supported by National Natural Science Foundation of China(grant No.82073602)Natural Science Foundation of Jilin Province(grant No.20200201081JC)+1 种基金the open project of the CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety(grant No.NSKF202006)the Graduate Innovation Fund of Jilin University(grant Nos.101832020CX273,101832020CX276).
文摘Hybrid composite materials with hierarchical structures have attracted continuing attention for their enhanced features and various applications.The new hybrid composites XW_(9)@PDA(XW_(9) means Na_(8)H[α-PW_(9)O_(34)],Na_(10)[α-SiW_(9)O_(34)]and Na_(10)[α-GeW_(9)O_(34)];PDA means polydopamine)have been synthesized for potential sensing applications.The effect of polyoxometalates on the formation of the hybrid composites was investigated.Scanning electron microscopy(SEM)supported the obtained XW_(9)@PDA were hierarchical microsphere.By monitoring the reaction of classical peroxidase substrate o-phenylenediamine(OPD)to form yellow 2,3-diaminophenazine(DAB)in the presence of H_(2)O_(2),the peroxidase-like activity of XW_(9)@PDA was calculated.The results showed that XW_(9)@PDA still keep the peroxidase-like activity and have 505.98%,208.58%and 582.78%enhancement in intrinsic catalytic activity for PW_(9)@PDA,SiW_(9)@PDA and GeW_(9)@PDA.Among the three composites,PW_(9)@PDA showed the highest peroxidase-like activity.Therefore,PW_(9)@PDA was applicable to the colorimetric and electrochemical sensing for H_(2)O_(2).
基金This work was financed by the National Natural Science Foundation of China(No.21675127)the Shaanxi Provincial Science Fund for Distinguished Young Scholars(No.2018JC-011)+2 种基金the Key Research and Development Plan of Shaanxi Province(No.2019NY-109)the Development Project of Qinghai Provincial Key Laboratory(No.2017-ZJ-Y10)the Capacity Building Project of Engineering Research Center of Qinghai Province(No.2017-GX-G03).
文摘The increasing accumulation of toxic mercury species in water environment has posed a serious health threat worldwide, making it inevitable to develop the versatile materials to achieve efficient prevention and remediation of mercury pollution. Guided by the solvent-assisted ligand exchange (SALE) approach, this work rationally constructed a mixed-ligand NH2-UiO-66-SH (NSU66) with hierarchical-pore structure by incorporating the thiol-rich ligands (H2DMBD) into the water-stable NH2-UiO-66 (NU66) precursor to act as a smart adsorbent equipped with sensitive detector for simultaneous sensing and removal of Hg2+. Unlike the traditional adsorbents, the as-prepared NSU66 not only exhibits a remarkable removal ability with fast capture rate (within 60.0 min), large uptake capacity (265.29 mg/g), and qualified selectivity, but also possesses satisfactory sensing capability, accompanied by low detection limit (3.50 × 10−2 µM), wide linear range (1.00–99.7 µM), high specificity, and strong anti-interference capability. The detection function plays a vital role in indicating the removal behavior and the pre-enrichment effect of adsorption process correspondingly improves the sensitivity of indicator. Notably, the sensing and trapping capabilities of NSU66 are significantly improved compared to the NU66, which stems from the delicate design of the mixed-ligand and hierarchical-pore structure. Furthermore, proven excellent stability and recyclability emphasize the feasibility of NSU66 in practical applications. These results suggest that the smart NSU66 adsorbent can serve as a favorable platform for early warning and guided removal of toxic Hg2+ in water.
基金supported by the National Key R&D Program of China(2023YFF1103900)National Natural Science Foundation of China(31902304,31972167)the Open Project Program of State Key Laboratory of Food Nutrition and Safety,Tianjin University of Science&Technology(SKLFNS-KF-202209)。
文摘Background:Bacterial infection,tissue hypoxia and inflammatory response can hinder infected wound repair.This study aimed to develop a multifunctional specific therapeutic photo activated release nanosystem[HMPB@MB@AuNPs@PMB@HA(HMAPH)]by loading photosen sitizer methylene blue(MB)into hollow mesoporous Prussian blue nanostructures and modifying the surface with gold particles,polymyxin B(PMB)and hydrophilic hyaluronic acid.Methods:The HMAPH was characterized using transmission electron microscopy,UV-vis,Fourier transform infrared spectroscopy,X-ray diffraction and X-ray photon spectroscopy.The photother mal performance,iron ion release and free radical generation of the HMAPH were measured under different conditions to investigate its thermo-responsive cascade reaction.The antibacterial ability of HMAPH was investigated using live/dead fluorescence tests.The morphology and membrane integrity of Pseudomonas aeruginosa(P.aeruginosa)were investigated using transmission electron microscopy.The anti-biofilm activity of HMAPH was evaluated using crystal violet and SYBR Green I staining.Finally,we established a mouse model of a skin wound infected by P.aeruginosa to confirm the in vivo effectiveness of HMAPH.We used immunofluorescent staining,hematoxylin-eosin staining,Masson staining and enzyme-linked immunosorbent assay to examine whether HMAPH promoted wound healing and reduced inflammatory damage.Results:In this study,hyaluronic acid was decomposed under the action of hyaluronidase.Also,the exposed nanomaterials specifically bound to the outer membrane of P.aeruginosa through PMB to increase the membrane sensitivity to photodynamic treatment.Under dual-light irradiation,a large amount of iron ions released by HMAPH underwent a Fenton reaction with H_(2)O_(2)in bacteria to generate hydroxyl radicals(·OH),enabling direct killing of cells by hyperthermia.Additionally,the photodynamic activity of MB released by photo-induced activation led to the generation of reactive oxygen species,achieving synergistic and effective inhibition of P.aeruginosa.HMAPH also inhibited biofilm formation and downregulated the expression of virulence factors.In vivo experiments revealed that HMAPH accelerated the healing of P.aeruginosa-infected wounds by promoting angiogenesis and skin regeneration,inhibiting the inflammatory response and promoting M1 to M2 polarization.Conclusions:Our study proposed a strategy against bacteria and biofilms through a synergistic photothermal-photodynamic-Fenton reaction,opening up new prospects for combating biofilmassociated infections.
基金supported by the National Key R&D Program of China(2023YFF1103900)National Natural Science Foundation of China(31902304,31972167)the Open Project Program of State Key Laboratory of Food Nutrition and Safety,Tianjin University of Science&Technology(SKLFNS-KF-202310).
文摘Considering the increasing abundance of antibiotic-resistant bacteria,novel antimicrobial approaches need to be investigated.Photothermal therapy(PTT),an innovative noninvasive therapeutic technique,has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms.However,when used in isolation,PTT requires higher-temperature conditions to effectively eradicate bacteria,thereby potentially harming healthy tissues and inducing new inflammation.This study aims to present a comprehensive review of nanomaterials with intrinsic antimicrobial properties,antimicrobial materials relying on photothermal action,and nanomaterials using drug delivery antimicrobial action,along with their applications in antimicrobials.Additionally,the synergistic mechanisms of these antimicrobial approaches are elucidated.The review provides a reference for developing multifunctional photothermal nanoplatforms for treating bacterially infected wounds.
