This study is part of an ongoing project to enable the full specification of the Design Space for roller compactor systems and shows how the processing parameters influence the behaviour of the product granulate from ...This study is part of an ongoing project to enable the full specification of the Design Space for roller compactor systems and shows how the processing parameters influence the behaviour of the product granulate from a placebo formulation. Granulate was produced using a proprietary roller compactor by varying the compaction pressure and gap width,and the dynamic, bulk and shear properties of the resultant granulates were measured.The results demonstrate several rheological properties of the granulate, which have been shown to be closely correlated with variance in die filling and tablet strength, and are predictably influenced by the processing parameters.展开更多
3D MicroPrint公司率先使用了增材制造(AM)来生产复杂、微米尺度的金属部件,公司正在使用英国富瑞曼科技公司的FT4粉体流变仪来识别超细粉能否有效加工,这家公司使用小于5pm的粉末来成型具有极高精度和分辨率的组件。FT4粉体流变仪能够...3D MicroPrint公司率先使用了增材制造(AM)来生产复杂、微米尺度的金属部件,公司正在使用英国富瑞曼科技公司的FT4粉体流变仪来识别超细粉能否有效加工,这家公司使用小于5pm的粉末来成型具有极高精度和分辨率的组件。FT4粉体流变仪能够区分出流动性优越的原材料,并成功应用于3DMicroPrint的微激光烧结(MLS),在医疗、半导体、航空航天、能源和化工等领域取得成功。展开更多
The shape and size of particles are understood to affect the bulk behaviour of powders, though there are but few studies that present quantitative information on the relationship between particle shape and the flow pr...The shape and size of particles are understood to affect the bulk behaviour of powders, though there are but few studies that present quantitative information on the relationship between particle shape and the flow properties of powder. This is due in part to the lack of techniques for rapidly determining both particle shape and the range of flow characteristics that describe the response of powders to the stress and shear experienced during their processing. This study presents data that quantifies the influence of particle shapeJsize of three different lactose powders on their respective flow and bulk characteristics. Two of the samples differ in size but have similar shapes; the third sample is more spherical but similar in size to one of the other two samples, The results demonstrate that in addition to particle size, particle shape significantly affect the flow characteristics of a powder over a wide range of stress conditions.展开更多
文摘This study is part of an ongoing project to enable the full specification of the Design Space for roller compactor systems and shows how the processing parameters influence the behaviour of the product granulate from a placebo formulation. Granulate was produced using a proprietary roller compactor by varying the compaction pressure and gap width,and the dynamic, bulk and shear properties of the resultant granulates were measured.The results demonstrate several rheological properties of the granulate, which have been shown to be closely correlated with variance in die filling and tablet strength, and are predictably influenced by the processing parameters.
文摘The shape and size of particles are understood to affect the bulk behaviour of powders, though there are but few studies that present quantitative information on the relationship between particle shape and the flow properties of powder. This is due in part to the lack of techniques for rapidly determining both particle shape and the range of flow characteristics that describe the response of powders to the stress and shear experienced during their processing. This study presents data that quantifies the influence of particle shapeJsize of three different lactose powders on their respective flow and bulk characteristics. Two of the samples differ in size but have similar shapes; the third sample is more spherical but similar in size to one of the other two samples, The results demonstrate that in addition to particle size, particle shape significantly affect the flow characteristics of a powder over a wide range of stress conditions.
