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一种新型KPC-2抑制剂:PHT427 被引量:1
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作者 李晓辉 王倩 +8 位作者 刘琛楠 韩江雪 刘思含 刘天俊 王倩 关艳 肖春玲 王潇 刘忆霜 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2023年第12期989-997,共9页
KPC-2型β-内酰胺酶对超广谱头孢菌素和碳青霉烯类抗生素具有耐药性,并已成为治疗革兰氏阴性菌感染的全球重大威胁,因此寻找新型抗菌剂和新的抗感染策略非常重要。我们前期经筛选发现PHT427是一种有效的NDM-1抑制剂,进一步研究发现其对K... KPC-2型β-内酰胺酶对超广谱头孢菌素和碳青霉烯类抗生素具有耐药性,并已成为治疗革兰氏阴性菌感染的全球重大威胁,因此寻找新型抗菌剂和新的抗感染策略非常重要。我们前期经筛选发现PHT427是一种有效的NDM-1抑制剂,进一步研究发现其对KPC-2也有明显的抑制活性。结果显示PHT427能够显著抑制KPC-2,IC50值为2.04μM,并且与美罗培南联用对大肠杆菌BL21(DE3)/p ET28a(+)-bla KPC-2具有明显的协同作用。荧光淬灭和SPR结果表明PHT427能够与KPC-2发生相互作用。分子对接与定点突变的结果进一步表明Arg220、Thr235和Thr237是促进这种相互作用的关键氨基酸残基。研究表明PHT427是一种具有潜力的KPC-2抑制剂并且能够协助碳青霉烯类抗生素抑制KPC-2产生菌。 展开更多
关键词 KPC-2 PHT427 抗生素耐药 抑制剂
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The scientific hypothesis of an 'energy system' in the human body 被引量:1
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作者 tianjun liu 《Journal of Traditional Chinese Medical Sciences》 2018年第1期29-34,共6页
This paper proposed the scientific hypothesis that human beings have an 'energy system' inside their body and put forward the necessity to propose the hypothesis.In details,this paper explained the hypothesis ... This paper proposed the scientific hypothesis that human beings have an 'energy system' inside their body and put forward the necessity to propose the hypothesis.In details,this paper explained the hypothesis from its existence,composition,functions,and possible verifying methods.This paper argues that the human body includes both visible and invisible parts.The former is the material system and the latter is the energetic system.As matter and energy can be converted into each other,it is important to study the human body from the perspective of both the material and energetic systems,which can complement each other.The nature of the energetic system is different from that of the material system.The traditional Chinese medicine (TCM) perspective is based on energy;therefore,extending research on the human energy system may lead to the establishment of a modern TCM research field that is firmly grounded in the principles of TCM.Such a research field might generate novel findings. 展开更多
关键词 ENERGY SYSTEM SCIENTIFIC HYPOTHESIS HUMAN BODY
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Improve the Competitiveness and Value of Rice Exports of the Mekong Delta Provinces
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作者 Nguyen Thi Tuong Vi tianjun liu 《Agricultural Sciences》 2019年第6期707-719,共13页
Purpose: Vietnam rice has long been a product of international stature. In the commodity export of Vietnam, rice always plays as key agricultural commodities, with contributions billions of dollars each year in total ... Purpose: Vietnam rice has long been a product of international stature. In the commodity export of Vietnam, rice always plays as key agricultural commodities, with contributions billions of dollars each year in total export value. It not only contributes to the overall growth of the economy, but also gradually affirms Vietnam’s position on the international rice market. According to General Statistics Office, in 2012, Vietnam produced 43.7 million tonnes of rice and exported record 8.047 million tonnes of rice, contributing to the total export value of $3.689 million. However, it has not still been commensurate with the value and potential of rice from Vietnam. In addition, the fact is that in recent years, although export rice increased sharply, bringing many records for Vietnam, it had lower prices than other rice exporting countries (Thailand, India, Pakistan). So what is the cause and solution to enhance competitiveness and promote export of rice products in Viet Nam? In the increasingly complex international context, besides socio-economic development, security and national defense, food security has become a matter of international concern. The article first discusses the competitiveness, the value of rice exports and the need to improve competitiveness and export value of rice in the Mekong Delta. Then, there are some solutions proposed to improve the competitiveness and export of rice in the Mekong Delta in the coming time. 展开更多
关键词 MEKONG DELTA Rice EXPORT FOOD Security The COMPETITIVENESS
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Polarization-insensitive silicon intensity modulator with a maximum speed of 224 Gb/s
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作者 ZANYUN ZHANG BEIJU HUANG +9 位作者 QIXIN WANG ZILONG CHEN KE LI KAIXIN ZHANG MEIXIN LI HAO JIANG JIAMING XING tianjun liu XIAOQING LV GRAHAM T.REED 《Photonics Research》 2025年第2期274-285,共12页
Polarization-insensitive optical modulators allow an external laser to be remotely interconnected by single-mode optical fibers while avoiding polarization controllers,which would be convenient and cost-effective for ... Polarization-insensitive optical modulators allow an external laser to be remotely interconnected by single-mode optical fibers while avoiding polarization controllers,which would be convenient and cost-effective for co-packaged optics,5G,and future 6G applications.In this article,a polarization-insensitive silicon intensity modulator is proposed and experimentally demonstrated based on two-dimensional centrally symmetric gratings,featuring a low polarization-dependent loss of 0.15 dB in minimum and polarization insensitivity of eye diagrams.The device exhibits a low fiber-to-fiber insertion loss of 9 dB and an electro-optic(EO)bandwidth of 49.8 GHz.A modulation speed of up to 224 Gb/s is also demonstrated. 展开更多
关键词 polarization controllerswhich G electro optic bandwidth polarization dependent loss G applications external laser polarization insensitive silicon intensity modulator
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The technique of transforming symptom’s symbol into emptiness:A mind-body therapy in the Chinese context
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作者 Haiqun Niu Yi Chen +2 位作者 Wen Zhou Yanqiang Tao tianjun liu 《PsyCh Journal》 2025年第2期172-178,共7页
The technique of transforming symptom’s symbol into emptiness(TSSE)is a new mind-body treatment method proposed by Tianjun Liu in 2008.It integrates Qigong and concrete object-image thinking rooted in traditional Chi... The technique of transforming symptom’s symbol into emptiness(TSSE)is a new mind-body treatment method proposed by Tianjun Liu in 2008.It integrates Qigong and concrete object-image thinking rooted in traditional Chinese culture into modern psychotherapy and proposes that mental and physical problems can be alleviated or eliminated in the process of movement.Accordingly,the therapist needs to guide the client with various symptoms to psychological nothingness where the client cannot see or feel these symptoms,and the purpose of healing can be achieved through the experience of emptiness.TSSE is divided into static and dynamic operations and consists of 10 steps.The static operation includes trio relaxation exercises(the body,breath,and mind),identifying the target symptom,visualizing the target symptom as an object-image,visualizing a symbolic carrier,and filling out record sheet A.The dynamic operation includes trio relaxation exercises again,moving the symbolic object into the carrier,moving the carrier with the symbolic object into psychological nothingness,moving back and assessment,and filling out record sheet B.The effectiveness of TSSE can be evaluated by the therapist’s judgment based on the client’s performance and by the difference between the symptom impact scores recorded in sheets A and B.TSSE has been proven to be an effective psychosomatic treatment solution by some empirical studies conducted in China.Future research can combine other technologies,such as fMRI and fNIRS,to further explore the potential effective mechanisms of TSSE. 展开更多
关键词 psychological nothingness Qigong TSSE
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Effect of government regulation on promotion of soil restoration practices among farmers in the Loess plateau:Unveiling the role of green ecological cognition
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作者 Xiaolan Wang Sixiao Li +3 位作者 Xiuguang Bai JoséA.Gómez tianjun liu Jundi liu 《International Soil and Water Conservation Research》 2025年第4期979-991,共13页
Soil remediation practices by farmers are crucial for improving soil quality and ensuring stable agri-cultural production.To analyze the factors influencing these practices,we surveyed 403 farmers in the Loess Plateau... Soil remediation practices by farmers are crucial for improving soil quality and ensuring stable agri-cultural production.To analyze the factors influencing these practices,we surveyed 403 farmers in the Loess Plateau of Shaanxi and Shanxi,China.Using an ordered Probit model and moderation effect analysis,we investigated the direct effects of government regulations-specifically subsidies and technical training and the moderating role of farmers' ecological cognition on technology adoption.Our findings indicate:(1)Farmers generally accept and implement soil remediation technologies,with deep plowing being the most prevalent;(2)Government regulations,particularly subsidies and training,significantly enhance farmers' soil restoration efforts;(3)Farmers' green ecological cognition positively influences their restoration practices and moderates the impact of government regulation;(4)The in-fluence of government regulation and cognition varies among farmers types,with subsidies being more crucial for smallholder,while training benefits larger operations more.These insights offer a new perspective for refining soil remediation policies and examining the global applicability of government regulation and farmers' cognition. 展开更多
关键词 Agricultural sustainability Behavioral economics Cognitive moderation Policy intervention Probit modeling
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