Hydrogen production from water electrolysis,in particular from proton exchange membrane water electrolyzers(PEMWE),is a key approach to realizing a carbon-free energy cycle.However,the high anodic potential and strong...Hydrogen production from water electrolysis,in particular from proton exchange membrane water electrolyzers(PEMWE),is a key approach to realizing a carbon-free energy cycle.However,the high anodic potential and strong acid in PEMWE systems pose a major challenge to the stability of electrocatalysts,and the development of efficient and corrosion-resistant catalysts is urgently needed.Currently,iridium(Ir)-based catalysts have gained great attention due to their promising activity and stability,while the extremely low reserves of Ir in the earth seriously hinder the commercialization of PEMWE.Therefore,a systematic understanding of the latest advances in Ir-based catalysts is necessary to guide their rational design to meet the industrial requirements.In this review,the general reaction mechanisms and advanced characterization techniques for mechanism recognition are first introduced.Afterwards,the systematic design strategies and performances of Ir-based catalysts,including metallic Ir,Ir oxides,and Ir-based perovskites,are summarized in detail.Finally,the conclusions,challenges,and prospects for Ir-based electrocatalysts are presented.展开更多
The proliferation of smart communities in Foshan has led to increasingly diverse and prevalent cybersecurity risks for residents.This trend has rendered traditional cybersecurity education models inadequate in address...The proliferation of smart communities in Foshan has led to increasingly diverse and prevalent cybersecurity risks for residents.This trend has rendered traditional cybersecurity education models inadequate in addressing the challenges of the digital era.Guided by the theory of collaborative governance and the framework of digital transformation,this paper examines the multi-stakeholder collaborative mechanism involving the government,businesses,community organizations,universities,and residents.It subsequently proposes a series of implementation strategies such as digitizing educational content,intellectualizing platforms,contextualizing delivery methods,and refining management precision.Studies demonstrate that this model enables effective resource integration,improves educational precision,and boosts resident engagement.It represents a fundamental shift from unilateral dissemination to multi-party interaction and from decentralized management to collaborative synergy,offering a replicable“Foshan Model”for digital governance at the community level.展开更多
Recently,exploration breakthroughs have been made in the Lower Cretaceous sandstone reservoirs in the Doseo Basin,but the identification of reservoir fluid property is difficult due to variable reservoir lithology,com...Recently,exploration breakthroughs have been made in the Lower Cretaceous sandstone reservoirs in the Doseo Basin,but the identification of reservoir fluid property is difficult due to variable reservoir lithology,complex oil-water contact within and faint responses of the oil zone,which causes the lower accuracy of reservoir fluid property identification with conventional mudlogging and wirelogging techniques.Applying the geochemical logging,fluorescent logging,mud logging and cutting logging technology,in combination with formation test data,this paper distinguishes the crude oil types,analyzes the logging response characteristics of oil zone after water washing,and establishes the interpretation charts and parameter standards for reservoir fluid properties.The crude oil can be divided into two types,namely viscous-heavy and thin-light,based on total hydrocarbon content and component concentration tested by mud logging,features of pyrolysis gas chromatogram and fluorescence spectroscopy.The general characteristics of oil layers experienced water washing include the decrease of total hydrocarbon content and component concentration from mud logging,the decrease of S1 and PS values from geochemical logging,the decrease of hydrocarbon abundance and absence of some light components in pyrolysis gas chromatogram,and the decrease of fluorescence area and intensity from fluorescence logging.According to crude oil types,the cross plots of S1 versus peak-baseline ratio,and the cross plots of rock wettability versus fluorescence area ratio are drawn and used to interpret reservoir fluid property.Meanwhile,the standards of reservoir fluid parameter are established combining with the parameters of PS and the parameters in above charts,and comprehensive multiparameter correlation in both vertical and horizontal ways is also performed to interpret reservoir fluid property.The application in the Doseo Basin achieved great success,improving interpretation ability of fluid property in the reservoir with complex oil-water contact,and also provided technical reference for the efficient exploration and development of similar reservoirs.展开更多
The selective electrochemical conversion of glycerol into value-added products is a green and sustainable strategy for the biomass utilization.In this work,Au nanowires(Au-NW)modified with polyethyleneimine(PEI)molecu...The selective electrochemical conversion of glycerol into value-added products is a green and sustainable strategy for the biomass utilization.In this work,Au nanowires(Au-NW)modified with polyethyleneimine(PEI)molecule(Au-NW@PEI)is obtained by an up-bottom post-modification approach.Physical characterization,molecular dynamics simulation and density functional theory demonstrate that the loose-packed PEI monolayer firmly and uniformly distribute on the Au-NW surface due to the strong Au-N interaction.Electrochemical experiments and product analysis display that PEI modification significantly enhance the electro-activity of Au-NW for the glycerol electro-oxidation reaction(GEOR)due to the electronic effect.Meanwhile,the steric hindrance and electrostatic effect of PEI layer make the optimizing adsorption of intermediates possible.Therefore,the selectivity of C3 product glyceric acid over Au-NW@PEI is increased by nearly 20%.The work thus indicates that the rational design of metal-organic interface can effectively elevate the electro-activity and selectivity of Au nanostructures,which may have wide application in biomass development.展开更多
BACKGROUND Liver injury is a common complication of infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus.The utility of laboratory hematology data in the diagnosis and risk stratification ...BACKGROUND Liver injury is a common complication of infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus.The utility of laboratory hematology data in the diagnosis and risk stratification of patients with coronavirus disease 2019(COVID-19)has not been comprehensively examined.AIM To address the following.(1)Are the abnormalities in hematologic parameters seen in the general population of patients with COVID-19 also seen in those patients with associated liver injury?(2)Is liver injury in COVID-19 a sign of severe disease and does liver injury correlate with hematologic markers of severe disease?And(3)What is the quality of this evidence?METHODS To address these questions,a comprehensive systematic review was performed.We searched the peer reviewed medical literature using MEDLINE(PubMed interface),Web of Science,and EMBASE for cohort studies that specifically addressed liver injury and COVID-19 without limitation of date of publication or language.A quality assessment of the studies was performed using the Newcastle-Ottawa Scale.RESULTS Thirty-two articles were suitable for inclusion in our systematic review.These included 22 articles with a cohort of COVID-19 patients with liver injury,5 comparing non-severe vs severe COVID-19 populations in which liver injury was addressed,and 5 other cohort studies with a focus on liver injury.White blood cell count,absolute neutrophil count,absolute lymphocyte count(ALC),and hemoglobin were the parameters most helpful in distinguishing COVID-19 with liver injury from COVID-19 without liver injury.ALC and d-dimer were identified as being potentially useful in distinguishing non-severe from severe COVID-19. Liver injury was more frequently seen in cohorts with severe disease.Most studies were of high quality (24/48, 86%) with 4/28 (14%) of moderatequality and 0 of low quality.CONCLUSIONOur study supports the use of select hematologic parameters in diagnosis and riskstratification of liver injury in COVID-19 patients. Although of overall highquality, the current medical literature is limited by the small number of studieswith high statistical power and the variable definition of COVID-19 liver injury inthe literature.展开更多
Objective:To establish an optimized aqueous extraction process for polysaccharides from Physalis alkekengi L.peel and to preliminarily explore its in vitro anti-inflammatory activity against colorectal cancer SW620 ce...Objective:To establish an optimized aqueous extraction process for polysaccharides from Physalis alkekengi L.peel and to preliminarily explore its in vitro anti-inflammatory activity against colorectal cancer SW620 cells.Methods:A single-factor test combined with orthogonal test analysis was used to evaluate the effects of the material-to-liquid ratio,extraction temperature,and extraction time on the yield of polysaccharides from Physalis alkekengi L.peel.The antioxidant activity of the polysaccharides was assessed by analyzing their free radical scavenging ability in vitro,and the anti-inflammatory effect was evaluated using SW620 cells.Results:The optimal extraction conditions were a material-to-liquid ratio of m(g):V(mL)=1:30,an extraction temperature of 100℃,and an extraction time of 40 minutes,with a predicted polysaccharide yield of 25.7%.The polysaccharides from Physalis peruviana peel effectively scavenged DPPH,superoxide anion,and hydroxyl radicals.After treatment with Physalis peruviana polysaccharides,the levels of IL-1β,IL-18,and TNF-αin the cell culture medium were significantly reduced,and the phosphorylation level of P65 protein in SW620 cells was decreased.Conclusion:This extraction method is stable and reliable,and the prepared Physalis alkekengi L.polysaccharides exhibit significant in vitro antioxidant and anti-inflammatory activities.This study provides a theoretical basis for developing drugs for the prevention and treatment of colorectal cancer.展开更多
Two-dimensional(2D)oxide nanomaterials have great potential for various applications but face challenges due to strong interlayer interactions.In this work,we propose a novel and facile method to exfoliate layered tra...Two-dimensional(2D)oxide nanomaterials have great potential for various applications but face challenges due to strong interlayer interactions.In this work,we propose a novel and facile method to exfoliate layered transition metal oxides into ultrathin nanosheets functionalized with phosphate species by the combination of ball-milling and liquid-exfoliation with phosphoric acid.The resulting HNb Mo O6nanosheets with supported Pd nanoparticles displayed excellent catalytic performance in the one-pot conversion of phenol into caprolactam(CPL),achieving a yield of up to 71.9%.This one-pot route avoids the energy-intensive intermediate separation process in conventional multi-step approaches to CPL.The superior catalytic performance of the catalysts is attributed to the tunable Bronsted acid/Lewis acid ratio and readily accessible active sites on the ultrathin nanosheets.This research demonstrates a new methodology for constructing ultrathin nanosheets and preparing bifunctional catalysts for tandem reactions,which opens the way for one-pot production of CPL.展开更多
Near-infrared II(NIR-II)photoacoustic imaging(PAI)technology is an emerging biomedical imaging modality characterized by high spatial resolution,deep tissue penetration,and high signal-to-noise ratio.NIR-II PAI enable...Near-infrared II(NIR-II)photoacoustic imaging(PAI)technology is an emerging biomedical imaging modality characterized by high spatial resolution,deep tissue penetration,and high signal-to-noise ratio.NIR-II PAI enables highly clear real-time monitoring of various physiological and pathological processes and visualizes different biological entities,making it crucial for advancements in life sciences and medicine.NIR-II PAI technology holds significant application potential in disease diagnosis and treatment,particularly in early diagnosis,precise localization,boundary delineation,and monitoring of treatment response for tumors and other conditions.By combining with multimodal or diagnostic-therapeutic integrated molecular probes,this technology enables accurate disease localization and guided treatment,which is crucial for early diagnosis and therapy.This review provides a detailed overview of research progress on NIR-II PAI probes,discussing the emergence and latest developments of various NIR-II PAI probes and their applications in early diagnosis and treatment of tumors,cerebrovascular systems,inflammation,and other tissues.Additionally,it summarizes the development status of these probes and outlines future prospects and challenges.展开更多
Background:Worldwide,the volume and availability of digestive endoscopy have undergone dramatic development in recent years,with increasing attention on quality assurance.We investigated the utilization and quality of...Background:Worldwide,the volume and availability of digestive endoscopy have undergone dramatic development in recent years,with increasing attention on quality assurance.We investigated the utilization and quality of digestive endoscopy in China from 2015 to 2019 and developed a quantitative quality evaluation tool for medical institutions.Methods:We invited all tertiary/secondary hospitals in Chinese mainland to participate in the survey annually.The questionnaires included the personnel,annual volume,and quality indicators of endoscopy.An endoscopy quality index(EQI)was developed based on recorded quality indicators using principal component analysis to determine the relative weight.Results:From 2015 to 2019,806,1412,2644,2468,and 2541 hospitals were respectively enrolled in this study.The average annual volume of endoscopy increased from 12,445 to 16,206(1.30-fold)and from 2938 to 4255(1.45-fold)in tertiary and secondary hospitals,respectively.The most obvious growth was observed in diagnostic colonoscopy(1.44-fold for all hospitals after standardization).The proportion of early cancer among all esophageal and gastric cancers during diagnostic esophagogastroduodenoscopy increased from 12.3%(55,210/448,861)to 17.7%(85,429/482,647)and from 11.4%(69,411/608,866)to 16.9%(107,192/634,235),respectively.The adenoma detection rate of diagnostic colonoscopy increased from 14.9%(2,118,123/14,215,592)to 19.3%(3,943,203/20,431,104).The EQI model included 12 quality indicators,incorporating 64.9%(7.792/12)of the total variance into one comprehensive index.According to the EQI measurements,the quality of endoscopy was higher in tertiary hospitals and hospitals in developed areas with higher volume or more endoscopists than that in other hospitals.Conclusions:Digestive endoscopy in China has developed considerably in recent years in terms of both volume and quality.The EQI is a promising tool to quantify the quality of endoscopy at different hospitals.展开更多
Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identif...Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.展开更多
Electrically responsive electrochemical actuators that contain a polymer electrolyte membrane laminated between two electrodes have attracted great attention due to their potential applications in smart electronics,we...Electrically responsive electrochemical actuators that contain a polymer electrolyte membrane laminated between two electrodes have attracted great attention due to their potential applications in smart electronics,wearable devices,and soft robotics.However,some challenges such as the achievement of large bending strain under low applied voltage and fast ion diffusion and accumulation still exist to be resolved.The key to the solution lies in the choice of electrode materials and the design of electrode structures.In this study,an engineering electrochemical actuator that presents large bending strain under low applied voltage based on MXene/polystyrene-MXene hybrid electrodes is developed.The developed electrochemical actuator based on the MXene/polystyrene-MXene 3D-structure is found to exhibit large bending strain(ca.1.18%),broad frequency bandwidth,good durability(90%retention after 10,000 cycles)and considerable Young’s modulus(ca.246 MPa).The high-performance actuation mainly stems from the excellent properties of MXene and 3D-structure of the electrode.The MXene provides excellent mechanical strength and high electrical conductivity which facilitate strong interaction and rapid electron transfer in electrodes.The 3D architectures formed by polystyrene microspheres generate unimpeded ion pathways for ionic short diffusion and fast injection.This study reveals that the 3D-structure hybrid electrodes play a crucial role in promoting the performance of such electrochemical actuators.展开更多
Electrochemical water splitting for hydrogen generation is considered one of the most promising strategies for reducing the use of fossil fuels and storing renewable electricity in hydrogen fuel.However,the anodic oxy...Electrochemical water splitting for hydrogen generation is considered one of the most promising strategies for reducing the use of fossil fuels and storing renewable electricity in hydrogen fuel.However,the anodic oxygen evolution process remains a bottleneck due to the remarkably high overpotential of about 300 mV to achieve a current density of 10 mA cm^(−2).The key to solving this dilemma is the development of highly efficient catalysts with minimized overpotential,long-term stability,and low cost.As a new 2D material,MXene has emerged as an intriguing material for future energy conversion technology due to its benefits,including superior conductivity,excellent hydrophilic properties,high surface area,versatile chemical composition,and ease of processing,which make it a potential constituent of the oxygen evolution catalyst layer.This review aims to summarize and discuss the recent development of oxygen evolution catalysts using MXene as a component,emphasizing the synthesis and synergistic effect of MXene-based composite catalysts.Based on the discussions summarized in this review,we also provide future research directions regarding electronic interaction,stability,and structural evolution of MXene-based oxygen evolution catalysts.We believe that a broader and deeper research in this area could accelerate the discovery of efficient catalysts for electrochemical oxygen evolution.展开更多
Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living...Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living organisms.Aptamers,short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically,are ideal molecular recognition elements for probe development in molecular imaging.This review summarizes the current state of aptamer-based biosensor development(probe design and imaging modalities)and their application in imaging small molecules,nucleic acids and proteins mostly in a cellular context with some animal studies.The article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.展开更多
基金supported by the National Natural Science Foundation of China(22202053,22109035,52362031,and 52274297)the start-up Research Foundation of Hainan University(KYQD(ZR)-20008,20083,20084,23068,and 23169)+4 种基金the Hainan Province Science and Technology Special Fund(ZDYF2024SHFZ074)the Collaborative Innovation Center of Marine Science and Technology,Hainan University(XTCX2022HYC04)the specific research fund of The Innovation Platform for Academicians of Hainan Province(YSPTZX202315)the Research Fund Program of Guangdong Provincial Key Laboratory of Fuel Cell Technology(FC202307)the Open Fund Project of Key Laboratory of Electrochemical Energy Storage and Energy Conversion in Hainan Province of China(KFKT2023002)。
文摘Hydrogen production from water electrolysis,in particular from proton exchange membrane water electrolyzers(PEMWE),is a key approach to realizing a carbon-free energy cycle.However,the high anodic potential and strong acid in PEMWE systems pose a major challenge to the stability of electrocatalysts,and the development of efficient and corrosion-resistant catalysts is urgently needed.Currently,iridium(Ir)-based catalysts have gained great attention due to their promising activity and stability,while the extremely low reserves of Ir in the earth seriously hinder the commercialization of PEMWE.Therefore,a systematic understanding of the latest advances in Ir-based catalysts is necessary to guide their rational design to meet the industrial requirements.In this review,the general reaction mechanisms and advanced characterization techniques for mechanism recognition are first introduced.Afterwards,the systematic design strategies and performances of Ir-based catalysts,including metallic Ir,Ir oxides,and Ir-based perovskites,are summarized in detail.Finally,the conclusions,challenges,and prospects for Ir-based electrocatalysts are presented.
基金2025 Foshan Social Science Planning Project,“Research on Pathways for Enhancing Cybersecurity Awareness Among Foshan Community Residents Empowered by Digital and Intelligent Technologies”(Project No.:2025-GJ091)。
文摘The proliferation of smart communities in Foshan has led to increasingly diverse and prevalent cybersecurity risks for residents.This trend has rendered traditional cybersecurity education models inadequate in addressing the challenges of the digital era.Guided by the theory of collaborative governance and the framework of digital transformation,this paper examines the multi-stakeholder collaborative mechanism involving the government,businesses,community organizations,universities,and residents.It subsequently proposes a series of implementation strategies such as digitizing educational content,intellectualizing platforms,contextualizing delivery methods,and refining management precision.Studies demonstrate that this model enables effective resource integration,improves educational precision,and boosts resident engagement.It represents a fundamental shift from unilateral dissemination to multi-party interaction and from decentralized management to collaborative synergy,offering a replicable“Foshan Model”for digital governance at the community level.
基金funded by a project entitled exploration field evaluation and target optimization of key basins in Chad and Niger(No.2019D-4308)initiated by the scientific research and technology development project of china national petroleum corporation.
文摘Recently,exploration breakthroughs have been made in the Lower Cretaceous sandstone reservoirs in the Doseo Basin,but the identification of reservoir fluid property is difficult due to variable reservoir lithology,complex oil-water contact within and faint responses of the oil zone,which causes the lower accuracy of reservoir fluid property identification with conventional mudlogging and wirelogging techniques.Applying the geochemical logging,fluorescent logging,mud logging and cutting logging technology,in combination with formation test data,this paper distinguishes the crude oil types,analyzes the logging response characteristics of oil zone after water washing,and establishes the interpretation charts and parameter standards for reservoir fluid properties.The crude oil can be divided into two types,namely viscous-heavy and thin-light,based on total hydrocarbon content and component concentration tested by mud logging,features of pyrolysis gas chromatogram and fluorescence spectroscopy.The general characteristics of oil layers experienced water washing include the decrease of total hydrocarbon content and component concentration from mud logging,the decrease of S1 and PS values from geochemical logging,the decrease of hydrocarbon abundance and absence of some light components in pyrolysis gas chromatogram,and the decrease of fluorescence area and intensity from fluorescence logging.According to crude oil types,the cross plots of S1 versus peak-baseline ratio,and the cross plots of rock wettability versus fluorescence area ratio are drawn and used to interpret reservoir fluid property.Meanwhile,the standards of reservoir fluid parameter are established combining with the parameters of PS and the parameters in above charts,and comprehensive multiparameter correlation in both vertical and horizontal ways is also performed to interpret reservoir fluid property.The application in the Doseo Basin achieved great success,improving interpretation ability of fluid property in the reservoir with complex oil-water contact,and also provided technical reference for the efficient exploration and development of similar reservoirs.
基金sponsored by National Natural Science Foundation of China(No.22202130)China Postdoctoral Science Foundation(No.2022M710088)+3 种基金Science and Technology Innovation Team of Shaanxi Province(Nos.2023-CX-TD-27 and 2022TD-35)Fundamental Research Funds for the Central Universities(Nos.GK202202001 and GK202101005)Open Funds of the State Key Laboratory of Electroanalytical Chemistry(No.SKLEAC202207)the 111 Project(No.B14041)。
文摘The selective electrochemical conversion of glycerol into value-added products is a green and sustainable strategy for the biomass utilization.In this work,Au nanowires(Au-NW)modified with polyethyleneimine(PEI)molecule(Au-NW@PEI)is obtained by an up-bottom post-modification approach.Physical characterization,molecular dynamics simulation and density functional theory demonstrate that the loose-packed PEI monolayer firmly and uniformly distribute on the Au-NW surface due to the strong Au-N interaction.Electrochemical experiments and product analysis display that PEI modification significantly enhance the electro-activity of Au-NW for the glycerol electro-oxidation reaction(GEOR)due to the electronic effect.Meanwhile,the steric hindrance and electrostatic effect of PEI layer make the optimizing adsorption of intermediates possible.Therefore,the selectivity of C3 product glyceric acid over Au-NW@PEI is increased by nearly 20%.The work thus indicates that the rational design of metal-organic interface can effectively elevate the electro-activity and selectivity of Au nanostructures,which may have wide application in biomass development.
文摘BACKGROUND Liver injury is a common complication of infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus.The utility of laboratory hematology data in the diagnosis and risk stratification of patients with coronavirus disease 2019(COVID-19)has not been comprehensively examined.AIM To address the following.(1)Are the abnormalities in hematologic parameters seen in the general population of patients with COVID-19 also seen in those patients with associated liver injury?(2)Is liver injury in COVID-19 a sign of severe disease and does liver injury correlate with hematologic markers of severe disease?And(3)What is the quality of this evidence?METHODS To address these questions,a comprehensive systematic review was performed.We searched the peer reviewed medical literature using MEDLINE(PubMed interface),Web of Science,and EMBASE for cohort studies that specifically addressed liver injury and COVID-19 without limitation of date of publication or language.A quality assessment of the studies was performed using the Newcastle-Ottawa Scale.RESULTS Thirty-two articles were suitable for inclusion in our systematic review.These included 22 articles with a cohort of COVID-19 patients with liver injury,5 comparing non-severe vs severe COVID-19 populations in which liver injury was addressed,and 5 other cohort studies with a focus on liver injury.White blood cell count,absolute neutrophil count,absolute lymphocyte count(ALC),and hemoglobin were the parameters most helpful in distinguishing COVID-19 with liver injury from COVID-19 without liver injury.ALC and d-dimer were identified as being potentially useful in distinguishing non-severe from severe COVID-19. Liver injury was more frequently seen in cohorts with severe disease.Most studies were of high quality (24/48, 86%) with 4/28 (14%) of moderatequality and 0 of low quality.CONCLUSIONOur study supports the use of select hematologic parameters in diagnosis and riskstratification of liver injury in COVID-19 patients. Although of overall highquality, the current medical literature is limited by the small number of studieswith high statistical power and the variable definition of COVID-19 liver injury inthe literature.
文摘Objective:To establish an optimized aqueous extraction process for polysaccharides from Physalis alkekengi L.peel and to preliminarily explore its in vitro anti-inflammatory activity against colorectal cancer SW620 cells.Methods:A single-factor test combined with orthogonal test analysis was used to evaluate the effects of the material-to-liquid ratio,extraction temperature,and extraction time on the yield of polysaccharides from Physalis alkekengi L.peel.The antioxidant activity of the polysaccharides was assessed by analyzing their free radical scavenging ability in vitro,and the anti-inflammatory effect was evaluated using SW620 cells.Results:The optimal extraction conditions were a material-to-liquid ratio of m(g):V(mL)=1:30,an extraction temperature of 100℃,and an extraction time of 40 minutes,with a predicted polysaccharide yield of 25.7%.The polysaccharides from Physalis peruviana peel effectively scavenged DPPH,superoxide anion,and hydroxyl radicals.After treatment with Physalis peruviana polysaccharides,the levels of IL-1β,IL-18,and TNF-αin the cell culture medium were significantly reduced,and the phosphorylation level of P65 protein in SW620 cells was decreased.Conclusion:This extraction method is stable and reliable,and the prepared Physalis alkekengi L.polysaccharides exhibit significant in vitro antioxidant and anti-inflammatory activities.This study provides a theoretical basis for developing drugs for the prevention and treatment of colorectal cancer.
基金supported by the National Key Research and Development Program of China(2022YFA1504901,2023YFA1508103)the National Natural Science Foundation of China(22293012,22179132,22293015,22121002)。
文摘Two-dimensional(2D)oxide nanomaterials have great potential for various applications but face challenges due to strong interlayer interactions.In this work,we propose a novel and facile method to exfoliate layered transition metal oxides into ultrathin nanosheets functionalized with phosphate species by the combination of ball-milling and liquid-exfoliation with phosphoric acid.The resulting HNb Mo O6nanosheets with supported Pd nanoparticles displayed excellent catalytic performance in the one-pot conversion of phenol into caprolactam(CPL),achieving a yield of up to 71.9%.This one-pot route avoids the energy-intensive intermediate separation process in conventional multi-step approaches to CPL.The superior catalytic performance of the catalysts is attributed to the tunable Bronsted acid/Lewis acid ratio and readily accessible active sites on the ultrathin nanosheets.This research demonstrates a new methodology for constructing ultrathin nanosheets and preparing bifunctional catalysts for tandem reactions,which opens the way for one-pot production of CPL.
基金supported by NSFC(82102200,and 82203889)CAMS Initiative for Innovative Medicine(2021-I2M-1-043)+1 种基金Science and Technology Program of Tianjin,China(22JCYBJC01000)the Fundamental Research Funds for the Central Universities(2021-RC350-006).
文摘Near-infrared II(NIR-II)photoacoustic imaging(PAI)technology is an emerging biomedical imaging modality characterized by high spatial resolution,deep tissue penetration,and high signal-to-noise ratio.NIR-II PAI enables highly clear real-time monitoring of various physiological and pathological processes and visualizes different biological entities,making it crucial for advancements in life sciences and medicine.NIR-II PAI technology holds significant application potential in disease diagnosis and treatment,particularly in early diagnosis,precise localization,boundary delineation,and monitoring of treatment response for tumors and other conditions.By combining with multimodal or diagnostic-therapeutic integrated molecular probes,this technology enables accurate disease localization and guided treatment,which is crucial for early diagnosis and therapy.This review provides a detailed overview of research progress on NIR-II PAI probes,discussing the emergence and latest developments of various NIR-II PAI probes and their applications in early diagnosis and treatment of tumors,cerebrovascular systems,inflammation,and other tissues.Additionally,it summarizes the development status of these probes and outlines future prospects and challenges.
基金supported by the National Health Commission of China, First Affiliated Hospital of Naval Medical University(No. 2019YXK006)the Science and Technology Commission of Shanghai Municipality(No. 21Y31900100)
文摘Background:Worldwide,the volume and availability of digestive endoscopy have undergone dramatic development in recent years,with increasing attention on quality assurance.We investigated the utilization and quality of digestive endoscopy in China from 2015 to 2019 and developed a quantitative quality evaluation tool for medical institutions.Methods:We invited all tertiary/secondary hospitals in Chinese mainland to participate in the survey annually.The questionnaires included the personnel,annual volume,and quality indicators of endoscopy.An endoscopy quality index(EQI)was developed based on recorded quality indicators using principal component analysis to determine the relative weight.Results:From 2015 to 2019,806,1412,2644,2468,and 2541 hospitals were respectively enrolled in this study.The average annual volume of endoscopy increased from 12,445 to 16,206(1.30-fold)and from 2938 to 4255(1.45-fold)in tertiary and secondary hospitals,respectively.The most obvious growth was observed in diagnostic colonoscopy(1.44-fold for all hospitals after standardization).The proportion of early cancer among all esophageal and gastric cancers during diagnostic esophagogastroduodenoscopy increased from 12.3%(55,210/448,861)to 17.7%(85,429/482,647)and from 11.4%(69,411/608,866)to 16.9%(107,192/634,235),respectively.The adenoma detection rate of diagnostic colonoscopy increased from 14.9%(2,118,123/14,215,592)to 19.3%(3,943,203/20,431,104).The EQI model included 12 quality indicators,incorporating 64.9%(7.792/12)of the total variance into one comprehensive index.According to the EQI measurements,the quality of endoscopy was higher in tertiary hospitals and hospitals in developed areas with higher volume or more endoscopists than that in other hospitals.Conclusions:Digestive endoscopy in China has developed considerably in recent years in terms of both volume and quality.The EQI is a promising tool to quantify the quality of endoscopy at different hospitals.
基金This work was supported by the National Key R&D Program of China(Grant No.2018YFD0502204)the Agricultural Science and Technology Innovation Program of China(Grant No.CAAS-ASTIP-2019-ISAPS)+1 种基金the Special Animal Genetic Resources Platform of National Scientific and Technical Infrastructure Center(Grant No.NSTIC TZDWZYK2019)the Sika deer Genome Project of China(Grant No.20140309016YY).
文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.
基金This work was supported by the National Key Basic Research Program of China(Grant No.2018YFA0208403)the National Natural Science Foundation of China(Grant Nos.51861165103,11832010,11890682,and 21721002)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant Nos.XDB36000000 and XDB30020100).
文摘Electrically responsive electrochemical actuators that contain a polymer electrolyte membrane laminated between two electrodes have attracted great attention due to their potential applications in smart electronics,wearable devices,and soft robotics.However,some challenges such as the achievement of large bending strain under low applied voltage and fast ion diffusion and accumulation still exist to be resolved.The key to the solution lies in the choice of electrode materials and the design of electrode structures.In this study,an engineering electrochemical actuator that presents large bending strain under low applied voltage based on MXene/polystyrene-MXene hybrid electrodes is developed.The developed electrochemical actuator based on the MXene/polystyrene-MXene 3D-structure is found to exhibit large bending strain(ca.1.18%),broad frequency bandwidth,good durability(90%retention after 10,000 cycles)and considerable Young’s modulus(ca.246 MPa).The high-performance actuation mainly stems from the excellent properties of MXene and 3D-structure of the electrode.The MXene provides excellent mechanical strength and high electrical conductivity which facilitate strong interaction and rapid electron transfer in electrodes.The 3D architectures formed by polystyrene microspheres generate unimpeded ion pathways for ionic short diffusion and fast injection.This study reveals that the 3D-structure hybrid electrodes play a crucial role in promoting the performance of such electrochemical actuators.
基金Start-up Research Foundation of Hainan University,Grant/Award Numbers:KYQD(ZR)-20008,KYQD(ZR)-20084,KYQD(ZR)-21170,KYQD(ZR)-23068Specific research fund of The Innovation Platform for Academicians of Hainan Province,Grant/Award Number:YSPTZX202315National Natural Science Foundation of China,Grant/Award Numbers:22109035,52164028,52274297,52362031。
文摘Electrochemical water splitting for hydrogen generation is considered one of the most promising strategies for reducing the use of fossil fuels and storing renewable electricity in hydrogen fuel.However,the anodic oxygen evolution process remains a bottleneck due to the remarkably high overpotential of about 300 mV to achieve a current density of 10 mA cm^(−2).The key to solving this dilemma is the development of highly efficient catalysts with minimized overpotential,long-term stability,and low cost.As a new 2D material,MXene has emerged as an intriguing material for future energy conversion technology due to its benefits,including superior conductivity,excellent hydrophilic properties,high surface area,versatile chemical composition,and ease of processing,which make it a potential constituent of the oxygen evolution catalyst layer.This review aims to summarize and discuss the recent development of oxygen evolution catalysts using MXene as a component,emphasizing the synthesis and synergistic effect of MXene-based composite catalysts.Based on the discussions summarized in this review,we also provide future research directions regarding electronic interaction,stability,and structural evolution of MXene-based oxygen evolution catalysts.We believe that a broader and deeper research in this area could accelerate the discovery of efficient catalysts for electrochemical oxygen evolution.
文摘Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living organisms.Aptamers,short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically,are ideal molecular recognition elements for probe development in molecular imaging.This review summarizes the current state of aptamer-based biosensor development(probe design and imaging modalities)and their application in imaging small molecules,nucleic acids and proteins mostly in a cellular context with some animal studies.The article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.
