Rare earth metal elements include lanthanide elements as well as scandium and yttrium,totaling seventeen metal elements.Due to the wide application prospects of rare earth metal elements in various fields such as lumi...Rare earth metal elements include lanthanide elements as well as scandium and yttrium,totaling seventeen metal elements.Due to the wide application prospects of rare earth metal elements in various fields such as luminescent materials,magnetic materials,catalytic materials,electronic devices,they have an important strategic position.In the field of electrocatalysis,rare earth metal elements have great potential for development due to their unique 4f electron layer structure,spin orbit coupling,high reactivity,controllable coordination number,and rich optical properties.However,there is currently a lack of systematic reviews on the modification strategies of rare earth metal elements and the latest developments in electrocatalysis.Therefore,in order to stimulate the enthusiasm of researchers,this review focuses on the application progress of rare earth metal element modified metal oxides in multiple fields such as wastewater treatment,hydrogen peroxide synthesis,hydrogen evolution reaction(HER),carbon dioxide reduction reaction(CO_(2)RR),nitrogen reduction reaction(NRR)and machine learning assisted research.In depth analysis of its electrocatalytic mechanism in various application scenarios and key factors affecting electrocatalytic performance.This review is of great significance for further developing high-performance and multifunctional electrocatalysts,and is expected to provide strong support for the development of energy,environment,and chemical industries.展开更多
Based on the difference of the Y-terminal functional group of the silane coupling agent(Y-Si(X)_(3)),four different silane coupling agents were employed to pretreat the surface of the NdFeB powders.The effects of sila...Based on the difference of the Y-terminal functional group of the silane coupling agent(Y-Si(X)_(3)),four different silane coupling agents were employed to pretreat the surface of the NdFeB powders.The effects of silane coupling agents on the flowability and compressibility of compounds for preparing bonded NdFeB magnets were studied.It is indicated that compounds pretreated by silane coupling agents have weaker friction and meshing force.The apparent density is increased by 0.3 g/cm^(3 )compared with the compound without silane coupling agent,and the radial crushing strength is significantly increased by about 3-4 times.In addition,the epoxy resin is more evenly distributed on the surface of the compounds treated by silane coupling agents observed by scanning electron microscopy,and some agglomerated particles are produced.Also,the compressibility of compounds with silane coupling agents is significantly improved due to the fact that hardening exponents are reduced.However,the addition of silane coupling agents has almost no effect on the magnetic properties of bonded magnets.The special energy was used to manifest the flowability of magnetic powder particles representing the macroscopic performance of the force between powder particles,providing a new direction for the study of the interface compatibility of two-phase or multiphase composite materials.展开更多
OBJECTIVE: To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor, Nogo for neuron A (No- go-A), and its associated signaling molecule, low-af- finity neurotr...OBJECTIVE: To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor, Nogo for neuron A (No- go-A), and its associated signaling molecule, low-af- finity neurotrophin receptor p75 (p75TR), in rats with cerebral ischemic stroke (CIS), with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following in- jury to the central nervous system. METHODS: A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method. Successful model rats were divided into placebo and herb groups at random; sham-operat- ed and control groups were set up simultaneously.Each of these groups was divided into six sub- groups at random. Expression of Nogo-A and p75TR was evaluated with immunofluorescence microsco- py at days 3, and weeks1, 2, 3, 4 and 8 after adminis- tration. RESULTS: Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75T (P〈0.05 and P〈0.01, respectively). CONCLUSION: Suppressing the expression of No- go-A and p75NTR is possibly one of the mechanisms underlying the ability of tonifying liver and kid- ney-essence herbs to promote recovery of the in- jured central nervous system.展开更多
Hydrogen production from electrochemical water splitting is a promising strategy to generate green energy,which requires the development of efficient and stable electrocatalysts for the hydrogen evolution reaction and...Hydrogen production from electrochemical water splitting is a promising strategy to generate green energy,which requires the development of efficient and stable electrocatalysts for the hydrogen evolution reaction and the oxygen evolution reaction(HER and OER).Ionic liquids(ILs)or poly(ionic liquids)(PILs),containing heteroatoms,metal-based anions,and various structures,have been frequently involved as precursors to prepare electrocatalysts for water splitting.Moreover,ILs/PILs possess high conductivity,wide electrochemical windows,and high thermal and chemical stability,which can be directly applied in the electrocatalysis process with high durability.In this review,we focus on the studies of ILs/PILs-derived electrocatalysts for HER and OER,where ILs/PILs are applied as heteroatom dopants and metal precursors to prepare catalysts or are directly utilized as the electrocatalysts.Due to those attractive properties,IL/PIL-derived electrocatalysts exhibit excellent performance for electrochemical water splitting.All these accomplishments and developments are systematically summarized and thoughtfully discussed.Then,the overall perspectives for the current challenges and future developments of ILs/PILs-derived electrocatalysts are provided.展开更多
Polyethylene terephthalate (PET) as one of non-degradable wastes has become a huge threat to the environment and human health.Chemical Recycle of PET is a sustainable way to release 1,4-benzenedicarboxylic acid (BDC) ...Polyethylene terephthalate (PET) as one of non-degradable wastes has become a huge threat to the environment and human health.Chemical Recycle of PET is a sustainable way to release 1,4-benzenedicarboxylic acid (BDC) the monomer of PET as common used organiclinker for synthesis of functional Metal–organic-frameworks (PET-derived MOFs) such as UiO-66, MIL-101, etc. This sustainable and costeffective“Waste-to-MOFs” model is of great significant to be intensively investigated in the past years. Attributes of substantial porosity, specificsurface area, exposed metal centers, uniform structure, and flexible morphology render PET-derived MOFs are well-suited for applications inadsorption, energy storage, catalysis, among others. Herein, in the present work, we have summarized recent advances in synthesis of PETderived MOFs using ex-situ and in-situ methods for typical applications of adsorption, catalysis and energy storage. Despite those improvementsin synthesis methods and potential applications, challenges still remain in development of green and economical routes to fully utilize waste PETfor massive manufacture of valuable MOF materials and chemicals. This review provides insights into the conversion of non-degradable PETwaste to value-added MOF materials, and further suggests promising perspectives to develop the sustainable “Waste-to-MOFs” model inaddressing environmental pollution and energy crises.展开更多
Recent advancements in thermal conductivity modulating strategies have shown promising enhancements to the thermal management capabilities of two-dimensional materials.In this article,both the iterative Boltzmann tran...Recent advancements in thermal conductivity modulating strategies have shown promising enhancements to the thermal management capabilities of two-dimensional materials.In this article,both the iterative Boltzmann transport equation solution and the two-temperature model were employed to investigate the efficacy of targeted phonon excitation applied to hexagonal boron nitride(hBN).The results indicate significant modifications to hBN's thermal conductivity,achieving increases of up to 30.1%as well as decreases of up to 59.8%.These findings validate the reliability of the strategy,expand its scope of applicability,and establish it as a powerful tool for tailoring thermal properties across a wider range of fields.展开更多
Objective: To explore the application effect of oral glucose combined with short-term intravenous nutrition in preventing postoperative hypoglycemia after painless endoscopic gastric polyp resection, and to provide gu...Objective: To explore the application effect of oral glucose combined with short-term intravenous nutrition in preventing postoperative hypoglycemia after painless endoscopic gastric polyp resection, and to provide guidance for better management of patients undergoing such procedures. Methods: A total of 886 patients who underwent painless endoscopic gastric polyp resection in the Department of Gastroenterology, the First Affiliated Hospital of Yangtze University, from January 2020 to December 2021, were selected as the study subjects. According to the random number table method, they were divided into an experimental group and a control group, with 443 cases in each group. Patients in the control group were subjected to routine fasting and water restriction for 8 hours before surgery, and routine fasting for 24 hours after surgery. Short-term intravenous nutrition support was provided through fluid supplementation, and finger blood glucose levels were monitored at 1 hour, 4 hours, and 8 hours after completion of intravenous infusion, or when symptoms such as palpitations and cold sweats occurred. The experimental group received oral administration of 5% glucose solution (500 ml) 2 hours before surgery based on the procedures of the control group. The incidence of preoperative discomfort (hunger, thirst, and fatigue), residual gastric fluid volume, and postoperative hypoglycemia were compared between the two groups. Results: The incidence of postoperative blood glucose Conclusion: Based on the study population, oral glucose combined with short-term intravenous nutrition can effectively prevent the incidence of hypoglycemia in patients undergoing painless endoscopic gastric polyp resection. However, due to the limitations of a single-center study and a small number of cases, its feasibility needs to be further validated with more data from multi-center and large-sample cases.展开更多
Objective: To investigate the effect of oral glucose combined with short-term intravenous nutrition on the prevention of hypoglycemia after endoscopic colorectal polypectomy and to provide guidance for better manageme...Objective: To investigate the effect of oral glucose combined with short-term intravenous nutrition on the prevention of hypoglycemia after endoscopic colorectal polypectomy and to provide guidance for better management of such patients. Methods: 860 patients who underwent endoscopic colorectal polypectomy for colorectal polyps in the Department of Gastroenterology of the First Affiliated Hospital of Yangtze University from January 2020 to December 2021 were selected for the study. The patients were divided into experimental and control groups according to the random number table method, with 430 patients in each group. In the control group, 3 L of polyethylene glycol electrolyte dispersion was used for preoperative intestinal preparation and postoperative fasting was performed routinely for 24 h. Short-term intravenous nutrition support was provided by rehydration, and finger blood glucose was monitored at 1, 4, and 8 h after intravenous infusion or when there were symptoms such as panic and cold sweat;in the experimental group, oral glucose intervention was implemented on the basis of the control group. The incidence of postoperative hypoglycemia, quality of bowel preparation, and tolerance of patients during bowel preparation were compared between the 2 groups. Results: The incidence of postoperative blood glucose Conclusion: Based on the present study population, oral glucose combined with short-term intravenous nutrition can effectively prevent the incidence of hypoglycemia in patients after endoscopic colorectal polypectomy;however, this was limited to a single-center study and the number of cases was small.展开更多
Anisotropic NdFeB/SmFeN hybrid bonded magnets were prepared by warm compaction process under an orientation magnetic field of 22 kOe,mixing with anisotropic SmFeN powders in different addition and HDDR-NdFeB powders i...Anisotropic NdFeB/SmFeN hybrid bonded magnets were prepared by warm compaction process under an orientation magnetic field of 22 kOe,mixing with anisotropic SmFeN powders in different addition and HDDR-NdFeB powders in different coercivity.With the addition of 20 wt% SmFeN,the density and remanence of hybrid magnets increase from 5.58 g/cm~3,8.4 kGs to 6.02 g/cm~3,9.0 kGs,respectively.And as the addition amount of SmFeN powders varies from 20 wt% to 40 wt%,the maximum energy product changes less than 0.5 MGOe.In addition,the magnetization process and the interactions between two powders were studied.It is found that the magnetization process of anisotropic NdFeB powders shows distinction in different initial states.The addition of SmFeN powders promotes the rotation of NdFeB powders together with applied field,which is beneficial to the degree of alignment of NdFeB powders.Because of the micron-sized long range coupling effect,the coercivity of hybrid magnets decreases slowly with the increase of low coercivity SmFeN.Meanwhile,the magnetization process of hybrid magnets is different from pure magnets,it increases rapidly at low field and then slowly,next leads to rapidity again and achieves the saturation magnetization finally.展开更多
Very recently,two-dimensional quantum dots(2D QDs)have been pioneeringly investigated as lubricant additives,which exhibit superior friction-reducing and wear resistance.Compared with 2D nanoparticles,2D QDs possess s...Very recently,two-dimensional quantum dots(2D QDs)have been pioneeringly investigated as lubricant additives,which exhibit superior friction-reducing and wear resistance.Compared with 2D nanoparticles,2D QDs possess small size(~10 nm)and abundant active groups.These distinguished advantages enable them to quickly disperse into common lube mediums and maintain long-term storage stability.The good dispersion stability of 2D QDs not only effectively improves their embedding capacity,but also enables continuous supplements of lubricants during the sliding process.Therefore,2D QDs are attracting increasing research interest as efficient lubricants with desirable service life.In this review,we focus on the latest studies of 2D QDs as liquid lubricant additives(both in polar and nonpolar mediums),self-lubricating solid coatings and gels,etc.Various advanced strategies for synthesis and modification of 2D QDs are summarized.A comprehensive insight into the tribological behavior of a variety of 2D QDs together with the associated mechanism is reviewed in detail.The superior lubricating performances of 2D QDs are attributed to various mechanisms,including rolling effect,self-mending performance,polishing effect,tribofilm formation,nanostructure transfer and synergistic effects,etc.Strategies for friction modulation of 2D QDs,including internal factors(surface modification,elemental doping)and extrinsic factors(counter surfaces,test conditions)are discussed,special attentions for achieving intelligent tribology toward superlubricity and bio-engineering,are also included.Finally,the future challenges and research directions regarding QDs as lubricants conforming to the concept of“green tribology”toward a sustainable society are discussed.展开更多
N-Heterocyclic carbene (NHC) enabled the highly efficient catalytic hydroboration of a wide range of ketones and aldehydes under mild conditions,and a new mechanism of catalytic hydroboration reaction which involves d...N-Heterocyclic carbene (NHC) enabled the highly efficient catalytic hydroboration of a wide range of ketones and aldehydes under mild conditions,and a new mechanism of catalytic hydroboration reaction which involves direct hydride transfer is proposed.展开更多
Background:Keloid scarring is caused by a fibroproliferative disorder due to abnormal activation of genes,the underlying mechanism of which is still unclear.The basic helix-loop-helix transcription factor Twist-relate...Background:Keloid scarring is caused by a fibroproliferative disorder due to abnormal activation of genes,the underlying mechanism of which is still unclear.The basic helix-loop-helix transcription factor Twist-related protein 1(TWIST1)controls cell proliferation and differentiation in tissue development and disease processes.In this study,we aimed to clarify the essential role of TWIST1 in the pathogenesis of keloids.Methods:Immunohistochemistry,cell counting kit-8 assays,western blotting,PCR,matrigel invasion assays and immunofluorescence assays were applied to demonstrate the effects and mechanisms of TWIST1 in fibroblasts derived from normal skin and keloids.Mass spectrometry,ubiquitination assays,chromatin immunoprecipitation and dual luciferase reporter assay were applied to explore the interaction of TWIST1 with downstream molecules.Results:In the present study,we confirmed that TWIST1 was upregulated in keloid tissue of patients and in keloid-derived fibroblasts(KFBs).In vitro,TWIST1 inhibition prevented KFB proliferation,invasion and activation.We also discovered a link between TWIST1 and the transforming growth factorβ(TGF-β)signaling related molecules TGF-βreceptor 1(TBR1),SMAD family member 2(Smad2)and Smad3,and the fibrosis markersα-smooth muscle actin,collagen type I and collagen type III in KFBs.Mechanistically,we uncovered a brand-new mechanism by which TWIST1 interacts with myocyte enhancer factor 2A(MEF2A)and suppresses its ubiquitination and degradation.Using chromatin immunoprecipitation and dual-luciferase reporter assay,TBR1 was identified as a novel downstream target of MEF2A,which directly binds to its promoter.Overexpression of TWIST1 promoted the recruitment of MEF2A to the TBR1 promoter and restored TBR1 functional expression.Conclusions:Our research highlights a significant function of TWIST1 in the development of keloid and its related fibroblasts,partially facilitated by elevated MEF2A-dependent TBR1 expression.Blocking the expression of TWIST1 in KFBs could potentially pave a novel therapeutic avenue for keloid treatment.展开更多
Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions.Dysregulation of phase separation might result in pathologi...Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions.Dysregulation of phase separation might result in pathological condensation or sequestration of biomolecules,leading to diseases.Thus,phase separation and phase separating factors may serve as drug targets for disease treatment.Nevertheless,such associations have not yet been integrated into phase separation-related databases.Therefore,based on MloDisDB,a database for membraneless organelle factor-disease associations previously developed by our lab,we constructed PhaSeDis,the phase separation-disease association database.We increased the number of phase separation entries from 52 to 185,and supplemented the evidence provided by the original articles verifying the phase separation nature of the factors.Moreover,we included the information of interacting small molecules with low-throughput or high-throughput evidence that might serve as potential drugs for phase separation entries.PhaSeDis strives to offer comprehensive descriptions of each entry,elucidating how phase separating factors induce pathological conditions via phase separation and the mechanisms by which small molecules intervene.We believe that PhaSeDis would be very important in the application of phase separation regulation in treating relateddiseases.PhaSeDis is availableathttp:/mlodis.phasep.pro.展开更多
Free cash flow and financing constraints can exert significant influences on the operational development of enterprises.Based on the pecking order theory and using data from A-share listed companies in China,this pape...Free cash flow and financing constraints can exert significant influences on the operational development of enterprises.Based on the pecking order theory and using data from A-share listed companies in China,this paper employs fixed-effects models and moderation effect models to examine the relationship and mechanisms between enterprises'free cash flow generation capacity and their financing constraints.The study found that:(1)Free cash flow can alleviate corporate financing constraints.(2)Corporate performance plays a positive moderating role in the impact of free cash flow on financing constraints.(3)The impact of free cash flow on financing constraints is weaker in state-owned enterprises compared to non-state-owned enterprises.The findings of this paper imply that free cash flow can have a significant impact on corporate financing activities.Therefore,enterprises should pay more attention to their cash flow indicators,signaling their operational stability and risk management capabilities to the outside world,thereby reducing the level of financing constraints faced by the enterprise.展开更多
In the era of digital economy,data and intelligent algorithms are driving profound changes in the economic field,which also presents new challenges for the cultivation of MPAcc talents.This paper focuses on this issue...In the era of digital economy,data and intelligent algorithms are driving profound changes in the economic field,which also presents new challenges for the cultivation of MPAcc talents.This paper focuses on this issue,analyzing the deficiencies in the current MPAcc talent cultivation system in terms of curriculum design,teaching methods,faculty teams,and school-enterprise cooperation.At the same time,it deeply analyzes the reconstruction requirements for accounting talent education in the digital economy era in terms of knowledge structure,comprehensive ability,and professional quality.Taking the University of Malaya as a case study,this paper analyzes the key points of its MPAcc education reform,including innovative curriculum design,the adoption of diversified teaching methods,optimization of faculty team construction,and deepening of school-enterprise cooperation.It also provides specific optimization paths,such as improving the dual-mentor system,promoting the construction of practice bases,integrating professional qualification certification,and broadening international horizons.This paper aims to provide ideas for the reconstruction and model optimization of China's accounting talent cultivation system,helping the accounting industry achieve transformation and upgrading.展开更多
Groundwater is a key part of the terrestrial ecosystem,but it is vulnerable to pollution in the context of chemical industry development.Treating contaminated groundwater is challenging due to its stable water quality...Groundwater is a key part of the terrestrial ecosystem,but it is vulnerable to pollution in the context of chemical industry development.Treating contaminated groundwater is challenging due to its stable water quality,hidden contamination,and complex treatment requirements.Current research focuses on advanced treatment technologies,among which the advanced oxidation process(AOPs) of peroxomonosulfate(PMS) has great potential.Although there are many reviews of PMS-based AOP,most of them focus on surface water.This review aims to explore the activation reaction of PMS to groundwater by in-situ chemical oxidation(ISCO) technology,further study the reaction mechanism,compare the treatment effect of characteristic pollutants in the groundwater of the chemical industry park,propose new activation methods and catalyst selection,and provide guidance for future groundwater treatment research.展开更多
Chirality, as one of the ubiquitous properties in nature, has aroused striking attention in the fields of physics and materials sciences. For tailoring of light with more degree of freedom, circular dichroism has been...Chirality, as one of the ubiquitous properties in nature, has aroused striking attention in the fields of physics and materials sciences. For tailoring of light with more degree of freedom, circular dichroism has been considered as the auxiliary dimension to improving such an issue. Inspired by the Born-Kuhn plasmonic oscillation model, we demonstrate and discuss a chiral resonator to reveal reverse circular dichroism within two separate frequency bands in the microwave regime. The underlying physical mechanisms of bonding and anti-bounding modes are analyzed via transmission/reflection spectra and surface current distributions for different chiral enantiomers. To leverage the proposed paradigm to the application levels, especially for metaholography, we conduct the numerical simulation and experimental demonstration of two proofs of principles. Based on the Pancharatnam-Berry phase/amplitude modulation and complex-amplitude manipulation, respectively, the meta-holograms with independent targets of reconstructing images in full-space and reflected regions are achieved. Significantly, our paradigm may promise further applications in spin-controlled meta-devices for image processing, information encryption, anti-counterfeiting,remote sensing, and radar systems.展开更多
基金supported by the National Key Research and Development Program of China(No.2023YFC3708005)The Fundamental Research Funds for the Central Universities,Nankai University(No.63241208)supported by the National Natural Science Foundation of China(Nos.21872102 and 22172080)。
文摘Rare earth metal elements include lanthanide elements as well as scandium and yttrium,totaling seventeen metal elements.Due to the wide application prospects of rare earth metal elements in various fields such as luminescent materials,magnetic materials,catalytic materials,electronic devices,they have an important strategic position.In the field of electrocatalysis,rare earth metal elements have great potential for development due to their unique 4f electron layer structure,spin orbit coupling,high reactivity,controllable coordination number,and rich optical properties.However,there is currently a lack of systematic reviews on the modification strategies of rare earth metal elements and the latest developments in electrocatalysis.Therefore,in order to stimulate the enthusiasm of researchers,this review focuses on the application progress of rare earth metal element modified metal oxides in multiple fields such as wastewater treatment,hydrogen peroxide synthesis,hydrogen evolution reaction(HER),carbon dioxide reduction reaction(CO_(2)RR),nitrogen reduction reaction(NRR)and machine learning assisted research.In depth analysis of its electrocatalytic mechanism in various application scenarios and key factors affecting electrocatalytic performance.This review is of great significance for further developing high-performance and multifunctional electrocatalysts,and is expected to provide strong support for the development of energy,environment,and chemical industries.
基金Project supported by Beijing Youth Top-notch Team Support Project of China(2018000021223TD10)Hebei Province Fund for Transformation of Major Science and Technology Achievements of China(19041029Z)Hebei Province International Science and Technology Cooperation Base Construction Project of China(20591002D)。
文摘Based on the difference of the Y-terminal functional group of the silane coupling agent(Y-Si(X)_(3)),four different silane coupling agents were employed to pretreat the surface of the NdFeB powders.The effects of silane coupling agents on the flowability and compressibility of compounds for preparing bonded NdFeB magnets were studied.It is indicated that compounds pretreated by silane coupling agents have weaker friction and meshing force.The apparent density is increased by 0.3 g/cm^(3 )compared with the compound without silane coupling agent,and the radial crushing strength is significantly increased by about 3-4 times.In addition,the epoxy resin is more evenly distributed on the surface of the compounds treated by silane coupling agents observed by scanning electron microscopy,and some agglomerated particles are produced.Also,the compressibility of compounds with silane coupling agents is significantly improved due to the fact that hardening exponents are reduced.However,the addition of silane coupling agents has almost no effect on the magnetic properties of bonded magnets.The special energy was used to manifest the flowability of magnetic powder particles representing the macroscopic performance of the force between powder particles,providing a new direction for the study of the interface compatibility of two-phase or multiphase composite materials.
基金Suppored by Special Project on Traditional Chinese Medicine Science and Technology of State Administration of Traditional Chinese Medicine of the PRC(No.06-07LB21)
文摘OBJECTIVE: To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor, Nogo for neuron A (No- go-A), and its associated signaling molecule, low-af- finity neurotrophin receptor p75 (p75TR), in rats with cerebral ischemic stroke (CIS), with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following in- jury to the central nervous system. METHODS: A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method. Successful model rats were divided into placebo and herb groups at random; sham-operat- ed and control groups were set up simultaneously.Each of these groups was divided into six sub- groups at random. Expression of Nogo-A and p75TR was evaluated with immunofluorescence microsco- py at days 3, and weeks1, 2, 3, 4 and 8 after adminis- tration. RESULTS: Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75T (P〈0.05 and P〈0.01, respectively). CONCLUSION: Suppressing the expression of No- go-A and p75NTR is possibly one of the mechanisms underlying the ability of tonifying liver and kid- ney-essence herbs to promote recovery of the in- jured central nervous system.
基金supported by the Natural Science Founda-tion of Chongqing(cstc2021jcyj-msxmX0420)Natural Science Foundation of Sichuan(2023NSFSC0088)。
文摘Hydrogen production from electrochemical water splitting is a promising strategy to generate green energy,which requires the development of efficient and stable electrocatalysts for the hydrogen evolution reaction and the oxygen evolution reaction(HER and OER).Ionic liquids(ILs)or poly(ionic liquids)(PILs),containing heteroatoms,metal-based anions,and various structures,have been frequently involved as precursors to prepare electrocatalysts for water splitting.Moreover,ILs/PILs possess high conductivity,wide electrochemical windows,and high thermal and chemical stability,which can be directly applied in the electrocatalysis process with high durability.In this review,we focus on the studies of ILs/PILs-derived electrocatalysts for HER and OER,where ILs/PILs are applied as heteroatom dopants and metal precursors to prepare catalysts or are directly utilized as the electrocatalysts.Due to those attractive properties,IL/PIL-derived electrocatalysts exhibit excellent performance for electrochemical water splitting.All these accomplishments and developments are systematically summarized and thoughtfully discussed.Then,the overall perspectives for the current challenges and future developments of ILs/PILs-derived electrocatalysts are provided.
基金supported by the National Natural Science Foundation of China(21902105,52274172)Shenzhen Science and Technology Program(JCYJ20210324094000001)Guangdong Basic and Applied Basic Research Foundation(2020A1515010471).
文摘Polyethylene terephthalate (PET) as one of non-degradable wastes has become a huge threat to the environment and human health.Chemical Recycle of PET is a sustainable way to release 1,4-benzenedicarboxylic acid (BDC) the monomer of PET as common used organiclinker for synthesis of functional Metal–organic-frameworks (PET-derived MOFs) such as UiO-66, MIL-101, etc. This sustainable and costeffective“Waste-to-MOFs” model is of great significant to be intensively investigated in the past years. Attributes of substantial porosity, specificsurface area, exposed metal centers, uniform structure, and flexible morphology render PET-derived MOFs are well-suited for applications inadsorption, energy storage, catalysis, among others. Herein, in the present work, we have summarized recent advances in synthesis of PETderived MOFs using ex-situ and in-situ methods for typical applications of adsorption, catalysis and energy storage. Despite those improvementsin synthesis methods and potential applications, challenges still remain in development of green and economical routes to fully utilize waste PETfor massive manufacture of valuable MOF materials and chemicals. This review provides insights into the conversion of non-degradable PETwaste to value-added MOF materials, and further suggests promising perspectives to develop the sustainable “Waste-to-MOFs” model inaddressing environmental pollution and energy crises.
基金supported by the National Key Research and Development Project of China(Grant No.2018YFE0127800)。
文摘Recent advancements in thermal conductivity modulating strategies have shown promising enhancements to the thermal management capabilities of two-dimensional materials.In this article,both the iterative Boltzmann transport equation solution and the two-temperature model were employed to investigate the efficacy of targeted phonon excitation applied to hexagonal boron nitride(hBN).The results indicate significant modifications to hBN's thermal conductivity,achieving increases of up to 30.1%as well as decreases of up to 59.8%.These findings validate the reliability of the strategy,expand its scope of applicability,and establish it as a powerful tool for tailoring thermal properties across a wider range of fields.
文摘Objective: To explore the application effect of oral glucose combined with short-term intravenous nutrition in preventing postoperative hypoglycemia after painless endoscopic gastric polyp resection, and to provide guidance for better management of patients undergoing such procedures. Methods: A total of 886 patients who underwent painless endoscopic gastric polyp resection in the Department of Gastroenterology, the First Affiliated Hospital of Yangtze University, from January 2020 to December 2021, were selected as the study subjects. According to the random number table method, they were divided into an experimental group and a control group, with 443 cases in each group. Patients in the control group were subjected to routine fasting and water restriction for 8 hours before surgery, and routine fasting for 24 hours after surgery. Short-term intravenous nutrition support was provided through fluid supplementation, and finger blood glucose levels were monitored at 1 hour, 4 hours, and 8 hours after completion of intravenous infusion, or when symptoms such as palpitations and cold sweats occurred. The experimental group received oral administration of 5% glucose solution (500 ml) 2 hours before surgery based on the procedures of the control group. The incidence of preoperative discomfort (hunger, thirst, and fatigue), residual gastric fluid volume, and postoperative hypoglycemia were compared between the two groups. Results: The incidence of postoperative blood glucose Conclusion: Based on the study population, oral glucose combined with short-term intravenous nutrition can effectively prevent the incidence of hypoglycemia in patients undergoing painless endoscopic gastric polyp resection. However, due to the limitations of a single-center study and a small number of cases, its feasibility needs to be further validated with more data from multi-center and large-sample cases.
文摘Objective: To investigate the effect of oral glucose combined with short-term intravenous nutrition on the prevention of hypoglycemia after endoscopic colorectal polypectomy and to provide guidance for better management of such patients. Methods: 860 patients who underwent endoscopic colorectal polypectomy for colorectal polyps in the Department of Gastroenterology of the First Affiliated Hospital of Yangtze University from January 2020 to December 2021 were selected for the study. The patients were divided into experimental and control groups according to the random number table method, with 430 patients in each group. In the control group, 3 L of polyethylene glycol electrolyte dispersion was used for preoperative intestinal preparation and postoperative fasting was performed routinely for 24 h. Short-term intravenous nutrition support was provided by rehydration, and finger blood glucose was monitored at 1, 4, and 8 h after intravenous infusion or when there were symptoms such as panic and cold sweat;in the experimental group, oral glucose intervention was implemented on the basis of the control group. The incidence of postoperative hypoglycemia, quality of bowel preparation, and tolerance of patients during bowel preparation were compared between the 2 groups. Results: The incidence of postoperative blood glucose Conclusion: Based on the present study population, oral glucose combined with short-term intravenous nutrition can effectively prevent the incidence of hypoglycemia in patients after endoscopic colorectal polypectomy;however, this was limited to a single-center study and the number of cases was small.
基金supported by the National Key Research and Development Program of China (2021YFB3500202,2021YFB3500201)the Beijing Youth Top-notch Team Support Project of China (2018000021223TD10)+2 种基金the Beijing NOVA Program (Z211100002121092)the Natural Science Foundation of Hebei Province (E2021103006)the Hebei Province International Science and Technology Cooperation Base Construction Project of China (20591002D)。
文摘Anisotropic NdFeB/SmFeN hybrid bonded magnets were prepared by warm compaction process under an orientation magnetic field of 22 kOe,mixing with anisotropic SmFeN powders in different addition and HDDR-NdFeB powders in different coercivity.With the addition of 20 wt% SmFeN,the density and remanence of hybrid magnets increase from 5.58 g/cm~3,8.4 kGs to 6.02 g/cm~3,9.0 kGs,respectively.And as the addition amount of SmFeN powders varies from 20 wt% to 40 wt%,the maximum energy product changes less than 0.5 MGOe.In addition,the magnetization process and the interactions between two powders were studied.It is found that the magnetization process of anisotropic NdFeB powders shows distinction in different initial states.The addition of SmFeN powders promotes the rotation of NdFeB powders together with applied field,which is beneficial to the degree of alignment of NdFeB powders.Because of the micron-sized long range coupling effect,the coercivity of hybrid magnets decreases slowly with the increase of low coercivity SmFeN.Meanwhile,the magnetization process of hybrid magnets is different from pure magnets,it increases rapidly at low field and then slowly,next leads to rapidity again and achieves the saturation magnetization finally.
基金This work was supported by the National Natural Science Foundation of China(No.52075264).
文摘Very recently,two-dimensional quantum dots(2D QDs)have been pioneeringly investigated as lubricant additives,which exhibit superior friction-reducing and wear resistance.Compared with 2D nanoparticles,2D QDs possess small size(~10 nm)and abundant active groups.These distinguished advantages enable them to quickly disperse into common lube mediums and maintain long-term storage stability.The good dispersion stability of 2D QDs not only effectively improves their embedding capacity,but also enables continuous supplements of lubricants during the sliding process.Therefore,2D QDs are attracting increasing research interest as efficient lubricants with desirable service life.In this review,we focus on the latest studies of 2D QDs as liquid lubricant additives(both in polar and nonpolar mediums),self-lubricating solid coatings and gels,etc.Various advanced strategies for synthesis and modification of 2D QDs are summarized.A comprehensive insight into the tribological behavior of a variety of 2D QDs together with the associated mechanism is reviewed in detail.The superior lubricating performances of 2D QDs are attributed to various mechanisms,including rolling effect,self-mending performance,polishing effect,tribofilm formation,nanostructure transfer and synergistic effects,etc.Strategies for friction modulation of 2D QDs,including internal factors(surface modification,elemental doping)and extrinsic factors(counter surfaces,test conditions)are discussed,special attentions for achieving intelligent tribology toward superlubricity and bio-engineering,are also included.Finally,the future challenges and research directions regarding QDs as lubricants conforming to the concept of“green tribology”toward a sustainable society are discussed.
基金This work was supported by the National Natural Science Foundation of China (Nos. 21632006 and 21472098).
文摘N-Heterocyclic carbene (NHC) enabled the highly efficient catalytic hydroboration of a wide range of ketones and aldehydes under mild conditions,and a new mechanism of catalytic hydroboration reaction which involves direct hydride transfer is proposed.
基金funded by the National High Level Hospital Clinical Research Funding,grant No.2022-PUMCH-C-041the Medical Science and Health Technology Innovation Project(2022-I2M-1-068)+1 种基金the Medical Science and Health Technology Innovation Project(2021-I2M-1-003)Young Scientists Fund of the Natural Science Foundation of Sichuan(2024NSFSC1505).
文摘Background:Keloid scarring is caused by a fibroproliferative disorder due to abnormal activation of genes,the underlying mechanism of which is still unclear.The basic helix-loop-helix transcription factor Twist-related protein 1(TWIST1)controls cell proliferation and differentiation in tissue development and disease processes.In this study,we aimed to clarify the essential role of TWIST1 in the pathogenesis of keloids.Methods:Immunohistochemistry,cell counting kit-8 assays,western blotting,PCR,matrigel invasion assays and immunofluorescence assays were applied to demonstrate the effects and mechanisms of TWIST1 in fibroblasts derived from normal skin and keloids.Mass spectrometry,ubiquitination assays,chromatin immunoprecipitation and dual luciferase reporter assay were applied to explore the interaction of TWIST1 with downstream molecules.Results:In the present study,we confirmed that TWIST1 was upregulated in keloid tissue of patients and in keloid-derived fibroblasts(KFBs).In vitro,TWIST1 inhibition prevented KFB proliferation,invasion and activation.We also discovered a link between TWIST1 and the transforming growth factorβ(TGF-β)signaling related molecules TGF-βreceptor 1(TBR1),SMAD family member 2(Smad2)and Smad3,and the fibrosis markersα-smooth muscle actin,collagen type I and collagen type III in KFBs.Mechanistically,we uncovered a brand-new mechanism by which TWIST1 interacts with myocyte enhancer factor 2A(MEF2A)and suppresses its ubiquitination and degradation.Using chromatin immunoprecipitation and dual-luciferase reporter assay,TBR1 was identified as a novel downstream target of MEF2A,which directly binds to its promoter.Overexpression of TWIST1 promoted the recruitment of MEF2A to the TBR1 promoter and restored TBR1 functional expression.Conclusions:Our research highlights a significant function of TWIST1 in the development of keloid and its related fibroblasts,partially facilitated by elevated MEF2A-dependent TBR1 expression.Blocking the expression of TWIST1 in KFBs could potentially pave a novel therapeutic avenue for keloid treatment.
基金supported by the National Key R&D Program of China(Grant No.2023YFF1204703)the Beijing Natural Science Foundation,China(Grant No.Z230014)the National Natural Science Foundation of China(Grant Nos.T2325003 and 31000609).
文摘Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions.Dysregulation of phase separation might result in pathological condensation or sequestration of biomolecules,leading to diseases.Thus,phase separation and phase separating factors may serve as drug targets for disease treatment.Nevertheless,such associations have not yet been integrated into phase separation-related databases.Therefore,based on MloDisDB,a database for membraneless organelle factor-disease associations previously developed by our lab,we constructed PhaSeDis,the phase separation-disease association database.We increased the number of phase separation entries from 52 to 185,and supplemented the evidence provided by the original articles verifying the phase separation nature of the factors.Moreover,we included the information of interacting small molecules with low-throughput or high-throughput evidence that might serve as potential drugs for phase separation entries.PhaSeDis strives to offer comprehensive descriptions of each entry,elucidating how phase separating factors induce pathological conditions via phase separation and the mechanisms by which small molecules intervene.We believe that PhaSeDis would be very important in the application of phase separation regulation in treating relateddiseases.PhaSeDis is availableathttp:/mlodis.phasep.pro.
文摘Free cash flow and financing constraints can exert significant influences on the operational development of enterprises.Based on the pecking order theory and using data from A-share listed companies in China,this paper employs fixed-effects models and moderation effect models to examine the relationship and mechanisms between enterprises'free cash flow generation capacity and their financing constraints.The study found that:(1)Free cash flow can alleviate corporate financing constraints.(2)Corporate performance plays a positive moderating role in the impact of free cash flow on financing constraints.(3)The impact of free cash flow on financing constraints is weaker in state-owned enterprises compared to non-state-owned enterprises.The findings of this paper imply that free cash flow can have a significant impact on corporate financing activities.Therefore,enterprises should pay more attention to their cash flow indicators,signaling their operational stability and risk management capabilities to the outside world,thereby reducing the level of financing constraints faced by the enterprise.
基金Supported by the Teaching Reform Project of Guangxi University of Finance and Economics(2024XJJGYB21)。
文摘In the era of digital economy,data and intelligent algorithms are driving profound changes in the economic field,which also presents new challenges for the cultivation of MPAcc talents.This paper focuses on this issue,analyzing the deficiencies in the current MPAcc talent cultivation system in terms of curriculum design,teaching methods,faculty teams,and school-enterprise cooperation.At the same time,it deeply analyzes the reconstruction requirements for accounting talent education in the digital economy era in terms of knowledge structure,comprehensive ability,and professional quality.Taking the University of Malaya as a case study,this paper analyzes the key points of its MPAcc education reform,including innovative curriculum design,the adoption of diversified teaching methods,optimization of faculty team construction,and deepening of school-enterprise cooperation.It also provides specific optimization paths,such as improving the dual-mentor system,promoting the construction of practice bases,integrating professional qualification certification,and broadening international horizons.This paper aims to provide ideas for the reconstruction and model optimization of China's accounting talent cultivation system,helping the accounting industry achieve transformation and upgrading.
基金supported by the National Key Research and Development Program of China (No.2023YFC3708005)the National Natural Science Foundation of China (Nos.21872102,22172080)the Fundamental Research Funds for the Central Universities (Nankai University,No.63241208)。
文摘Groundwater is a key part of the terrestrial ecosystem,but it is vulnerable to pollution in the context of chemical industry development.Treating contaminated groundwater is challenging due to its stable water quality,hidden contamination,and complex treatment requirements.Current research focuses on advanced treatment technologies,among which the advanced oxidation process(AOPs) of peroxomonosulfate(PMS) has great potential.Although there are many reviews of PMS-based AOP,most of them focus on surface water.This review aims to explore the activation reaction of PMS to groundwater by in-situ chemical oxidation(ISCO) technology,further study the reaction mechanism,compare the treatment effect of characteristic pollutants in the groundwater of the chemical industry park,propose new activation methods and catalyst selection,and provide guidance for future groundwater treatment research.
基金supported by the National Key Research and Development Program of China (Grant No. 2021YFA1401200)the National Natural Science Foundation of China (Grant Nos. 61971437, 92050117, and U21A20140)+2 种基金the Beijing Outstanding Young Scientist Program (Grant No.BJJWZYJH01201910007022)the Natural Science Foundation of Shaanxi Province (Grant Nos. 2020JM-342, and 2022JM-352)the Beijing Institute of Technology Research Fund Program for Young Scholars (Grant No. XSQD-201904005)。
文摘Chirality, as one of the ubiquitous properties in nature, has aroused striking attention in the fields of physics and materials sciences. For tailoring of light with more degree of freedom, circular dichroism has been considered as the auxiliary dimension to improving such an issue. Inspired by the Born-Kuhn plasmonic oscillation model, we demonstrate and discuss a chiral resonator to reveal reverse circular dichroism within two separate frequency bands in the microwave regime. The underlying physical mechanisms of bonding and anti-bounding modes are analyzed via transmission/reflection spectra and surface current distributions for different chiral enantiomers. To leverage the proposed paradigm to the application levels, especially for metaholography, we conduct the numerical simulation and experimental demonstration of two proofs of principles. Based on the Pancharatnam-Berry phase/amplitude modulation and complex-amplitude manipulation, respectively, the meta-holograms with independent targets of reconstructing images in full-space and reflected regions are achieved. Significantly, our paradigm may promise further applications in spin-controlled meta-devices for image processing, information encryption, anti-counterfeiting,remote sensing, and radar systems.
