Objectives: To evaluate the efficacy of large loop excision of the transformat ion zone (LLETZ) combined with a single application of the cone probe of a Semm Cold Coagulator as a new treatment for women with cervical...Objectives: To evaluate the efficacy of large loop excision of the transformat ion zone (LLETZ) combined with a single application of the cone probe of a Semm Cold Coagulator as a new treatment for women with cervical intraepithelial neopl asia (CIN). Methods: Retrospective case-record review of 666 women treated with large loop excision and cold coagulation (LLECC) from 1992 to 2000. Results: Of the women who had high-grade CIN at their initial consultation, 4.2%had abnor mal cytologic results 6 months after treatment and 0.6%had abnormal cytologic r esults at 12 months. Of the women who had low-grade CIN at initial presentation , 3.8%had abnormal cytologic results 6 months after treatment and none (0%) at 12 months. Furthermore, there were no reported cases of cervical cancer in this cohort of women during the follow-up period. Short-term bleeding complication s (within 24 h of the proce-dure) occurred in 1%of the women assessed. Conclus ions: Large loop excision combined with cold coagulation is a new and effective treatment for CIN. Randomized controlled trials are required to confirm these fi ndings and determine the longterm safety of the technique.展开更多
文摘Objectives: To evaluate the efficacy of large loop excision of the transformat ion zone (LLETZ) combined with a single application of the cone probe of a Semm Cold Coagulator as a new treatment for women with cervical intraepithelial neopl asia (CIN). Methods: Retrospective case-record review of 666 women treated with large loop excision and cold coagulation (LLECC) from 1992 to 2000. Results: Of the women who had high-grade CIN at their initial consultation, 4.2%had abnor mal cytologic results 6 months after treatment and 0.6%had abnormal cytologic r esults at 12 months. Of the women who had low-grade CIN at initial presentation , 3.8%had abnormal cytologic results 6 months after treatment and none (0%) at 12 months. Furthermore, there were no reported cases of cervical cancer in this cohort of women during the follow-up period. Short-term bleeding complication s (within 24 h of the proce-dure) occurred in 1%of the women assessed. Conclus ions: Large loop excision combined with cold coagulation is a new and effective treatment for CIN. Randomized controlled trials are required to confirm these fi ndings and determine the longterm safety of the technique.
