Dear Editor,Although primary metabolism is assumed to be highly evolutionarily conserved in plants,specialized metabolism is more prone to active diversification to allow adaptation to changing environments.Notably,th...Dear Editor,Although primary metabolism is assumed to be highly evolutionarily conserved in plants,specialized metabolism is more prone to active diversification to allow adaptation to changing environments.Notably,this diversification results from core metabolic enzyme hijacking or gene duplication events that are highly prevalent in plants,as observed for cytochrome P450s.展开更多
Synthetic biology is constantly making progress for producing compounds on demand.Recently,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisom...Synthetic biology is constantly making progress for producing compounds on demand.Recently,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal membrane.This allowed access to an untapped resource of acetyl-CoA and stimulated the synthesis of a valuable polyketide.展开更多
基金supported by the Agence Nationale de la Recherche(ANR,project MIACYC-ANR-20-CE43-0010)the Région Centre-Val de Loire(ARP-IR ScaleBio project)the European Union’s Horizon Europe Framework(project COMBO under agreement N°101135438).
文摘Dear Editor,Although primary metabolism is assumed to be highly evolutionarily conserved in plants,specialized metabolism is more prone to active diversification to allow adaptation to changing environments.Notably,this diversification results from core metabolic enzyme hijacking or gene duplication events that are highly prevalent in plants,as observed for cytochrome P450s.
基金funding from the EU Horizon 2020 research and innovation program(MIAMi project-Grant agreement N°814645)ARD-CVL Biopharmaceutical program of the Region Centre Val de Loire(ETOPOCentre project),Le Studium Institute(Consortium Fellowship)and ANR(project MIACYC-ANR-20-CE43-0010).
文摘Synthetic biology is constantly making progress for producing compounds on demand.Recently,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal membrane.This allowed access to an untapped resource of acetyl-CoA and stimulated the synthesis of a valuable polyketide.
